Abstract: Instalments and methods are described for performing endoscopically guided operative procedures. According to some embodiments, a re-usable portion of the instrument includes a handle, electronics and an integrated display screen while a fluid hub and a cannula which includes a CMOS imaging module and LED lighting, form a single use portion of the instrument. The cannula includes a working channel configured to accept an operative device for performing the operative procedures.

Abstract: A single use medical device can include a single use medical device module configured for use within a body of a subject receiving a medical procedure. It can also include an electronic component having a one-time programmable (“OTP”) component that is configured to render the single use medical device module unusable after being used in the medical procedure in the subject.

Abstract: Installments and methods are described for performing endoscopically guided operative procedures. According to some embodiments, a re-usable portion of the instrument includes a handle, electronics and an integrated display screen while a fluid hub and a cannula which includes a CMOS imaging module and LED lighting, form a single use portion of the instrument. The cannula includes a working channel configured to accept an operative device for performing the operative procedures.

Abstract: A handheld surgical endoscope has a disposable, single-use handle, cannula and distal tip. The distal tip includes LED illumination and an imaging module that feeds live video to a re-usable display module that connects off-axis to the disposable handle. A rechargeable battery module also attaches to the handle. The cannula includes two lumens for separate fluid in-flow and out-flow channels, as well as providing a working channel through which a surgical implement can be used. Extruded cannula and molded distal tip parts can be separately formed which aids in manufacturing and assembly. The working channel can have a substantially straight proximal access port.

Abstract: Instruments and methods are described for performing hysteroscopy and/or combined hysteroscopy and endometrial biopsy. According to some embodiments, the handle, electronics and integrated display screen form a re-usable portion of the instrument while the fluid hub and cannula which includes a CMOS imaging module and LED lighting, form a single use portion of the instrument. The cannula is semi-flexible such that the operator can easily grasp the cannula at some intermediate point along the shaft (e.g. 5 inches from the distal tip) to bend and/or steer the cannula during use. According to some embodiments, the distal tip has a larger diameter than the shaft which has been found to improve fluid management during use in some applications.

Abstract: Installments and methods are described for performing endoscopically guided operative procedures. According to some embodiments, a re-usable portion of the instrument includes a handle, electronics and an integrated display screen while a fluid hub and a cannula which includes a CMOS imaging module and LED lighting, form a single use portion of the instrument. The cannula includes a working channel configured to accept an operative device for performing the operative procedures.

Abstract: Instruments and methods are described for performing hysteroscopy and/or combined hysteroscopy and endometrial biopsy. According to some embodiments, the handle, electronics and integrated display screen form a re-usable portion of the instrument while the fluid hub and cannula which includes a CMOS imaging module and LED lighting, form a single use portion of the instrument. The cannula is semi-flexible such that the operator can easily grasp the cannula at some intermediate point along the shaft (e.g. 5 inches from the distal tip) to bend and/or steer the cannula during use. According to some embodiments, the distal tip has a larger diameter than the shaft which has been found to improve fluid management during use in some applications.

Abstract: Aspects of the invention include minimally invasive tissue modification systems. Embodiments of the systems include a minimally invasive access device having a proximal end, a distal end and an internal passageway. Positioned among the distal ends of the devices are a visualization element and an illumination element. Also provided are methods of using the systems in tissue modification applications, as well as kits for practicing the methods of the invention. Internal tissue visualization devices having RF-shielded visualization sensor modules are also provided. Minimally invasive RF tissue modulation devices are provided. In some aspects, the devices include a hand-held control unit and an elongated member. In some aspects, RF tissue modulation devices are provided and include an adapter that operably couples to a hand-held medical device. The adapter generates RF energy for delivery to a plasma generator on an elongated member.

Abstract: Instruments and methods are described for performing hysteroscopy and/or combined hysteroscopy and endometrial biopsy. According to some embodiments, the handle, electronics and integrated display screen form a re-usable portion of the instrument while the fluid hub and cannula which includes a CMOS imaging module and LED lighting, form a single use portion of the instrument. The cannula is semi-flexible such that the operator can easily grasp the cannula at some intermediate point along the shaft (e.g. 5 inches from the distal tip) to bend and/or steer the cannula during use. According to some embodiments, the distal tip has a larger diameter than the shaft which has been found to improve fluid management during use in some applications.

Abstract: Methods and devices are described for performing a combined hysteroscopy and endometrial sampling. Techniques for improving visual images include forward facing fluid ports for clearing tissue debris and LED positioning and design. Manufacturability is improved through separately formed tip and shaft pieces. User interface features are described including user-friendly handle-mounted buttons as well the use of an interactive integrated touch screen display. The handle and display can be mated to a docking station for storage and recharging batteries.

