Abstract: The present disclosure relates to salts of (R)-1-(3,4-dihydro-1H-[1,4]oxazino[4,3-b]indazol-1-yl)-N-methylmethanamine, crystalline forms thereof, and methods of preparation thereof, which are useful in the treatment of CNS disorders.

Abstract: The present invention provides a compound of formula (1) and a pharmaceutical composition comprising the compound useful as a nerve regeneration promoter wherein R1-L- is R1—OC(O)—, or the like, R1 is hydrogen atom, optionally-substituted C1-6 alkyl group, optionally-substituted 3- to 8-membered cycloalkyl group, or the like, R2 is hydrogen atom or the like, Ring A is formula (2) or formula (3) wherein R3 is hydrogen atom, optionally-substituted C1-6 alkyl group, or the like, the part of X, Y, and Z is X?Y—Z, X—Y?Z, or X—Y—Z, X is nitrogen atom, NR4 (R4 is hydrogen atom, optionally-substituted C1-6 alkyl group, or the like), or the like, Y is carbon atom or the like, and Z is carbon atom, nitrogen atom or the like.

Abstract: An image forming apparatus includes a control circuit having a plurality of semiconductor elements configured to perform switching between ON and OFF of a plurality of heat generating blocks, and a power interrupting unit configured to be activated so as to interrupt power being supplied to the plurality of semiconductor elements when a heater overheats. Of the plurality of semiconductor elements, a first semiconductor element to supply power to a first heat generating block, is connected, in series, to a second semiconductor element to supply power to a second heat generating block. In addition, when the power interrupting unit is not activated, the second heat generating block is controlled by controlling only the second semiconductor element, and, when the power interrupting unit is not activated, the first heat generating block is controlled by controlling the first semiconductor element and the second semiconductor element.

Abstract: The present invention provides a compound of formula (1) and a pharmaceutical composition comprising the compound useful as a nerve regeneration promoter wherein R1-L- is R1—OC(O)—, or the like, R1 is hydrogen atom, optionally-substituted C1-6 alkyl group, optionally-substituted 3- to 8-membered cycloalkyl group, or the like, R2 is hydrogen atom or the like, Ring A is formula (2) or formula (3) wherein R3 is hydrogen atom, optionally-substituted C1-6 alkyl group, or the like, the part of X, Y, and Z is X?Y—Z, X—Y?Z, or X—Y—Z, X is nitrogen atom, NR4 (R4 is hydrogen atom, optionally-substituted C1-6 alkyl group, or the like), or the like, Y is carbon atom or the like, and Z is carbon atom, nitrogen atom or the like.

Abstract: The present invention provides a compound of formula (1) and a pharmaceutical composition comprising the compound useful as a nerve regeneration promoter wherein R1-L- is R1—OC(O)—, or the like, R1 is hydrogen atom, optionally-substituted C1-6 alkyl group, optionally-substituted 3- to 8-membered cycloalkyl group, or the like, R2 is hydrogen atom or the like, Ring A is formula (2) or formula (3) wherein R3 is hydrogen atom, optionally-substituted C1-6 alkyl group, or the like, the part of X, Y, and Z is X?Y—Z, X—Y?Z, or X—Y—Z, X is nitrogen atom, NR4 (R4 is hydrogen atom, optionally-substituted C1-6 alkyl group, or the like), or the like, Y is carbon atom or the like, and Z is carbon atom, nitrogen atom or the like.

Abstract: According to the present invention, a first semiconductor element to supply power to a first heat generating block out of a plurality of heat generating blocks is connected, in series, to a second semiconductor element to supply power to a second heat generating block out of a plurality of heat generating blocks. The second heat generating block is controlled by controlling the second semiconductor element, and the first heat generating block is controlled by controlling the first semiconductor element and the second semiconductor element.

Abstract: An image heating apparatus including a supporting member having (a) a hole in which a temperature detecting element is disposed so as to contact a second surface of a heat-conductive member, and (b) an opposing surface that (i) opposes the second surface of the heat-conductive member, and (ii) includes a contact region contacting the second surface of the heat-conductive member, the opposing surface of the supporting member being provided adjacent to the hole of the supporting member in a longitudinal direction of the heater. The contact region of the supporting member presses, toward the heater, a part of the heat-conductive member corresponding to the contact region of the supporting member, and the temperature detecting element presses, toward the heater, a part of the heat-conductive member corresponding to the hole of the supporting member.

Abstract: A controller controls first and second switching elements so that, in both of the waveforms of alternating currents flowing through the first and second heating elements, a first period including both of a phase control waveform in which a current flows in a part of a half cycle of alternately current and a wave-number control waveform in which a current flows or does not flow over a half cycle of alternately current and a second period including only the wave-number control waveform alternately appear in a control cycle; when the first heating element operates in the first/second period, the second heating element operates in the second/first period; and both the waveforms of the alternating currents flowing through the first and second heating elements are electrically symmetric in the positive and negative directions during the control cycle.

Abstract: An image heating apparatus includes: a heater including a substrate and a heat generating element; a supporting member; a high heat-conductive member. The recording material on which an image is formed is heated by heat from the heater. The supporting member has a bottom region, where the supporting member supports the heater, including a first region where the supporting member contacts the high heat-conductive member so as to apply pressure between the heater and the high heat-conductive member and including a second region where the supporting member is recessed from the high heat-conductive member relative to the first region. At least a part of the first region overlaps, with respect to a movement direction of the recording material, with a region where the heat generating element is provided.

