Patents by Inventor Wilson Romero Caparros-Wanderley
Wilson Romero Caparros-Wanderley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230233660Abstract: The present specification discloses recombinant nucleic acid constructs encoding an immunogenic multiepitope polypeptide comprising two or more polypeptides, recombinant nucleic acid constructs encoding at least two epitopes from two or more internal proteins of influenza virus, compositions comprising such recombinant nucleic acid constructs and methods of eliciting a T cell immune response against an influenza virus in a vertebrate using such recombinant nucleic acid constructs and compositions.Type: ApplicationFiled: September 9, 2022Publication date: July 27, 2023Applicant: PepTcell LimitedInventors: Gregory A. Stoloff, Wilson Romero Caparros-Wanderley
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Patent number: 11439702Abstract: The present specification discloses recombinant nucleic acid constructs encoding an immunogenic multiepitope polypeptide comprising two or more polypeptides, recombinant nucleic acid constructs encoding at least two epitopes from two or more internal proteins of influenza virus, compositions comprising such recombinant nucleic acid constructs and methods of eliciting a T cell immune response against an influenza virus in a vertebrate using such recombinant nucleic acid constructs and compositions.Type: GrantFiled: September 4, 2020Date of Patent: September 13, 2022Assignee: PepTcell LimitedInventors: Gregory A. Stoloff, Wilson Romero Caparros-Wanderley
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Publication number: 20200397889Abstract: The present specification discloses recombinant nucleic acid constructs encoding an immunogenic multiepitope polypeptide comprising two or more polypeptides, recombinant nucleic acid constructs encoding at least two epitopes from two or more internal proteins of influenza virus, compositions comprising such recombinant nucleic acid constructs and methods of eliciting a T cell immune response against an influenza virus in a vertebrate using such recombinant nucleic acid constructs and compositions.Type: ApplicationFiled: September 4, 2020Publication date: December 24, 2020Applicant: PepTcell LimitedInventors: Gregory A. Stoloff, Wilson Romero Caparros-Wanderley
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Patent number: 10765734Abstract: The present specification discloses recombinant nucleic acid constructs encoding an immunogenic multiepitope polypeptide comprising two or more polypeptides, recombinant nucleic acid constructs encoding at least two epitopes from two or more internal proteins of influenza virus, compositions comprising such recombinant nucleic acid constructs and methods of eliciting a T cell immune response against an influenza virus in a vertebrate using such recombinant nucleic acid constructs and compositions.Type: GrantFiled: March 7, 2019Date of Patent: September 8, 2020Assignee: PepTcell LimitedInventors: Gregory A. Stoloff, Wilson Romero Caparros-Wanderley
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Publication number: 20190365883Abstract: The present specification discloses recombinant nucleic acid constructs encoding an immunogenic multiepitope polypeptide comprising two or more polypeptides, recombinant nucleic acid constructs encoding at least two epitopes from two or more internal proteins of influenza virus, compositions comprising such recombinant nucleic acid constructs and methods of eliciting a T cell immune response against an influenza virus in a vertebrate using such recombinant nucleic acid constructs and compositions.Type: ApplicationFiled: August 14, 2019Publication date: December 5, 2019Applicant: PepTcell LimitedInventors: Gregory A. Stoloff, Wilson Romero Caparros-Wanderley
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Publication number: 20190201519Abstract: The present specification discloses recombinant nucleic acid constructs encoding an immunogenic multiepitope polypeptide comprising two or more polypeptides, recombinant nucleic acid constructs encoding at least two epitopes from two or more internal proteins of influenza virus, compositions comprising such recombinant nucleic acid constructs and methods of eliciting a T cell immune response against an influenza virus in a vertebrate using such recombinant nucleic acid constructs and compositions.Type: ApplicationFiled: March 7, 2019Publication date: July 4, 2019Applicant: PepTcell LimitedInventors: Gregory A. Stoloff, Wilson Romero Caparros-Wanderley
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Patent number: 10335480Abstract: The present specification discloses recombinant nucleic acid constructs encoding an immunogenic multiepitope polypeptide comprising two or more polypeptides, recombinant nucleic acid constructs encoding at least two epitopes from two or more internal proteins of influenza virus, compositions comprising such recombinant nucleic acid constructs and methods of eliciting a T cell immune response against an influenza virus in a vertebrate using such recombinant nucleic acid constructs and compositions.Type: GrantFiled: January 22, 2018Date of Patent: July 2, 2019Assignee: PepTcell LimitedInventors: Gregory A. Stoloff, Wilson Romero Caparros-Wanderley
