Abstract: A Fc-CD80 fusion protein has a CD80 extracellular domain (ECD) linked to a C-terminal of an immunoglobulin Fc domain. The Fc-CD80 fusion protein can be used for the preparation of a conjugate, the conjugate including the Fc-CD80 fusion protein as a first component, and a second component containing a second effector molecule, the second component being located at an N-terminal of the first component. In addition, a conjugate including the Fc-CD80 fusion protein, a pharmaceutical composition including the Fc-CD80 fusion protein and/or the conjugate are effective for the treatment or prevention of cancerous diseases in individuals.

Abstract: Provided are a bispecific antibody and use thereof. The bispecific antibody comprises a B7-H4-targeting antigen-binding domain and a 4-1BB-targeting antigen-binding domain. The bispecific antibody has one or two or three sites for binding to 4-1BB, along with a novel fully human B7-H4 antibody. The bispecific antibody specifically binds to tumor cells by targeting B7-H4, reducing toxicity induced by 4-1BB activation. In addition, the bispecific antibody of the present invention comprises a human Fc fragment, and thus retains the binding of Fc to FcRn and has a longer half-life.

Abstract: Apparatus and methods for determining the blood glucose concentration of a patient are disclosed A saliva glucose measurement strip is used in conjunction with a glucose measurement device to measure an electrochemical signal of a saliva sample and the measured electrochemical signal is correlated to a blood glucose convention.

Abstract: The invention relates to the field of medical biotechnology. Specifically, the present invention relates to a fusion protein containing an anti-interleukin-17 antibody and a tumor necrosis factor receptor extracellular region, a polynucleotide encoding the fusion protein, a vector comprising the polynucleotide, a host cell comprising the polynucleotide or the vector, and the use of the fusion protein for the treatment, prevention, and/or diagnosis of a related disease in an individual.

Abstract: A method and device for coding and decoding are disclosed. The method includes: dividing a picture to be encoded into several slices, each containing macroblocks continuous in a designated scanning sequence in the picture; dividing slices in the picture into one or more slice sets according to attribute information of the slices, each slice set containing one or more slices; and encoding the slices in the slice sets according to slice and slice set division information to get a coded bit stream of the picture. The decoding method includes: obtaining slice and slice set division information from a bit stream to be decoded and decoding the bit stream according to the obtained slice and slice set division information. The invention improves the performance of video transmission effectively and realizes region based coding. The implementation of coding and decoding is simple and the complexity of coding and decoding systems is reduced.

Abstract: The present invention provides a method for improving the stability of pramipexole or its salt preparation, and further provides a pramipexole hydrochloride oral liquid with excellent stability and oral absorption effect. The pramipexole hydrochloride oral liquid of the present invention is prepared through a simple process, and shows bioequivalence with the tablet containing pramipexole hydrochloride. The invention perfectly realizes multi-dose administration of pramipexole hydrochloride and improves the compliance and accessibility of medication for patients.

Abstract: Provided is an anti-PD-L1 antigen binding protein, capable of binding to primate-derived PD-L1 with a KD value of 1×10?8 M or less. The antigen binding protein can block the binding of PD-1 and CD80 to PD-L1, stimulate the secretion of cytokines in immune cells, and can inhibit tumor growth and/or tumor cell proliferation. Also provided is a fusion protein, comprising human TGFBRII or a fragment thereof and the antigen binding protein. Also provided is an application of the antigen binding protein and/or the fusion protein in the prevention and treatment of tumors or cancers.

Abstract: Related are an anti-TSLP antibody or an antigen-binding fragment thereof, nucleic acid molecules coding the same, and a method for preparing the same. The anti-TSLP antibody or the antigen-binding fragment thereof have high affinity to TSLP, capable of effectively binding with TSLP and blocking the proliferative effect of TSLP with respect to Ba/F3-hTSLPR-hIL7R? cells, and blocking the capability of TSLP in activating and secreting cytokines with respect to PBMC. At the same time, further related are a medicinal composition comprising the antibody or the antigen-binding fragment thereof, and uses of the composition in preparing a medicament for preventing and/or treating asthma, allergic inflammation, an allergic reaction or autoimmune disease.

Abstract: A method of providing optimized settings of graphics parameters for a computer gaming application includes: consolidating data related to settings of graphics parameters for different computer hardware equipment and respective performance values; training a machine learning model based on the consolidated data; determining a weight for each setting of a graphics parameter, by the trained machine learning model; for each set of graphics parameters, predicting a performance value achievable by the computer gaining application when it is executed on a specific type of computer, by the trained machine learning model; assigning a priority value to each graphics parameter based on its contribution to the performance value; choosing or generating at least one set of graphics parameters providing an optimized performance value, based on the predicted performance value associated with each set of graphics parameters and the determined weight for each graphics parameter and/or based on the assigned priority value.

