Patents by Inventor Wolfgang J. Wrasidlo

Wolfgang J. Wrasidlo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS AND COMPOSITIONS AS MODULATORS OF TLR SIGNALING
    Publication number: 20240043395
    Abstract: The present disclosure relates to compounds, pharmaceutical compositions comprising such compounds, and use of such compounds in methods of treatment or in medicaments for treatment of inflammatory diseases and certain neurological disorders that are related to inflammatory signaling processes, including but not limited to misfolded proteins.
    Type: Application
    Filed: September 24, 2021
    Publication date: February 8, 2024
    Inventors: Srinivasa Reddy NATALA, Wolfgang J. WRASIDLO, Emily M. STOCKING
  • SUBSTITUTED PHENYL SULFONYL PHENYL TRIAZOLE THIONES AND USES THEREOF
    Publication number: 20230391734
    Abstract: The present disclosure relates to substituted phenyl sulfonyl phenyl triazole thiones, pharmaceutical compositions containing them, and methods of using them.
    Type: Application
    Filed: June 5, 2023
    Publication date: December 7, 2023
    Applicant: Neuropore Therapies, Inc.
    Inventors: Wolfgang J. WRASIDLO, Emily M. STOCKING, Srinivasa Reddy NATALA, Diana Luz PRICE
  • TRI-SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF PI3-KINASE AND AUTOPHAGY PATHWAYS
    Publication number: 20230265086
    Abstract: The present disclosure relates to tri-substituted aryl and heteroaryl derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for modulating autophagy or preventing, reversing, slowing or inhibiting the PI3K-AKT-MTOR pathway, and methods of treating diseases that are associated with autophagy or the PI3K-AKT-MTOR pathway.
    Type: Application
    Filed: November 7, 2022
    Publication date: August 24, 2023
    Applicant: Neuropore Therapies, Inc.
    Inventors: Emily M. STOCKING, Wolfgang J. WRASIDLO
  • Substituted phenyl sulfonyl phenyl triazole thiones and uses thereof
    Patent number: 11708338
    Abstract: The present disclosure relates to substituted phenyl sulfonyl phenyl triazole thiones, pharmaceutical compositions containing them, and methods of using them.
    Type: Grant
    Filed: April 6, 2021
    Date of Patent: July 25, 2023
    Assignee: Neuropore Therapies, Inc.
    Inventors: Wolfgang J. Wrasidlo, Emily M. Stocking, Srinivasa Reddy Natala, Diana Luz Price
  • Tri-substituted aryl and heteroaryl derivatives as modulators of PI3-kinase and autophagy pathways
    Patent number: 11492348
    Abstract: The present disclosure relates to tri-substituted aryl and heteroaryl derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for modulating autophagy or preventing, reversing, slowing or inhibiting the PI3K-AKT-MTOR pathway, and methods of treating diseases that are associated with autophagy or the PI3K-AKT-MTOR pathway.
    Type: Grant
    Filed: April 9, 2019
    Date of Patent: November 8, 2022
    Assignee: Neuropore Therapies, Inc.
    Inventors: Emily M. Stocking, Wolfgang J. Wrasidlo
  • COMPOUNDS AND COMPOSITIONS AS MODULATORS OF TLR SIGNALING
    Publication number: 20220298155
    Abstract: The present disclosure relates to compounds, pharmaceutical compositions comprising such compounds, and use of such compounds in methods of treatment or in medicaments for treatment of inflammatory diseases and certain neurological disorders that are related to inflammatory signaling processes, including but not limited to misfolded proteins.
    Type: Application
    Filed: February 10, 2022
    Publication date: September 22, 2022
    Applicant: Neuropore Therapies, Inc.
    Inventors: Srinivasa Reddy NATALA, Wolfgang J. WRASIDLO, Emily M. STOCKING
  • SCINTILLATOR NANOCRYSTAL-CONTAINING COMPOSITIONS AND METHODS FOR THEIR USE
    Publication number: 20220265826
    Abstract: There are provided, inter alia, compositions including a scintillator nanocrystal linked to a chemical agent moiety through a scintillator-activated photocleavable linker, and methods of use thereof.
