Abstract: The present invention discloses a pre-lithiated silicon-carbon multilayer composite negative electrode material for lithium ion batteries and a preparation method thereof. The composite negative electrode material includes an amorphous carbon matrix, pre-lithiated silicon monoxide particles and graphene materials; the graphene materials are uniformly coated on the outer surface of the pre-lithiated silicon monoxide to form composite particles; and the composite particles are uniformly dispersed in the amorphous carbon matrix. According to the present invention, the silicon monoxide particles are pre-lithiated to greatly improve the initial coulombic efficiency (ICE) of the silicon-based negative electrode material; the graphene materials greatly improve the mechanical performance and conductivity of the composite materials due to the light weight, high strength and excellent conductivity thereof.

Abstract: The present invention relates to the field of medical biology, and discloses a single domain antibody and derivative proteins thereof against CTLA4. In particular, the present invention discloses a CTLA4 binding protein and the use thereof, especially the use for treating and/or preventing CTLA4 relevant diseases such as tumor.

Abstract: The present application provides tricyclic urea compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

Abstract: The disclosure provides methods and image processing devices for image super resolution, image enhancement, and convolutional neural network (CNN) model training. The method for image super resolution includes the following steps. An original image is received, and a feature map is extracted from the original image. The original image is segmented into original patches. Each of the original patches is classified respectively into one of patch clusters according to the feature map. The original patches are processed respectively by different pre-trained CNN models according to the belonging patch clusters to obtain predicted patches. A predicted image is generated based on the predicted patches.

Abstract: Systems, apparatuses and methods may provide for technology that determines a plurality of memory operations associated with a data-flow graph that represents a computer code, where a spatial architecture executes the data-flow graph and the spatial architecture includes a plurality of memory controllers, randomly assigns one or more of the plurality of memory operations to one or more of the plurality of memory controllers to generate a first allocation of the plurality of memory operations to the memory controllers, and determines that the first allocation is to be stored as a permanent memory allocation based on a first performance metric associated with the first allocation.

Abstract: The present application provides tricyclic pyridone compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

Abstract: The present disclosure relates to a bacterium-alga coupled sewage treatment device based on energy recycling and a use method thereof. The device comprises a pretreatment device, a photobioreactor, an alga separation apparatus, a continuous flow bioreactor and a secondary sedimentation tank which are sequentially connected in order, the pretreatment device being connected to a municipal sewage inlet pipe, the photobioreactor being connected to a carbon dioxide gas charging device through a gas filling pipeline, one part of a sludge thickening tank being connected to the secondary sedimentation tank, the other part thereof being connected to remaining sludge of the pretreatment device, carbon dioxide generated from the sludge which flows through the thickening tank and is thermally-hydrolyzed and anaerobically-acidified being connected to the photobioreactor through a gas inlet pipeline, and the alga separation apparatus being further connected to a filter press.

Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting ALK2 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with ALK2 activity such as cancer.

Abstract: A memory management method includes: determining that available storage space of a first memory in a network device is less than a first threshold, where the first threshold is greater than 0 and the first memory stores a first packet queue; and deleting at least one packet at the tail of the first packet queue from the first memory based on the available storage space of the first memory being less than the first threshold. When the available storage space of the first memory is less than the first threshold, a packet queue, namely, the first packet queue, is selected and a packet at the tail of the packet queue is deleted from the first memory.

Abstract: The present disclosure discloses a method and an apparatus for point cloud registration. The method includes: segmenting a source point cloud and a destination point cloud respectively into different categories of attribute features based on semantic; segmenting the source point cloud and the destination point cloud into a plurality of grids based on the attribute features; calculating a current similarity between the source point cloud and the destination point cloud based on the plurality of grids; determining whether the current similarity and a current iterative number satisfy a preset condition; when the current similarity and the current iterative number satisfy the preset condition, performing a registration on the source point cloud and the destination point cloud to obtain a registered result; and based on the registered result, adjusting a position of the source point cloud, updating the current iterative number.

Abstract: The present invention relates to the field of medical biology, and discloses a single domain antibody and derivative proteins thereof against CTLA4. In particular, the present invention discloses a CTLA4 binding protein and the use thereof, especially the use for treating and/or preventing CTLA4 relevant diseases such as tumor.

Abstract: The present invention belongs to the technical field of machining of fiber-reinforced composites, and relates to a method for measuring distribution of a thrust force during drilling of a unidirectional composite along with a fiber cutting angle. The method includes: cutting the surface a composite sample piece to form a groove; drilling on an existing experimental platform for measuring a thrust force during drilling, where a through hole obtained through the drilling is required to intersect with the groove; obtaining a curve of the thrust force during drilling, comparing the curve with a conventional curve of the thrust force to find a mutation point, and determining the mutation point, namely a fiber cutting angle at the groove; and calculating fluctuation periods of the thrust force according to machining parameters to reckon the distribution of the thrust force along with the fiber cutting angle in all the periods.

Abstract: This disclosure relates to methods for deconvolving bulk or spatial RNA-sequencing data, computer readable medium storing processor-executable instructions adapted to deconvolve bulk or spatial RNA-sequencing data, and systems for deconvolving bulk or spatial RNA-sequencing data to characterize cell type compositions.

Abstract: Methods and compositions are provided for generating F0 fertile XY female animals. The methods and compositions involve making XY pluripotent or totipotent animal cells, in vitro cell cultures, or embryos that are capable of producing a fertile female XY animal in an F0 generation. Such cells, embryos, and animals can be made by silencing a region of the Y chromosome. Optionally, the cells can also be cultured in feminizing medium such as a low-osmolality medium and/or can be modified to decrease the level and/or activity of an Sry protein. Methods and compositions are also provided for silencing a region of the Y chromosome in an XY pluripotent or totipotent animal cell, or in vitro cell cultures, embryos, or animals derived therefrom, by maintaining an XY pluripotent or totipotent animal cell in a feminizing medium.

Abstract: The disclosure provides methods and image processing devices for image super resolution, image enhancement, and convolutional neural network (CNN) model training. The method for image super resolution includes the following steps. An original image is received, and a feature map is extracted from the original image. The original image is segmented into original patches. Each of the original patches is classified respectively into one of patch clusters according to the feature map. The original patches are processed respectively by different pre-trained CNN models according to the belonging patch clusters to obtain predicted patches. A predicted image is generated based on the predicted patches.

Abstract: Systems, methods, and apparatuses relating to memory interface circuit allocation in a configurable spatial accelerator are described. In one embodiment, a configurable spatial accelerator (CSA) includes a plurality of processing elements; a plurality of request address file (RAF) circuits, and a circuit switched interconnect network between the plurality of processing elements and the RAF circuits. As a dataflow architecture, embodiments of CSA have a unique memory architecture where memory accesses are decoupled into an explicit request and response phase allowing pipelining through memory. Certain embodiments herein provide for an improved memory sub-system design via the improvements to allocation discussed herein.

Abstract: Methods and compositions are provided for generating F0 fertile XY female animals. The methods and compositions involve making XY pluripotent or totipotent animal cells, in vitro cell cultures, or embryos that are capable of producing a fertile female XY animal in an F0 generation. Such cells, embryos, and animals can be made by silencing a region of the Y chromosome. Optionally, the cells can also be cultured in feminizing medium such as a low-osmolality medium and/or can be modified to decrease the level and/or activity of an Sry protein. Methods and compositions are also provided for silencing a region of the Y chromosome in an XY pluripotent or totipotent animal cell, or in vitro cell cultures, embryos, or animals derived therefrom, by maintaining an XY pluripotent or totipotent animal cell in a feminizing medium.