Patents by Inventor Yasmin A. Chandrasekher

Yasmin A. Chandrasekher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunoconjugates of anti-IL-20 antibodies and hybridoma cell lines expressing anti-IL-20 antibodies
    Patent number: 7393684
    Abstract: The present invention relates to blocking the activity of IL-20 polypeptide molecules. IL-20 is a cytokine that is involved in inflammatory processes and human disease. IL-20RA/IL-20RB is a common receptor for IL-20. The present invention includes anti-IL-20 antibodies and binding partners, as well as methods for antagonizing IL-20 using such antibodies and binding partners.
    Type: Grant
    Filed: November 19, 2004
    Date of Patent: July 1, 2008
    Assignee: ZymoGenetics, Inc.
    Inventors: Wenfeng Xu, Wayne R. Kindsvogel, Zhi Chen, Steven D. Hughes, Yasmin A. Chandrasekher, Stacey R. Dillon, Joyce M. Lehner, Anthony W. Siadak, Pallavur V. Sivakumar, Margaret D. Moore
  • Method for treating inflammation
    Patent number: 7364732
    Abstract: A method for treating IL-20 induced inflammation. An antagonist to IL-20 is administered to treat inflammation and associated diseases. The antagonist can be an antibody that binds to IL-20 or its receptor or a soluble receptor that binds to IL-20. Examples of such diseases are adult respiratory disease, psoriasis, eczema, contact dermatitis, atopic dermatitis, septic shock, multiple organ failure, inflammatory lung injury, bacterial pneumonia, inflammatory bowel disease, rheumatoid arthritis, asthma, ulcerative colitis and Crohn's disease.
    Type: Grant
    Filed: July 19, 2006
    Date of Patent: April 29, 2008
    Assignee: ZymoGenetics, Inc.
    Inventors: Penny Thompson, Hal Blumberg, Yasmin A. Chandrasekher
  • ANTI-IL-TIF ANTIBODIES AND METHODS OF USING IN INFLAMMATION
    Publication number: 20080033148
    Abstract: The present invention relates to blocking the activity of IL-TIF polypeptide molecules. IL-TIF is a cytokine involved in inflammatory processes and human disease. The present invention includes anti-IL-TIF antibodies and binding partners, as well as methods for antagonizing IL-TIF using such antibodies and binding partners in IL-TIF-related human inflammatory diseases, amongst other uses disclosed.
    Type: Application
    Filed: July 27, 2007
    Publication date: February 7, 2008
    Inventors: Wenfeng Xu, Wayne Kindsvogel, Steven Hughes, Yasmin Chandrasekher
  • Use of interleukin-24 to treat ovarian cancer
    Patent number: 7323164
    Abstract: The present invention relates to the anti-cancer activity of IL-24 polypeptide molecules. IL-24 is a cytokine involved in inflammatory processes and human disease. The present invention includes Use of IL-24 for decreasing proliferation of ovarian cancer cells, treating ovarian cancer, amongst other uses disclosed. IL-24 polypeptides can be administered alone, or can be fused to cytotoxic moieties, and can be administered in conjunction with radiation or chemotherapeutic agents.
    Type: Grant
    Filed: April 8, 2003
    Date of Patent: January 29, 2008
    Assignee: ZymoGenetics, Inc.
    Inventors: Yasmin A. Chandrasekher, Patricia A. McKernan
  • USE OF INTERLEUKIN-19 TO TREAT CERVICAL CANCER
    Publication number: 20070269407
    Abstract: The present invention relates to the anti-cancer activity of IL-19 polypeptide molecules. IL-19 is a cytokine involved in inflammatory processes and human disease. The present invention includes Use of IL-19 for decreasing proliferation of cervical cancer cells, treating cervical cancer, amongst other uses disclosed. IL-19 polypeptides can be administered alone, or can be fused to cytotoxic moieties, and can be administered in conjunction with radiation or chemotherapeutic agents.
