Abstract: Compounds having affinity for integrins, the synthesis of these compounds, and the use of these compounds as ligands to facilitate the delivery of cargo molecules to cells expressing integrins are described. The described integrin targeting ligands have serum stability and affinity for ?v?3 integrin and/or ?v?5 integrin, and are suitable for conjugation to cargo molecules, such as such as oligonucleotide-based therapeutic agents (e.g., RNAi agents), to facilitate delivery of the cargo molecules to cells and tissues, such as tumor cells, that express integrin ?v?3, integrin ?v?5, or both integrin ?v?3 and integrin ?v?5. Compositions that include integrin targeting ligands and methods of use are also described.

Abstract: An optical system may include equipment with a housing that is configured to receive external equipment such as a cellular telephone. The external equipment may include a display. To control the persistence of the display, the optical system may include a light modulating layer. The light modulating layer may switch between a transparent state in which display image light is passed through the light modulating layer to reach the viewer and an opaque state in which display image light is blocked by the light modulating layer from reaching the viewer. The light modulating layer may be placed in the transparent state for a portion of each display frame and the opaque state for the remaining portion of each display frame. The light modulating layer may be formed in the housing of the equipment that receives the external equipment or may be formed with the external equipment directly.

Abstract: An electronic device such as a head-mounted device may have a display that produces a display image. The head-mounted device may have an optical system that merges real-world images from real-world objects with display images. The optical system provides the real-world images and display images to an eye box for viewing by a user. The optical system may use time interleaving techniques and/or polarization effects to merge real-world and display images. Switchable devices such as polarization switches and tunable lenses may be controlled in synchronization with frames of display images. Geometrical phase lenses may be used that exhibit different lens powers to different polarizations of light.

Abstract: An electronic device such as a head-mounted device may have a display that produces a display image. The head-mounted device may have an optical system that merges real-world images from real-world objects with display images. The optical system provides the real-world images and display images to an eye box for viewing by a user. The optical system may use time interleaving techniques and/or polarization effects to merge real-world and display images. Switchable devices such as polarization switches and tunable lenses may be controlled in synchronization with frames of display images. Geometrical phase lenses may be used that exhibit different lens powers to different polarizations of light.

Abstract: An electronic device such as a head-mounted device may have a display that displays computer-generated content for a user. The head-mounted device may have an optical system that directs the computer-generated content towards eye boxes for viewing by a user. The optical system may include a spatially addressable adjustable optical component. The adjustable optical component may have first and second electrodes and an electrically adjustable material between the first and second electrodes. The electrically adjustable material may include a transparent conductive material such as indium tin oxide that includes a pattern of segmented trenches configured to provide the transparent conductive material with electrical anisotropy. Contacts may be coupled to the transparent conductive material. Control circuitry can adjust the electrically adjustable material to form a spatially addressable light modulator or adjustable lens.

Abstract: An electronic device may include display layers such as liquid crystal display layers and a backlight unit that provides illumination for the display layers. The backlight unit may include light-emitting diodes that emit light into the edge of a light guide film. To minimize the inactive area of the display, the light-emitting diodes may be tightly spaced to approximate a line light source instead of point light sources. Color and/or luminance compensation layers may be incorporated at various locations within the backlight structures to ensure that the backlight provided to the display layers is homogenous. A thin-film transistor layer of the display may be coupled to a printed circuit board by a flexible printed circuit. The flexible printed circuit may have additional solder mask layers to improve robustness, may include encapsulation, and may have traces with a varying pitch.

Abstract: A flat-panel display device and method to unify response times for all possible grey level transitions in a flat-panel display or an augmented reality display. A pixel drive compensator receives a frame from a graphics processing unit and two-dimensional temperature for pixels at a display panel to compensate for temperature variation across the display panel.

Abstract: A flat-panel display device and method to unify response times for all possible grey level transitions in a flat-panel display or an augmented reality display. A pixel drive compensator compares the current frame from a graphics processing unit and feedback from a previous frame to compensate for grey-level changes at a pixel level.

Abstract: A flat-panel display device and method to unify response times for all possible grey level transitions in a flat-panel display or an augmented reality display. A pixel drive compensator receives a frame from a graphics processing unit and two-dimensional temperature for pixels at a display panel to compensate for temperature variation across the display panel.

Abstract: A flat-panel display device and method to unify response times for all possible grey level transitions in a flat-panel display or an augmented reality display. A pixel drive compensator compares the current frame from a graphics processing unit and two previous frames to compensate for grey-level changes at a pixel level.

