Abstract: The present invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: The present invention belongs to the bioengineering field, and relates to a method for fermentation production of L-theanine by using an Escherichia coli genetically engineered bacterium. The engineered bacterium is obtained by serving a strain as an original strain, wherein the strain is obtained after performing a single copy of T7RNAP, a dual copy of gmas, xylR knockout, and sucCD knockout on an Escherichia coli W3110 genome, and by integrating genes xfp, pta, acs, gltA, and ppc, and knocking out ackA on the genome. The present invention has a high yield, and stable production performance; after 20-25 h, L-theanine has a titer of 75-80 g/L, and the yield is up to 52-55%. The fermentation broth is purified by membrane separation in combination with a cation-anion resin series technique. Moreover, the one-step crystallization yield is 72.3% and the L-theanine final product has a purity of 99%.

Abstract: A hearing aid includes a plurality of electrode units, where each of the plurality of electrode units includes an electrode configured to provide an electrical stimulation to a user of the hearing aid and/or to measure a bio response signal of the user; a plurality of electrode channel circuits, where each of the plurality of electrode channel circuits includes: an operational amplifier comprising a first input terminal configured to receive the bio response signal and provide an amplified bio response signal, and the operational amplifier includes a first load input; a first DC offset unit configured to reduce the impact of DC offset in the electrode channel circuit of the plurality of electrode channel circuits by receiving a part of the amplified bio response signal and converting it to a feedback current signal which is transmitted to the first load input for providing balanced drain currents in the operational amplifier.

Abstract: An apparatus is described. The apparatus includes an accelerator to be coupled to a memory region that the accelerator shares with a virtualization environment comprising a guest OS, a guest VM and an SSD device driver. The accelerator is to forward a submission queue doorbell setting made by the SSD device driver in the shared memory to a corresponding submission queue doorbell in an SSD controller.

Abstract: The invention provides methods and compositions for producing a multi-layered cellular structure or blastocyst-like structure from a cell population of reprogrammed somatic cells.

Abstract: Systems and methods are disclosed for dynamically adjusting effective sensor coverage coordinates of a sensor used to assist in navigating an autonomous driving vehicle (ADV) in response to environmental conditions that may affect the ideal operation of the sensor. An ADV includes a navigation system and a safety monitor system that monitors some, or all, of the navigation system, including monitoring: dynamic adjustment of effective sensor coverage coordinates of a sensor and localization of the ADV within a high-definition map. The ADV safety monitor system further determines safety-critical objects surrounding the ADV, determines safe areas to navigate the ADV, and ensures that the ADV navigates only to safe areas. An automated system performance monitor determines whether to pass-through ADV navigation control commands, limit one or more control commands, or perform a fail-operational behavior, based on the ADV safety monitor systems.

Abstract: The present invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof; (I) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: A downhole throttling device based on wireless control includes an inlet nozzle, a throttling assembly, an electrical sealing cylinder, a gas guide cylinder, a lower adapter sleeve, an end socket, a female sleeve, and electrical components. The inlet nozzle is connected to the throttling assembly, the throttling assembly is connected to the electrical sealing cylinder and the gas guide cylinder, the electrical sealing cylinder and the gas guide cylinder are both connected to the lower adapter sleeve, the lower adapter sleeve is respectively connected to the end socket and the female sleeve, and the electrical components are arranged in the electrical sealing cylinder. A throttling effect is achieved by detecting the temperature and pressure in a tube by a temperature/pressure sensor in the electrical components and controlling a motor to rotate a movable valve in the throttling assembly by a circuit control assembly, thereby achieving wireless control over downhole throttling.

Abstract: The present disclosure discloses a conjugate compound or a pharmaceutically acceptable salt thereof, comprising a payload and two targeting molecules. Further disclosed herein is a pharmaceutical composition, comprising the conjugate compound or the pharmaceutically acceptable salt thereof. The present disclosure additionally relates to a method for delivering a payload to a subject in need thereof, and a method for treating a disease, wherein the methods comprise administering to the subject a therapeutically effective amount of the conjugate compound or the pharmaceutically acceptable salt thereof, or the pharmaceutical composition as disclosed herein.

Abstract: The present invention relates to stem cells derived from a multi-layered cellular structure or blastocyst structure, compositions comprising the same, and methods for obtaining the same.

Abstract: A wrist-worn device is provided, which includes a device main body and an earphone. An accommodating groove for placing the earphone is provided on the device main body, a key is slidably mounted on one of the device main body and fee earphone. A clamping groove is provided on the other one of the device main body and the earphone, and a snapin head cooperating with the clamping groove is provided at a top of the key. The key is provided with a first attraction portion, the device main body or the earphone having the clamping groove is provided with a second attraction portion, and the first attraction portion is magnetically attracted with the second attraction portion in a case that the key slides forward until the snapin head is inserted into the clamping groove.