    Type: Application
    Filed: June 19, 2007
    Publication date: November 22, 2007
    Inventors: Yasmin Chandrasekher, Patricia McKernan
  • Anti-IL-TIF antibodies and methods of making
    Patent number: 7265211
    Abstract: The present invention relates to blocking the activity of IL-TIF polypeptide molecules. IL-TIF is a cytokine involved in inflammatory processes and human disease. The present invention includes anti-IL-TIF antibodies and binding partners, as well as methods for antagonizing IL-TIF using such antibodies and binding partners in IL-TIF-related human inflammatory diseases, amongst other uses disclosed.
    Type: Grant
    Filed: March 24, 2003
    Date of Patent: September 4, 2007
    Assignee: ZymoGenetics, Inc.
    Inventors: Wenfeng Xu, Wayne Kindsvogel, Steven D. Hughes, Yasmin A. Chandrasekher
  • METHODS OF USING SOLUBLE HETERODIMERIC CYTOKINE RECEPTOR
    Publication number: 20070173451
    Abstract: A soluble receptor that binds to IL-20 having two polypeptide subunits, IL-22R and IL-20RB. The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.
    Type: Application
    Filed: March 26, 2007
    Publication date: July 26, 2007
    Inventors: Yasmin Chandrasekher, Julia Novak, Donald Foster, Wenfeng Xu, Stephen Jaspers
  • Use of interleukin-19 to treat cervical cancer
    Patent number: 7247444
    Abstract: The present invention relates to the anti-cancer activity of IL-19 polypeptide molecules. IL-19 is a cytokine involved in inflammatory processes and human disease. The present invention includes Use of IL-19 for decreasing proliferation of cervical cancer cells, treating cervical cancer, amongst other uses disclosed. IL-19 polypeptides can be administered alone, or can be fused to cytotoxic moieties, and can be administered in conjunction with radiation or chemotherapeutic agents.
    Type: Grant
    Filed: April 8, 2003
    Date of Patent: July 24, 2007
    Assignee: ZymoGenetics, Inc.
    Inventors: Yasmin A. Chandrasekher, Patricia A. McKernan
  • Method for treating inflammation
    Patent number: 7189394
    Abstract: A method for treating IL-20 induced inflammation. An antagonist to IL-20 is administered to treat inflammation and associated diseases. The antagonist can be an antibody that binds to IL-20 or its receptor or a soluble receptor that binds to IL-20. Examples of such diseases are adult respiratory disease, psoriasis, eczema, contact dermatitis, atopic dermatitis, septic shock, multiple organ failure, inflammatory lung injury, bacterial pneumonia, inflammatory bowel disease, rheumatoid arthritis, asthma, ulcerative colitis and Crohn's disease.
    Type: Grant
    Filed: April 28, 2003
    Date of Patent: March 13, 2007
    Assignee: ZymoGenetics, Inc.
    Inventors: Penny Thompson, Donald C. Foster, Wenfeng Xu, Hal Blumberg, Yasmin A. Chandrasekher
  • METHOD FOR TREATING INFLAMMATION
    Publication number: 20060269551
    Abstract: A method for treating IL-20 induced inflammation. An antagonist to IL-20 is administered to treat inflammation and associated diseases. The antagonist can be an antibody that binds to IL-20 or its receptor or a soluble receptor that binds to IL-20. Examples of such diseases are adult respiratory disease, psoriasis, eczema, contact dermatitis, atopic dermatitis, septic shock, multiple organ failure, inflammatory lung injury, bacterial pneumonia, inflammatory bowel disease, rheumatoid arthritis, asthma, ulcerative colitis and Crohn's disease.
