Abstract: The present invention provides a multi-targeting fusion protein that blocks the growth of vascular endothelial cells and activates T cells, which comprises (i) a vascular endothelial cell growth inhibitory domain; (ii) an immunoglobulin Fc domain; and (iii) CD80 extracellular domain (ECD). The present invention also provides a polynucleotide encoding the multi-targeting fusion protein, a vector containing the polynucleotide, a host cell comprising the polynucleotide or the vector, and pharmaceutical composition comprising the multi-targeting fusion protein and an anti-PD-1 antibody. The multi-targeting fusion protein and pharmaceutical composition of the present invention can treat or prevent cancerous diseases in individuals.

Abstract: An encoding method with multiple image block division manners is disclosed, including: determining a division manner and a division direction of an image block; dividing the image block to obtain image subblocks sequentially arranged horizontally or vertically; determining whether the image subblocks need subdivision, and if subdivision is not needed, predicting the encoding object in the frame according to the image subblocks, to obtain residual data; performing transformation, quantization, and entropy encoding for the residual data so as to obtain coded residual data; and writing the division manner of the image block, the division direction of the image block, an identifier indicating whether the image subblocks need subdivision, and the coded residual data into a bitstream. By applying the encoding method, better prediction accuracy can be achieved when the image block presents a small change of pixel value in the horizontal or vertical direction.

Abstract: Methods and apparatus for coding and decoding a MATRIX. A coding method includes: dividing a MATRIX into layers according to a preset quantity of layers, and grouping MATRIX elements into different layers; performing, according to a determined to-be-coded layer number and in an order of layers one by one, coding processing on MATRIX elements at each layer to be coded; for a layer having a layer number less than or equal to the to-be-coded layer number, writing residual data between an original MATRIX element value corresponding to the layer and a corresponding MATRIX element predicted value into a bit stream; for a layer having a layer number greater than the to-be-coded layer number, writing no coded data of the layer into the bit stream; and coding the to-be-coded layer number and writing the coded layer number of the coded layer into the bit stream.

Abstract: The present invention relates to a nitrogen-containing fused ring compound, a preparation method and use thereof. Specifically, the present invention relates to a compound having the structure of Formula (X), a stereoisomer, tautomer or mixture thereof, a pharmaceutically acceptable salt, co-crystal, polymorph or solvate thereof, or a stable isotope derivative, metabolite or prodrug thereof. The compound of the invention may have the structure of Formula (I) or Formula (II). These compounds are useful for the treatment of an abnormal cell proliferation disease (e.g., cancer).

Abstract: Disclosed are isolated monoclonal antibodies, comprising a CD152-binding domain, wherein the antibodies bind specifically to human CD152. Methods of making and using the antibodies to treat diseases including cancers and autoimmune diseases are also provided.

Abstract: A first set of features associated with a neural network are parameterized. A decision tree is generated from the first set of features. One or more adjustments for the neural network are received at the decision tree. A second set of features associated with the adjustments at the decision tree are parameterized. The parameterized first and second set of features are combined into a plurality of parameters. From the plurality, an adjusted neural network is generated.

Abstract: The invention relates to the field of medical biotechnology. Specifically, the present invention relates to a fusion protein containing an anti-interleukin-17 antibody and a tumor necrosis factor receptor extracellular region, a polynucleotide encoding the fusion protein, a vector comprising the polynucleotide, a host cell comprising the polynucleotide or the vector, and the use of the fusion protein for the treatment, prevention, and/or diagnosis of a related disease in an individual.

Abstract: Disclosed are isolated monoclonal antibodies, comprising a CD152-binding domain, wherein the antibodies bind specifically to human CD152. Methods of making and using the antibodies to treat diseases including cancers and autoimmune diseases are also provided.

Abstract: Disclosed are compositions and methods for the electrochemical detection of enzymes, such as enzymes that are indicative of disease, disorders, or pathogens, such as viruses, bacteria, and fungi, or other disorders. These methods can be used in point-of-care diagnostic assays for the detection of disease, disorder, or pathogen (e.g., to identify the strain of pathogen infecting a patient in a healthcare setting). The electrochemical methods described herein can also be used to assess the susceptibility of a pathogen to an antipathogen drug. Also provided are probes suitable for use in conjunction with the methods described herein.

Abstract: A building-information management (BIM) system receives a set of wind vectors that identify wind speeds and directions at the surfaces of physical structures within a volume of air. The system stratifies the volume into vertically stacked layers that each contains similar wind vectors. Each layer is then divided horizontally into rectangular cells that each at least partially encloses a cluster of the structures. The system infers cell-specific relationships that relate physical attributes of the enclosed structures with the cell's incoming and outgoing airflows, from which the system builds a wind-propagation model for each cell. These cell-specific models are combined into a regional wind-propagation model that predicts how winds entering the volume will be propagated as outgoing wind vectors. The regional model is used by downstream modules of the BIM system to account for airflow effects when designing a planned building.

Abstract: This application provides a transform method and an inverse transform method for a picture block, and an apparatus. The transform method for a picture block in this application includes: obtaining a to-be-encoded picture block in a to-be-processed picture, where the to-be-encoded picture block is an object on which encoding is performed; splitting the to-be-encoded picture block to obtain a plurality of picture subblocks; and transforming at least one of the picture subblocks. In this application, picture encoding efficiency is improved.

