Abstract: Disclosed are a polyethylene glycol conjugate drug, and a preparation method therefor and the use thereof. Specifically, the present invention relates to a polyethylene glycol conjugate drug represented by formula A or a pharmaceutically acceptable salt thereof, a method for preparing the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof, an intermediate for preparing the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof, and the use of the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof in the preparation of a drug.

Abstract: A fully-automatic aluminum thermal-spraying corrosion prevention production line based on robots and visual recognition is provided. The production line comprises an automatic feeding system comprising feeding carrying and conveying mechanisms; a laser derusting system comprising a derusting robot, a laser cleaning nozzle and derusting conveying mechanisms; an aluminum thermal-spraying system comprising an aluminum spraying robot and an aluminum thermal-spraying gun; an automatic rolling system comprising a rolling pedestal, a first rolling wheel, a second rolling wheel and a rolling drive mechanism; a laser cutting system; and a discharging and stacking system.

Abstract: The present invention is to provide an image signal detection circuit, a control method, and a motion detection method. The image signal detection circuit comprises at least one acquisition module, the acquisition module comprises at least one acquisition sub-module, the acquisition sub-module comprises a capacitor to acquire the difference between a pair of two consecutive frames of pixel signals by taking a reference voltage as a reference. The image signal detection circuit and a motion detection circuit are structurally simple and easy to implement. It can realize motion detection at increased difference detection speed without analog-to-digital conversion.

Abstract: The present invention provides a clock circuit comprises an oscillator circuit and a power-on reset circuit, the oscillator circuit comprises a current generating module and a loop oscillation module connected together; the current generating module is used for outputting a control current to the loop oscillation module; the loop oscillation module is used for outputting an oscillation signal with a set frequency under action of the control current; and the power-on reset circuit is used for providing an enabling control signal to the loop oscillation module after a power supply is powered on; the power-on reset circuit is connected to the loop oscillation module.

Abstract: The disclosure discloses a CMOS image sensor, which includes a plurality of image sensor units and a resistance-to-digital converting unit. Each image sensor unit includes a pixel unit and a resistive random access memory unit connected to the pixel unit, the pixel unit is configured to convert a received optical signal into an analog signal and the resistive random access memory unit is configured to convert the analog electrical signal into a resistance value. The resistance-to-digital converting unit is connected to the plurality of the image sensor units, and is configured to convert the resistance value into a digital signal. The resistive random access memory unit is adopted in the present disclosure to replace a transistor device and is configured to convert resistance information of the resistive random access memory unit into a digital signal and output. Thus, digital quantization of image information is completed.

Abstract: A pen needle assembly apparatus includes a housing (30), a movable gripping assembly (32) for gripping a pen needle assembly (18), and an actuator (108). The housing (30) has a top end (34), a bottom end (36), and an inner cavity (38) for storing used pen needle assemblies. The gripping assembly (32) in one embodiment includes two movable jaws (58) that are movable to engage and grip the outer cover (22) of the pen needle assembly (18) so that the needle hub (16) can be separated from the outer cover (22) and placed back in the outer cover (22) after use of the pen needle. The actuator (108) is connected to the jaws (58) where movement of the actuator separates the jaws to release the outer cover of the pen needle assembly. The housing (30) has an opening 160) for engaging the inner shield (24) of the pen needle assembly to remove the inner shield (24) from the needle hub (16).

Abstract: A pen needle assembly apparatus (60) includes a housing (30), a movable support (40) for supporting a pen needle (18), an ejector (80) for ejecting a used pen needle from the support, and an actuator (56). The support (40) is rotated relative to the housing (30) to index the pen needles to a position where the pen needle can be accessed and coupled to a delivery device (10). The used pen needle (18) is returned to the well (42) in the support and the support rotated toward the ejector (80) where the used pen needle is ejected to a compartment (50) in the housing for disposal. A cover (60) on the housing includes at least one opening (65) for accessing the pen needle when the support is rotated to position a pen needle relative to the opening in the cover.

