Abstract: The invention provides methods of treating diseases, such as various cancers, neoplasms, autoimmune diseases, and infectious diseases, among others, by clamping the skin of a subject in need of treatment so as to apply a compressive force that is sufficient to cause damage, often manifested in pain or bruising, to the underlying tissue. The invention additionally provides kits containing clamps capable of regulating the distance between the arms of the clamp such that a user of the clamp will apply a safe amount of pressure to the skin of a subject that is sufficient to cause tissue bruising and/or pain.

Abstract: An eye imaging system, including: a light source module; a radial splitting module; a common optical module; an image receiver; a power supply module for the light source module; a driver module for the image receiver; a processing-displaying module; and a motion driving module. The image receiver is an area array sensor. The motion driving module is connected to the light source module and drives the light source module to move in a radial direction of an upstream illuminating optical path formed by the light source module and the radial splitting module. The image receiver continually opens for exposure in a radial direction of a downstream observation optical path formed by the radial splitting module and the image receiver. The continual opening of the image receiver for signal acquisition is synchronous with the movement of the light source module.

Abstract: The present patent application discloses a digital slit-lamp microscope system and the methods of the electronic recording and remote diagnosis. The present patent application relates to the field of optical instrument and remote communication control. The purpose is to solve the problems of the electronic recording, reappearing and remote diagnosis of the slit-lamp image. The digital slit-lamp microscope system comprises digital slit-lamp microscope side, communication unit and client side. The digital slit-lamp microscope side includes a build-in slit-lamp microscope and is connected to the communication unit and the client side in sequence. The digital slit-lamp microscope side irradiates the eyes of the patient, and then transmits the pathology information of the eyes of the patient to the communication unit and the client side in sequence.

Abstract: An eye imaging system, including: a light source module; a radial splitting module; a common optical module; an image receiver; a power supply module for the light source module; a driver module for the image receiver; a processing-displaying module; and a motion driving module. The image receiver is an area array sensor. The motion driving module is connected to the light source module and drives the light source module to move in a radial direction of an upstream illuminating optical path formed by the light source module and the radial splitting module. The image receiver continually opens for exposure in a radial direction of a downstream observation optical path formed by the radial splitting module and the image receiver. The continual opening of the image receiver for signal acquisition is synchronous with the movement of the light source module.

Abstract: The invention features salvinorin compositions that are selective for kappa opioid receptors; methods of treating mania by using a selective kappa receptor agonist; and methods of treating mood disorders, such as depressive disorders and manic disorders, using salvinorin compositions.

Abstract: The methods, kits, articles, and compositions of the invention feature a natural product (e.g., Sargassum fusiforme), an extract thereof, and fatty acid components of the extract (e.g., palmitic acid) for the treatment of a viral infection, e.g., HIV or herpes. The natural products used in the methods and compositions of the invention include brown algae, specifically algae of the Sargassum fusiforme species. The Sargassum fusiforme algae, extracts thereof, specific components of the extract, and related compounds of the invention may be used to treat or prevent HIV and herpes infections.

Abstract: The invention features salvinorin compositions that are selective for kappa opioid receptors; methods of treating mania by using a selective kappa receptor agonist; and methods of treating mood disorders, such as depressive disorders and manic disorders, using salvinorin compositions.

Abstract: An androgenic steroid compound of the formula: wherein: X, Y, Z, R1, R2, R3, R5 and R6 are as defined herein.

Abstract: A blade dispenser including a dispenser body including a cavity shaped to store a plurality of blades therein. The blade dispenser includes a pivotable plate located in or adjacent to the cavity such that the plate can receive at least one blade stored in the cavity thereon. The plate is pivotable such that a blade located thereon can be moved at least partially outside of the cavity when the plate is pivoted such that a user can access a blade located on the plate. The plate includes a magnet located thereon to magnetically interact with a blade located on the plate to maintain the blade on the plate.

Abstract: An androgenic steroid compound of the formula: 1

Abstract: An androgenic steroid compound of the formula: wherein: X, Y, Z, R1, R2, R3, R5 and R6 are as defined herein.

Abstract: An androgenic steroid compound of the formula: 1

Abstract: An androgenic steroid compound of the formula: wherein: X Y, Z, R1, R2, R3, R5 and R6 are as defined herein.

Abstract: An androgenic steroid compound of the formula: 1

Abstract: The invention is directed to a novel class of steroids which exhibit potent antiprogestational activity.

Abstract: The retinoblastoma protein (Rb) is the product of the retinoblastoma gene and has been found to contain mutations in retinoblastoma tumor cells. Two nuclear proteins that bind to Rb, p48 and p46 have been isolated and the genes have been cloned. These proteins bind to Rb competitively with the SV40 T antigen. p48 is shown to suppress heat shock sensitive Ras mutations in yeast and is implicated as a modulator of the retinoblastoma suppressor function of Rb.

Abstract: The invention is directed to 20-keto-11.beta.-arylsteroids of formula I: ##STR1## wherein R.sup.1, R.sup.6, R.sup.7, R.sup.9, R.sup.12 and X are as defined by the specification. The compounds exhibit progestational and antiprogestational activities.

Abstract: The invention is directed to 11.beta.-arylsteroids of formula II: ##STR1## wherein R.sup.1, R.sup.6, R.sup.8, R.sup.12 and X are as defined by the specification. The compounds exhibit potent antiprogestational activity and are useful in the treatment of fibroids, endometriosis, cervical ripening prior to delivery, hormone replacement therapy and in the control of fertility.

Abstract: The invention is directed to 17.beta.-nitro-11.beta.-arylsteroids of formula I: ##STR1## wherein R.sup.1, R.sup.6, R.sup.7, R.sup.12 and X are as defined by the specification. The compounds exhibit potent antiprogestational activity and are useful in the treatment of fibroids, endometriosis, cervical ripening prior to delivery, hormone replacement therapy and in the control of fertility.

Abstract: Hexahydroindenopyridine compounds having the following formula and relative stereochemistry ##STR1## where R.sup.1 is C.sub.1-6 alkyl; R.sup.2 is hydrogen or C.sub.1-6 alkyl; R.sup.3 is carboxyl or a group which is metabolized to a carboxyl group under mammalian physiological conditions; R.sup.4 is halogen; mixtures of said compound and acid addition salts thereof exhibit potent antispermatogenic activity and are useful in a method of inhibiting spermatogenesis in mammals.