Abstract: Methods and devices are described for performing a combined hysteroscopy and endometrial sampling. Techniques for improving visual images include forward facing fluid ports for clearing tissue debris and LED positioning and design. Manufacturability is improved through separately formed tip and shaft pieces. User interface features are described including user-friendly handle-mounted buttons as well the use of an interactive integrated touch screen display. The handle and display can be mated to a docking station for storage and recharging batteries.

Abstract: An imaging system can include a base unit and one or more imaging units. The base unit can include a main interface that has a plurality of main electrical connectors and one or more main mechanical connectors. A mechanical system is located in the base unit. Each imaging unit can include an elongate support member having a proximal end, a proximal section, a bendable section, and a distal end. Also, an imaging interface that couples with the main interface can be included on the proximal end of the elongate support member. The imaging interface includes a plurality of imaging electrical connectors that correspond and connect with the main electrical connectors of the main interface and includes one or more imaging mechanical connectors that correspond and connect with main mechanical connectors of the main interface. Mechanical actuators can bend the bendable section under control from the base unit.

Abstract: An imaging device can include: an imaging module; a lens associated with the imaging module; and an optically transmissive inflatable member surrounding the lens. The inflation tube can be fluidly coupled with the inflatable member. An inflation port can be fluidly coupling the inflation tube and inflatable member. A fastener that fastens the inflatable member can be coupled to a housing of the imaging module. A flushing tube can be fluidly coupled to a flushing port that is directed outward from a housing of the imaging module. The inflation tube and/or flushing tube are coupled to a pneumatic system that can pump fluid therethrough. The inflatable member can be an inflatable membrane, balloon, bladder, or bag.

Abstract: An imaging system can include a base unit and one or more imaging units. The base unit can include a main interface that has a plurality of main electrical connectors and one or more main mechanical connectors. A mechanical system is located in the base unit. Each imaging unit can include an elongate support member having a proximal end, a proximal section, a bendable section, and a distal end. Also, an imaging interface that couples with the main interface can be included on the proximal end of the elongate support member. The imaging interface includes a plurality of imaging electrical connectors that correspond and connect with the main electrical connectors of the main interface and includes one or more imaging mechanical connectors that correspond and connect with main mechanical connectors of the main interface. Mechanical actuators can bend the bendable section under control from the base unit.

Abstract: Aspects of the invention include minimally invasive imaging system. Systems according to embodiments of the invention include: an access device having a proximal end and distal end and an internal passageway extending from the proximal to distal end; and an elongated member dimensioned to be slidably moved through the internal passageway of the access device and having a proximal and distal end. In the systems of the invention, at least one of multiple visualization elements and multiple illumination elements are positioned among the distal ends of the access device and the elongated member. Also provided are methods of using the systems in imaging applications, as well as kits for performing the methods.

Abstract: Methods and devices are described for performing a combined hysteroscopy and endometrial sampling. Techniques for improving visual images include forward facing fluid ports for clearing tissue debris and LED positioning and design. Manufacturability is improved through separately formed tip and shaft pieces. User interface features are described including user-friendly handle-mounted buttons as well the use of an interactive integrated touch screen display. The handle and display can be mated to a docking station for storage and recharging batteries.

Abstract: Methods and devices are described for performing a combined hysteroscopy and endometrial sampling. Techniques for improving visual images include forward facing fluid ports for clearing tissue debris and LED positioning and design. Manufacturability is improved through separately formed tip and shaft pieces. User interface features are described including user-friendly handle-mounted buttons as well the use of an interactive integrated touch screen display. The handle and display can be mated to a docking station for storage and recharging batteries.

Abstract: An imaging system can include a base unit and one or more imaging units. The base unit can include a main interface that has a plurality of main electrical connectors and one or more main mechanical connectors. A mechanical system is located in the base unit. Each imaging unit can include an elongate support member having a proximal end, a proximal section, a bendable section, and a distal end. Also, an imaging interface that couples with the main interface can be included on the proximal end of the elongate support member. The imaging interface includes a plurality of imaging electrical connectors that correspond and connect with the main electrical connectors of the main interface and includes one or more imaging mechanical connectors that correspond and connect with main mechanical connectors of the main interface. Mechanical actuators can bend the bendable section under control from the base unit.

Abstract: A single use medical device can include a single use medical device module configured for use within a body of a subject receiving a medical procedure. It can also include an electronic component having a one-time programmable (“OTP”) component that is configured to render the single use medical device module unusable after being used in the medical procedure in the subject.

Abstract: Hand-held minimally dimensioned diagnostic devices having integrated distal end visualization are provided. Also provided are systems that include the devices, as well as methods of using the devices, e.g., to visualize internal tissue of a subject.