Abstract: The present invention relates to the field of bio-pharmaceuticals and, in particular, to an anti-Siglec-15 antibody or an antigen binding fragment thereof, a nucleic acid sequence encoding the anti-Siglec-15 antibody of the present invention or an antigen binding fragment thereof, an expression vector containing the nucleic acid sequence, a host cell containing the expression vector, a composition or a bispecific antibody comprising the anti-Siglec-15 antibody of the present invention or an antigen binding fragment thereof, an immune conjugate comprising the anti-Siglec-15 antibody of the present invention or an antigen binding fragment thereof linked to a therapeutic agent, as well as use of the anti-Siglec-15 antibody of the present invention or an antigen binding fragment thereof in the preparation of a medicament for treatment of cancer.

Abstract: Disclosed in the present disclosure is a double-deck multi-span bridge construction method. According to the double-deck bridge construction method of the present disclosure, construction is carried out by using a method of disassembling a support jig frame in a graded and span-separated mode, an upper chord jig frame and a lower chord jig frame can be used in a recycle manner, and construction costs are reduced. In addition, a construction period of building the support jig frame is shortened, and other construction operations can be synchronously carried out on a span in which the jig frame is disassembled, for example, fire retardant coating construction can be carried out on a mounted bridge deck after the jig frame is disassembled, and the construction period of a double-deck multi-span bridge is effectively shortened.

Abstract: A method of crowdsourcing annotation for medical image data based on image comparison, includes developing an annotation task; acquiring and verifying medical images according to requirements of the annotation task, and performing statistics on the medical images that meet verification standards to obtain an amount of image data acquired; archiving the medical images that meet the verification standards to form a medical image database; setting up annotation rules, and generating annotation schemes and annotation samples according to the requirements of the annotation task and annotation rules; distributing the medical images in the medical image database to multiple crowdsourcing annotation sides, so that each medical image being annotated by the multiple crowdsourcing annotation sides; annotating, by the crowdsourcing annotation sides, the distributed medical images according to the annotation schemes and the annotation examples to form the annotated images; and merging multiple annotated images correspondi

Abstract: A resonant converter has a primary resonant tank circuit and a secondary resonant tank circuit. An inverter circuit converts an input DC voltage received by the resonant converter at an input voltage node to a pulsating signal that is fed to the primary resonant tank circuit to generate a resonant tank current that flows through a primary winding of a transformer. The resonant tank current induces current in a secondary winding of the transformer. The induced current is rectified by a rectifier and the rectified signal is filtered to generate an output DC voltage at an output voltage node. The secondary resonant tank circuit is disposed between the secondary winding of the transformer and the output voltage node, and a tank node of the secondary resonant tank is connected to the primary resonant tank circuit through the inverter circuit.

Abstract: The present disclosure relates to compounds of Formula I: that act as inhibitors of NLRP3 inflammasomes; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with inflammation and inflammaging, including hearing loss and other diseases associated with aging.

Abstract: A single groove single-sided fastener comprises: a rivet consisting of a rivet head, a polish rod, a locking groove, a tail pulling groove and a tail tooth in sequence, and a lantern ring consisting of a sleeve and a dead head; a tail of the rivet is of a single groove short-tail structure, a ratio of a length of the tail pulling groove to a total length of the tail tooth is 0.1˜1.5, an included angle between a bottom generatrix of the tail pulling groove and an axis of the rivet is ?30°˜0°, two axial ends of the bottom of the tail pulling groove and the tail of the tail tooth are of a fillet transition structure, a ratio of a length of a straight part of the tail tooth to the total length of the tail tooth is 0.1˜1.

Abstract: Computer software architectures are disclosed that use improved machine learning techniques for data science and data clustering. Computer operations are improved by more efficiently and effectively processing relevant data. Based on a clustering model, initial clusters of taxonomical pairs of entity classifications and entity sub-classifications using taxonomical-level textual data representative of one or more aspects of electronic transactions associated with the taxonomical pairs can be determined, wherein the clustering model has been generated based on machine learning applied to past clusters of past taxonomical pairs of entity classifications and entity sub-classifications other than the initial clusters of the taxonomical pairs, and iteratively refining the initial clusters, according to a similarity criterion, resulting in tuned clusters.

Abstract: The invention discloses a pulling rivet for fasten-connecting a conductive material. It consists of a rivet and a lantern ring, wherein the rivet comprises a dead head, a polish rod, a locking groove, a pulling groove and a short tail, the lantern ring comprises a flange, a deformation area and a clamping tooth, and a sharp protrusion is arranged on a contact surface of an inner side of the dead head and a fasten-coupling piece. The sharp protrusions of the present invention can be embedded into the surface of the fastening piece to prevent the sliding between the fasten-coupling piece and the rivet, and because the sharp protrusions are embedded into the surface of the fasten-coupling piece to form a tightly fitted whole, which improves the conductivity of the rivet and the frame.

