Patents by Inventor Yariv Donde

Yariv Donde has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents
    Patent number: 7863319
    Abstract: A compound comprising or a pharmaceutically acceptable salt or a prodrug thereof, having the groups described in detail herein is disclosed. Also disclosed herein are compounds comprising or derivatives thereof, or pharmaceutically acceptable salts, tetrazoles, or prodrugs of compounds of the structure or derivatives thereof, said derivatives being described in detail herein. Also disclosed herein are methods of treating diseases or conditions, including glaucoma and elevated intraocular pressure. Compositions and methods of manufacturing medicaments related thereto are also disclosed.
    Type: Grant
    Filed: January 16, 2007
    Date of Patent: January 4, 2011
    Assignee: Allergan, Inc.
    Inventors: Yariv Donde, Robert M. Burk, Michael E. Garst
  • Treatment of inflammatory bowel disease
    Patent number: 7855226
    Abstract: Disclosed herein is a method comprising administering a compound to a mammal suffering from an inflammatory bowel disease for the treatment of said disease, said compound having a structure according to Formula I wherein X, Y, B, R2, R3, R4, R5, R6 and n have the meanings found herein.
    Type: Grant
    Filed: March 17, 2005
    Date of Patent: December 21, 2010
    Assignee: Allergan, Inc.
    Inventors: Yariv Donde, Jeremiah H. Nguyen, Karen M. Kedzie, Daniel W. Gil, John E. Donello, Wha-Bin Im
  • THERAPEUTIC COMPOUNDS
    Publication number: 20100317872
    Abstract: A compound having a substituted five or six-membered carbocycle or heterocycle directly bonded to a substituted aryl or heteroaryl ring, wherein said compound has an EC50 value of 20 nM or less at the prostaglandin EP2 receptor according to the cAMP assay. Methods, compositions, and medicaments related thereto are also disclosed.
    Type: Application
    Filed: August 20, 2010
    Publication date: December 16, 2010
    Applicant: ALLERGAN, INC.
    Inventors: Yariv Donde, Robert M. Burk, David W. Old
  • Therapeutic compounds
    Patent number: 7799821
    Abstract: A compound having a substituted five or six-membered carbocycle or heterocycle directly bonded to a substituted aryl or heteroaryl ring, wherein said compound has an EC50 value of 20 nM or less at the prostaglandin EP2 receptor according to the cAMP assay. Methods, compositions, and medicaments related thereto are also disclosed.
    Type: Grant
    Filed: May 30, 2006
    Date of Patent: September 21, 2010
    Assignee: Allergan, Inc.
    Inventors: Yariv Donde, Robert M. Burk, David W. Old
  • THERAPEUTIC COMPOUNDS
    Publication number: 20100173981
    Abstract: Disclosed herein is a compound according to one of the formulas or a pharmaceutically acceptable salt thereof, medicaments for the treatment of glaucoma or ocular hypertension and compositions related thereto, as further elaborated herein.
    Type: Application
    Filed: January 30, 2008
    Publication date: July 8, 2010
    Applicant: Allergan, Inc.
    Inventors: Brent A. Johnson, David W. Old, Yariv Donde, Robert M. Burk
  • Therapeutic substituted cyclopentanes
    Patent number: 7732443
    Abstract: Therapeutic compounds are disclosed herein. Methods, compositions, and medicaments related thereto are also disclosed. The compounds described herein are used to treat ocular conditions, bowel disease and baldness.
    Type: Grant
    Filed: March 16, 2009
    Date of Patent: June 8, 2010
    Inventors: Yariv Donde, Robert M. Burk, Jeremiah H. Nguyen
  • SUBSTITUTED ARYLCYCLOPENTENES AS THERAPEUTIC AGENTS
    Publication number: 20100137347
    Abstract: Disclosed herein is a compound of the formula (I). Therapeutic methods, compositions, and medicaments, related thereto are also disclosed.
    Type: Application
    Filed: January 21, 2008
    Publication date: June 3, 2010
    Applicant: ALLERGAN, INC.
    Inventors: Yariv Donde, Jeremiah H. Nguyen
  • Substituted arylcyclopentenes as therapeutic agents
    Patent number: 7713968
    Abstract: Compounds comprising or a pharmaceutically acceptable salt or a prodrug thereof, are disclosed, wherein Y, A, and B are as described. Methods, compositions, and medicaments related thereto are also disclosed.
    Type: Grant
    Filed: April 22, 2009
    Date of Patent: May 11, 2010
    Assignee: Allergan, Inc.
    Inventors: Yariv Donde, Jeremiah H. Nguyen
  • 10-hydroxy-11-dihydroprostaglandin analogs as selective EP4 agonists
    Patent number: 7652063
    Abstract: A compound comprising or a pharmaceutically acceptable salt or a prodrug thereof, wherein the dashed line represents the presence or absence of a double bond; J is C?O or CHOH; A is —(CH2)6—, or cis —CH2CH?CH—(CH2)3—, wherein 1 or 2 carbons may be substituted with S or O; B is CO2H, or CO2R, CONR2, CONHCH2CH2OH, CON(CH2CH2OH)2, CH2OR, P(O)(OR)2, CONRSO2R, SONR2, or R is H, C1-6 alkyl; D is —(CH2)n—, —X(CH2)n, or —(CH2)nX—, wherein n is from 0 to 3 and X is S or O; and E is an aromatic or heteroaromatic moiety having from 0 to 4 substituents, said substituents each comprising from 1 to 6 non-hydrogen atoms is disclosed herein. Methods, compositions, and medicaments related thereto, as well as experimental results showing prostaglandin EP4 selective agonist activity for certain compounds disclosed herein, are also disclosed.
