Patents by Inventor William J. Harrison
William J. Harrison has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20090098057Abstract: A nanoparticulate imaging probe with an oxide core, a biocompatible polymeric shell covalently attached to the oxide core, a dye, and a cleavable spacer that covalently binds the dye to the probe. When the spacer is cleaved, the dye is liberated from the probe. The emissions of the dye are quenched when the dye is bound to the probe and not quenched when the dye is liberated from the probe. The spacer can be, for example, a peptide. The oxide core can be, for example, a silicon oxide core.Type: ApplicationFiled: October 16, 2007Publication date: April 16, 2009Inventors: Shiying Zheng, Lijun Dai, Ruizheng Wang, Tiecheng A. Qiao, Wenyi Che, William J. Harrison
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Publication number: 20080206886Abstract: The present invention relates to a diagnostic contrast agent comprising a water dispersible, near-infrared tricarbocyanine, enamine-functionalized dye having a Stoke shift of greater than 50 and represented by five general formulae. The present invention also relates to a method for making a dye-conjugate utilizing the novel dye and a method of identifying a biological compound using the novel dye conjugate.Type: ApplicationFiled: February 28, 2007Publication date: August 28, 2008Inventors: Ruizheng Wang, John W. Harder, David A. Stegman, William J. Harrison, Hans F. Schmitthenner
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Publication number: 20080181965Abstract: The present invention relates to a loaded latex particle comprising a latex material made from a mixture represented by formula (X)m-(Y)n-(Z)o-(W)p, wherein Y is at least one monomer with at least two ethylenically unsaturated chemical functionalities; Z is at least one polyethylene glycol macromonomer with an average molecular weight of between 300 and 10,000; W is an ethylenic monomer different from X, Y, or Z; and X is at least one water insoluble, alkoxethyl containing monomer; and m, n, o, and p are the respective weight percentages of each monomer. The particle may be loaded with a fluorescent dye.Type: ApplicationFiled: April 3, 2007Publication date: July 31, 2008Inventors: Jeffrey W. Leon, William J. Harrison, Brian J. Kelley, James R. Bennett, David A. Stegman, Ruizheng Wang, John W. Harder
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Patent number: 7384545Abstract: A fluid container and method for inhibiting the growth of microbes in liquid nutrient in a container, the container having an interior surface having a metal-ion sequestering agent and/or antimicrobial agent provided in a localized area of the container formed by a two shot molding, insert molding or two shot injection stretch blow molding process, said metal ion sequestering agent provided for the removing and/or inhibiting growth of microbes in the liquid nutrient.Type: GrantFiled: November 10, 2004Date of Patent: June 10, 2008Assignee: Eastman Kodak CompanyInventors: David L. Patton, Joseph F. Bringley, Richard W. Wien, John M. Pochan, Yannick J. F. Lerat, William J. Harrison
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Patent number: 7344549Abstract: A self-expanding cage for use in conjunction with an embolic filtering device includes a circumferential member adapted to expand from an unexpanded position to a expanded position within the patient's body vessel. A proximal strut and distal strut are attached to the circumferential member to form the cage. A plurality of proximal and distal struts may be attached the circumferential member. Additionally, a second circumferential member can be attached to the first circumferential member. Each circumferential member can be connected by a single or a plurality of connecting struts. One embodiment of the cage utilizes a single wire to form to the cage. A delivery system attached to the single wire cage moves the cage and its associated filter element between the expanded and unexpanded positions through relative movement of the distal delivery system.Type: GrantFiled: January 31, 2002Date of Patent: March 18, 2008Assignee: Advanced Cardiovascular Systems, Inc.Inventors: William J. Boyle, William J. Harrison, Benjamin C. Huter, Scott J. Huter, Paul F. Muller, John E. Papp
