Abstract: Non-human animals, methods and compositions for making and using the same, are provided, wherein the non-human animals comprise a humanized programmed death-ligand 1 (PD-L1, PDL1, or B7-H1). Such non-human animals may be described, in some embodiments, as having a genetic modification to an endogenous PD-L1 gene so that the non-human animals express a humanized PD-L1 protein that includes a human portion and an endogenous portion (e.g., a non-human portion).

Abstract: The present disclosure relates to the genetically modified non-human animals that express a human or chimeric OX40, and methods of use thereof.

Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) programmed cell death protein 1 (PD-1), and methods of use thereof. In one aspect, the animals have an insertion of a sequence encoding a human or humanized programmed cell death protein 1 (PD-1) at an endogenous PD-1 gene locus. This animal model can express a PD-1 protein containing a functional domain of the human PD-1 protein, and can be used as an animal model for developing therapeutics for human diseases and disorders, and assessing the toxicity and/or the efficacy of these human therapeutics.

Abstract: Provided is a method for preparing a PD-1 gene-modified humanized animal model. The method utilizes the CRIPSR/Cas9 technique to replace partial fragments of a mouse PD-1 gene with fragments of a human PD-1 gene using homologous recombination by constructing a targeting vector, thereby preparing a gene-modified humanized mouse. This mouse can normally express a PD-1 protein containing the functional domain of the human PD-1 protein, and can be used as an animal model for mechanism research regarding PD-1, PD-L1 and other signals, for screening regulators, and for toxicological research. The method has an important and high application value in studies on functions of the PD-1 gene and in the development of new drugs.

Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) IL4R and/or IL4, and methods of use thereof.

Abstract: The present disclosure relates to genetically modified animals that express a canine or chimeric (e.g., caninized) programmed cell death protein 1 (PD-1), and methods of use thereof.

Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) IL4R and/or IL4, and methods of use thereof.

Abstract: Systems and methods for recommending transportation means are provided. The method may include obtaining current travel information of a target user and historical travel information and social information of the target user, respectively. The method may further include determining a user type based on the historical travel information, the user type being a first type or a second type. The method may further include, in response to determining that the target user is a user of the first type, determining a first clustering model based on the historical travel information; or in response to determining that the target user is a user of the second type, determining a second clustering model based on the social information. The method may further include recommending a transportation means to the target user based on the clustering model and the current travel information of the target user.

Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) CD3e (T-cell surface glycoprotein CD3 epsilon chain), and methods of use thereof.

Abstract: The present disclosure relates to a head-mounted display device, comprising a device body, a front cover and a remote controller, wherein one end of the device body is a display end, the front cover is disposed on the device body and is opposite to the display end, and he front cover and the display end enable a display to be inserted therebetween when in use; and wherein the front cover is provided with a through hole opposite to the display end, in which the remote controller can be received and fixed. One technical effect of the present disclosure is that the remote controller herein is easy to store and can be carried integrally with the device body.

Abstract: Systems and methods for recommending transportation means are provided. The method may include obtaining current travel information of a target user and historical travel information and social information of the target user, respectively. The method may further include determining a user type based on the historical travel information, the user type being a first type or a second type. The method may further include, in response to determining that the target user is a user of the first type, determining a first clustering model based on the historical travel information; or in response to determining that the target user is a user of the second type, determining a second clustering model based on the social information. The method may further include recommending a transportation means to the target user based on the clustering model and the current travel information of the target user.

Abstract: This disclosure relates to genetically modified animal expressing human or chimeric (e.g., humanized) programmed death-ligand 1 (PD-L1, PDL1, or B7-H1), and methods of use thereof. In one aspect, the disclosure relates to genetically-modified, non-human animals whose genome comprises at least one chromosome comprising a sequence encoding a human or chimeric programmed death-ligand 1 (PD-L1).

Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) CD3e (T-cell surface glycoprotein CD3 epsilon chain), and methods of use thereof.

Abstract: Provided are a humanized transgenic non-human animal, especially a rodent, in particular a transgenic mouse containing a human interleukin 17A (IL-17A) gene, a human gene 17RA (IL-17RA) and/or a human TNF-alpha gene, and a preparation method therefor and the use thereof.

Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) IL4R and/or IL4, and methods of use thereof.

Abstract: Provided is a method for preparing a PD-1 gene-modified humanized animal model. The method utilizes the CRIPSR/Cas9 technique to replace partial fragments of a mouse PD-1 gene with fragments of a human PD-1 gene using homologous recombination by constructing a targeting vector, thereby preparing a gene-modified humanized mouse. This mouse can normally express a PD-1 protein containing the functional domain of the human PD-1 protein, and can be used as an animal model for mechanism research regarding PD-1, PD-L1 and other signals, for screening regulators, and for toxicological research. The method has an important and high application value in studies on functions of the PD-1 gene and in the development of new drugs.

Abstract: A photoelectric hybrid connection system includes a photoelectric hybrid distribution box, an photoelectric hybrid main feeder assembly and a fan-out assembly; The photoelectric hybrid main feeder assembly is terminated with a photoelectric hybrid main feeder connector, and the photoelectric hybrid main feeder connector is matched with the photoelectric hybrid input end connector of the photoelectric hybrid distribution box. The fan-out assembly comprises corrugated tubes, a plurality of fan-out structures connected to corrugated tubes, and a hybrid photoelectric jumper connector; The photoelectric hybrid jumper connector is matched with the photoelectric hybrid output end connector of the photoelectric hybrid distribution box. Some advantages of certain embodiments of the invention are that it can reduces field connections and fixation work which fan-out requires, and can reduces the number of lines to be manipulated.

Abstract: This disclosure relates to genetically modified animal expressing human or chimeric (e.g., humanized) programmed death-ligand 1 (PD-L1, PDL1, or B7-H1), and methods of use thereof.

Abstract: Provided is a method for preparing a PD-1 gene-modified humanized animal model. The method utilizes the CRIPSR/Cas9 technique to replace partial fragments of a mouse PD-1 gene with fragments of a human PD-1 gene using homologous recombination by constructing a targeting vector, thereby preparing a gene-modified humanized mouse. This mouse can normally express a PD-1 protein containing the functional domain of the human PD-1 protein, and can be used as an animal model for mechanism research regarding PD-1, PD-L1 and other signals, for screening regulators, and for toxicological research. The method has an important and high application value in studies on functions of the PD-1 gene and in the development of new drugs.

Abstract: The present disclosure relates to the genetically modified non-human animals that express a human or chimeric OX40, and methods of use thereof.