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Patent number: 10279032Abstract: The present specification discloses recombinant nucleic acid constructs encoding an immunogenic multiepitope polypeptide comprising two or more polypeptides, recombinant nucleic acid constructs encoding at least two epitopes from two or more internal proteins of influenza virus, compositions comprising such recombinant nucleic acid constructs and methods of eliciting a T cell immune response against an influenza virus in a vertebrate using such recombinant nucleic acid constructs and compositions.Type: GrantFiled: January 8, 2018Date of Patent: May 7, 2019Assignee: PepTcell LimitedInventors: Gregory A. Stoloff, Wilson Romero Caparros-Wanderley
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Publication number: 20180185470Abstract: The present specification discloses recombinant nucleic acid constructs encoding an immunogenic multiepitope polypeptide comprising two or more polypeptides, recombinant nucleic acid constructs encoding at least two epitopes from two or more internal proteins of influenza virus, compositions comprising such recombinant nucleic acid constructs and methods of eliciting a T cell immune response against an influenza virus in a vertebrate using such recombinant nucleic acid constructs and compositions.Type: ApplicationFiled: January 22, 2018Publication date: July 5, 2018Applicant: PepTcell LimitedInventors: Gregory A. Stoloff, Wilson Romero Caparros-Wanderley
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Publication number: 20180147277Abstract: The present specification discloses recombinant nucleic acid constructs encoding an immunogenic multiepitope polypeptide comprising two or more polypeptides, recombinant nucleic acid constructs encoding at least two epitopes from two or more internal proteins of influenza virus, compositions comprising such recombinant nucleic acid constructs and methods of eliciting a T cell immune response against an influenza virus in a vertebrate using such recombinant nucleic acid constructs and compositions.Type: ApplicationFiled: January 8, 2018Publication date: May 31, 2018Applicant: PepTcell LimitedInventors: Gregory A. Stoloff, Wilson Romero Caparros-Wanderley
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Patent number: 9889191Abstract: Provided is a polypeptide having no more than 100 amino acids, which polypeptide comprises one or more sequences having at least 60% homology with any of SEQ ID 1-6, or comprises two or more epitopes having 7 amino acids or more, each epitope having at least 60% homology with a sub-sequence of any of SEQ ID 1-6 that has the same length as the epitope: SEQ?ID?1 DLEALMEWLKTRPILSPLTKGILGFVFTLTVP SEQ?ID?2 LLYCLMVMYLNPGNYSMQVKLGTLCALCEKQASHS SEQ?ID?3 DLIFLARSALILRGSVAHKSC SEQ?ID?4 PGIADIEDLTLLARSMVVVRP SEQ?ID?5 LLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQ SEQ?ID?6 IIGILHLILWILDRLFFKCIYRLF wherein, the polypeptide is immunogenic in a vertebrate expressing a major histocompatibility complex (MHC) allele, and wherein the polypeptide is not a complete influenza virus protein.Type: GrantFiled: August 8, 2016Date of Patent: February 13, 2018Assignee: PepTcell LimitedInventors: Gregory Alan Stoloff, Wilson Romero Caparros-Wanderley
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Publication number: 20170049702Abstract: A composition comprising liposomes associated with a nucleic acid operatively encoding an antigenic protein and with an assistor protein, wherein the assistor protein shares at least one epitope with the antigenic protein, and wherein the nucleic acid and said assistor protein are associated with the same liposomes is described. The composition provides an improved immune response compared to mixtures of liposomes some of which are associated with the nucleic acid and some of which are associated with the assistor protein.Type: ApplicationFiled: November 8, 2016Publication date: February 23, 2017Applicant: Lipoxen Technologies LimitedInventors: Andrew David Bacon, Peter Laing, Gregory Gregoriadis, Wilson Romero Caparros-Wanderley
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Publication number: 20170028053Abstract: Provided is a polypeptide having no more than 100 amino acids, which polypeptide comprises one or more sequences having at least 60% homology with any of SEQ ID 1-6, or comprises two or more epitopes having 7 amino acids or more, each epitope having at least 60% homology with a sub-sequence of any of SEQ ID 1-6 that has the same length as the epitope: SEQ?ID?1 DLEALMEWLKTRPILSPLTKGILGFVFTLTVP SEQ?ID?2 LLYCLMVMYLNPGNYSMQVKLGTLCALCEKQASHS SEQ?ID?3 DLIFLARSALILRGSVAHKSC SEQ?ID?4 PGIADIEDLTLLARSMVVVRP SEQ?ID?5 LLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQ SEQ?ID?6 IIGILHLILWILDRLFFKCIYRLF wherein, the polypeptide is immunogenic in a vertebrate expressing a major histocompatibility complex (MHC) allele, and wherein the polypeptide is not a complete influenza virus protein.Type: ApplicationFiled: August 8, 2016Publication date: February 2, 2017Applicant: PepTcell LimitedInventors: Gregory Alan Stoloff, Wilson Romero Caparros-Wanderley
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Patent number: 9486510Abstract: A composition comprising liposomes associated with a nucleic acid operatively encoding an antigenic protein and with an assistor protein, wherein the assistor protein shares at least one epitope with the antigenic protein, and wherein the nucleic acid and said assistor protein are associated with the same liposomes is described. The composition provides an improved immune response compared to mixtures of liposomes some of which are associated with the nucleic acid and some of which are associated with the assistor protein.Type: GrantFiled: July 30, 2014Date of Patent: November 8, 2016Assignee: LIPOXEN TECHNOLOGIES LIMITEDInventors: Andrew David Bacon, Peter Laing, Gregory Gregoriadis, Wilson Romero Caparros-Wanderley
