Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) CD3e (T-cell surface glycoprotein CD3 epsilon chain), and methods of use thereof.

Abstract: The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) programmed cell death protein 1 (PD-1), and methods of use thereof.

Abstract: The present disclosure relates to the genetically modified non-human animals that express a human or chimeric OX40, and methods of use thereof.

Abstract: The present disclosure relates to the genetically modified non-human animals that express a human or chimeric TIGIT (e.g., humanized TIGIT), and methods of use thereof.

Abstract: Provided is a method for preparing a PD-1 gene-modified humanized animal model. The method utilizes the CRIPSR/Cas9 technique to replace partial fragments of a mouse PD-1 gene with fragments of a human PD-1 gene using homologous recombination by constructing a targeting vector, thereby preparing a gene-modified humanized mouse. This mouse can normally express a PD-1 protein containing the functional domain of the human PD-1 protein, and can be used as an animal model for mechanism research regarding PD-1, PD-L1 and other signals, for screening regulators, and for toxicological research. The method has an important and high application value in studies on functions of the PD-1 gene and in the development of new drugs.

Abstract: The present disclosure relates to the genetically modified non-human animals that express a human or chimeric TIGIT (e.g., humanized TIGIT), and methods of use thereof.

Abstract: This disclosure relates to genetically modified animal expressing human or chimeric (e.g., humanized) programmed death-ligand 1 (PD-L1, PDL1, or B7-H1), and methods of use thereof.

Abstract: A method and a device for rapidly editing sending content based on a receiver. A sending-content-learning module is used to learn sending content to generate a content fragment for a receiver, and perform word frequency statistics on the content fragment; a corresponding list is generated from receiver information, the content fragment, and the word frequency statistics, and is stored; for the receiver and the word frequency statistics, the content fragment is displayed for a sender to edit the sending content, so as to send the sending content to a corresponding receiver. When a user edits a short message or an email, a content fragment commonly used for a corresponding receiver is displayed in a display box, and a sender can rapidly complete editing by selecting a required content fragment, thereby facilitating fast and convenient input and improving the user experience.

Abstract: A system of managing collaborative session control when controller is lost or changes to passive-control mode in a data communication network comprising of a control-capable terminal device that can generate and send user preferences on successive controller selection and control policy, a master server device that can make control transfer decisions or take over control upon events, a normal terminal device that can process and response to master server queries on control capacity and its willingness to take over control. These apparatus are connected to each other inside one collaborative session, regardless of their subscriptions. A method of control management of the collaborative session without constant enrollment of controller comprises the steps of sending different types of preferences to master server device; making control transfer or handover decision; and interacting with affected terminals.

Abstract: A multi-touch supporting parallel-tapping input method comprising the following steps: obtaining multiple input operations of a user at the same time; converting the input operations of the user into characters, permuting and combining the characters, and selecting a correct character combination sequence; displaying the selected character combination sequence as a candidate character sequence in a candidate display unit for the user to select; and displaying the character combination sequence selected by the user. The method may be implemented using a multi-touch supporting virtual keyboard, so that multiple fingers can select multiple keys at the same time to perform parallel-tapping input. Through intelligent error correction, multiple keys tapped in parallel are permutated and combined to provide a candidate correct combination for a user to select, so as to improve the speed and efficiency of text inputting of the user.

Abstract: A method and a device for rapidly editing sending content based on a receiver. A sending-content-learning module is used to learn sending content to generate a content fragment for a receiver, and perform word frequency statistics on the content fragment; a corresponding list is generated from receiver information, the content fragment, and the word frequency statistics, and is stored; for the receiver and the word frequency statistics, the content fragment is displayed for a sender to edit the sending content, so as to send the sending content to a corresponding receiver. When a user edits a short message or an email, a content fragment commonly used for a corresponding receiver is displayed in a display box, and a sender can rapidly complete editing by selecting a required content fragment, thereby facilitating fast and convenient input and improving the user experience.

Abstract: A system of managing collaborative session control when controller is lost or changes to passive-control mode in a data communication network comprising of a control-capable terminal device that can generate and send user preferences on successive controller selection and control policy, a master server device that can make control transfer decisions or take over control upon events, a normal terminal device that can process and response to master server queries on control capacity and its willingness to take over control. These apparatus are connected to each other inside one collaborative session, regardless of their subscriptions. A method of control management of the collaborative session without constant enrollment of controller comprises the steps of sending different types of preferences to master server device; making control transfer or handover decision; and interacting with affected terminals.