Abstract: Methods and compositions are disclosed to target tumor cells with embodiments of the LIGHT proteins linked fused or conjugated to a targeting agent. These compositions bind to both human and mouse receptors with affinity sufficient to conduct preclinical and clinical trials, and with increased affinity as compared to the wild type human LIGHT protein. The targeting of embodiments of LIGHT to tumor cells reduces tumor growth and reduces metastases.

Abstract: Mutant LIGHT expressed in a tumor environment elicited high levels of chemokines and adhesion molecules, accompanied by massive infiltration of naïve T lymphocytes. Methods and compositions to elicit immune responses against tumors including tumor volume reduction and eradication of metastasis using mutant LIGHT are disclosed.

Abstract: An optical fiber connector includes a main body (1), a sleeve (2), and a plug (3).The main body (1) includes a first cube and a second cube that are formed by means of injection molding, where a first cavity (1o) is disposed inside the first cube, and the first cavity (1o) is used to adapt to an optical fiber sub-assembly inserted from a first end face of the first cube; at least two hook-like structures (1n) are formed, by means of injection molding, on the first cube extending from a second end face that is parallel to the first end face into the first cavity (1o), and the hook-like structures (1n) are used to tightly lock the optical fiber sub-assembly when the optical fiber sub-assembly is inserted from the first end face.

Abstract: A system, method, and apparatus are provided for promoting achievement of a goal within a professional community, such as an online professional network. A member is selected as a candidate for assistance based on her level of usage of the community and/or other factors, and a goal of the member may be learned explicitly or implicitly. Based on her goal and her level of proficiency within the community, which may be determined based on the number of discrete tasks or metrics she has accomplished, a set of milestones is suggest to her. The milestones are both related to the member's goal and customized to her level of proficiency. Upon completion of the milestones, she may be given a reward that is related to the goal.

Abstract: One side-effect arising from the use of antibodies against TNF receptor family members as therapeutics can be liver damage which precludes the completion of clinical trial. A novel LT-dependent pathway is described that mediates liver cell injury in several disease models.

Abstract: Techniques for dynamically generating feedback based on contextual information and providing the feedback to a user are provided. A service provider determines, based on contextual information related to a user (such as personal information previously provided by the user) interactive data to display to the user. The type of interactive data may correspond to the type of personal information submitted by the user or derived by the service provider. The interactive data may be based on other users that have already registered with the service provider. In this way, a user is able to (1) view current and relevant information that is related to the user and (2) see the value that the user receives by providing additional personal information. Subsequent interactive data may be based on multiple personal data items that the service provider receives from the user. These techniques are also applicable after a user has registered with a service provider.

Abstract: Provided is a muscle stem cell in vitro culture method. A muscle stem cell is cultivated in vitro by using a cell culture medium of a cell factor added with a blood cell or a conditioned medium of the blood cell. Also provided is a culture medium used in the muscle stem cell in vitro culture method and an application thereof.

Abstract: Mutant LIGHT expressed in a tumor environment elicited high levels of chemokines and adhesion molecules, accompanied by massive infiltration of naïve T lymphocytes. Methods and compositions to elicit immune responses against tumors including tumor volume reduction and eradication of metastasis using mutant LIGHT are disclosed.

Abstract: Techniques for optimizing a guided edit process for editing a member profile page are described. According to various embodiments, incomplete member profile fields in a member profile associated with member of an online social networking service are identified. Profile completion score weight values associated with the incomplete member profile fields in the member profile are then determined. Thereafter, the incomplete member profile fields in the member profile are ranked, based on the profile completion score weight values associated with each of the incomplete member profile fields. A list of one or more of the highest ranked incomplete member profile fields are then displayed, together with a prompt recommending the member to complete the identified incomplete member profile fields.

Abstract: A case can include a front cover and a back cover. The back cover can include a back edge, a device support assembly including a main device region and a tab, and a flap including an exposure region and a tab region. The case can include a top edge and a bottom edge. The back cover can be configured to be removably coupled to a first electronic device. The back cover can be configured to be removably coupled to a second electronic device when the first electronic device is not coupled to the back cover. The first electronic device can include a first camera lens and first dimensions. The second electronic device can include a second camera lens and second dimensions different from the first dimensions of the first electronic device. The flap can be configured to be placed in an exposed configuration and a closed configuration. Other embodiments are provided.

