Patents by Inventor Yuji Ishihara
Yuji Ishihara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7601868Abstract: The present invention provides a compound represented by the formula or salts thereof, wherein, Ar1, Ar, R, R1, R2, Ra1, Ra2, Ra3, Ra4 and Y have meanings described in the specification, having a melanin-concentrating hormone antagonistic, action and useful as an agent for the prophylaxis or treatment of obesity and the like.Type: GrantFiled: February 12, 2004Date of Patent: October 13, 2009Assignee: Takeda Pharmaceutical Company LimitedInventors: Yuji Ishihara, Makoto Kamata, Shiro Takekawa
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Patent number: 7462963Abstract: A motor cooling apparatus and method to auto-circulate coolant to reduce the weight and size of the cooling system. The cooling apparatus includes a coolant path disposed at hot areas of the motor. A reservoir tank is located above the coolant path and gravity feeds coolant to the coolant path. Coolant in the vapor phase discharged from the coolant path is liquefied by a condenser located in a coolant return path. Coolant in the liquid phase is expelled to the reservoir tank under pressure of the vapor-phase coolant in the coolant path to provide for the auto-circulating coolant. Expansion pressure of the coolant supplied by an motor inverter can further increase the pressure of the coolant in the discharging coolant path to improve coolant circulation efficiency to prevent dry out in the coolant path.Type: GrantFiled: November 28, 2005Date of Patent: December 9, 2008Assignee: Nissan Motor Co., Ltd.Inventors: Yuji Ishihara, Keiko Shishido, Hitoshi Shimonosono
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Patent number: 7462628Abstract: Preventives/remedies for voiding disturbance containing a compound having both of an acetylcholinesterase inhibitory action and an ?1 antagonistic action which exhibits an excellent effect of improving the urinary function of the bladder (i.e., effects of improving urine flow rate and voiding efficiency) without affecting the urinary pressure or the blood pressure.Type: GrantFiled: January 18, 2006Date of Patent: December 9, 2008Assignee: Takeda Pharmaceutical Company LimitedInventors: Yuji Ishihara, Yuji Ishichi, Takayuki Doi, Hiroshi Nagabukuro, Naoyuki Kanzaki, Motoki Ikeuchi
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Publication number: 20080253245Abstract: A DSP (digital signal processor) of a DVD recorder has a pulse type setting section that sets the type of write pulse, a reference power setting section that sets a reference power that is a reference value of the drive power of the write pulse, a pulse type checking section that checks whether or not the type of write pulse thus set is a write pulse consisting of a plurality of pulses, the write pulse being of a type that allows the drive power to be set for each of the plurality of pulses, a power correcting section that corrects, if the set type of write pulse is found to be a write pulse consisting of a plurality of pulses, the drive power of at least one pulse of the plurality of pulses constituting the write pulse by adding a previously set correction power to the set reference power, and a drive control section that applies to an LD the write pulse consisting of the pulse with the set reference power and the pulse with the corrected drive power.Type: ApplicationFiled: April 8, 2008Publication date: October 16, 2008Inventor: Yuji ISHIHARA
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Publication number: 20070199339Abstract: A cooling apparatus for cooling a heat-generating member includes a cooling flow path, a condenser, a coolant-returning flow path, a first check valve and a second check valve. The cooling flow path is thermally connected to the heat-generating member. The condenser is connected to a downstream portion of the cooling flow path and condenses a coolant contained in the cooling apparatus after the coolant is evaporated in the cooling flow path. The coolant-returning flow path returns the coolant condensed by the condenser to an upstream portion of the cooling flow path. The first check valve is disposed between the coolant-returning flow path and prevents the coolant from flowing in a reverse direction from the cooling flow path to the first coolant-returning flow path. The second check valve is disposed between the condenser and the coolant-returning flow path and prevents the coolant from flowing in a reverse direction from the first coolant-returning flow path to the condenser.Type: ApplicationFiled: February 7, 2007Publication date: August 30, 2007Inventors: Yuji Ishihara, Hitoshi Shimonosono, Keiko Shishido