Abstract: An image heating device includes, a moving member configured to move while contacting a recording material at one surface of the moving member, a backup member configured to contact the other surface of the moving member, a holding member configured to hold the backup member, a nip portion forming member contacting the one surface of the moving member, and configured to form a nip portion in corporation with the backup member via the moving member, and a high thermal conductive member held between the holding member and the backup member, wherein the recording material on which an image has been formed is heated by heat received from the moving member while being nipped and conveyed at the nip portion, and wherein the holding member includes a recessed portion configured not to apply pressure to the high thermal conductive member.

Abstract: An image heating apparatus includes: a heater including a substrate and a heat generating element; a supporting member; a high heat-conductive member. The recording material on which an image is formed is heated by heat from the heater. The supporting member has a bottom region, where the supporting member supports the heater, including a first region where the supporting member contacts the high heat-conductive member so as to apply pressure between the heater and the high heat-conductive member and including a second region where the supporting member is recessed from the high heat-conductive member relative to the first region. At least a part of the first region overlaps, with respect to a movement direction of the recording material, with a region where the heat generating element is provided.

Abstract: An actuator includes a movable member that, when moving, abuts against a key (performance operator) to move the key. A first sensor detects motion of the key. A second sensor detects motion of the movable member. A processor determines, based on outputs of the sensors, whether or not the key and the movable member are currently in a mutually separated state. When the key and the movable member are in the mutually separated state, the processor controls the actuator in such a manner that the key and the movable member are in contact with each other. When the key and the movable member are not in the mutually separated state, the processor controls the actuator by use of feedback information based on the output of the first sensor, whereas, in the mutually separated state, the actuator is controlled by feedback information based on at least the second sensor output.

Abstract: An actuator includes a movable member that, when moving, abuts against a key (performance operator) to move the key. A first sensor detects motion of the key. A second sensor detects motion of the movable member. A processor determines, based on outputs of the sensors, whether or not the key and the movable member are currently in a mutually separated state. When the key and the movable member are in the mutually separated state, the processor controls the actuator in such a manner that the key and the movable member are in contact with each other. When the key and the movable member are not in the mutually separated state, the processor controls the actuator by use of feedback information based on the output of the first sensor, whereas, in the mutually separated state, the actuator is controlled by feedback information based on at least the second sensor output.

Abstract: A heater used for a fixing device includes a substrate, first and second conductor patterns formed at either end of the substrate in the short direction of the substrate, a third conductor pattern formed between the first and second conductor patterns and separated from the two conductor patterns, a first heating member disposed between the first and third conductor patterns and electrically connected to the two conductor patterns, and a second heating member disposed between the second and third conductor patterns and electrically connected to the conductor patterns. The heater has both end regions in which the widths of the third conductor pattern in the short direction is smaller than that of a middle portion of the third conductor pattern. The widths of the first and second heating members in the end regions are smaller than the widths of the first and second heating members in the other region, respectively.

Abstract: A controller controls first and second switching elements so that, in both of the waveforms of alternating currents flowing through the first and second heating elements, a first period including both of a phase control waveform in which a current flows in a part of a half cycle of alternately current and a wave-number control waveform in which a current flows or does not flow over a half cycle of alternately current and a second period including only the wave-number control waveform alternately appear in a control cycle; when the first heating element operates in the first/second period, the second heating element operates in the second/first period; and both the waveforms of the alternating currents flowing through the first and second heating elements are electrically symmetric in the positive and negative directions during the control cycle.

Abstract: An image heating apparatus includes: a heater; a supporting member for supporting the heater; and a high heat-conductive sheet sandwiched between a part of the heater and the supporting member. A recording material on which an image is formed is heated by heat from the heater. The supporting member includes a bearing surface contacting the sheet so as to apply pressure between the heater and the sheet and includes an opposing portion opposing a part of the heater not sandwiching the sheet. In a state in which the pressure is applied between the heater and the sheet, the thickness of the sheet is not less than the height of the stepped portion between the bearing portion and the opposing portion.

Abstract: An image heating apparatus includes: a heater including a substrate and a heat generating element; a supporting member; a high heat-conductive member. The recording material on which an image is formed is heated by heat from the heater. The supporting member has a bottom region, where the supporting member supports the heater, including a first region where the supporting member contacts the high heat-conductive member so as to apply pressure between the heater and the high heat-conductive member and including a second region where the supporting member is recessed from the high heat-conductive member relative to the first region. At least a part of the first region overlaps, with respect to a movement direction of the recording material, with a region where the heat generating element is provided.

Abstract: Dampers provided in corresponding relation to a plurality of keys are each controlled in response to both an operation of a pedal and an operation of the corresponding key. One half region or half point is determined based on a plurality of half pedal regions or half pedal points, in a stroke of the pedal, specific to the individual dampers. Performance data instructing a pedal operation is generated and recorded on the basis of a stroke position detected in response to a pedal operation and the determined one half region or half point. For each of the keys, a key-damper half region or key-damper half point in a stroke of the key is identified in advance. Performance data instructing key operations is generated and recorded on the basis of the key-damper half regions or key-damper half points specific to the keys and stroke positions detected in response to key operations.

Abstract: On a second surface of a contact member opposite to a first surface in contact with an endless film, a plurality of sheets, each having a thermal conductivity in a planar direction higher than in a thickness direction and having a thickness of less than 100 ?m, are superposed.

Abstract: An image heating apparatus includes: a heater including a substrate and a heat generating element; a supporting member; and a high heat-conductive member. The recording material on which an image is formed is heated by heat from the heater. The supporting member has a bottom region, where the supporting member supports the heater, including a first region where the supporting member contacts the high heat-conductive member so as to apply pressure between the heater and the high heat-conductive member and including a second region where the supporting member is recessed from the high heat-conductive member relative to the first region. At least a part of the first region overlaps, with respect to a movement direction of the recording material, with a region where the heat generating element is provided.