Abstract: The present invention provides a method of producing a multipotent stem cell, said method comprising culturing at least one fibroblast cell in the presence of an effective amount of at least one small molecule reprogramming factor(s) that induces the cell to de-differentiate into a multipotent stem cell, wherein the method excludes the use of reprogramming factor(s) that are not small molecules. The small molecule reprogramming factor(s) may include a G9a HMTase inhibitor(s) and/or a MEK inhibitor(s) optionally in combination with other small molecule reprogramming factor(s). The invention also includes methods of differentiating the multipotent stem cells, cells produced by the methods, assays using the cells and kits for use in the methods.

Abstract: Antibody-LIGHT fusion products or conjugates stimulate immunity against tumors and eradicate metastases. Tumor-specific antibodies coupled with LIGHT effectively target metastatic tumors and reduces cancer metastases.

Abstract: Antibody-LIGHT fusion products or conjugates stimulate immunity against tumors and eradicate metastases. Tumor-specific antibodies coupled with LIGHT effectively target metastatic tumors and reduces cancer metastases.

Abstract: The present invention relates to methods of treating and/or preventing obesity comprising the administration of an inhibitor of lymphotoxin, IL-22 and/or IL-23 to a subject having or at risk of developing obesity.

Abstract: A case can include a front cover and a back cover. The back cover can include a back edge, a device support assembly including a main device region and a tab, and a flap including an exposure region and a tab region. The case can include a top edge and a bottom edge. The back cover can be configured to be removably coupled to a first electronic device. The back cover can be configured to be removably coupled to a second electronic device when the first electronic device is not coupled to the back cover. The first electronic device can include a first camera lens and first dimensions. The second electronic device can include a second camera lens and second dimensions different from the first dimensions of the first electronic device. The flap can be configured to be placed in an exposed configuration and a closed configuration. Other embodiments are provided.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for identifying listings of multi-site entities based on user behavior signals. In one aspect, a method exploits user behavioral signals that are strong indicators of whether a search result previously presented for a multi-site-entity search query is, in fact, a relevant result, and affords sufficient weight to these behavioral signals to overcome other signals of relevance for the search result. Two such strong user behavior signals include (i) users invoking an information window from a search result and (ii) users submitting a direction request related to a search result. A black list of search results and/or a search result index can be generated based on how the two strong behavior signals associated with the search results compare to threshold values set for the two strong behavior signals.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for identifying listings of multi-site entities based on user behavior signals. In one aspect, a method exploits user behavioral signals that are strong indicators of whether a search result previously presented for a multi-site-entity search query is, in fact, a relevant result, and affords sufficient weight to these behavioral signals to overcome other signals of relevance for the search result. Two such strong user behavior signals include (i) users invoking an information window from a search result and (ii) users submitting a direction request related to a search result. A black list of search results and/or a search result index can be generated based on how the two strong behavior signals associated with the search results compare to threshold values set for the two strong behavior signals.

Abstract: Methods and compositions are disclosed to target tumor cells with embodiments of the LIGHT proteins linked fused or conjugated to a targeting agent. These compositions bind to both human and mouse receptors with affinity sufficient to conduct preclinical and clinical trials, and with increased affinity as compared to the wild type human LIGHT protein. The targeting of embodiments of LIGHT to tumor cells reduces tumor growth and reduces metastases.

Abstract: The disclosed embodiments relate to a system for analyzing performance in an online professional network. During operation, the system receives time series data for user actions, wherein for each user action, the time series data comprises a series of numbers associated with consecutive time intervals, wherein a given number indicates a number of times the user action occurred during the time interval. The system also receives time series data for performance metrics, wherein for each performance metric, the time series data comprises a series of numbers associated with consecutive time intervals, wherein a given number indicates the number of times the performance metric occurred during the time interval. The system then performs a time series analysis on the received time series data for user actions and performance metrics to determine relationships between the user actions and the performance metrics.

Abstract: Disclosed is a device and method for dynamic extrusion molding of plastic articles having variable micro-channel. The device mainly includes a single-screw extruder, a dynamic extrusion die, a fluid source, a water sink, a tractor, a winding device, and a data acquisition and control system. Near outlet of extrusion die, when the end portion of a syringe needle is at different positions, the inner diameter of the micro-channel of the extrusion molded plastic article is also different. When the hollow syringe core within the dynamic extrusion die performs a high-frequency short-range vibration along an extrusion direction, the inner diameter of the micro-channel of the extruded plastic articles is dynamically variable. The plastic articles of variable micro-channel of the present invention has novel structure with high dimensional accuracy, and a variety of varying patterns, it can be stably produced by simple processing equipment with high level of automation.