Patents by Inventor Xiyun Zhang

Xiyun Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ADDITIONAL PHYTASE VARIANTS AND METHODS
    Publication number: 20200299656
    Abstract: The present invention relates to variant phytase enzymes and their use thereof.
    Type: Application
    Filed: September 10, 2019
    Publication date: September 24, 2020
    Inventors: Khin Oo, Jie Yang, Xiyun Zhang, Goutami Banerjee, Tatsuya Fukushima, Eric Lin Hu, Imad N. Sawaya, Stephen Joshua Macaso Millet, Jijiao Zeng, Wenhua Lu
  • Penicillin-G acylases
    Patent number: 10781436
    Abstract: The present disclosure relates to engineered penicillin G acylase (PGA) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes.
    Type: Grant
    Filed: July 29, 2019
    Date of Patent: September 22, 2020
    Assignee: Codexis, Inc.
    Inventors: Goutami Banerjee, Jie Yang, Xiyun Zhang, Erika M. Milczek, Melissa Ann Mayo, Stephan Jenne
  • NOVEL P450-BM3 VARIANTS WITH IMPROVED ACTIVITY
    Publication number: 20200291365
    Abstract: The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a wide range of substrates.
    Type: Application
    Filed: June 2, 2020
    Publication date: September 17, 2020
    Inventors: Robert Osborne, Vesna Mitchell, Khin Yu Naing Htwe, Xiyun Zhang, Erika M. Milczek, Jeffrey C. Moore
  • AUTOMATED SCREENING OF ENZYME VARIANTS
    Publication number: 20200277597
    Abstract: Disclosed are methods for identifying bio-molecules with desired properties (or which are most suitable for a round of directed evolution) from complex bio-molecule libraries or sets of such libraries. Some embodiments of the present disclosure provide methods for virtually screening proteins for beneficial properties. Some embodiments of the present disclosure provide methods for virtually screening enzymes for desired activity and/or selectivity for catalytic reactions involving particular substrates. Some embodiments combine screening and directed evolution to design and develop proteins and enzymes having desired properties. Systems and computer program products implementing the methods are also provided.
    Type: Application
    Filed: May 15, 2020
    Publication date: September 3, 2020
    Inventors: Xiyun Zhang, Russell Javiniar Sarmiento, Donald Scott Baskerville, Gjalt W. Huisman
  • TRANSGLUTAMINASE VARIANTS
    Publication number: 20200263150
    Abstract: The present invention provides engineered transglutamirase enzymes, polynucleotides encoding the enzymes, compositions comprising the enzymes, methods of producing these enzymes, and methods of using the engineered transglutaminase enzymes.
    Type: Application
    Filed: November 2, 2018
    Publication date: August 20, 2020
    Inventors: Jovana Nazor, Jie Yang, Goutami Banerjee, Xiyun Zhang, James Nicholas Riggins, Erika M. Milczek, Jeffrey C. Moore
  • ENGINEERED PHENYLALANINE AMMONIA LYASE POLYPEPTIDES
    Publication number: 20200231959
    Abstract: The present invention provides engineered phenylalanine ammonia-lyase (PAL) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia-lyase (PAL) polypeptides.
    Type: Application
    Filed: March 26, 2020
    Publication date: July 23, 2020
    Inventors: Gjalt W. Huisman, Nicholas J. Agard, Benjamin Mijts, Jonathan Vroom, Xiyun Zhang
  • ENDOGLUCANASE COMPOSITIONS AND METHODS
    Publication number: 20200231955
    Abstract: The invention is directed to novel variant endoglucanases.
    Type: Application
    Filed: January 15, 2020
    Publication date: July 23, 2020
    Inventors: Jie Yang, Khin Oo, Goutami Banerjee, Xiyun Zhang, Wenhua Lu, Stephen Joshua Macaso Millet, Tatsuya Fukushima, Eric Lin Hu, Imad N. Sawaya, Marielle De Jesus Palatino
  • Engineered phenylalanine ammonia lyase polypeptides
    Patent number: 10717974
    Abstract: The present invention provides engineered phenylalanine ammonia-lyase (PAL) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia-lyase (PAL) polypeptides.
    Type: Grant
    Filed: April 19, 2019
    Date of Patent: July 21, 2020
    Assignee: Codexis, Inc.
    Inventors: Gjalt W. Huisman, Nicholas J. Agard, Benjamin Mijts, Jonathan Vroom, Xiyun Zhang
  • P450-BM3 variants with improved activity
    Patent number: 10704030
    Abstract: The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a wide range of substrates.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: July 7, 2020
    Assignee: Codexis, Inc.
    Inventors: Robert Osborne, Vesna Mitchell, Khin Yu Naing Htwe, Xiyun Zhang, Erika M. Milczek, Jeffrey C. Moore
  • Automated screening of enzyme variants
    Patent number: 10696964
    Abstract: Disclosed are methods for identifying bio-molecules with desired properties (or which are most suitable for a round of directed evolution) from complex bio-molecule libraries or sets of such libraries. Some embodiments of the present disclosure provide methods for virtually screening proteins for beneficial properties. Some embodiments of the present disclosure provide methods for virtually screening enzymes for desired activity and/or selectivity for catalytic reactions involving particular substrates. Some embodiments combine screening and directed evolution to design and develop proteins and enzymes having desired properties. Systems and computer program products implementing the methods are also provided.
