Abstract: A coolant passageway (2) of a heat sink (1) has a coolant lead-in part (21), a coolant lead-out part (22), coolant-contact parts (23), coolant-transit parts (25), and connecting parts (24). The coolant-contact parts (23) are disposed spaced apart from one another along a coolant path leading from the coolant lead-in part (21) to the coolant lead-out part (22) and are configured such that they bring the coolant into contact with a cooling-wall part. The coolant-transit parts (25) are disposed between adjacent coolant-contact parts (23) and are configured such that the coolant can transit from upstream-side coolant-contact parts (23) to downstream-side coolant-contact parts (23) in the coolant paths. The connecting parts (24) are interposed between the coolant-transit parts (25) and the coolant-contact parts (23) and have a passageway cross-sectional area that is smaller than those of the coolant-contact parts (23) and the coolant-transit parts (25).

Abstract: A monoclonal antibody is provided which binds to a human CC chemokine receptor 1 (CCR1) and inhibits activation of the human CCR1, or an antibody fragment thereof. The monoclonal antibody binds to an extracellular region of a human CCR1 and inhibits activation of the human CCR1 by a human CC chemokine ligand 15 (CCL15). An antibody fragment thereof, a hybridoma producing the antibody, a nucleic acid having a nucleotide sequence encoding the antibody or the antibody fragment, a transformant cell containing a vector containing the nucleic acid, a method for producing the antibody or the antibody fragment using the hybridoma or the transformant cell; a therapeutic agent and a diagnostic agent containing the antibody or the antibody fragment, and a method for treating and diagnosing a CCR1-related disease using the antibody or the antibody fragment are also provided.

Abstract: A monoclonal antibody is provided which binds to a human CC chemokine receptor 1 (CCR1) and inhibits activation of the human CCR1, or an antibody fragment thereof. The monoclonal antibody binds to an extracellular region of a human CCR1 and inhibits activation of the human CCR1 by a human CC chemokine ligand 15 (CCL15). An antibody fragment thereof, a hybridoma producing the antibody, a nucleic acid having a nucleotide sequence encoding the antibody or the antibody fragment, a transformant cell containing a vector containing the nucleic acid, a method for producing the antibody or the antibody fragment using the hybridoma or the transformant cell; a therapeutic agent and a diagnostic agent containing the antibody or the antibody fragment, and a method for treating and diagnosing a CCR1-related disease using the antibody or the antibody fragment are also provided.

Abstract: A coolant passageway (2) of a heat sink (1) has a coolant lead-in part (21), a coolant lead-out part (22), coolant-contact parts (23), coolant-transit parts (25), and connecting parts (24). The coolant-contact parts (23) are disposed spaced apart from one another along a coolant path leading from the coolant lead-in part (21) to the coolant lead-out part (22) and are configured such that they bring the coolant into contact with a cooling-wall part. The coolant-transit parts (25) are disposed between adjacent coolant-contact parts (23) and are configured such that the coolant can transit from upstream-side coolant-contact parts (23) to downstream-side coolant-contact parts (23) in the coolant paths. The connecting parts (24) are interposed between the coolant-transit parts (25) and the coolant-contact parts (23) and have a passageway cross-sectional area that is smaller than those of the coolant-contact parts (23) and the coolant-transit parts (25).

Abstract: The disclosure includes a method of preparing a cancer spheroid, a method of selecting a colorectal cancer patient being sensitive to an FGFR inhibitor, and a pharmaceutical composition for treating colorectal cancer comprising an FGFR inhibitor.

Abstract: An object of the present invention is to provide a monoclonal antibody which binds to a human CC chemokine receptor 1 (CCR1) and inhibits activation of the human CCR1, or an antibody fragment thereof. The present invention relates to a monoclonal antibody which binds to an extracellular region of a human CCR1 and inhibits activation of the human CCR1 by a human CC chemokine ligand 15 (CCL15), or an antibody fragment thereof, a hybridoma producing the antibody, a nucleic acid having a nucleotide sequence encoding the antibody or the antibody fragment, a transformant cell containing a vector containing the nucleic acid, a method for producing the antibody or the antibody fragment using the hybridoma or the transformant cell; a therapeutic agent and a diagnostic agent containing the antibody or the antibody fragment, and a method for treating and diagnosing a CCR1-related disease using the antibody or the antibody fragment.

Abstract: An energy absorbing member (20) is formed of an aluminum alloy extruded material having a substantially quadrangular outer shape. Straight portions of a pair of long sides of a quadrangular shape are each segmented into three side walls (21a, 21b, 21c) by two arcuate internal projections (26) that project inward. Vertices of opposing internal projections (26) are joined by a rib (25). Accordingly, the energy absorbing member (20) is configured to have a shape in which three cylindrical portions having hollow portions (24a, 24b, 24c) are joined. Arc-shaped internal projections (23) that each project inward are provided in four corners of the quadrangular shape.

Abstract: An energy absorbing member (20) is formed of an aluminum alloy extruded material having a substantially quadrangular outer shape. Straight portions of a pair of long sides of a quadrangular shape are each segmented into three side walls (21a, 21b, 21c) by two arcuate internal projections (26) that project inward. Vertices of opposing internal projections (26) are joined by a rib (25). Accordingly, the energy absorbing member (20) is configured to have a shape in which three cylindrical portions having hollow portions (24a, 24b, 24c) are joined. Arc-shaped internal projections (23) that each project inward are provided in four corners of the quadrangular shape.