Abstract: Systems and methods are disclosed for an ADV to leverage pre-defined static objects along a planned route of travel to detect and counter attacks that attempt to change the destination or the planned route. The ADV may detect updates to the static objects if the planned route is changed. Based on the updated static objects, the ADV determines if there is an abnormal re-routing of the planned route or if there is a new route due to a suspicious destination change. The ADV may also leverage the static objects to detect spoofing attacks against the sensor system. The ADV may evaluate if sensors of the sensor system are able to detect and identify the static objects to identify an impaired sensor. The ADV may perform cross-check on the ability of the sensors to detect and identify dynamic objects to gain confidence that the impaired sensor is due to spoofing attacks.

Abstract: Knowledge graphs can greatly improve the quality of content recommendation systems. There is a broad variety of knowledge graphs in the domain including clicked user-ad graphs, clicked query-ad graphs, keyword-display URL graphs etc. A hierarchical Transformer model learns entity embeddings in knowledge graphs. The model consists of two different Transformer blocks where the bottom block generates relation-dependent embeddings for the source entity and its neighbors, and the top block aggregates the outputs from the bottom block to produce the target entity embedding. To balance the information from contextual entities and the source entity itself, a masked entity model (MEM) task is combined with a link prediction task in model training.

Abstract: Systems and method are provided that are directed to tuning a hyperparameter associated with a small neural network model and transferring the hyperparameter to a large neural network model. At least one neural network model may be received along with a request for one or more tuned hyperparameters. Prior to scaling the large neural network, the large neural network is parameterized in accordance with a parameterizing schemed. The large neural network is then scaled and reduced in size such that a hyperparameter tuning process may be performed. A tuned hyperparameter may then be provided to a requestor such that the hyperparameter can be directly input into the large neural network. By tuning a hyper parameter using a small neural network, significant computation cycles and energy may be saved.

Abstract: An image processing method performed by image processing device having an operating system includes receiving, by an image processing module of the operating system, an instruction of a first application program to call the image processing module of the operating system, where the instruction carries a to-be-displayed image and a resolution of the to-be-displayed image. The image processing method further includes when the resolution of the to-be-displayed image is less than a first threshold, performing, by the image processing module, super-resolution processing on the to-be-displayed image, and displaying an image obtained after the super-resolution processing.

Abstract: The present invention discloses an electrocatalytic Fenton oxidation-electrochemical oxidation coupling process and apparatus for efficient treatment of chemical wastewater, and belongs to the field of sewage treatment. The process includes an electrocatalytic Fenton oxidation step, an electrochemical oxidation step, and a pH adjustment step. A spacing between a cathode and an anode in the electrocatalytic Fenton oxidation step is controlled, so that oxygen produced at the anode reacts at the cathode to produce H2O2. The treatment requirements can be met without external aeration or external addition of H2O2, and meanwhile, the efficiency of COD removal by electro-Fenton oxidation is effectively improved.

Abstract: The invention provides a terminal device having a main body, a sounding assembly and a cover plate. The sounding assembly includes a housing and a sounding body. The housing has an accommodating groove and a first sounding channel. The main body has a second sounding channel and a first sound emitting hole. The cover plate has a first through hole. When the sounding assembly is located at the first position, the sound is propagated to the outside through the first through hole, the second sounding channel and the first sound emitting hole in sequence. When the sounding assembly is located at the second position, the sound is propagated to the outside through the first sounding channel. The present invention improves the problem that the sound effect is affected by airflow sound, piano sound, etc., generated by the terminal device in the speaker mode.

Abstract: In one embodiment, a method for performing an obstacle detection for an ADV includes detecting an obstacle by a primary ADS and a secondary ADS using an obstacle detection algorithm based on sensor data provided by sensors on the ADV. In response to detecting the obstacle, a first controlled stop distance and a second controlled stop distance are calculated by the primary ADS and secondary ADS respectively based on a speed and a deceleration capability of the ADV. The first and second controlled stop distances between the primary ADS and secondary ADS are exchanged to determine a third controlled stop distance which is the maximum of the two. In response to determining that the ADV reaches within the third controlled distance between the ADV and the obstacle, a controlled stop operation is activated by the primary ADS to decelerate the ADV based on the third controlled stop distance.

Abstract: The present invention provides a sound transducer structure of electronic device relating to the technical field of acoustics. The sound transducer structure includes a housing having an accommodating cavity, a sound generator received in the accommodating cavity, and a sound outlet disposed in the housing. A sound guiding groove communicates between the sound generator and the sound outlet, so that a sound generated at the sound generator is conducted along the sound guiding groove and is transmitted out of the housing from the sound outlet. The sound outlet includes a first sound outlet for transmitting sound in a receiver mode and a second sound outlet for transmitting sound in a loudspeaker mode. The second sound outlet is covered with a sound pressure sensitive member.

Abstract: A video file processing method includes: obtaining, by an electronic device, first video information, where the first video information includes at least a part of a target video or a target picture, recognizing, by the electronic device, a target element included in the first video information, and generating, by the electronic device based on the first video information, the target video or the target picture that includes the target element.