Abstract: Synthetic av?6 integrin ligands of Formula I having serum stability and affinity for integrin av?6, which is a receptor expressed in a variety of cell types, are described. The described ligands are useful for delivering cargo molecules, such as RNAi agents or other oligonucleotide-based compounds, to cells that express integrin av?6, and thereby facilitating the uptake of the cargo molecules into these cells. Compositions that include avB6 integrin ligands and methods of use are also described.

Abstract: Presently provided are inhibitors of cellularly expressed TDO2 and pharmaceutical compositions thereof, useful for modulating an activity of tryptophan 2, 3 dioxygenase; treating immunosuppression; treating a medical conditions that benefit from the inhibition of tryptophan degradation; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; and treating tumor-specific immunosuppression associated with cancer.

Abstract: An electronic device may include display layers such as liquid crystal display layers and a backlight unit that provides illumination for the display layers. The backlight unit may include light-emitting diodes that emit light into the edge of a light guide film. To minimize the inactive area of the display, the light-emitting diodes may be tightly spaced to approximate a line light source instead of point light sources. Color and/or luminance compensation layers may be incorporated at various locations within the backlight structures to ensure that the backlight provided to the display layers is homogenous. A thin-film transistor layer of the display may be coupled to a printed circuit board by a flexible printed circuit. The flexible printed circuit may have additional solder mask layers to improve robustness, may include encapsulation, and may have traces with a varying pitch.

Abstract: Aspects of the subject technology relate to displays for electronic devices and methods of operating the displays. The display may include an array of display pixels arranged in rows and columns. A v-drive operation in which rows are alternatingly operated about a center of each of two halves of the display is provided. Data rendering operations are provided that generate a virtual frame rate boost.

Abstract: An electronic device may have a display. Input-output circuitry in the electronic device may be used to gather input from a viewer of the display. The input-output circuitry may include a gaze tracking system that gathers point-of-gaze information, vergence information, and head position information, may be a biometric sensor, may be an input device such as a button or touch sensor, may capture hand gestures, and/or may gather other information. The display may include a pixel array for producing images. An adjustable reflectance and transmittance layer may overlap the pixel array. Control circuitry in the electronic device may individually adjust different areas of the adjustable reflectance and transmittance layer. The control circuitry may place each area in a reflective mirror more or in a content-displaying mode and may move the areas in response to the information.

Abstract: Aspects of the subject technology relate to display circuitry including pixel overdrive circuitry. The pixel overdrive circuitry includes a compression engine that compresses a previous display frame, for storage and comparison to a current display frame without compression or decompression of the current display frame. The compression engine compresses the previous frame in such a way that the maximum compression error is always known and can be used to determine whether to perform overdrive operations for the current frame without compressing and decompressing the current display frame. The compression engine selects gradient encoding or decimation encoding for the compression of the previous display frame and can perform successive decimation operations within the gradient encoding operations to help reduce the size of the compressed previous frame while maintaining the quality of the ultimate overdriven current frame.

Abstract: An electronic device may include a display for displaying image content to a user and dynamic image stabilization circuitry for dynamically compensating the image content if the device is moving unpredictably to help keep the image content aligned with the user's gaze. The electronic device may include sensors for detecting the displacement of the device. The dynamic image stabilization circuitry may include a usage scenario detection circuit and a content displacement compensation calculation circuit. The usage scenario detection circuit receives data from the sensors and infers a usage scenario based on the sensor data. The content displacement compensation calculation circuit uses the inferred usage scenario to compute a displacement amount by which to adjust image content. When motion stops, the image content may gradually drift back to the center of the display.

Abstract: Aspects of the subject technology relate to pulsed backlight operation for a display backlight. Backlight pulse patterns are provided that include steady state pulse patterns to be applied during operation of a liquid crystal display unit of the display at a corresponding frame rate. The backlight pulse patterns can be arranged to prevent visible artifacts such as flicker or strobing, particularly at or near a transition between LCD frame rates.

Abstract: Aspects of the subject technology relate to display circuitry including pixel overdrive circuitry. The pixel overdrive circuitry includes one more lookup tables of boost values to be applied to pixel display values of a frame to be displayed, for overdrive of that frame. Each lookup table includes a lightness-blur-edge-width-based boost value. The lightness-blur-edge-width-based boost value matches a lightness-blur-edge-width of an intermediate grey-to-grey transition to a lightness-blur-edge-width of a maximum grey-to-grey transition.

Abstract: Provided herein are compounds of formula (I) which are, inter alia, useful allosteric inhibitors of Hsp70. The compounds and methods provided are useful for the treatment of cancer, infectious and neurodegenerative diseases.