Abstract: The present application provides tricyclic pyridone compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

Abstract: A foldable grip is provided on the back panel of a mobile device to enable comfortable and secure holding of the device even during extended use. The grip structure has two main parts, a base that is integrally connected to the panel, and a grip element that is mounted to the base. The grip element moves from a resting position that is flat and flush with the panel of the mobile device to a deployed position in which at least a portion of the grip element folds and curves away from the base to provide a curved surface for a user’s hand to engage.

Abstract: The present disclosure belongs to the technical field of sewage treatment, and discloses a method and system for enhanced culture of aerobic granular sludge. The system includes a reaction tank, a water inlet and outlet unit, an aeration unit, and a sludge discharge unit. The water inlet and outlet unit includes a water inlet pump, a water inlet electric valve, a liquid flowmeter, a sewage uniform distribution treatment device, buffers, a water drainage pipe, and a water drainage electric valve. The aeration unit includes a blower, microporous aerators, and a gas flowmeter. The sludge discharge unit includes sludge discharge pumps, a sludge discharge pipe, a sludge discharge electric valve, and a sludge concentration meter. In the present disclosure, a multi-point uniform water distribution method is used.

Abstract: Disclosed are a blockchain-based user information processing method and a system. The method is applied to any application node in a blockchain, the blockchain includes a plurality of application nodes, the method includes: receiving a user information change request sent by a user terminal, the user information change request carries first identity information of the user and new user information to be changed; verifying the first identity information and the new user information through a plurality of verification application nodes in the blockchain respectively, the verification application nodes are application nodes in the blockchain; and changing user information of the user stored in the blockchain based on the new user information if the first identity information and the new user information pass verification.

Abstract: The present disclosure relates to a bacterium-alga coupled sewage treatment device based on energy recycling and a use method thereof. The device comprises a pretreatment device, a photobioreactor, an alga separation apparatus, a continuous flow bioreactor and a secondary sedimentation tank which are sequentially connected in order, the pretreatment device being connected to a municipal sewage inlet pipe, the photobioreactor being connected to a carbon dioxide gas charging device through a gas filling pipeline, one part of a sludge thickening tank being connected to the secondary sedimentation tank, the other part thereof being connected to remaining sludge of the pretreatment device, carbon dioxide generated from the sludge which flows through the thickening tank and is thermally-hydrolyzed and anaerobically-acidified being connected to the photobioreactor through a gas inlet pipeline, and the alga separation apparatus being further connected to a filter press.

Abstract: A memory management method includes: determining that available storage space of a first memory in a network device is less than a first threshold, where the first threshold is greater than 0 and the first memory stores a first packet queue; and deleting at least one packet at the tail of the first packet queue from the first memory based on the available storage space of the first memory being less than the first threshold. When the available storage space of the first memory is less than the first threshold, a packet queue, namely, the first packet queue, is selected and a packet at the tail of the packet queue is deleted from the first memory.

Abstract: Provided are a method for constructing a three-dimensional map in a high-definition map, a device and a storage medium. The method includes: acquiring vehicle trajectory data, where the vehicle trajectory data is three-dimensional trajectory data; matching the vehicle trajectory data with a lane in a two-dimensional map and determining vehicle trajectory data matched with the lane; and assigning a height to the lane in the two-dimensional map according to the matched vehicle trajectory data to obtain a three-dimensional map.

Abstract: A method for processing map data, a device, and a medium, which relates to a field of computer technology, in particular to fields of intelligent transportation technology and autonomous driving technology. The method for processing map data includes: acquiring an initial change information for a traffic object; acquiring incremental map data corresponding to the initial change information; determining, from the initial change information, a target change information based on the incremental map data and historical map data; and updating the historical map data based on the target change information.