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Patent number: 7252675Abstract: An expandable frame for an embolic filtering device used to capture embolic debris in a body vessel includes a first half frame having a first control arm connected to a second control arm by a partial loop and a second half frame having a first control arm connected to a second control arm by a partial loop. The partial loops cooperatively form a composite loop for attachment of a filtering element which will expand in the body vessel to capture embolic debris entrained in the fluid of the vessel. The lengths and positioning of the first and second control arms of each half frame can be varied to create an expandable frame which conforms to the size and shape of the body vessel in which the filtering device is deployed. Additionally, the radius of the partial loops, along with the length of the arc of the partial loops, can be varied on each of the frames to create a composite filtering assembly that can easily adapt to the size and shape of the body vessel.Type: GrantFiled: September 30, 2002Date of Patent: August 7, 2007Assignee: Advanced Cardiovascular, Inc.Inventors: Andy E. Denison, William J. Harrison, Benjamin C. Huter, Scott J. Huter, John E. Papp, Steven T. Saville, Kent C. B. Stalker
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Patent number: 7097651Abstract: A basket for an embolic protection filtering device to be deployed within a body lumen for capturing embolic debris is disclosed. In one embodiment, a strut pattern forming the basket includes V-shaped struts having an internal radius at the apex with a kerf on each strut arm beginning at the radius and extending toward an opposite end of the strut. The apex may have a bulbous shape. In another embodiment, the strut arms of the basket include undulations. Also, the apices may be situated so that one apex is longitudinally staggered from an adjacent apex. The combination of features enables the basket to be crimped to a small profile while distributing stress away from the apices of the V's in the strut pattern.Type: GrantFiled: September 6, 2001Date of Patent: August 29, 2006Assignee: Advanced Cardiovascular Systems, Inc.Inventors: William J. Harrison, Anuja H. Patel
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Patent number: 6794121Abstract: This invention relates to a method of spectrally sensitizing a silver halide emulsion comprising the following steps in the following order a) providing a silver halide emulsion comprising tabular silver halide grains having an inner dye layer adjacent to the silver halide grain, said dye layer comprising at least one dye (Dye 1) that is capable of spectrally sensitizing silver halide, b) adding to the emulsion at least one dye (Dye 2) capable of providing a second dye layer adjacent to the inner dye layer, and c) adding to the emulsion a non-cationic surfactant or a scavenger for oxidized developer, or a combination of the two, to form a silver halide emulsion comprising silver halide grains having associated therewith two dye layers, wherein the dye layers are held together by non-covalent forces or by in situ bond formation; the outer dye layer adsorbs light at equal or higher energy than the inner dye layer; and the energy emission wavelength of the outer dye layer overlaps with the energy absorptionType: GrantFiled: January 17, 2003Date of Patent: September 21, 2004Assignee: Eastman Kodak CompanyInventors: David R. Foster, Stephen P. Singer, William J. Harrison, Alan R. Pitt
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Patent number: 6790602Abstract: This invention relates to a method of spectrally sensitizing a silver halide emulsion comprising the following steps in the following order a) providing a silver halide emulsion comprising tabular silver halide grains having an inner dye layer adjacent to the silver halide grain, said dye layer comprising at least one dye (Dye 1) that is capable of spectrally sensitizing silver halide, b) adding to the emulsion at least one dye (Dye 2) capable of providing a second dye layer adjacent to the inner dye layer, and c) adding to the emulsion a non-cationic surfactant or a scavenger for oxidized developer, or a combination of the two, to form a silver halide emulsion comprising silver halide grains having associated therewith two dye layers, wherein the dye layers are held together by non-covalent forces or by in situ bond formation; the outer dye layer adsorbs light at equal or higher energy than the inner dye layer; and the energy emission wavelength of the outer dye layer overlaps with the energy absorptionType: GrantFiled: January 17, 2003Date of Patent: September 14, 2004Assignee: Eastman Kodak CompanyInventors: David R. Foster, Stephen P. Singer, William J. Harrison, Alan R. Pitt
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Patent number: 6787297Abstract: This invention provides a silver halide photographic element comprising at least one silver halide emulsion comprising silver halide grains which have associated therewith at least an inner dye layer and an outer dye layer wherein the outer dye layer comprises a dye having at least one substituent that has a positive charge, said photographic element further comprising a cyanine dye of formula (I) or (II) (as described in the specification) that is capable of spectrally sensitizing a silver halide emulsion.Type: GrantFiled: May 12, 2003Date of Patent: September 7, 2004Assignee: Eastman Kodak CompanyInventors: Steven G. Link, Richard L. Parton, Robert D. Wilson, Roger A. Bryant, William J. Harrison