Abstract: The present disclosure relates to a method and system for monitoring on route transportations. The method includes obtaining a driving route of a target vehicle; obtaining a reference position on the driving route away from a first current position of the target vehicle; determining a second current position of the target vehicle after a reference time; determining a distance between the second current position and the reference position is greater than a preset distance; and sending a signal to a target terminal indicating that the target vehicle is off-route.

Abstract: A single groove single-sided fastener comprises: a rivet consisting of a rivet head, a polish rod, a locking groove, a tail pulling groove and a tail tooth in sequence, and a lantern ring consisting of a sleeve and a dead head; a tail of the rivet is of a single groove short-tail structure, a ratio of a length of the tail pulling groove to a total length of the tail tooth is 0.1˜1.5, an included angle between a bottom generatrix of the tail pulling groove and an axis of the rivet is ?30°˜?0°, two axial ends of the bottom of the tail pulling groove and the tail of the tail tooth are of a fillet transition structure, a ratio of a length of a straight part of the tail tooth to the total length of the tail tooth is 0.1˜1.

Abstract: Disclosed in embodiments of the present invention are a synchronous control method and system for a laser test of an optical engine. The operation of a laser can be driven by the synchronous control system. When a test of a data point is finished and the optical engine stops for optical window cleaning, the laser may still maintain stable operation under the driving of the synchronous control system, experiments may be directly carried out next time, and thus, laser test efficiency of the optical engine can be improved. Moreover, the synchronous control system is adopted to independently drive the laser to achieve energy stability before experiments, preventing an influence of long-term operation on the performance of the optical engine, and improving test accuracy.

Abstract: An indazole hydrazide compound, as represented in formula (I); wherein, R is selected from substituted alkyl, substituted alkenyl and substituted phenyl; substituent in the substituted alkyl and substituted alkenyl includes phenyl and/or substituted phenyl; R? is selected from H and alkyl. Compared with the prior art, the above indole hydrazide compound can be used as integrin av?3 receptor antagonist. Besides, it has obvious anti-prostate cancer activity and has a significant inhibitory effect on enzalutamide-resistant cell lines. In addition, the above-mentioned compound has obvious anti-tumor angiogenesis activity and can be used in the preparation of anti-tumor angiogenesis drugs to inhibit tumor angiogenesis.

Abstract: A printer head for three-dimensional printing of a continuous fiber-reinforced thermoset composite may include a deposition syringe, a fiber housing, and a feeding tube. The deposition syringe may define a resin reservoir, an air chamber, and a first inlet port configured to deliver a first flow of air to the air chamber. The deposition syringe may include a syringe body and a piston. The syringe body may include an inlet section, a needle section, and a converging section disposed between the inlet section and the needle section. The fiber housing may define a fiber chamber and a second inlet port configured to deliver a second flow of air to the fiber chamber. The feeding tube may extend from the fiber chamber to the needle section and may be configured to receive the second flow of air therein and to guide a fiber from the fiber chamber to the needle section.

Abstract: Disclosed are a mobile Internet-based integrated vehicle energy replenishment system and method, and a storage medium.

Abstract: The present disclosure relates to a method and system for monitoring on route transportations. The method includes obtaining a driving route of a target vehicle; obtaining a reference position on the driving route away from a first current position of the target vehicle; determining a second current position of the target vehicle after a reference time; determining a distance between the second current position and the reference position is greater than a preset distance; and sending a signal to a target terminal indicating that the target vehicle is off-route.

Abstract: Disclosed in embodiments of the present invention are a synchronous control method and system for a laser test of an optical engine. The operation of a laser can be driven by the synchronous control system. When a test of a data point is finished and the optical engine stops for optical window cleaning, the laser may still maintain stable operation under the driving of the synchronous control system, experiments may be directly carried out next time, and thus, laser test efficiency of the optical engine can be improved. Moreover, the synchronous control system is adopted to independently drive the laser to achieve energy stability before experiments, preventing an influence of long-term operation on the performance of the optical engine, and improving test accuracy.

Abstract: The present disclosure relates to compounds that act as inhibitors of NLRP3 inflammasomes; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with inflammation and inflammaging, including hearing loss and other diseases associated with aging.

Abstract: Embodiments of this application provide a method of distributing information from an allocator terminal to a client terminal over a communication network. Information allocation data in an information allocation system is collected by processing circuitry. The information allocation system is configured to allocate the information to a client terminal. The information allocation data includes data associated with a process of allocating the information. Data of actual effect and estimated effect of allocating the information is calculated according to the information allocation data. An allocation instruction is generated according to a comparison between the actual effect data and the corresponding estimated effect data. The allocation instruction is provided to the allocator terminal.

Abstract: The present disclosure relates to a method and system for monitoring on route transportations. The method includes obtaining a driving route of a target vehicle; obtaining a reference position on the driving route away from a first current position of the target vehicle; determining a second current position of the target vehicle after a reference time; determining a distance between the second current position and the reference position is greater than a preset distance; and sending a signal to a target terminal indicating that the target vehicle is off-route.