Abstract: The present invention relates to a method for determining prognosis of cancer in a subject, which comprises the step of detecting phosphorylation of a tyrosine residue at position 2681 of TRIO in a sample obtained from the subject.

Abstract: The present invention relates to a method for determining prognosis of cancer in a subject, which comprises the step of detecting phosphorylation of a tyrosine residue at position 2681 of TRIO in a sample obtained from the subject.

Abstract: An object of the present invention is to realize an antibody or a fragment thereof specifically recognizing a cofilin 1 protein, and a method for detecting and testing gastrointestinal cancer with high detection performance, which comprises performing immunoassay of the cofilin 1 protein using the antibody or a fragment thereof. An immunoassay of cofilin 1 protein is characterized by measuring cofilin 1 or a fragment thereof in a sample using 2 or more types of anti-cofilin 1 monoclonal antibody or fragments thereof specifically recognizing different peptide regions in the amino acid sequence constituting the cofilin 1 protein.

Abstract: It is intended to provide a method for detecting gastric cancer, which is low invasive to a human test subject and has high detection sensitivity and accuracy. The present invention provides a method comprising measuring in vitro the amount of COTL1 protein, a variant thereof, and/or a fragment thereof in a body fluid sample derived from a human test subject, and detecting the presence or absence of gastric cancer affecting the test subject on the basis of the amount, and a kit for gastric cancer diagnosis comprising an antibody capable of specifically binding to the protein.

Abstract: This invention relates to a method for detecting or examining a cancer selected from colorectal cancer and esophageal cancer with high detection sensitivity and accuracy and with less invasiveness to a subject. Specifically, it relates to a method for examining a cancer comprising measuring in vitro a COTL1 protein in a body fluid sample from a subject and evaluating whether or not the subject suffers from the cancer based on the measured amount of the COTL1 protein. It further relates to a kit for diagnosis of a cancer selected from colorectal cancer and esophageal cancer comprising an antibody or a fragment thereof capable of specifically binding to the protein.

Abstract: An object of the present invention is to realize an antibody or a fragment thereof specifically recognizing a cofilin 1 protein, and a method for detecting and testing gastrointestinal cancer with high detection performance, which comprises performing immunoassay of the cofilin 1 protein using the antibody or a fragment thereof. An immunoassay of cofilin 1 protein is characterized by measuring cofilin 1 or a fragment thereof in a sample using 2 or more types of anti-cofilin 1 monoclonal antibody or fragments thereof specifically recognizing different peptide regions in the amino acid sequence constituting the cofilin 1 protein.

Abstract: It is intended to provide a method for detecting gastric cancer, which is low invasive to a human test subject and has high detection sensitivity and accuracy. The present invention provides a method comprising measuring in vitro the amount of Cofilin 1 protein, a variant thereof, and/or a fragment thereof in a body fluid sample derived from a human test subject, and detecting the presence or absence of gastric cancer affecting the test subject on the basis of the amount, and a kit for gastric cancer diagnosis comprising an antibody capable of specifically binding to the protein.

Abstract: It is intended to provide a method for detecting gastric cancer, which is low invasive to a human test subject and has high detection sensitivity and accuracy. The present invention provides a method comprising measuring in vitro the amount of COTL1 protein, a variant thereof, and/or a fragment thereof in a body fluid sample derived from a human test subject, and detecting the presence or absence of gastric cancer affecting the test subject on the basis of the amount, and a kit for gastric cancer diagnosis comprising an antibody capable of specifically binding to the protein.

Abstract: Immediately before a robot 20 starts to move at a high speed, a monitoring area 53 is expanded in a returning direction Y, and absence of an obstacle in the monitoring area 53 is confirmed. During the high speed movement of the robot 20, the monitoring area 53 is expanded forward, so that a safety of an operator is secured, an effective use of a working station area can be made, and an improvement of productivity can be achieved.

Abstract: Immediately before a robot 20 starts to move at a high speed, a monitoring area 53 is expanded in a returning direction Y, and absence of an obstacle in the monitoring area 53 is confirmed. During the high speed movement of the robot 20, the monitoring area 53 is expanded forward, so that a safety of an operator is secured, an effective use of a working station area can be made, and an improvement of productivity can be achieved.

Abstract: To provide an assist transportation device capable of properly communicating a reaction force to a worker due to contact without damaging any product and obstacle even if the product contacts the obstacle under work. The assist transportation device for reducing a load applied to the worker when the worker operates transportation means to transport an instrument panel P includes instrument panel holding means 27 for holding the instrument panel P, floating mechanism 30 set to the connection portion between the instrument panel holding means 27 and the transportation means, displacement sensor 61 for detecting the displacement value of the floating mechanism 30, and position instruction computing portion 62 for computing the displacement value detected by the displacement sensor 61 to calculate a reaction force, in which the reaction force is transferred to the worker operating the transportation means.

Abstract: A polarized-light converting elemental device which can produce an accurately unidirectionally and circularly polarized light with a minimized loss of light and a projection-type display device using said unidirectionally-polarized-light converting elemental device are provided. A polarized-light converting elemental device comprises a mirror glass portion consisting of an array of mirror glass blocks each having a first reflecting optical element and a second reflecting optical element and a cholesteric-liquid-crystal glass portion including a cholesteric liquid crystal layer for reflecting either clockwise circularly polarized component or anticlockwise circularly polarized component and transmitting the other.