Abstract: Internal tissue visualization devices having RF-shielded visualization sensor modules are provided. Also provided are systems that include the devices, as well as methods of visualizing internal tissue of a subject using the tissue visualization devices and systems.

Abstract: Tissue visualization systems having image processing modules configured to generate an alert signal are provided. Image processing modules of systems of the invention are configured to receive image data of an internal region of interest. The image processing module is further configured to compare the received image data with a reference that includes at least one of color descriptor data and anatomical descriptor data to make a determination as to whether an alert signal should be generated. Also provided are methods of visualizing internal tissue of a subject using the tissue visualization systems.

Abstract: Aspects of the invention include minimally invasive imaging system. Systems according to embodiments of the invention include: an access device having a proximal end and distal end and an internal passageway extending from the proximal to distal end; and an elongated member dimensioned to be slidably moved through the internal passageway of the access device and having a proximal and distal end. In the systems of the invention, at least one of multiple visualization elements and multiple illumination elements are positioned among the distal ends of the access device and the elongated member. Also provided are methods of using the systems in imaging applications, as well as kits for performing the methods.

Abstract: Aspects of the invention include minimally invasive internal target tissue site imaging devices. Devices according to embodiments of the invention include an elongate member dimensioned to access an internal target tissue location, e.g., an intervertebral disc, and having a proximal end and a distal end; a white light source at the distal end; a near-infra-red light source the distal end; and an imaging sensor at the distal end. Also provided are methods of using the systems in imaging applications, as well as kits for performing the methods.

Abstract: Aspects of the invention include minimally invasive tissue modification systems. Embodiments of the systems include a minimally invasive access device having a proximal end, a distal end and an internal passageway. Also part of the system is an elongated tissue modification device having a proximal end and a distal end. The tissue modification device is dimensioned to be slidably moved through the internal passageway of the access device. The tissue modification device includes a tissue modifier. Positioned among the distal ends of the devices are a visualization element and an illumination element. Also provided are methods of using the systems in tissue modification applications, as well as kits for practicing the methods of the invention.