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Publication number: 20070173498Abstract: A melanin-concentrating hormone antagonist which comprises a compound of the formula: wherein Ar1 is a cyclic group which may have substituents; X is a spacer having a main chain of 1 to 6 atoms; Y is a bond or a spacer having a main chain of 1 to 6 atoms; Ar is a monocyclic aromatic ring which may be condensed with a 4 to 8 membered non-aromatic ring, and may have further substituents; R1 and R2 are independently hydrogen atom or a hydrocarbon group which may have substituents; R1 and R2, together with the adjacent nitrogen atom, may form a nitrogen-containing hetero ring which may have substituents; R2 may form a spiro ring together with Ar; or R2, together with the adjacent nitrogen atom and Y, may form a nitrogen-containing hetero ring which may have substituents; or a salt thereof; which is useful as an agent for preventing or treating obesity, etc.Type: ApplicationFiled: September 12, 2005Publication date: July 26, 2007Inventors: Kaneyoshi Kato, Jun Terauchi, Masaaki Mori, Nobuhiro Suzuki, Yukio Shimomura, Shiro Takekawa, Yuji Ishihara
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Patent number: 7229986Abstract: A melanin-concentrating hormone antagonist comprising a compound of the formula: wherein R is hydrogen atom or a cyclic group which may be substituted; X is a bond or a spacer having a main chain of 1 to 10 atoms; Y is a spacer having a main chain of 1 to 6 atoms; ring A is benzene ring which may be further substituted; ring B is a 5- to 9-membered nitrogen-containing non-aromatic heterocyclic ring which may be further substituted; R1 and R2 are the same or different and are hydrogen atom, a hydrocarbon group which may be substituted or a heterocyclic group which may be substituted; or R1 and R2, together with the adjacent nitrogen atom, may form a nitrogen-containing heterocyclic ring which may be substituted; or R2, together with the adjacent nitrogen atom and Y, may form a nitrogen-containing heterocyclic ring which may be substituted; or a salt thereof is useful as a preventive or therapeutic agent for obesity, etc.Type: GrantFiled: May 15, 2001Date of Patent: June 12, 2007Assignee: Takeda Pharmaceutical Company Ltd.Inventors: Yuji Ishihara, Jun Terauchi, Nobuhiro Suzuki, Shiro Takekawa, Kazuyoshi Aso
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Patent number: 7183415Abstract: A compound, which has a melanin-concentrating hormone antagonistic action and useful as an agent for preventing or treating obesity, and which is represented by the formula: wherein Ar is a cyclic group optionally having substituent(s); X is a bond or a spacer having a main chain of 1 to 6 atoms; R1 and R2 are the same or different and each is a hydrogen atom or a hydrocarbon group optionally having substituent(s), or R1 and R2 may form, together with the adjacent nitrogen atom, a nitrogen-containing heterocycle optionally having substituent(s); Y is a divalent hydrocarbon group optionally having substituent(s) (except CO); R3 is a hydrogen atom or a hydrocarbon group optionally having substituent(s); and ring A and ring B may further have substituents, and when ring B further has a substituent, the substituent may be linked to R1 to form a ring, or a salt thereof, or a prodrug thereof, is provided.Type: GrantFiled: October 24, 2002Date of Patent: February 27, 2007Assignee: Takeda Pharmaceutical Company LimitedInventors: Yuji Ishihara, Makoto Kamata, Shiro Takekawa, Nobuhiro Suzuki, Koki Kato
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Patent number: 7138533Abstract: Preventives/remedies for voiding disturbance containing a compound having both of an acetylcholinesterase inhibitory action and an ?1 antagonistic action which exhibits an excellent effect of improving the urinary function of the bladder (i.e., effects of improving urine flow rate and voiding efficiency) without affecting the urinary pressure or the blood pressure.Type: GrantFiled: September 8, 2004Date of Patent: November 21, 2006Assignee: Takeda Pharmaceutical Company LimitedInventors: Yuji Ishihara, Yuji Ishichi, Takayuki Doi, Hiroshi Nagabukuro, Naoyuki Kanzaki, Motoki Ikeuchi
