Patents by Inventor Yoshinori Tamura
Yoshinori Tamura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7825146Abstract: A compound represented by the general formula (I-A): wherein R1 is hydroxy and the like; R2 is optionally substituted lower alkyl and the like; R3 is hydrogen atom and the like; R4 is optionally substituted arylene and the like; R5 is a group represented by the formula: R6 is optionally substituted aryl and the like, its optically active substance, their pharmaceutically acceptable salt, or a solvate thereof; and a metalloproteinase inhibitor containing them.Type: GrantFiled: July 28, 2004Date of Patent: November 2, 2010Assignee: Shionogi & Co., Ltd.Inventors: Fumihiko Watanabe, Naoki Yoshikawa, Yoshinori Tamura
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Publication number: 20090203723Abstract: A novel compound which is useful as an agent for treating and/or preventing emesis, vomiting and/or constipation. A compound represented by the formula (I): wherein R1 and R2 are each independently hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted cycloalkyl, optionally substituted aryl etc., R3 is hydrogen, hydroxy, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted lower alkoxy etc., R4 is hydrogen or lower alkyl, R5 is hydrogen, lower alkyl, cycloalkyl lower alkyl or lower alkenyl, or a pharmaceutically acceptably salt, or a solvate thereof is provided.Type: ApplicationFiled: May 25, 2006Publication date: August 13, 2009Inventors: Masanao Inagaki, Shin-ichiro Hara, Nobuhiro Haga, Yoshinori Tamura, Yoshihisa Goto, Tsuyoshi Hasegawa
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Publication number: 20090124523Abstract: The present invention provides a thickening/foam-promoting agent having thickening/foam-promoting properties and a low odor, as well as a detergent composition containing the same therein. The thickening/foam-promoting agent is composed of the following component (A): (A) a compound represented by the following general formula (1): R1O—(PO)n/(EO)m—R2??(1) (wherein, R1 represents a linear alkyl or an alkenyl group having 8 to 10 carbon atoms, PO represents a propyleneoxy group, EO represents an ethyleneoxy group, an average added molar number n represents a number of 1.5 to 3.0, an average added molar number m represents a number of 0 to 1.0, and R2 represents a hydrogen atom or a methyl group), wherein, the content of an alcohol of the formula (1), wherein n=0, m=0 and R2 is a hydrogen atom, is not more than 3000 ppm, and the detergent composition contains the component (A) and a surfactant (B).Type: ApplicationFiled: October 31, 2006Publication date: May 14, 2009Applicant: KAO CORPORATIONInventors: Yasuhiro Dol, Masaki Inoue, Kaoru Omae, Yoshinori Tamura
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Patent number: 7435710Abstract: Provided is a detergent composition having components (A) and (B1): (A) a phosphate monoester (1), and (B1) a phosphate monoester (2), wherein n=1; components (A), (B1) and (B2): (A) a phosphate monoester (1), (B1) a phosphate monoester (2), wherein n=1, and (B2) a phosphate monoester (2), wherein n=2; components (A), (B1) and (B2): (A) a phosphate monoester (1), (B1) a phosphate monoester (2) wherein n=1, and (B2) a phosphate monoester (2), wherein n=2; components (A) and (C): (A) a phosphate monoester (1), and (C) a phosphate monoester (3); or a phosphate-based surfactant produced by reacting a compound obtained by adding to an alcohol an alkylene oxide of 2 to 4 carbon atoms, with phosphoric acid, a polyphosphoric acid or P2O5: The detergent composition is mild to the skin, is high in versatility, and has a good foaming property in weak acidic water or in hard water.Type: GrantFiled: January 12, 2007Date of Patent: October 14, 2008Assignee: Kao CorporationInventors: Yoshinori Tamura, Ryosuke Fujii, Tomoko Uchiyama
