Patents by Inventor Xiyun Zhang

Xiyun Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Additional Endoglucanase Variants and Methods
    Publication number: 20220204956
    Abstract: The invention is directed to novel variant endoglucanases and their use thereof.
    Type: Application
    Filed: December 20, 2021
    Publication date: June 30, 2022
    Applicant: Fornia BioSolutions, Inc.
    Inventors: Jie Yang, Xiyun Zhang, William Buchanan Porterfield, Wenhua Lu, Khin Oo, Goutami Banerjee, Tatsuya Fukushima, Eric Lin Hu
  • Xylanase Variants and Methods
    Publication number: 20220195410
    Abstract: The present invention relates to variant xylanase enzymes and their use thereof.
    Type: Application
    Filed: December 16, 2021
    Publication date: June 23, 2022
    Applicant: Fornia BioSolutions, Inc.
    Inventors: Jie Yang, William Buchanan Porterfield, Xiyun Zhang, Goutami Banerjee, Khin Oo, Wenhua Lu
  • NOVEL P450-BM3 VARIANTS WITH IMPROVED ACTIVITY
    Publication number: 20220169994
    Abstract: The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a wide range of substrates.
    Type: Application
    Filed: February 15, 2022
    Publication date: June 2, 2022
    Inventors: Robert Osborne, Vesna Mitchell, Khin Yu Naing Htwe, Xiyun Zhang, Erika M. Milczek, Jeffrey C. Moore
  • Methods and systems for engineering biomolecules
    Patent number: 11342046
    Abstract: Disclosed are methods for building a sequence activity model with reference to structural data, which model can be used to guide directed evolution of proteins having beneficial properties. Some embodiments use genetic algorithms and structural data to filter out uninformative data. Some embodiments use a support vector machine to train the sequence activity model. The filtering and training methods can generate a sequence activity model having higher predictive power than conventional modeling methods. Systems and computer program products implementing the methods are also provided.
    Type: Grant
    Filed: June 6, 2019
    Date of Patent: May 24, 2022
    Assignee: Codexis, Inc.
    Inventors: Russell Javiniar Sarmiento, Donald Scott Baskerville, Xiyun Zhang
  • Transglutaminase variants
    Patent number: 11319531
    Abstract: The present invention provides engineered transglutamirase enzymes, polynucleotides encoding the enzymes, compositions comprising the enzymes, methods of producing these enzymes, and methods of using the engineered transglutaminase enzymes.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: May 3, 2022
    Assignee: Codexis, Inc.
    Inventors: Jovana Nazor, Jie Yang, Goutami Banerjee, Xiyun Zhang, James Nicholas Riggins, Erika M. Milczek, Jeffrey C. Moore
  • P450-BM3 variants with improved activity
    Patent number: 11279917
    Abstract: The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a wide range of substrates.
    Type: Grant
    Filed: May 13, 2020
    Date of Patent: March 22, 2022
    Assignee: Codexis, Inc.
    Inventors: Robert Osborne, Vesna Mitchell, Khin Yu Naing Htwe, Xiyun Zhang, Erika M. Milczek, Jeffrey C. Moore
  • Human alpha-galactosidase variants
    Patent number: 11278600
    Abstract: The present invention provides engineered human alpha-galactosidase polypeptides and compositions thereof. The engineered human alpha-galactosidase polypeptides have been optimized to provide improved stability under both acidic (pH<4.5) and basic (pH>7) conditions. The invention also relates to the use of the compositions comprising the engineered human alpha-galactosidase polypeptides for therapeutic purposes.
    Type: Grant
    Filed: August 5, 2020
    Date of Patent: March 22, 2022
    Assignee: Codexis, Inc.
    Inventors: Nicholas J. Agard, Mathew G. Miller, Xiyun Zhang, Gjalt W. Huisman
  • PENICILLIN-G ACYLASES
    Publication number: 20220042004
    Abstract: The present disclosure relates to engineered penicillin G acylase (PGA) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes.
    Type: Application
    Filed: October 19, 2021
    Publication date: February 10, 2022
    Inventors: Goutami Banerjee, Jie Yang, Xiyun Zhang, Erika M. Milczek, Melissa Ann Mayo, Stephan Jenne
  • Variant penicillin-G acylases
    Patent number: 11180747
    Abstract: The present disclosure relates to engineered penicillin G acylase (PGA) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes.
    Type: Grant
    Filed: August 17, 2020
    Date of Patent: November 23, 2021
    Assignee: Codexis, Inc.
    Inventors: Goutami Banerjee, Jie Yang, Xiyun Zhang, Erika M. Milczek, Melissa Ann Mayo, Stephan Jenne
  • ENONE REDUCTASES
    Publication number: 20210324344
    Abstract: The disclosure relates to engineered enone reductase polypeptides having improved properties, polynucleotides encoding the engineered polypeptides, related vectors, host cells, and methods for making the engineered enone reductase polypeptides. The disclosure also provides methods of using the engineered enone reductase polypeptides for chemical transformations.
    Type: Application
    Filed: March 30, 2021
    Publication date: October 21, 2021
    Inventors: Christopher K. Savile, Vesna Mitchell, Xiyun Zhang, Gjalt W. Huisman
  • Engineered phenylalanine ammonia lyase polypeptides
    Patent number: 11136571
    Abstract: The present invention provides engineered phenylalanine ammonia-lyase (PAL) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia-lyase (PAL) polypeptides.
    Type: Grant
    Filed: October 14, 2019
    Date of Patent: October 5, 2021
    Assignee: Codexis, Inc.