Abstract: A method of removing fixed pattern noise, comprising: S01: performing a single-frame segmented exposure on a pixel array; S02: reading a of the pixel array, comprising: S021: performing a soft reset, so as to set the reset signal of the pixel unit to an intermediate voltage, and reading a differential reset signal; S022: performing a hard reset so as to set the reset signal of the pixel unit to a high voltage; S023: turning on a transmission MOS transistor to enable an exposure signal of to photodiode to transmitted to the floating diffusion area, and reading a differential pixel transmission signal; S03: subtracting the differential reset signal from the differential pixel transmission signal to obtain an exposure signal with fixed pattern noise removed. Another method is removing fixed pattern noise and an image sensor are further provided.

Abstract: A storage device (30) for storing a pen needle assembly (10) includes a housing (30) having first wells (44) with a dimension for receiving the pen needle assembly and second wells (46) for receiving an inner shield (24) of the pen needle assembly. The second wells (46) have a diameter less than a diameter of the first wells (44). An ejector (40) in the housing (34) can be actuated to eject the used needle hub (16) and outer covers (22) from the first well (44) and the inner shield (24) from the second well (46) for disposal. A method of coupling a pen needle delivery device to a needle hub positions a needle hub assembly (18) in the first well (44) and inserts the coupling end of the delivery device (10) into the first well (44) and is coupled to the needle hub. The needle hub is pulled from the outer cover (22). The inner shield (24) is inserted into the second well (46) to remove the inner shield from the needle hub.

Abstract: A method of removing fixed pattern noise, comprising: S01: performing a single-frame segmented exposure on a pixel array; S02: reading a signal of the pixel array, comprising: S021: performing a soft reset, so as to set the reset signal of the pixel unit to an intermediate voltage, and reading a differential reset signal; S022: performing a hard reset so as to set the reset signal of the pixel unit to a high voltage; S023: turning on a transmission MOS transistor to enable an exposure signal of the photodiode to be transmitted to the floating diffusion area, and reading a differential pixel transmission signal; S03: subtracting the differential reset signal from the differential pixel transmission signal to obtain an exposure signal with fixed pattern noise removed. Another method of removing fixed pattern noise and an image sensor are further provided.

Abstract: The disclosure discloses a CMOS image sensor, which includes a plurality of image sensor units and a resistance-to-digital converting unit. Each image sensor unit includes a pixel unit and a resistive random access memory unit connected to the pixel unit, the pixel unit is configured to convert a received optical signal into an analog signal and the resistive random access memory unit is configured to convert the analog electrical signal into a resistance value. The resistance-to-digital converting unit is connected to the plurality of the image sensor units, and is configured to convert the resistance value into a digital signal. The resistive random access memory unit is adopted in the present disclosure to replace a transistor device and is configured to convert resistance information of the resistive random access memory unit into a digital signal and output. Thus, digital quantization of image information is completed.

Abstract: The present disclosure provides a method and apparatus for extracting a video preview, a device and a computer storage medium. The method comprises: inputting a video into a video classification model obtained by pre-training; obtaining weights of respective video frames output by an attention module in the video classification model; extracting continuous N video frames whose total weight value satisfies a preset requirement, as the video preview of the target video, N being a preset positive integer. It is possible to, in the manner provided by the present disclosure, automatically extract continuous video frames from the video as the video preview, without requiring manual clipping, and with manpower costs being reduced.

Abstract: A needle hub assembly for coupling to a pen needle delivery device (10) includes an outer cover (30) having a first well (40) receiving the needle hub (16) and inner shield (24) covering a cannula (20) of the needle hub (16). A second well (42) is spaced from the first well (40) and has a dimension for receiving the inner shield (24). In use, the pen delivery device (10) is coupled to the connecting end of the needle hub (16) to withdraw the needle hub (16) and inner shield (24) from the first well (40). The inner shield (24) is inserted into the second well (42) where the inner shield (24) is gripped so that the inner shield can be separated from the needle hub (16) without the user handling the outer cover (30) or the inner shield (24). After use, the needle hub (16) is inserted into the first well (40) and the pen needle delivery device is separated from the needle hub (16).