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Publication number: 20080119513Abstract: It is considered that MMP-13 inhibitors contribute to the treatment or prevention against the diseases caused by or related to activity of MMP-13, especially osteoarthritis (OA). Therefore, the development of MMP-13 inhibitors has been desired. A compound represented by the general formula (I): wherein Z is 1,4-phenylene and the like; R1 is hydroxy and the like; R2 is hydrogen atom, optionally substituted lower alkyl, and the like; R12 is hydrogen atom; or R2 and R12 taken together with the adjacent carbon atom may form a ring; R3 is hydrogen atom, optionally substituted lower alkyl, and the like; R4 is halogen, lower alkyl, and the like; m is 0, 1, or 2; X is a bond, —C?C—, and the like; Y is optionally substituted phenyl, optionally substituted naphthyl, and the like, its optically active substance, their pharmaceutically acceptable salt, or a solvate thereof.Type: ApplicationFiled: September 6, 2004Publication date: May 22, 2008Inventors: Fumihiko Watanabe, Yoshinori Tamura, Naoki Yoshikawa
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Publication number: 20070111922Abstract: Provided is a detergent composition having components (A) and (B1): (A) a phosphate monoester (1), and (B1) a phosphate monoester (2), wherein n=1; components (A), (B1) and (B2): (A) a phosphate monoester (1), (B1) a phosphate monoester (2), wherein n=1, and (B2) a phosphate monoester (2), wherein n=2; components (A), (B1) and (B2): (A) a phosphate monoester (1), (B1) a phosphate monoester (2) wherein n=1, and (B2) a phosphate monoester (2), wherein n=2; components (A) and (C): (A) a phosphate monoester (1), and (C) a phosphate monoester (3); or a phosphate-based surfactant produced by reacting a compound obtained by adding to an alcohol an alkylene oxide of 2 to 4 carbon atoms, with phosphoric acid, a polyphosphoric acid or P2O5: The detergent composition is mild to the skin, is high in versatility, and has a good foaming property in weak acidic water or in hard water.Type: ApplicationFiled: January 12, 2007Publication date: May 17, 2007Applicant: KAO CORPORATIONInventors: Yoshinori TAMURA, Ryosuke Fujii, Tomoko Uchiyama
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Patent number: 7183244Abstract: Provided is a detergent composition having components (A) and (B1): (A) a phosphate monoester (1), and (B1) a phosphate monoester (2), wherein n=1; components (A), (B1) and (B2): (A) a phosphate monoester (1), (B1) a phosphate monoester (2), wherein n=1, and (B2) a phosphate monoester (2), wherein n=2; components (A), (B1) and (B2): (A) a phosphate monoester (1), (B1) a phosphate monoester (2), wherein n=1, and (B2) a phosphate monoester (2), wherein n=2; components (A) and (C): (A) a phosphate monoester (1), and (C) a phosphate monoester (3); or a phosphate-based surfactant produced by reacting a compound obtained by adding to an alcohol an alkylene oxide of 2 to 4 carbon atoms, with phosphoric acid, a polyphosphoric acid or P2O5: The detergent composition is mild to the skin, is high in versatility, and has a good foaming property in weak acidic water or in hard water.Type: GrantFiled: December 22, 2004Date of Patent: February 27, 2007Assignee: Kao CorporationInventors: Yoshinori Tamura, Ryosuke Fujii, Tomoko Uchiyama
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Publication number: 20060183770Abstract: A compound represented by the general formula (I-A): wherein R1 is hydroxy and the like; R2 is optionally substituted lower alkyl and the like; R3 is hydrogen atom and the like; R4 is optionally substituted arylene and the like; R5 is a group represented by the formula: R6 is optionally substituted aryl and the like, its optically active substance, their pharmaceutically acceptable salt, or a solvate thereof; and a metalloproteinase inhibitor containing them.Type: ApplicationFiled: July 28, 2004Publication date: August 17, 2006Applicant: SHIONOGI & CO., LTD.Inventors: Fumihiko Watanabe, Naoki Yoshikawa, Yoshinori Tamura