Abstract: Disclosed are a CD3-targeting antibody, a bispecific antibody and the use thereof. The CD3-targeting antibody comprises a light chain variable region (VL) and a heavy chain variable region (VH). The VL has the amino acid sequence as shown in SEQ ID NO: 56 or a mutation thereof. The VH has mutations on the amino acid sequence as shown in SEQ ID NO: 42, and the mutations occur at one or more of the sites of amino acid residues selected from positions 30, 73, 76, 78, 93 and 94. The bispecific antibody comprises a first protein functional region and a second protein functional region, wherein the first protein functional region comprises the CD3-targeting antibody as described above. The CD3-targeting antibody reduces the toxicity caused by cytokine release syndrome, and the bispecific antibody prepared therefrom is stable and has the ability to bind to T cells, and also reduces the difficulty of producing.

Abstract: Provided are an antibody targeting BCMA, a bispecific antibody targeting BCMA and CD3, and applications thereof. The antibody targeting BCMA comprises two heavy chain variable regions, the heavy chain variable regions comprising HCDR1, HCDR2, and HCDR3 as shown in the amino acid sequences of SEQ ID NO: 22, SEQ ID NO: 33 and SEQ ID NO: 42, or HCDR1, HCDR2, and HCDR3 as shown in the amino acid sequences of SEQ ID NO: 26, SEQ ID NO: 37 and SEQ ID NO: 41. The antibody effectively targets human BCMA and binds to cynomolgus BCMA; the bispecific antibody effectively targets both human BCMA and human CD3, and can bind to cynomolgus BCMA and cynomolgus CD3.

Abstract: The present disclosure provide a transform method in picture block encoding, an inverse transform method in picture block decoding, and an apparatus. The inverse transform method includes: determining, in a target transform set, a corresponding transform pair of each region of at least two regions that constitute a to-be-decoded current block; inverse transforming each region based on the corresponding transform pair of each region to obtain an inverse transform result of each region; and obtaining an inverse transform result of the current block based on the inverse transform result of each region and a position of each region in the current block, where the at least two regions do not overlap each other, the target transform set includes a correspondence between a transform pair and a position of a region in the current block, and the transform pair includes a horizontal transform core and a vertical transform core.

Abstract: Automated uploading of user and system data from one or more source computing systems to one or more destination storage repositories is provided. A data uploader module is installed on each computing system or is accessible by each computing system from which user and/or system data may need to be exported to a destination repository. Upon command, a data uploader module reads desired user data or system data from the computing system. The read data is transformed, if required, and the data is then exported to a destination storage repository. The exported data may be stored and analyzed at the destination storage repository from which it may be subsequently exported to other destinations, including back to the source computing system from which it was originally extracted.

Abstract: A conjugate provided. The conjugate is a compound represented by Formula (I), or the conjugate is a stereoisomer, tautomer, homologue, solvate, metabolite, pharmaceutically acceptable salt, or prodrug of the compound represented by Formula (I): where A is a linker, and B is a dihydrofolate reductase inhibitor; R1, R2, R3, R4, and R5 are independently selected from H or C1-6 alkyl; and n1, n2, and n3 are each an integer selected from 0 to 6.

Abstract: The present invention discloses a 3D print head for FDM rubber material and a 3D printer using same. The 3D print head for FDM rubber material comprises a motor, a feeding assembly, a radiator, a heating block and an extrusion nozzle, and further comprises a venturi assembly. The venturi is installed between the radiator and the heating block by the mounting component, and a gap is formed between an upper end face of the venturi and the radiator. The motor drives the feeding assembly to feed material to the heating block through the venturi and extrude the material through the extrusion nozzle. The venturi of the present invention can greatly reduce the heat conduction through the venturi, to guarantee that thermo-plastic-rubber material used for printing is not softened and all the fed low-hardness and high-elasticity material can be effectively transferred before entering the heating block.

Abstract: An decoding method is disclosed, including: parsing a bitstream to obtain a first flag, wherein the first flag specifies whether a current coding block is required to be partitioned; when the first flag specifies that the current coding block is required to be partitioned, parsing the bitstream to obtain a second flag, wherein the second flag specifies whether the current coding blocks is partitioned in a horizontal direction or a vertical direction; partitioning the current coding block into four first rectangular subblocks in the horizontal direction or four second rectangular subblocks in the vertical direction; and reconstructing the current coding block based on the four first rectangular subblocks or the four second rectangular subblocks.