Abstract: Devices used to cue a user to take a step when experiencing a walking disorder, such as a freezing of gait episode, are disclosed. The devices are configured to cue the user with a visual and/or audible cue. The devices include an activation module and a cueing module. The cueing module includes a metronome and a laser light source. The devices are mounted on an assistive mobility device or on the user.

Abstract: The present invention relates to a class of N-cyanopyrrolidines with activity as inhibitors of the deubiquitylating enzyme USP30, having utility in a variety of therapeutic areas, including conditions involving mitochondrial dysfunction, cancer and fibrosis: Formula (I), Formula (II).

Abstract: Devices used to cue a user to take a step when experiencing a walking disorder, such as a freezing of gait episode, are disclosed. The devices are configured to cue the user with a visual and/or audible cue. The devices include an activation module and a cueing module. The cueing module includes a metronome and a laser light source. The devices are mounted on an assistive mobility device or on the user.

Abstract: An apparatus includes a surge protection device, a current sensor configured to sense a current through the surge protection device, and a surge discriminator circuit coupled to the current sensor and configured to discriminate among a plurality of surge levels for the surge protective device responsive to the sensed current. The current sensor may include a current transformer configured to generate a secondary current responsive to the sensed current and the surge discriminator circuit may be configured to discriminate among a plurality of surge levels responsive to the generated secondary current.

Abstract: One embodiment provides an electronic circuit device, including: a first electronic circuit board; a second electronic circuit board separated from the first electronic circuit board; at least one capacitor including two electrodes, wherein one of the two electrodes is mounted to the first electronic circuit board and wherein the other of the two electrodes is mounted to the second electronic circuit board; and at least one connector electrically coupled to at least one of the first electronic circuit board and the second electronic circuit board. Other aspects are described and claimed.

Abstract: The present invention relates to a class of N-cyanopyrrolidines with activity as inhibitors of the deubiquitylating enzyme USP30, having utility in a variety of therapeutic areas, including conditions involving mitochondrial dysfunction, cancer and fibrosis.

Abstract: Provided are systems and methods for improving movement irregularities.

Abstract: Presented systems and methods facilitate efficient and effective generation and delivery of radiation. In one embodiment, an accelerator system includes a particle source, an acceleration portion, a high intensity target, and a target location control component. The particle source is configured to generate charged particles. The acceleration portion is configured to accelerate the charged particles. The high intensity target is configured to generate Bremsstrahlung radiation in response to impact by the charged particles. The target location control component configured to change the location of charged particle impacts on the high intensity target. In one exemplary implementation the change of location of charged particle impact is based on thermal diffusion and said location of charged particle impacts is moved at a rate greater than a rate of diffusion of detrimental heat impacts on the high intensity target.

Abstract: Presented systems and methods facilitate efficient and effective generation and delivery of radiation. In one embodiment, a radiation system includes a patient station, wherein the patient station includes a plurality of accelerator systems, and a microwave generation system configured to generate microwaves for the plurality of accelerators. The plurality of accelerators can be configured to provide substantially simultaneous multiple radiation beams from the plurality of accelerators. In one exemplary implementation, the microwave generation system includes a plurality of radio frequency (RF) sources, wherein respective ones of the plurality of RF sources generate separate microwave signals for corresponding respective ones of the plurality of accelerator systems, and a plurality of modulators, wherein respective ones of the plurality of modulators modulate generation of the separate microwave signals by the respective ones of the plurality of RF sources.

Abstract: Presented systems and methods facilitate efficient and effective generation and delivery of radiation. In one embodiment, a radiation generation component includes a high intensity target that produces Bremsstrahlung radiation in response to impacts by charged particles, wherein the high intensity target is configured with operating limitations based primarily on catastrophic failure mechanisms rather than fatigue failure mechanisms. The high intensity target is configured to be compatible with a loading system of a radiation generation system. The high intensity target can have a catastrophic failure strain percentage in the range of 0.5 to 4.0 percent. The catastrophic failure mechanisms can include at least one selected from the group comprising ultimate tensile strength, fracture strain, and melting point. The high intensity target can have a product life in a low cycle fatigue regime range. The high intensity target can comprise a material with a melting temperature in the range of 800 C to 3,700 C.

