Abstract: The present technology relates generally to oligolactic acid conjugates and stereocomplexes of conjugates of gemcitabine and gemcitabine derivatives, micelle compositions containing such conjugates or stereocomplexes of conjugates, and methods of preparing and using such compositions to treat various cancers. The oligolactic acid conjugates and stereocomplexes of conjugates may include oligolactic acid comprising 2 to 20 lactic acid subunits and may be attached through an amide linkage to the nitrogen of the 4(N) of the gemcitabine or gemcitabine derivative. Compositions comprising water and a micelle comprising a polylactic acid-containing polymer and the oligolactic acid conjugate or stereocomplex of conjugates may be readily prepared. Methods of inhibiting or killing cancer cells and treating gemcitabine sensitive cancers are also provided.

Abstract: The present technology relates generally to oligolactic acid conjugates of paclitaxel, rapamycin, selumetinib, and other anticancer agents, micelle compositions containing such conjugates and methods of preparing and using such compositions to treat various cancers. Specifically, there are provided oligolactic acid conjugates wherein the oligolactic acid comprises 2 to 24 lactic acid subunits and is attached through an ester linkage to the oxygen of the 7-hydroxyl of the paclitaxel or paclitaxel derivative, the 40-hydroxyl of the rapamycin or rapamycin derivative, and the 2?-hydroxyl of the selumetinib or selumetinib derivative. Compositions comprising water and a micelle comprising a polylactic acid-containing polymer and the oligolactic acid conjugate may be readily prepared. Methods of inhibiting or killing cancer cells and treating paclitaxel, rapamycin, and/or selumetinib cancers are also provided.

Abstract: A sequence signal generator and a sequence signal generation method are provided. In the sequence signal generation method, a waveform output instruction sent by a host computer is received to acquire waveform data. The waveform data includes original square wave sequence data and target square wave sequence data, and the target square wave sequence data includes a preliminary delay parameter and a secondary delay parameter. An original square wave sequence signal is acquired according to the original square wave sequence data. According to the preliminary delay parameter, preliminary delay processing is performed on the original square wave sequence signal to acquire an intermediate square wave sequence signal, and according to the secondary delay parameter, secondary delay processing is performed on the intermediate square wave sequence signal to acquire a target square wave sequence signal.

Abstract: A collision monitoring apparatus can include a camera to acquire a video image of surroundings of at least one target protection component on the C-arm X-ray machine system; an image processor to determine a scene of the surroundings of the at least one target protection component according to the video image; and a controller to control a C-arm X-ray machine system to stop moving or slow down when it is determined that a possible collision exists according to the scene of the surroundings of the at least one target protection component. Advantageously the apparatus effectively prevents patients, operators, patient examination beds and other obstacles from suffering a serious collision with the C-arm itself.

Abstract: Systems and methods for a muscle signal-driven cycling system for persons with disability for rehabilitation are provided. A system comprises integrating both motor power and muscle power to facilitate rehabilitation cycling-based exercises. By using the intensity of real-time muscle activity signals as inputs, a motor applies either assistive or resistive force to rotate a gear at different speeds to facilitate or impede the cycling motion, and the electrical pulses from an electrical stimulation device can be provided to stimulate target muscles to generate muscle contraction to support the continuous cycling movement.

Abstract: The present technology relates generally to oligolactic acid conjugates of paclitaxel, rapamycin, selumetinib, and other anticancer agents, micelle compositions containing such conjugates and methods of preparing and using such compositions to treat various cancers. Specifically, there are provided oligolactic acid conjugates wherein the oligolactic acid comprises 2 to 24 lactic acid subunits and is attached through an ester linkage to the oxygen of the 7-hydroxyl of the paclitaxel or paclitaxel derivative, the 40-hydroxyl of the rapamycin or rapamycin derivative, and the 2?-hydroxyl of the selumetinib or selumetinib derivative. Compositions comprising water and a micelle comprising a polylactic acid-containing polymer and the oligolactic acid conjugate may be readily prepared. Methods of inhibiting or killing cancer cells and treating paclitaxel, rapamycin, and/or selumetinib cancers are also provided.

Abstract: According to various embodiments, a device may be provided. The device may include: a housing comprising a first engaging member; and a foot comprising a second engaging member. The first engaging member and the second engaging member may be configured to engage in at least one of a first way or a second way. When the first engaging member and the second engaging member engage in the first way, the housing may have a first orientation relative to a pre-determined portion of the foot. When the first engaging member and the second engaging member engage in the second way, the housing may have a second orientation relative to the pre-determined portion of the foot.

Abstract: Systems and methods for a muscle signal-driven cycling system for persons with disability for rehabilitation are provided. A system comprises integrating both motor power and muscle power to facilitate rehabilitation cycling-based exercises. By using the intensity of real-time muscle activity signals as inputs, a motor applies either assistive or resistive force to rotate a gear at different speeds to facilitate or impede the cycling motion, and the electrical pulses from an electrical stimulation device can be provided to stimulate target muscles to generate muscle contraction to support the continuous cycling movement.