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Patent number: 6949566Abstract: A compound of the formula (I): wherein R1 is hydroxy and the like; R2 is optionally substituted lower alkyl and the like; R3 is hydrogen atom and the like; R4 is optionally substituted arylene and the like; R5 is a group represented by the formula: and the like; R6 is optionally substituted aryl and the like, its optically active substance, its prodrug, their pharmaceutically acceptable salt, or solvate thereof and metalloproteinase inhibitors containing them.Type: GrantFiled: September 28, 2001Date of Patent: September 27, 2005Assignee: Shionogi & Co. Ltd.Inventors: Fumihiko Watanabe, Yoshinori Tamura
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Publication number: 20050159331Abstract: Provided is a detergent composition having components (A) and (B1): (A) a phosphate monoester (1), and (B1) a phosphate monoester (2), wherein n=1; components (A), (B1) and (B2): (A) a phosphate monoester (1), (B1) a phosphate monoester (2), wherein n=1, and (B2) a phosphate monoester (2), wherein n=2; components (A), (B1) and (B2): (A) a phosphate monoester (1), (B1) a phosphate monoester (2), wherein n=1, and (B2) a phosphate monoester (2), wherein n=2; components (A) and (C): (A) a phosphate monoester (1), and (C) a phosphate monoester (3); or a phosphate-based surfactant produced by reacting a compound obtained by adding to an alcohol an alkylene oxide of 2 to 4 carbon atoms, with phosphoric acid, a polyphosphoric acid or P2O5: The detergent composition is mild to the skin, is high in versatility, and has a good foaming property in weak acidic water or in hard water.Type: ApplicationFiled: December 22, 2004Publication date: July 21, 2005Applicant: KAO CORPORATIONInventors: Yoshinori Tamura, Ryosuke Fujii, Tomoko Uchiyama
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Patent number: 6897237Abstract: A compound of the formula (I): wherein R1 is hydroxy and the like; R2 is optionally substituted lower alkyl and the like; R3 is hydrogen atom and the like; R4 is optionally substituted arylene and the like; R5 is —C?C— and the like; R6 is optionally substituted naphtyl and the like its optically active substance, its prodrug, their pharmaceutically acceptable salt, or solvate thereof.Type: GrantFiled: April 23, 2001Date of Patent: May 24, 2005Assignee: Shionogi & Co. Ltd.Inventors: Yozo Hori, Fumihiko Watanabe, Hiroshige Tsuzuki, Shingo Furue, Yoshinori Tamura
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Patent number: 6878739Abstract: A composition for treating or preventing glomerulopathy which contains a compound of the formula (I): wherein, for example, R1 and R2 are each independently hydrogen atom, optionally substituted lower alkyl, optionally substituted aralkyl, etc.; R3 is 1,4-phenylene and 2,5-thiophendiyl; R4 is the substituents represented by the formula, etc.: wherein R5 is hydrogen atom, optionally substituted amino, etc.; and Y is NHOH or OH, its optically active substance, their pharmaceutically acceptable salt, or hydrate thereof.Type: GrantFiled: June 6, 2002Date of Patent: April 12, 2005Assignee: Shionogi & Co., Ltd.Inventors: Hidetake Kurihara, Fumihiko Watanabe, Yoshinori Tamura, Toshihiro Sinosaki
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Patent number: 6830754Abstract: Described in the present invention are a dispersion which comprises, as a dispersoid, (a) 5 to 40 wt. % of an amphipatic lipid containing, in the molecule thereof, at least one hydroxy and amide group, and (b) 2 to 55 wt. % of a surfactant in an aqueous medium; a washing-away type cosmetic composition comprising the dispersion; and a washing-away type cosmetic composition comprising (A) 0.01 to 10 wt. % of an amphipatic lipid which contains, in the molecule thereof, at least one hydroxy and amide group and having a melting point not less than 30° C. and (B) 5 to 95 wt. % of a surfactant. The dispersion according to the present invention is useful as a component of a washing-away type cosmetic composition having both an emulsion-like or pearl-lustrous appearance and low skin irritation.Type: GrantFiled: December 21, 1999Date of Patent: December 14, 2004Assignee: Kao CorporationInventors: Keiko Hasebe, Juri Sata, Yasuhiro Doi, Yoshinori Tamura, Masaki Inoue, Hiroshi Sonohara