    Type: Application
    Filed: July 19, 2006
    Publication date: November 30, 2006
    Inventors: Penny Thompson, Donald Foster, Wenfeng Xu, Karen Madden, James Kelly, Cindy Sprecher, Hal Blumberg, Maribeth Eagan, Stephen Jaspers, Yasmin Chandrasekher, Julia Novak
  • Use of interleukin-19 to treat ovarian cancer
    Patent number: 7074575
    Abstract: The present invention relates to the anti-cancer activity of IL-19 polypeptide molecules. IL-19 is a cytokine involved in inflammatory processes and human disease. The present invention includes Use of IL-19 for decreasing proliferation of ovarian cancer cells, treating ovarian cancer, amongst other uses disclosed. IL-19 polypeptides can be administered alone, or can be fused to cytotoxic moieties, and can be administered in conjunction with radiation or chemotherapeutic agents.
    Type: Grant
    Filed: April 8, 2003
    Date of Patent: July 11, 2006
    Assignee: ZymoGenetics, Inc.
    Inventors: Yasmin A. Chandrasekher, Patricia A. McKernan
  • Anti-IL-22RA antibodies and binding partners and methods of using in inflammation
    Publication number: 20060141582
    Abstract: The present invention relates to blocking, inhibiting, reduceing, antagonizing or neutralizing the activity of IL-22, IL-20, or both IL-20 and IL-22 polypeptide molecules. IL-20 and IL-22 are cytokines that are involved in inflammatory processes and human disease. IL-22RA (zcytor11) is a common receptor for IL-20 and IL-22. The present invention includes anti-IL-22RA antibodies and binding partners, as well as methods for antagonizing IL-22 or both IL-20 and IL-22 using such antibodies and binding partners.
    Type: Application
    Filed: October 21, 2005
    Publication date: June 29, 2006
    Inventors: Wenfeng Xu, Wayne Kindsvogel, Yasmin Chandrasekher, Stacey Dillon, Joyce Lehner, Anthony Siadak, Pallavur Sivakumar, Margaret Moore
  • Anti-IL-20 antibodies and binding partners and methods of using in inflammation
    Publication number: 20060134756
    Abstract: The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-20 polypeptide molecules. IL-20 and IL-22 are cytokines that are involved in inflammatory processes and human disease. The present invention includes anti-IL-20 and anti-IL-22RA antibodies and binding partners, as well as methods for antagonizing IL-20 using such antibodies and binding partners.
    Type: Application
    Filed: March 24, 2004
    Publication date: June 22, 2006
    Inventors: Wenfeng Xu, Wayne Kindsvogel, Yasmin Chandrasekher, Stacey Dillon, Joyce Lehner, Anthony Siadak, Pallavur Sivakumar, Margaret Moore
  • Anti-IL-20 receptor antibodies and binding partners and methods of using in inflammation
    Publication number: 20050170468
    Abstract: The present invention relates to blocking the activity of IL-20 receptor polypeptide molecules. IL-20 is a cytokine that is involved in inflammatory processes and human disease. IL-20RA/IL-20RB is a common receptor for IL-20. The present invention includes anti-IL-20 receptor antibodies and binding partners, including anti-IL-20RA, anti-IL-20RB and anti-IL-20RA/IL-20RB antibodies as well as methods for antagonizing IL-20RA and IL-20RB, either individually or together, using such antibodies and binding partners.
    Type: Application
    Filed: November 19, 2004
    Publication date: August 4, 2005
    Inventors: Wenfeng Xu, Wayne Kindsvogel, Zhi Chen, Steven Hughes, Yasmin Chandrasekher, Stacey Dillon, Joyce Lehner, Anthony Siadak, Pallavur Sivakumar, Margaret Moore
  • Anti-IL-20 antibodies and binding partners and methods of using in inflammation
    Publication number: 20050136004
    Abstract: The present invention relates to blocking the activity of IL-20 polypeptide molecules. IL-20 is a cytokine that is involved in inflammatory processes and human disease. IL-20RA/IL-20RB is a common receptor for IL-20. The present invention includes anti-IL-20 antibodies and binding partners, as well as methods for antagonizing IL-20 using such antibodies and binding partners.