Abstract: The technology of this application relates to a flow characteristic extraction method and apparatus, and belongs to the field of network technologies. The method includes a network device that determines a burst parameter of a burst traffic segment of a received first packet flow, and determines a burst parameter of the first packet flow based on the burst parameter of the burst traffic segment of the first packet flow. The first packet flow is an elephant flow, the burst traffic segment indicates a burst degree of traffic within one period of time, the burst parameter of the burst traffic segment is a parameter used to describe the burst traffic segment, and the burst parameter of the first packet flow is a parameter used to describe at least one burst traffic segment included in the first packet flow.

Abstract: A large-scale and high-precision absolute distance measurement system based on an all-fiber femtosecond laser, including: a first all-fiber femtosecond laser, a second all-fiber femtosecond laser, a fiber optic splitter, a first fiber optic circulator, a wavelength division multiplexer, an achromatic fiber collimator, a first fiber optic combiner, a second fiber optic combiner, a second fiber optic circulator, a semiconductor laser, a first photodetector, a second photodetector, and a data acquisition and processing module.

Abstract: Provided herein are methods for accurately determining the alleles present at a locus that is broadly applicable to any locus, including highly polymorphic loci such as HLA loci, BGA loci and HV loci. Embodiments of the disclosed methods are useful in a wide range of applications, including, for example, organ transplantation, personalized medicine, diagnostics, forensics and anthropology.

Abstract: The present disclosure provides anti-FGFR2b antibodies or antigen-binding fragments thereof, isolated polynucleotides encoding the same, pharmaceutical compositions comprising the same, and the uses thereof.

Abstract: Provided are anti-FGFR2b antibodies or antigen-binding fragments thereof, isolated polynucleotides encoding the same, pharmaceutical compositions comprising the same, and the uses thereof.

Abstract: Provided are anti-FGFR2b antibodies or antigen-binding fragments thereof, isolated polynucleotides encoding the same, pharmaceutical compositions comprising the same, and the uses thereof.

Abstract: An embodiment of an integrated circuit comprises circuitry to generate a cache tag for data to be stored in a cache memory, store a first portion of the cache tag in a primary tag memory, and store a second portion of the cache tag in a secondary tag memory, wherein a size of the first portion is smaller than a size of the second portion. Other embodiments are disclosed and claimed.

Abstract: The present invention belongs to the technical field of machining of fiber-reinforced composites, and relates to a method for measuring distribution of a thrust force during drilling of a unidirectional composite along with a fiber cutting angle. The method includes: cutting the surface a composite sample piece to form a groove; drilling on an existing experimental platform for measuring a thrust force during drilling, where a through hole obtained through the drilling is required to intersect with the groove; obtaining a curve of the thrust force during drilling, comparing the curve with a conventional curve of the thrust force to find a mutation point, and determining the mutation point, namely a fiber cutting angle at the groove; and calculating fluctuation periods of the thrust force according to machining parameters to reckon the distribution of the thrust force along with the fiber cutting angle in all the periods.

Abstract: A method and apparatus for controlling an unmanned device, a storage medium, and an electronic device are provided. In some embodiments, not only a control policy is determined according to a single frame of a current image, but a safety representation value of an unmanned device at a current moment and safety representation values of the unmanned device at respective historical moments are respectively determined according to a current image and environment images of several historical moments. In those embodiments, a control policy of the unmanned device at a next moment is determined according to a safety representation value of the unmanned device at current moment and the safety representation values of the unmanned device at respective historical moments.

Abstract: An example of a system using two-stage, the cache tag is stored in a primary and a secondary tag memories. When requesting data, the system searches the cache to retrieve the data, an operation that involves cache tag lookup. Cache tag lookup is performed by cache management. The cache management receives a cache tag for reading data from the cache memory. The cache management selects a hash function from a group of hash functions and computes a primary lookup tag using the selected hash function and the cache tag. The cache management compares the primary lookup tag to the contents of the primary tag memory to determine if there is a hit. If there is no hit, the cache management selects another hash function and repeats the search in the primary tag memory.