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Patent number: 7132547Abstract: Preventives/remedies for voiding disturbance containing a compound having both of an acetylcholinesterase inhibitory action and an ?1 antagonistic action which exhibits an excellent effect of improving the urinary function of the bladder (i.e., effects of improving urine flow rate and voiding efficiency) without affecting the urinary pressure or the blood pressure.Type: GrantFiled: December 26, 2002Date of Patent: November 7, 2006Assignee: Takeda Pharmaceutical Company LimitedInventors: Yuji Ishihara, Yuji Ishichi, Takayuki Doi, Hiroshi Nagabukuro, Naoyuki Kanzaki, Motoki Ikeuchi
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Patent number: 7115750Abstract: A melanin-concentrating hormone antagonist which comprises a compound of the formula: wherein Ar1 is a cyclic group which may have substituents; X is a spacer having a main chain of 1 to 6 atoms; Y is a bond or a spacer having a main chain of 1 to 6 atoms; Ar is a monocyclic aromatic ring which may be condensed with a 4 to 8 membered non-aromatic ring, and may have further substituents; R1 and R2 are independently hydrogen atom or a hydrocarbon group which may have substituents; R1 and R2, together with the adjacent nitrogen atom, may form a nitrogen-containing hetero ring which may have substituents; R2 may form a spiro ring together with Ar; or R2, together with the adjacent nitrogen atom and Y, may form a nitrogen-containing hetero ring which may have substituents; or a salt thereof; which is useful as an agent for preventing or treating obesity, etc.Type: GrantFiled: September 19, 2000Date of Patent: October 3, 2006Assignee: Takeda Pharmaceutical Company LimitedInventors: Kaneyoshi Kato, Jun Terauchi, Masaaki Mori, Nobuhiro Suzuki, Yukio Shimomura, Shiro Takekawa, Yuji Ishihara
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Publication number: 20060211675Abstract: Preventives/remedies for voiding disturbance containing a compound having both of an acetylcholinesterase inhibitory action and an al antagonistic action which exhibits an excellent effect of improving the urinary function of the bladder (i.e., effects of improving urine flow rate and voiding efficiency) without affecting the urinary pressure or the blood pressure.Type: ApplicationFiled: January 18, 2006Publication date: September 21, 2006Inventors: Yuji Ishihara, Yuji Ishichi, Takayuki Doi, Hiroshi Nagabukuro, Naoyuki Kanzaki, Motoki Ikeuchi
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Publication number: 20060128690Abstract: The present invention provides a compound represented by the formula wherein Ar1 is a cyclic group optionally having substituent(s); R is a hydrogen atom, an optionally halogenated C1-6 alkyl, a phenyl optionally having substituent(s) or a pyridyl optionally having substituent(s); Ra1, Ra2, Ra3 and Ra4 are the same or different and each is a hydrogen atom, an optionally halogenated C1-6 alkyl or the like; Ar is a monocyclic aromatic ring optionally having substituent(s); Y is an optionally halogenated alkylene group; and R1 and R2 are (1) the same or different and each is a hydrogen atom or a C1-6 alkyl, (2) R1 and R2 form a nitrogen-containing heterocycle optionally having substituent(s) together with the adjacent nitrogen atom, or (3) R1 and Y form a nitrogen-containing heterocycle optionally having substituent(s) together with the adjacent nitrogen atom, and R2 is a hydrogen atom or a C1-6 alkyl; provided that when the nitrogen-containing heterocycle formed by R1 and R2 together with the adjacentType: ApplicationFiled: February 12, 2004Publication date: June 15, 2006Inventors: Yuji Ishihara, Makoto Kamata, Shiro Takekawa
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Publication number: 20060113851Abstract: A motor cooling apparatus and method to auto-circulate coolant to reduce the weight and size of the cooling system. The cooling apparatus includes a coolant path disposed at hot areas of the motor. A reservoir tank is located above the coolant path and gravity feeds coolant to the coolant path. Coolant in the vapor phase discharged from the coolant path is liquefied by a condenser located in a coolant return path. Coolant in the liquid phase is expelled to the reservoir tank under pressure of the vapor-phase coolant in the coolant path to provide for the auto-circulating coolant. Expansion pressure of the coolant supplied by an motor inverter can further increase the pressure of the coolant in the discharging coolant path to improve coolant circulation efficiency to prevent dry out in the coolant path.Type: ApplicationFiled: November 28, 2005Publication date: June 1, 2006Applicant: NISSAN MOTOR CO., LTD.Inventors: Yuji Ishihara, Keiko Shishido, Hitoshi Shimonosono