    Type: Application
    Filed: December 29, 2021
    Publication date: August 25, 2022
    Inventors: Milan T. Makale, Wolfgang J. Wrasidlo, Santosh Kesari, Joanna McKittrick, Gustavo A. Hirata Flores, Olivia Graeve
  • Compounds and compositions as modulators of TLR signaling
    Patent number: 11299487
    Abstract: The present disclosure relates to substituted aryl and heteroaryl compounds, pharmaceutical compositions comprising such compounds, and use of such compounds in methods of treatment or in medicaments for treatment of inflammatory diseases and certain neurological disorders that are related to inflammatory signaling processes, including but not limited to misfolded proteins.
    Type: Grant
    Filed: March 25, 2020
    Date of Patent: April 12, 2022
    Assignee: Neuropore Therapies, Inc.
    Inventors: Srinivasa Reddy Natala, Wolfgang J. Wrasidlo, Emily M. Stocking
  • Morpholine derivates as inhibitors of Vps34
    Patent number: 11236079
    Abstract: The present disclosure relates to thiazole- or diathiazole-substituted aryl and heteroaryl compounds (I), pharmaceutical compositions containing them, and methods of using them, including treatment of disorders or disease related to regulation of the Vps34/PI3K III signaling pathway.
    Type: Grant
    Filed: April 9, 2019
    Date of Patent: February 1, 2022
    Assignee: Neuropore Therapies, Inc.
    Inventors: Emily M. Stocking, Wolfgang J. Wrasidlo
  • Scintillator nanocrystal-containing compositions and methods for their use
    Patent number: 11224656
    Abstract: There are provided, inter alia, compositions including a scintillator nanocrystal linked to a chemical agent moiety through a scintillator-activated photocleavable linker, and methods of use thereof.
    Type: Grant
    Filed: November 16, 2020
    Date of Patent: January 18, 2022
    Assignee: The Regents of the University of California
    Inventors: Milan T. Makale, Wolfgang J. Wrasidlo, Santosh Kesari, Joanna McKittrick, Gustavo A. Hirata Flores, Olivia Graeve
  • SUBSTITUTED PHENYL SULFONYL PHENYL TRIAZOLE THIONES AND USES THEREOF
    Publication number: 20210300881
    Abstract: The present disclosure relates to substituted phenyl sulfonyl phenyl triazole thiones, pharmaceutical compositions containing them, and methods of using them.
    Type: Application
    Filed: April 6, 2021
    Publication date: September 30, 2021
    Applicant: Neuropore Therapies, Inc.
    Inventors: Wolfgang J. WRASIDLO, Emily M. STOCKING, Srinivasa Reddy NATALA, Diana Luz PRICE
  • METHOD OF TREATING A CONDITION ASSOCIATED WITH NEURODEGENERATION USING INHIBITORS OF OAT3
    Publication number: 20210290597
    Abstract: The present disclosure relates to therapeutic agents that may be useful intreatment and prophylaxis of neurodegenerative disorders and/or neural inflammation.
    Type: Application
    Filed: June 20, 2019
    Publication date: September 23, 2021
    Applicant: Neuropore Therapies, Inc.
    Inventors: Douglas W. BONHAUS, Wolfgang J. WRASIDLO, Emily M. STOCKING, Srinivasa Reddy NATALA
  • TRI-SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF PI3-KINASE AND AUTOPHAGY PATHWAYS
    Publication number: 20210163462
    Abstract: The present disclosure relates to tri-substituted aryl and heteroaryl derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for modulating autophagy or preventing, reversing, slowing or inhibiting the PI3K-AKT-MTOR pathway, and methods of treating diseases that are associated with autophagy or the PI3K-AKT-MTOR pathway.
    Type: Application
    Filed: April 9, 2019
    Publication date: June 3, 2021
    Applicant: Neuropore Therapies, Inc.