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Patent number: 9446116Abstract: Provided is a polypeptide having no more than 100 amino acids, which polypeptide comprises one or more sequences having at least 60% homology with any of SEQ ID 1-6, or comprises two or more epitopes having 7 amino acids or more, each epitope having at least 60% homology with a sub-sequence of any of SEQ ID 1-6 that has the same length as the epitope: SEQ?ID?1 DLEALMEWLKTRPILSPLTKGILGFVFTLTVP SEQ?ID?2 LLYCLMVMYLNPGNYSMQVKLGTLCALCEKQASHS SEQ?ID?3 DLIFLARSALILRGSVAHKSC SEQ?ID?4 PGIADIEDLTLLARSMVVVRP SEQ?ID?5 LLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQ SEQ?ID?6 IIGILHLILWILDRLFFKCIYRLF wherein, the polypeptide is immunogenic in a vertebrate expressing a major histocompatibility complex (MHC) allele, and wherein the polypeptide is not a complete influenza virus protein.Type: GrantFiled: May 30, 2013Date of Patent: September 20, 2016Assignee: PepTCell LimitedInventors: Gregory Alan Stoloff, Wilson Romero Caparros-Wanderley
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Patent number: 9056140Abstract: Provided is a compound comprising: (a) a first component capable of binding to ER+ cell receptors; and (b) a second component; wherein the second component is a ribosome inactivating toxin and is conjugated to the first component.Type: GrantFiled: September 11, 2008Date of Patent: June 16, 2015Assignee: Biocopea, Ltd.Inventors: Gregory Alan Stoloff, Wilson Romero Caparros-Wanderley
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Patent number: 8986703Abstract: Provided is a polypeptide composition comprising one or more polypeptides, which polypeptides are immunogenic in a vertebrate such that they cause the vertebrate to produce immune system cells capable of recognizing at least one epitope from an arthropod saliva protein fraction, wherein the arthropod saliva protein fraction has a mass of 40 kDA or less, and wherein the polypeptides are selected independently from: the polypeptide sequences of SEQ ID 1-44 or sub-sequences from these sequences, the sub-sequences having 7 amino acids or more; or from polypeptide sequences having 85% homology or more with one or more of the above sequences and contained in one or more of the following databases: GenBank, Protein Data Bank (PDB), SwissProt, Protein Information Resource (PIR), Protein Research Foundation (PRF), or CDS translations of these.Type: GrantFiled: September 5, 2008Date of Patent: March 24, 2015Assignee: PepTcell, Ltd.Inventors: Gregory Alan Stoloff, Wilson Romero Caparros-Wanderley
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Publication number: 20140341980Abstract: A composition comprising liposomes associated with a nucleic acid operatively encoding an antigenic protein and with an assistor protein, wherein the assistor protein shares at least one epitope with the antigenic protein, and wherein the nucleic acid and said assistor protein are associated with the same liposomes is described. The composition provides an improved immune response compared to mixtures of liposomes some of which are associated with the nucleic acid and some of which are associated with the assistor protein.Type: ApplicationFiled: July 30, 2014Publication date: November 20, 2014Applicant: LIPOXEN TECHNOLOGIES LIMITEDInventors: Andrew David Bacon, Peter Laing, Gregory Gregoriadis, Wilson Romero Caparros-Wanderley
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Patent number: 8828405Abstract: A composition comprising liposomes associated with a nucleic acid operatively encoding an antigenic protein and with an assistor protein, wherein the assistor protein shares at least one epitope with the antigenic protein, and wherein the nucleic acid and said assistor protein are associated with the same liposomes is described. The composition provides an improved immune response compared to mixtures of liposomes some of which are associated with the nucleic acid and some of which are associated with the assistor protein.Type: GrantFiled: November 9, 2011Date of Patent: September 9, 2014Assignee: Lipoxen Technologies LimitedInventors: Andrew David Bacon, Peter Laing, Gregory Gregoriadis, Wilson Romero Caparros-Wanderley
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Patent number: RE47222Abstract: Provided is a polypeptide composition comprising one or more polypeptides, which polypeptides are immunogenic in a vertebrate such that they cause the vertebrate to produce immune system cells capable of recognizing at least one epitope from an arthropod saliva protein fraction, wherein the arthropod saliva protein fraction has a mass of 40 kDA or less, and wherein the polypeptides are selected independently from: the polypeptide sequences of SEQ ID 1-44 or sub-sequences from these sequences, the sub-sequences having 7 amino acids or more; or from polypeptide sequences having 85% homology or more with one or more of the above sequences and contained in one or more of the following databases: GenBank, Protein Data Bank (PDB), SwissProt, Protein Information Resource (PIR), Protein Research Foundation (PRF), or CDS translations of these.Type: GrantFiled: March 24, 2017Date of Patent: February 5, 2019Assignee: Pep Tcell, Ltd.Inventors: Gregory Alan Stoloff, Wilson Romero Caparros-Wanderley