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Publication number: 20040146817Abstract: This invention relates to a method of spectrally sensitizing a silver halide emulsion comprising the following steps in the following orderType: ApplicationFiled: January 17, 2003Publication date: July 29, 2004Inventors: David R. Foster, Stephen P. Singer, William J. Harrison, Alan R. Pitt
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Publication number: 20040142290Abstract: This invention relates to a method of spectrally sensitizing a silver halide emulsion comprising the following steps in the following orderType: ApplicationFiled: January 17, 2003Publication date: July 22, 2004Inventors: David R. Foster, Stephen P. Singer, William J. Harrison, Alan R. Pitt
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Publication number: 20040093009Abstract: An expandable frame for an embolic filtering device used to capture embolic debris in a body vessel includes a first half frame having a first control arm connected to a second control arm by a partial loop and a second half frame having a first control arm connected to a second control arm by a partial loop. The partial loops cooperatively form a composite loop for attachment of a filtering element which will expand in the body vessel to capture embolic debris entrained in the fluid of the vessel. The lengths and positioning of the first and second control arms of each half frame can be varied to create an expandable frame which conforms to the size and shape of the body vessel in which the filtering device is deployed. Additionally, the radius of the partial loops, along with the length of the arc of the partial loops, can be varied on each of the frames to create a composite filtering assembly that can easily adapt to the size and shape of the body vessel.Type: ApplicationFiled: September 30, 2002Publication date: May 13, 2004Inventors: Andy E. Denison, William J. Harrison, Benjamin C. Huter, Scott J. Huter, John E. Papp, Steven T. Saville, Kent C.B. Stalker
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Patent number: 6620581Abstract: This invention comprises a silver halide photographic material comprising at least one silver halide emulsion comprising silver halide grains having associated therewith at least two dyes: (a) a first dye that has at least one anionic substituent and that is capable of spectrally sensitizing a silver halide emulsion; and (b) a second dye that absorbs light at an equal or shorter wavelength than the first dye and that has at least one cationic substituent and that is highly fluorescent.Type: GrantFiled: October 16, 2000Date of Patent: September 16, 2003Assignee: Eastman Kodak CompanyInventors: Richard L. Parton, Joseph C. Deaton, William J. Harrison, Margaret J. Helber
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Patent number: 6605110Abstract: The invention is directed to an expandable self-expanding stent for implantation in a body lumen, such as an artery. The stent is made with a plurality of cylindrical elements which are interconnected by a plurality of interconnecting members which connect adjacent cylindrical elements, some of the interconnecting members have one or more bending points formed therein for promoting the bendability of the interconnecting member. The bending point can be formed by reducing the strut wall thickness of the interconnecting member to promote the bending of the strut or it can be formed by reducing the strut width of the interconnecting member, or a combination of both. The bending points on the interconnecting member enhances the bendability and flexibility of the composite stent device by creating mechanical hinges which help to bend the stent as it is delivered through the tortuous anatomy of the patient or conforms to a curved portion of a body vessel, where the stent may be implanted.Type: GrantFiled: June 29, 2001Date of Patent: August 12, 2003Assignee: Advanced Cardiovascular Systems, Inc.Inventor: William J. Harrison