    Type: Grant
    Filed: September 15, 2006
    Date of Patent: January 26, 2010
    Assignee: Allergan, Inc.
    Inventor: Yariv Donde
  • Therapeutic Compounds
    Publication number: 20090281104
    Abstract: Compounds comprising or a pharmaceutically acceptable salt or a prodrug thereof, are disclosed, wherein J, B, Y, and A are as described. Methods, compositions, and medicaments related thereto are also disclosed.
    Type: Application
    Filed: May 1, 2009
    Publication date: November 12, 2009
    Applicant: ALLERGAN, INC.
    Inventors: Yariv Donde, Jeremiah H. Nguyen
  • THERAPEUTIC COMPOUNDS
    Publication number: 20090275646
    Abstract: Compounds having a structure are disclosed herein. Compositions, methods, and medicaments related to the therapeutic use of these compounds are also disclosed.
    Type: Application
    Filed: April 21, 2009
    Publication date: November 5, 2009
    Applicant: ALLERGAN, INC.
    Inventors: Yariv Donde, Jeremiah H. Nguyen, Mark Holoboski, Mari Posner, Robert M. Burk
  • Prostaglandin EPantagonists
    Patent number: 7612082
    Abstract: Disclosed herein are methods and compositions related to compound 1 or compound 2 or pharmaceutically acceptable salts, or prodrugs thereof, which are antagonists of a prostaglandin EP4 receptor, or are prostaglandin EP4 antagonists.
    Type: Grant
    Filed: October 28, 2004
    Date of Patent: November 3, 2009
    Assignee: Allergan, Inc.
    Inventors: Larry A. Wheeler, Michael E. Garst, Yanbin Liang, David F. Woodward, Achim H.-P. Krauss, Robert M. Burk, Yariv Donde, Mark Holoboski, David W. Old, June Chen
  • SUBSTITUTED ARYLCYCLOPENTENES AS THERAPEUTIC AGENTS
    Publication number: 20090270387
    Abstract: Compounds comprising or a pharmaceutically acceptable salt or a prodrug thereof, are disclosed, wherein Y, A, and B are as described. Methods, compositions, and medicaments related thereto are also disclosed.
    Type: Application
    Filed: April 22, 2009
    Publication date: October 29, 2009
    Applicant: ALLERGAN, INC.
    Inventors: Yariv Donde, Jeremiah H. Nguyen
  • THERAPEUTIC SUBSTITUTED CYCLOPENTANES
    Publication number: 20090239869
    Abstract: Therapeutic compounds are disclosed herein. Methods, compositions, and medicaments related thereto are also disclosed. The compounds described herein are used to treat ocular conditions, bowel disease and baldness.
    Type: Application
    Filed: March 16, 2009
    Publication date: September 24, 2009
    Applicant: ALLERGAN, INC.
    Inventors: Yariv Donde, Robert M. Burk, Jeremiah H. Nguyen
  • THERAPEUTIC CYCLOPENTANE DERIVATIVES
    Publication number: 20090233921
    Abstract: Compounds comprising or a pharmaceutically acceptable salt or a prodrug thereof, are disclosed, wherein Y, A, and B are as described. Methods, compositions, and medicaments related thereto are also disclosed.
    Type: Application
    Filed: March 6, 2009
    Publication date: September 17, 2009
    Applicant: ALLERGAN, INC.
    Inventor: Yariv Donde
  • SUBSTITUTED CYCLOPENTANES HAVING PROSTAGLANDIN ACTIVITY
    Publication number: 20090227573
    Abstract: Disclosed herein are compounds represented by the formula: Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
    Type: Application
    Filed: February 25, 2009
    Publication date: September 10, 2009
    Applicant: ALLERGAN, INC.
    Inventors: Mark Holoboski, Robert M. Burk, Mari Posner, Yariv Donde, David W. Old
  • Therapeutic substituted cyclopentanes
    Patent number: 7585895
    Abstract: Therapeutic prostaglandin compounds are disclosed herein.
    Type: Grant
    Filed: August 14, 2008
    Date of Patent: September 8, 2009
    Assignee: Allergan, Inc.
    Inventors: Yariv Donde, Robert M. Burk
  • THERAPEUTIC COMPOUNDS
    Publication number: 20090186885
    Abstract: Disclosed herein is a compound according to one of the formulas wherein R Additionally, pharmaceutically acceptable salt thereof, and methods of treating disease, medicaments, and compositions related thereto, are further elaborated herein.
    Type: Application
    Filed: January 13, 2009
    Publication date: July 23, 2009
    Inventors: Brent A. Johnson, David W. Old, Yariv Donde, Robert M. Burk
  • Therapeutic cyclopentane derivatives
    Patent number: 7547727
    Abstract: Disclosed herein is a compound having a structure or a pharmaceutically acceptable salt, or a prodrug thereof. Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
    Type: Grant
    Filed: May 11, 2007
    Date of Patent: June 16, 2009
    Assignee: Allergan, Inc.
    Inventors: Yariv Donde, Jeremiah H. Nguyen
  • SUBSTITUTED CYCLOPENTANES HAVING PROSTAGLANDIN ACTIVITY
    Publication number: 20090124676
    Abstract: Disclosed herein are compounds having a formula: Therapeutic methods, medicaments, and compositions related thereto are also disclosed.
    Type: Application
    Filed: November 5, 2008
    Publication date: May 14, 2009
    Inventor: Yariv Donde