    Inventors: Emily M. STOCKING, Wolfgang J. WRASIDLO
  • MORPHOLINE DERIVATES AS INHIBITORS OF VPS34
    Publication number: 20210163467
    Abstract: The present disclosure relates to thiazole- or diathiazole-substituted aryl and heteroaryl compounds (I), pharmaceutical compositions containing them, and methods of using them, including treatment of disorders or disease related to regulation of the Vps34/PI3K III signaling pathway.
    Type: Application
    Filed: April 9, 2019
    Publication date: June 3, 2021
    Applicant: Neuropore Therapies, Inc.
    Inventors: Emily M. STOCKING, Wolfgang J. WRASIDLO
  • Substituted phenyl sulfonyl phenyl triazole thiones and uses thereof
    Patent number: 11008294
    Abstract: The present disclosure relates to substituted phenyl sulfonyl phenyl triazole thiones, pharmaceutical compositions containing them, and methods of using them.
    Type: Grant
    Filed: October 24, 2019
    Date of Patent: May 18, 2021
    Assignee: Neuropore Therapies, Inc.
    Inventors: Wolfgang J. Wrasidlo, Emily M. Stocking, Srinivasa Reddy Natala, Diana Luz Price
  • SCINTILLATOR NANOCRYSTAL-CONTAINING COMPOSITIONS AND METHODS FOR THEIR USE
    Publication number: 20210069331
    Abstract: There are provided, inter alia, compositions including a scintillator nanocrystal linked to a chemical agent moiety through a scintillator-activated photocleavable linker, and methods of use thereof.
    Type: Application
    Filed: November 16, 2020
    Publication date: March 11, 2021
    Inventors: Milan T. Makale, Wolfgang J. Wrasidlo, Santosh Kesari, Joanna McKittrick, Gustavo A. Hirata Flores, Olivia Graeve
  • Scintillator nanocrystal-containing compositions and methods for their use
    Patent number: 10864272
    Abstract: There are provided, inter alia, compositions including a scintillator nanocrystal linked to a chemical agent moiety through a scintillator-activated photocleavable linker, and methods of use thereof.
    Type: Grant
    Filed: February 24, 2016
    Date of Patent: December 15, 2020
    Assignee: The Regents of the University of California
    Inventors: Milan T. Makale, Wolfgang J. Wrasidlo, Santosh Kesari, Joanna McKittrick, Gustavo A. Hirata Flores, Olivia Graeve
  • COMPOUNDS AND COMPOSITIONS AS MODULATORS OF TLR SIGNALING
    Publication number: 20200308163
    Abstract: The present disclosure relates to compounds, pharmaceutical compositions comprising such compounds, and use of such compounds in methods of treatment or in medicaments for treatment of inflammatory diseases and certain neurological disorders that are related to inflammatory signaling processes, including but not limited to misfolded proteins.
    Type: Application
    Filed: March 25, 2020
    Publication date: October 1, 2020
    Applicant: Neuropore Therapies, Inc.
    Inventors: Srinivasa Reddy NATALA, Wolfgang J. WRASIDLO, Emily M. STOCKING
  • SUBSTITUTED PHENYL SULFONYL PHENYL TRIAZOLE THIONES AND USES THEREOF
    Publication number: 20200123116
    Abstract: The present disclosure relates to substituted phenyl sulfonyl phenyl triazole thiones, pharmaceutical compositions containing them, and methods of using them.
    Type: Application
    Filed: October 24, 2019
    Publication date: April 23, 2020
    Applicant: Neuropore Therapies, Inc.
    Inventors: Wolfgang J. WRASIDLO, Emily M. STOCKING, Srinivasa Reddy NATALA, Diana Luz PRICE
  • Substituted phenyl sulfonyl phenyl triazole thiones and uses thereof
    Patent number: 10501423
    Abstract: The present disclosure relates to substituted phenyl sulfonyl phenyl triazole thiones, pharmaceutical compositions containing them, and methods of using them.
    Type: Grant
    Filed: March 27, 2019
    Date of Patent: December 10, 2019
    Assignee: Neuropore Therapies, Inc.
    Inventors: Wolfgang J. Wrasidlo, Emily M. Stocking, Srinivasa Reddy Natala, Diana Luz Price