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Publication number: 20030144685Abstract: A self-expanding cage for use in conjunction with an embolic filtering device includes a circumferential member adapted to expand from an unexpanded position to a expanded position within the patient's body vessel. A proximal strut and distal strut are attached to the circumferential member to form the cage. A plurality of proximal and distal struts may be attached the circumferential member. Additionally, a second circumferential member can be attached to the first circumferential member. Each circumferential member can be connected by a single or a plurality of connecting struts. One embodiment of the cage utilizes a single wire to form to the cage. A delivery system attached to the single wire cage moves the cage and its associated filter element between the expanded and unexpanded positions through relative movement of the distal delivery system.Type: ApplicationFiled: January 31, 2002Publication date: July 31, 2003Inventors: William J. Boyle, William J. Harrison, Benjamin C. Huter, Scott J. Huter, Paul F. Muller, John E. Papp
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Patent number: 6558893Abstract: This invention comprises a silver halide photographic material comprising at least one silver halide emulsion comprising silver halide grains having associated therewith a combination of two or more dyes comprising: (a) a first dye which is a cyanine dye of formula Ia and has a net charge of zero or −1 wherein the substituents are as defined in the specification; (b) a second dye which has at least one substituent that has a positive charge, and is a cyanine dye a merocyanine dye, arylidene dye, complex cyanine dye, complex merocyanine dye, homopolar cyanine dye, hemicyanine dye, styryl dye, hemioxonol dye, oxonol dye, anthraquinone dye, triphenylmethane dye, azo dye type, azomethines, or a coumarin dye, with the proviso that if the second dye is a cyanine dye, it is of formula IIa: wherein the substituents are as defined in the specification; and wherein (c) the wavelength of maximum light absorption, in nanometers (nm), of the first dye and the waveleType: GrantFiled: November 17, 2000Date of Patent: May 6, 2003Assignee: Eastman Kodak CompanyInventors: Richard L. Parton, Andrei Andrievsky, Thomas L. Penner, William J. Harrison
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Publication number: 20030045898Abstract: A basket for an embolic protection filtering device to be deployed within a body lumen for capturing embolic debris is disclosed. In one embodiment, a strut pattern forming the basket includes V-shaped struts having an internal radius at the apex with a kerf on each strut arm beginning at the radius and extending toward an opposite end of the strut. The apex may have a bulbous shape. In another embodiment, the strut arms of the basket include undulations. Also, the apices may be situated so that one apex is longitudinally staggered from an adjacent apex. The combination of features enables the basket to be crimped to a small profile while distributing stress away from the apices of the V's in the strut pattern.Type: ApplicationFiled: September 6, 2001Publication date: March 6, 2003Inventors: William J. Harrison, Anuja H. Patel
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Patent number: 6527977Abstract: This invention comprises dispersion comprising a solvent having dispersed therein a liquid-crystal forming dye of structural Formula I: [D-(X)m]-(Y)n wherein: D is a light-absorbing chromophore other than a cyanine dye or a barbituric acid oxonol dye; each Y contains an ionic or a nonionic solubilizing substituent or a group with a pKa value of less than 4 in water; each X is a nonionic substituent; n is 0 to 10; m is 0-10; and the resulting dye forms a liquid-crystalline phase in solvent. The dispersion is particularly useful in imaging and photographic elements.Type: GrantFiled: January 12, 2001Date of Patent: March 4, 2003Assignee: Eastman Kodak CompanyInventors: Margaret J. Helber, William J. Harrison, Raymond P. Scaringe
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Publication number: 20030014101Abstract: The invention is directed to an expandable self-expanding stent for implantation in a body lumen, such as an artery. The stent is made with a plurality of cylindrical elements which are interconnected by a plurality of interconnecting members which connect adjacent cylindrical elements, some of the interconnecting members have one or more bending points formed therein for promoting the bendability of the interconnecting member. The bending point can be formed by reducing the strut wall thickness of the interconnecting member to promote the bending of the strut or it can be formed by reducing the strut width of the interconnecting member, or a combination of both. The bending points on the interconnecting member enhances the bendability and flexibility of the composite stent device by creating mechanical hinges which help to bend the stent as it is delivered through the tortuous anatomy of the patient or conforms to a curved portion of a body vessel, where the stent may be implanted.Type: ApplicationFiled: June 29, 2001Publication date: January 16, 2003Inventor: William J. Harrison