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Publication number: 20060063769Abstract: Preventives/remedies for voiding disturbance containing a compound having both of an acetylcholinesterase inhibitory action and an ?1 antagonistic action which exhibits an excellent effect of improving the urinary function of the bladder (i.e., effects of improving urine flow rate and voiding efficiency) without affecting the urinary pressure or the blood pressure.Type: ApplicationFiled: December 26, 2002Publication date: March 23, 2006Inventors: Yuji Ishihara, Yuji Ishichi, Takayuki Doi, Hiroshi Nagabukuro, Naoyuki Kanzaki, Motoki Ikeuchi
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Publication number: 20050209213Abstract: A compound, which has a melanin-concentrating hormone antagonistic action and useful as an agent for preventing or treating obesity, and which is represented by the formula: wherein Ar is a cyclic group optionally having substituent(s); X is a bond or a spacer having a main chain of 1 to 6 atoms; R1 and R2 are the same or different and each is a hydrogen atom or a hydrocarbon group optionally having substituent(s), or R1 and R2 may form, together with the adjacent nitrogen atom, a nitrogen-containing heterocycle optionally having substituent(s); Y is a divalent hydrocarbon group optionally having substituent(s) (except CO); R3 is a hydrogen atom or a hydrocarbon group optionally having substituent(s); and ring A and ring B may further have substituents, and when ring B further has a substituent, the substituent may be linked to R1 to form a ring, or a salt thereof, or a prodrug thereof, is provided.Type: ApplicationFiled: October 24, 2002Publication date: September 22, 2005Applicant: Takeda Chemical Industries, Ltd.Inventors: Yuji Ishihara, Makoto Kamata, Shiro Takekawa, Nobuhiro Suzuki, Koki Kato
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Publication number: 20050197362Abstract: Preventives/remedies for voiding disturbance containing a compound having both of an acetylcholinesterase inhibitory action and an ?1 antagonistic action which exhibits an excellent effect of improving the urinary function of the bladder (i.e., effects of improving urine flow rate and voiding efficiency) without affecting the urinary pressure or the blood pressure.Type: ApplicationFiled: September 8, 2004Publication date: September 8, 2005Inventors: Yuji Ishihara, Yuji Ishichi, Takayuki Doi, Hiroshi Nagabukuro, Naoyuki Kanzaki, Motoki Ikeuchi
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Patent number: 6930185Abstract: A melanin-concentrating hormone antagonist comprising a compound of the formula (I): wherein Ar1 is a cyclic group which may be substituted; X and Y are the same or different and are a spacer having a main chain of 1 to 6 atoms; Ar is a condensed polycyclic aromatic ring which may be substituted; R1 and R2 are the same or different and are hydrogen atom or a hydrocarbon group which may be substituted; or R1 and R2, together with the adjacent nitrogen atom, may form a nitrogen-containing heterocyclic ring which may be substituted; or R2, together with the adjacent nitrogen atom and Y, may form a nitrogen-containing heterocyclic ring which may be substituted; or R2, together with the adjacent nitrogen atom, Y and Ar, may form a condensed ring; or a salt thereof is useful as an agent for preventing or treating obesity, etc.Type: GrantFiled: April 26, 2001Date of Patent: August 16, 2005Assignee: Takeda Chemical Industries, Ltd.Inventors: Yuji Ishihara, Nobuhiro Suzuki, Shiro Takekawa
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Publication number: 20040116457Abstract: Agents for improving excretory potency of the urinary bladder which comprises an amine compound of non-carbamate-type having an acetylcholinesterase-inhibiting action.Type: ApplicationFiled: December 4, 2003Publication date: June 17, 2004Inventors: Yuji Ishihara, Takayuki Doi, Hiroshi Nagabukuro, Yuji Ishichi
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Publication number: 20040077628Abstract: A melanin-concentrating hormone antagonist comprising a compound of the formula (I): 1Type: ApplicationFiled: October 24, 2002Publication date: April 22, 2004Inventors: Yuji Ishihara, Nobuhiro Suzuki, Shiro Takekawa