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Publication number: 20040024029Abstract: A compound of the formula (I): 1Type: ApplicationFiled: March 24, 2003Publication date: February 5, 2004Inventors: Fumihiko Watanabe, Yoshinori Tamura
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Publication number: 20030158155Abstract: A compound of the formula (1): 1Type: ApplicationFiled: October 15, 2002Publication date: August 21, 2003Inventors: Yozo Hori, Fumihiko Watanabe, Hiroshige Tsuzuki, Shingo Furue, Yoshinori Tamura
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Publication number: 20030078434Abstract: A composition for treating or preventing glomerulopathy which contains a compound of the formula (1): 1Type: ApplicationFiled: June 6, 2002Publication date: April 24, 2003Applicant: Shionogi & Co., Ltd.Inventors: Hidetake Kurihara, Fumihiko Watanabe, Yoshinori Tamura, Toshihiro Sinosaki
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Patent number: 6495578Abstract: Sulfonamide derivatives having a matrix metalloprotease inhibiting effect, which are compounds represented by general formula (I), optical isomers of the same, pharmaceutically acceptable salts of both, or solvates of them: wherein R1 and R2 are each independently hydrogen atom, optionally substituted lower alkyl or the like; R3 is optionally substituted aryl, optionally substituted heteroaryl or the like; X is —CH═CH—, —O—, or —S—; Y is NHOH, hydroxy, or lower alkyloxy.Type: GrantFiled: October 17, 2001Date of Patent: December 17, 2002Assignee: Shionogi & Co., Ltd.Inventors: Fumihiko Watanabe, Yoshinori Tamura, Yasuhiko Fujii
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Patent number: 6423729Abstract: A composition for treating or preventing glomerulopathy which contains a compound of the formula (I): wherein, for example, R1 and R2 are each independently hydrogen atom, optionally substituted lower alkyl, optionally substituted aralkyl, etc.; R3 is 1,4-phenylene and 2,5-thiophendiyl; R4 is the substituents represented by the formula, etc.: wherein R6 is hydrogen atom, optionally substituted amino, etc.; and Y is NHOH or OH, its optically active substance, their pharmaceutically acceptable salt, or hydrate thereof.Type: GrantFiled: December 30, 1999Date of Patent: July 23, 2002Assignee: Shionogi & Co., Ltd.Inventors: Hidetake Kurihara, Fumihiko Watanabe, Yoshinori Tamura, Toshihiro Sinosaki
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Publication number: 20020058052Abstract: Described in the present invention are a dispersion which comprises, as a dispersoid, (a) 5 to 40 wt. % of an amphipatic lipid containing, in the molecule thereof, at least one hydroxy and amide group, and (b) 2 to 55 wt. % of a surfactant in an aqueous medium; a washing-away type cosmetic composition comprising the dispersion; and a washing-away type cosmetic composition comprising (A) 0.01 to 10 wt. % of an amphipatic lipid which contains, in the molecule thereof, at least one hydroxy and amide group and having a melting point not less than 30° C. and (B) 5 to 95 wt. % of a surfactant. The dispersion according to the present invention is useful as a component of a washing-away type cosmetic composition having both an emulsion-like or pearl-lustrous appearance and low skin irritation.Type: ApplicationFiled: December 21, 1999Publication date: May 16, 2002Inventors: KEIKO HASEBE, JURI SATA, YASUHIRO DOI, YOSHINORI TAMURA, MASAKI INOUE, HIROSHI SONOHARA
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Patent number: 6066674Abstract: A germicidal-disinfectant detergent composition comprising (a) a cationic germicide, (b) a metal chelating agent and (c) at least one surfactant selected from anionic surfactants, nonionic surfactants and amphoteric surfactants is described. Excellent detergency and germicidal action are provided.Type: GrantFiled: December 18, 1997Date of Patent: May 23, 2000Assignee: Kao CorporationInventors: Yuichi Hioki, Tadashi Moriyama, Chikako Matsumoto, Juri Sata, Yoshinori Tamura