Abstract: This application provides a picture block splitting method and an apparatus. The picture block splitting method in this application includes: obtaining a picture block in a to-be-processed picture, where the picture block is an object on which encoding is performed; determining, based on a length of a first side and a length of a second side of the picture block, a block splitting method used for the picture block, where the first side and the second side are two neighboring sides of the picture block, the first side is a horizontal line, and the second side is a vertical line; and splitting the picture block according to the block splitting method. In this application, an unnecessary block splitting method is omitted, operation overheads are reduced, and picture encoding efficiency is improved.

Abstract: A method and device for coding and decoding are disclosed. The method includes: dividing a picture to be encoded into several slices, each containing macroblocks continuous in a designated scanning sequence in the picture; dividing slices in the picture into one or more slice sets according to attribute information of the slices, each slice set containing one or more slices; and encoding the slices in the slice sets according to slice and slice set division information to get a coded bit stream of the picture. The decoding method includes: obtaining slice and slice set division information from a bit stream to be decoded and decoding the bit stream according to the obtained slice and slice set division information. The invention improves the performance of video transmission effectively and realizes region based coding. The implementation of coding and decoding is simple and the complexity of coding and decoding systems is reduced.

Abstract: Embodiments of this application relate to the video coding and compression field, and disclose an encoding method and apparatus, and a decoding method and apparatus, to resolve a problem that an existing split mode cannot satisfy a relatively complex texture requirement. The decoding method specifically includes: parsing a bitstream to determine a basic split mode for a current to-be-decoded picture block and a target derivation mode for a subpicture block of the current to-be-decoded picture block; splitting the current to-be-decoded picture block into N subpicture blocks in the basic split mode, where N is an integer greater than or equal to 2; deriving one derived picture block from at least two adjacent subpicture blocks in the N subpicture blocks in the target derivation mode; and decoding the derived picture block.

Abstract: An encoding method with multiple image block division manners is disclosed, including: determining a division manner and a division direction of an image block; dividing the image block to obtain image subblocks sequentially arranged horizontally or vertically; determining whether the image subblocks need subdivision, and if subdivision is not needed, predicting the encoding object in the frame according to the image subblocks, to obtain residual data; performing transformation, quantization, and entropy encoding for the residual data so as to obtain coded residual data; and writing the division manner of the image block, the division direction of the image block, an identifier indicating whether the image subblocks need subdivision, and the coded residual data into a bitstream. By applying the encoding method, better prediction accuracy can be achieved when the image block presents a small change of pixel value in the horizontal or vertical direction.

Abstract: A method and device for coding and decoding are disclosed. The method includes: dividing a picture to be encoded into several slices, each containing macroblocks continuous in a designated scanning sequence in the picture; dividing slices in the picture into one or more slice sets according to attribute information of the slices, each slice set containing one or more slices; and encoding the slices in the slice sets according to slice and slice set division information to get a coded bit stream of the picture. The decoding method includes: obtaining slice and slice set division information from a bit stream to be decoded and decoding the bit stream according to the obtained slice and slice set division information. The invention improves the performance of video transmission effectively and realizes region based coding. The implementation of coding and decoding is simple and the complexity of coding and decoding systems is reduced.

Abstract: The present disclosure provide a transform method in picture block encoding, an inverse transform method in picture block decoding, and an apparatus. The inverse transform method includes: determining, in a target transform set, a corresponding transform pair of each region of at least two regions that constitute a to-be-decoded current block; inverse transforming each region based on the corresponding transform pair of each region to obtain an inverse transform result of each region; and obtaining an inverse transform result of the current block based on the inverse transform result of each region and a position of each region in the current block, where the at least two regions do not overlap each other, the target transform set includes a correspondence between a transform pair and a position of a region in the current block, and the transform pair includes a horizontal transform core and a vertical transform core.

Abstract: An encoding method with multiple image block division manners is disclosed, including: determining a division manner and a division direction of an image block; dividing the image block to obtain image subblocks sequentially arranged horizontally or vertically; determining whether the image subblocks need subdivision, and if subdivision is not needed, predicting the encoding object in the frame according to the image subblocks, to obtain residual data; performing transformation, quantization, and entropy encoding for the residual data so as to obtain coded residual data; and writing the division manner of the image block, the division direction of the image block, an identifier indicating whether the image subblocks need subdivision, and the coded residual data into a bitstream. By applying the encoding method, better prediction accuracy can be achieved when the image block presents a small change of pixel value in the horizontal or vertical direction.

Abstract: Automated uploading of user and system data from one or more source computing systems to one or more destination storage repositories is provided. A data uploader module is installed on each computing system or is accessible by each computing system from which user and/or system data may need to be exported to a destination repository. Upon command, a data uploader module reads desired user data or system data from the computing system. The read data is transformed, if required, and the data is then exported to a destination storage repository. The exported data may be stored and analyzed at the destination storage repository from which it may be subsequently exported to other destinations, including back to the source computing system from which it was originally extracted.

Abstract: Methods and apparatus for coding and decoding a MATRIX. A coding method includes: dividing a MATRIX into layers according to a preset quantity of layers, and grouping MATRIX elements into different layers; performing, according to a determined to-be-coded layer number and in an order of layers one by one, coding processing on MATRIX elements at each layer to be coded; for a layer having a layer number less than or equal to the to-be-coded layer number, writing residual data between an original MATRIX element value corresponding to the layer and a corresponding MATRIX element predicted value into a bit stream; for a layer having a layer number greater than the to-be-coded layer number, writing no coded data of the layer into the bit stream; and coding the to-be-coded layer number and writing the coded layer number of the coded layer into the bit stream.