    Type: Application
    Filed: November 19, 2004
    Publication date: June 23, 2005
    Inventors: Wenfeng Xu, Wayne Kindsvogel, Zhi Chen, Steven Hughes, Yasmin Chandrasekher, Stacey Dillon, Joyce Lehner, Anthony Siadak, Pallavur Sivakumar, Margaret Moore
  • Anti-IL-22RA antibodies and binding partners and methods of using in inflammation
    Publication number: 20040209330
    Abstract: The present invention relates to blocking, inhibiting, reduceing, antagonizing or neutralizing the activity of IL-22, IL-20, or both IL-20 and IL-22 polypeptide molecules. IL-20 and IL-22 are cytokines that are involved in inflammatory processes and human disease. IL-22RA (zcytor11) is a common receptor for IL-20 and IL-22. The present invention includes anti-IL-22RA antibodies and binding partners, as well as methods for antagonizing IL-22 or both IL-20 and IL-22 using such antibodies and binding partners.
    Type: Application
    Filed: March 24, 2004
    Publication date: October 21, 2004
    Inventors: Wenfeng Xu, Wayne Kindsvogel, Yasmin A. Chandrasekher, Stacey R. Dillon, Joyce M. Lehner, Anthony W. Siadak, Pallavur V. Sivakumar, Margaret D. Moore
  • Soluble heterodimeric cytokine receptor
    Publication number: 20040086908
    Abstract: A soluble receptor that binds to IL-20 having two polypeptide subunits, IL-22R and IL-20RB. The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.
    Type: Application
    Filed: September 8, 2003
    Publication date: May 6, 2004
    Inventors: Yasmin A. Chandrasekher, Julia E. Novak, Donald C. Foster, Wenfeng Xu, Stephen R. Jaspers
  • Anti-IL-TIF antibodies and methods of using in inflammation
    Publication number: 20040023341
    Abstract: The present invention relates to blocking the activity of IL-TIF polypeptide molecules. IL-TIF is a cytokine involved in inflammatory processes and human disease. The present invention includes anti-IL-TIF antibodies and binding partners, as well as methods for antagonizing IL-TIF using such antibodies and binding partners in IL-TIF-related human inflammatory diseases, amongst other uses disclosed.
    Type: Application
    Filed: March 24, 2003
    Publication date: February 5, 2004
    Inventors: Wenfeng Xu, Wayne Kindsvogel, Steven D. Hughes, Yasmin A. Chandrasekher
  • Method for treating inflammation
    Publication number: 20040005320
    Abstract: A method for treating IL-20 induced inflammation. An antagonist to IL-20 is administered to treat inflammation and associated diseases. The antagonist can be an antibody that binds to IL-20 or its receptor or a soluble receptor that binds to IL-20. Examples of such diseases are adult respiratory disease, psoriasis, eczema, contact dermatitis, atopic dermatitis, septic shock, multiple organ failure, inflammatory lung injury, bacterial pneumonia, inflammatory bowel disease, rheumatoid arthritis, asthma, ulcerative colitis and Crohn's disease.
    Type: Application
    Filed: April 28, 2003
    Publication date: January 8, 2004
    Inventors: Penny Thompson, Donald C. Foster, Wenfeng Xu, Karen L. Madden, James D. Kelly, Cindy A. Sprecher, Hal Blumberg, Maribeth A. Eagan, Stephen R. Jaspers, Yasmin A. Chandrasekher, Julia E. Novak
  • Use of interleukin-19 to treat ovarian cancer
    Publication number: 20030223958
    Abstract: The present invention relates to the anti-cancer activity of IL-19 polypeptide molecules. IL-19 is a cytokine involved in inflammatory processes and human disease. The present invention includes Use of IL-19 for decreasing proliferation of ovarian cancer cells, treating ovarian cancer, amongst other uses disclosed. IL-19 polypeptides can be administered alone, or can be fused to cytotoxic moieties, and can be administered in conjunction with radiation or chemotherapeutic agents.
    Type: Application
    Filed: April 8, 2003
    Publication date: December 4, 2003
    Inventors: Yasmin A. Chandrasekher, Patricia A. McKernan