Abstract: Embodiments described herein relate to managing firewall rules. Embodiments include identifying a plurality of firewall rules for request handling. Embodiments include determining a deny count for each given firewall rule of the plurality of firewall rules based on a number of requests flagged on account of the given firewall rule. Embodiments include determining an anomaly score for each given firewall rule of the plurality of firewall rules indicating a severity of attacks the given firewall rule protects against. Embodiments include determining an urgency measure for each given firewall rule of the plurality of firewall rules based on the deny count for the given firewall rule and the anomaly score for the given firewall rule. Embodiments include determining an update to at least one firewall rule of the plurality of firewall rules based on the urgency measure for each given firewall rule of the plurality of firewall rules.

Abstract: A pen needle apparatus includes a housing (32), a movable gripping mechanism (34) for gripping a pen needle assembly (18), and an actuator (36). The gripping mechanism (34) includes first and second pivoting arms (44) that pivot between a first closed position and a second open position. In the closed position, the arms engage and grip the outer cover (22) of the pen needle assembly (18) so that the needle hub (16) can be separated from the outer cover (22) and the pen needle placed back in the outer cover (22) after use of the pen needle. The actuator (36) is connected to the arms (44) where movement of the actuator pivots the arms to a second open position to release the outer cover of the pen needle assembly. The arms include a gripping surface for engaging the inner shield (24) of the pen needle assembly to assist in removing the inner shield (24) from the needle hub (16).

Abstract: A needle hub assembly for coupling to a pen needle delivery device includes an outer cover having a first well receiving the needle hub and inner shield covering a cannula of the needle hub. A second well is spaced from the first well and receives the inner shield. In use, the pen delivery device is coupled to the connecting end of the needle hub to withdraw the needle hub and inner shield from the first well. The inner shield is inserted into the second well where the inner shield is gripped so that the inner shield can be separated from the needle hub without the user handling the outer cover or the inner shield. After use, the needle hub is inserted into the first well and the pen needle delivery device is separated from the needle hub. The needle hub is retained within the first well where the outer cover containing the used needle hub and inner shield can be discarded as a single unit.

Abstract: A storage device (30) for storing a pen needle assembly (10) includes a housing (30) having first wells (44) with a dimension for receiving the pen needle assembly and second wells (46) for receiving an inner shield (24) of the pen needle assembly. The second wells (46) have a diameter less than a diameter of the first wells (44). An ejector (40) in the housing (34) can be actuated to eject the used needle hub (16) and outer covers (22) from the first well (44) and the inner shield (24) from the second well (46) for disposal. A method of coupling a pen needle delivery device to a needle hub positions a needle hub assembly (18) in the first well (44) and inserts the coupling end of the delivery device (10) into the first well (44) and is coupled to the needle hub. The needle hub is pulled from the outer cover (22). The inner shield (24) is inserted into the second well (46) to remove the inner shield from the needle hub.

Abstract: The invention provides pigment particles and an organic modification layer formed on a surface of the pigment particles; the organic modification layer is a surfactant layer or a polymer material layer formed on the surface of the pigment particles; an organic matter content over the specific surface area Wsurf of the pigment particles is in a range of 0.1-2% g/m2. The surface-modified pigment particles provided by the invention have good stability, and the electrophoretic display prepared by using the surface-modified pigment particles of the invention has good optical performance.

Abstract: A storage device (30) for storing a pen needle assembly (10) includes a housing (30) having first wells (44) with a dimension for receiving the pen needle assembly and second wells (46) for receiving an inner shield (24) of the pen needle assembly. The second wells (46) have a diameter less than a diameter of the first wells (44). An ejector (40) in the housing (34) can be actuated to eject the used needle hub (16) and outer covers (22) from the first well (44) and the inner shield (24) from the second well (46) for disposal. A method of coupling a pen needle delivery device to a needle hub is also provided.

Abstract: The present invention discloses a motion detection circuit applied to CIS and a motion detection method.