    Inventors: Gjalt W. Huisman, Nicholas J. Agard, Benjamin Mijts, Jonathan Vroom, Xiyun Zhang
  • Engineered phenylalanine ammonia lyase polypeptides
    Patent number: 11130947
    Abstract: The present invention provides engineered phenylalanine ammonia-lyase (PAL) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia-lyase (PAL) polypeptides.
    Type: Grant
    Filed: October 14, 2019
    Date of Patent: September 28, 2021
    Assignee: Codexis, Inc.
    Inventors: Gjalt W. Huisman, Nicholas J. Agard, Benjamin Mijts, Jonathan Vroom, Xiyun Zhang
  • ENGINEERED TYROSINE AMMONIA LYASE
    Publication number: 20210254041
    Abstract: The present invention provides engineered tyrosine ammonia-lyase (TAL) polypeptides and compositions thereof. In some embodiments, the engineered TAL polypeptides have been optimized to provide enhanced catalytic activity while reducing sensitivity to proteolysis and increasing tolerance to acidic pH levels. The invention also provides methods for utilization of the compositions comprising the engineered TAL polypeptides for therapeutic and industrial purposes.
    Type: Application
    Filed: April 27, 2021
    Publication date: August 19, 2021
    Inventors: Gjalt W. Huisman, Nicholas J. Agard, David Elgart, Xiyun Zhang
  • HUMAN ALPHA-GALACTOSIDASE VARIANTS
    Publication number: 20210244804
    Abstract: The present invention provides engineered human alpha-galactosidase polypeptides and compositions thereof. The engineered human alpha-galactosidase polypeptides have been optimized to provide improved stability under both acidic (pH<4.5) and basic (pH>7) conditions. The invention also relates to the use of the compositions comprising the engineered human alpha-galactosidase polypeptides for therapeutic purposes.
    Type: Application
    Filed: March 9, 2021
    Publication date: August 12, 2021
    Inventors: Nicholas J. Agard, Mathew G. Miller, Xiyun Zhang, Gjalt W. Huisman
  • CARBOXYESTERASE POLYPEPTIDES FOR AMIDE COUPLING
    Publication number: 20210238565
    Abstract: The present invention provides engineered carboxyesterase enzymes having improved properties as compared to a naturally occurring wild-type carboxyesterase enzymes, as well as polynucleotides encoding the engineered carboxyesterase enzymes, host cells capable of expressing the engineered carboxyesterase enzymes, and methods of using the engineered carboxyesterase enzymes in amidation reactions.
    Type: Application
    Filed: April 21, 2021
    Publication date: August 5, 2021
    Inventors: Rama Voladri, David Entwistle, Christopher Michael Micklitsch, Vesna Mitchell, Nikki Dellas, Xiyun Zhang, Antoinette Sero, Brent Dorr, Douglas E. Fuerst
  • TRANSAMINASE POLYPEPTIDES
    Publication number: 20210230564
    Abstract: The present disclosure provides engineered transaminase enzymes having improved properties as compared to a naturally occurring wild-type transaminase enzyme. Also provided are polynucleotides encoding the engineered transaminase enzymes, host cells capable of expressing the engineered transaminase enzymes, and methods of using the engineered transaminase enzymes to synthesize a variety of chiral compounds.
    Type: Application
    Filed: April 6, 2021
    Publication date: July 29, 2021
    Inventors: Ish K. Dhawan, Gregory Miller, Xiyun Zhang
  • ENGINEERED PHENYLALANINE AMMONIA LYASE POLYPEPTIDES
    Publication number: 20210222146
    Abstract: The present invention provides engineered phenylalanine ammonia-lyase (PAL) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia-lyase (PAL) polypeptides.
    Type: Application
    Filed: April 1, 2021
    Publication date: July 22, 2021
    Inventors: Gjalt W. Huisman, Nicholas J. Agard, Benjamin Mijts, Jonathan Vroom, Xiyun Zhang
  • NOVEL P450-BM3 VARIANTS WITH IMPROVED ACTIVITY
    Publication number: 20210214694
    Abstract: The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a wide range of substrates.
    Type: Application
    Filed: March 16, 2021
    Publication date: July 15, 2021
    Inventors: Robert Osborne, Vesna Mitchell, Khin Yu Naing Htwe, Xiyun Zhang, Erika M. Milczek, Jeffrey C. Moore
  • Carboxyesterase polypeptides for amide coupling
    Patent number: 11015180
    Abstract: The present invention provides engineered carboxyesterase enzymes having improved properties as compared to a naturally occurring wild-type carboxyesterase enzymes, as well as polynucleotides encoding the engineered carboxyesterase enzymes, host cells capable of expressing the engineered carboxyesterase enzymes, and methods of using the engineered carboxyesterase enzymes in amidation reactions.
    Type: Grant
    Filed: December 12, 2018
    Date of Patent: May 25, 2021
    Assignee: Codexis, Inc.
    Inventors: Rama Voladri, David Entwistle, Christopher Michael Micklitsch, Vesna Mitchell, Nikki Dellas, Xiyun Zhang, Antoinette Sero, Brent Dorr, Douglas E. Fuerst
  • Polynucleotides encoding engineered tyrosine ammonia lyase variants
    Patent number: 11015184
    Abstract: The present invention provides engineered tyrosine ammonia-lyase (TAL) polypeptides and compositions thereof. In some embodiments, the engineered TAL polypeptides have been optimized to provide enhanced catalytic activity while reducing sensitivity to proteolysis and increasing tolerance to acidic pH levels. The invention also provides methods for utilization of the compositions comprising the engineered TAL polypeptides for therapeutic and industrial purposes.
    Type: Grant
    Filed: November 20, 2019
    Date of Patent: May 25, 2021
    Assignee: Codexis, Inc.
    Inventors: Gjalt W. Huisman, Nicholas J. Agard, David Elgart, Xiyun Zhang