Abstract: Gearboxes for a skid steered vehicle including layouts in which all electric propulsion drive motors and electric steering motors are located on one side of the gearbox, and layouts in which the drive inputs of the electric propulsion drive motors are located face to face. Gear change units and gear packaging configurations suitable for such gearboxes.

Abstract: A drive unit for a skid steered vehicle includes a controlled differential positioned between two shafts. The end of each shaft forms an output of the drive unit connected directly to the differential outputs via the shafts. A steer motor is in driveable communication with the differential, and an electric propulsion motor is in driveable communication with the shaft outputs. A gear reduction unit, and optional gear change unit, is positioned between the differential and the electric propulsion motor. The electric propulsion motor, the gear reduction unit and optional gear change unit are connected in a parallel connection with an output of the differential to the shaft outputs. The optional gear change unit includes an epicyclic gear reduction unit having an input and an output which provides drive input from the gear change unit to the shaft.

Abstract: An apparatus includes a surge protection device, a current sensor configured to sense a current through the surge protection device, and a surge discriminator circuit coupled to the current sensor and configured to discriminate among a plurality of surge levels for the surge protective device responsive to the sensed current. The current sensor may include a current transformer configured to generate a secondary current responsive to the sensed current and the surge discriminator circuit may be configured to discriminate among a plurality of surge levels responsive to the generated secondary current.

Abstract: A pin grabber coupler and method for locking and unlocking a tool to a machine is disclosed. The pin grabber coupler may comprise a tertiary lock configured to pivot between an unlocked TL position and a locked TL position. The tertiary lock may include a first and second shoulders, a leg, a tab, a latch, a bias member and a detent. The bias member may be configured to exert a biasing force on the tertiary lock to urge the tertiary lock to the locked TL position. The detent may be configured to exert, when in a hold position, a holding force against the latch that is greater than the biasing force exerted by the bias member. When the detent is in a release position, the holding force applied by the detent against the latch is less than the biasing force applied by the bias member.

Abstract: A method of enhancing a resolution of an EDS image of a sample includes generating an EDS image of the sample, generating a non-EDS image of the sample generating, using a machine learning algorithm, an enhanced resolution EDS image of the sample based on the generated feature map and based on the first EDS image, where a resolution of the enhanced resolution EDS image is higher than a resolution of the first EDS image.

Abstract: The present invention relates to a class of substituted-cyanopyrrolidines with activity as inhibitors of the deubiquitylating enzyme USP30, having utility in a variety of therapeutic areas, including conditions involving mitochondrial dysfunction, cancer and fibrosis: (I).

Abstract: A method for forming a hydrophobic coating on a substrate by a thermal spray deposition process is described. The method may comprise feeding a thermal spray apparatus with a coating precursor consisting of particles having an initial particle morphology, and heating the particles with the thermal spray apparatus to cause the particle to at least partially melt. The method may further comprise accelerating the particles towards the substrate, and forming the hydrophobic coating on the substrate by allowing the particles to impact the substrate in a partially melted state in which a fraction of the initial particle morphology of at least some of the particles is retained.

Abstract: A touchless skin sanitization system, device and method. The sanitizing device is configurable to sense an object and radiate the sensed object with UV light for a predetermined amount of time. A touchless switch activates the sanitizing device upon sensing the object, while a timer deactivates the sanitizing device after the predetermined amount of time. The sanitizing device provides an outer cover adapted to move between a closed condition and an open condition for maintenance. The outer cover is also adapted to mount the sanitizing device in a downward orientation relative to the UV radiating device.

Abstract: Some embodiments are directed to an electric hub drive with a braking assembly. The hub drive includes a housing; a rotary drive transmission system mounted within the housing; and a braking assembly positioned within the housing. The braking assembly includes a braking formation that is coupled to be rotationally driven by the rotary drive transmission system. Advantageously or preferably, the braking formation is coupled to be rotationally driven by a part of the rotary drive transmission system that has a higher angular velocity than the output shaft. This enables the braking formation to rotate at a faster speed than the wheel hub.

Abstract: A method for automated cleaning of an immersion tank (14) includes: substantially enclosing an interior volume (30) of the immersion tank (14); increasing the temperature and humidity in the interior volume (30) of the immersion tank (14); then applying cleaning solution to interior surfaces of the immersion tank (14); and rinsing the cleaning solution and soil off the interior surfaces of the immersion tank (14).