    Type: Grant
    Filed: September 26, 2014
    Date of Patent: June 30, 2020
    Assignee: Codexis, Inc.
    Inventors: Xiyun Zhang, Russell Javiniar Sarmiento, Donald Scott Baskerville, Gjalt W. Huisman
  • ENGINEERED PHENYLALANINE AMMONIA LYASE POLYPEPTIDES
    Publication number: 20200199566
    Abstract: The present invention provides engineered phenylalanine ammonia-lyase (PAL) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia-lyase (PAL) polypeptides.
    Type: Application
    Filed: March 9, 2020
    Publication date: June 25, 2020
    Inventors: Gjalt W. Huisman, Nicholas J. Agard, Benjamin Mijts, Jonathan Vroom, Xiyun Zhang
  • VARIANT G6P G7P GLUCOAMYLASE COMPOSITIONS AND METHODS
    Publication number: 20200199560
    Abstract: The invention is directed to novel variant glucoamylases.
    Type: Application
    Filed: November 12, 2019
    Publication date: June 25, 2020
    Inventors: Xiyun ZHANG, Jie YANG, Goutami BANERJEE, Khin OO, Marielle De Jesus PALATINO, Eric Lin HU, Imad N. SAWAYA, Tatsuya FUKUSHIMA, Jijiao ZENG, Wenhua LU
  • VARIANT G6P G7P GLUCOAMYLASE COMPOSITIONS AND METHODS
    Publication number: 20200199561
    Abstract: The invention is directed to novel variant glucoamylases.
    Type: Application
    Filed: February 6, 2020
    Publication date: June 25, 2020
    Inventors: Jie YANG, Xiyun ZHANG, Goutami BANERJEE, Khin OO
  • P450-BM3 variants with improved activity
    Patent number: 10689627
    Abstract: The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a wide range of substrates.
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: June 23, 2020
    Assignee: Codexis, Inc.
    Inventors: Robert Osborne, Vesna Mitchell, Khin Yu Naing Htwe, Xiyun Zhang, Erika M. Milczek, Jeffrey C. Moore
  • Engineered phenylalanine ammonia lyase polypeptides
    Patent number: 10640759
    Abstract: The present invention provides engineered phenylalanine ammonia-lyase (PAL) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia-lyase (PAL) polypeptides.
    Type: Grant
    Filed: October 14, 2019
    Date of Patent: May 5, 2020
    Assignee: Codexis, Inc.
    Inventors: Gjalt W. Huisman, Nicholas J. Agard, Benjamin Mijts, Jonathan Vroom, Xiyun Zhang
  • TRANSAMINASE POLYPEPTIDES
    Publication number: 20200109380
    Abstract: The present disclosure provides engineered transaminase enzymes having improved properties as compared to a naturally occurring wild-type transaminase enzyme. Also provided are polynucleotides encoding the engineered transaminase enzymes, host cells capable of expressing the engineered transaminase enzymes, and methods of using the engineered transaminase enzymes to synthesize a variety of chiral compounds.
    Type: Application
    Filed: December 17, 2019
    Publication date: April 9, 2020
    Inventors: Ish K. Dhawan, Gregory Miller, Xiyun Zhang
  • ENGINEERED TYROSINE AMMONIA LYASE
    Publication number: 20200071688
    Abstract: The present invention provides engineered tyrosine ammonia-lyase (TAL) polypeptides and compositions thereof. In some embodiments, the engineered TAL polypeptides have been optimized to provide enhanced catalytic activity while reducing sensitivity to proteolysis and increasing tolerance to acidic pH levels. The invention also provides methods for utilization of the compositions comprising the engineered TAL polypeptides for therapeutic and industrial purposes.
    Type: Application
    Filed: November 20, 2019
    Publication date: March 5, 2020
    Inventors: Gjalt W. Huisman, Nicholas J. Agard, David Elgart, Xiyun Zhang
  • ENONE REDUCTASES
    Publication number: 20200040311
    Abstract: The disclosure relates to engineered enone reductase polypeptides having improved properties, polynucleotides encoding the engineered polypeptides, related vectors, host cells, and methods for making the engineered enone reductase polypeptides. The disclosure also provides methods of using the engineered enone reductase polypeptides for chemical transformations.
    Type: Application
    Filed: October 17, 2019
    Publication date: February 6, 2020
    Inventors: Christopher K. Savile, Vesna Mitchell, Xiyun Zhang, Gjalt W. Huisman
  • ENGINEERED PHENYLALANINE AMMONIA LYASE POLYPEPTIDES
    Publication number: 20200040325
    Abstract: The present invention provides engineered phenylalanine ammonia-lyase (PAL) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia-lyase (PAL) polypeptides.
    Type: Application
    Filed: October 14, 2019
    Publication date: February 6, 2020
    Inventors: Gjalt W. Huisman, Nicholas J. Agard, Benjamin Mijts, Jonathan Vroom, Xiyun Zhang
  • Transaminase polypeptides
    Patent number: 10550370
    Abstract: The present disclosure provides engineered transaminase enzymes having improved properties as compared to a naturally occurring wild-type transaminase enzyme. Also provided are polynucleotides encoding the engineered transaminase enzymes, host cells capable of expressing the engineered transaminase enzymes, and methods of using the engineered transaminase enzymes to synthesize a variety of chiral compounds.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: February 4, 2020
    Assignee: Codexis, Inc.
    Inventors: Ish K. Dhawan, Gregory Miller, Xiyun Zhang