Abstract: The objective of the present invention is to provide a technology capable of estimating a battery condition in conjunction with charging/discharging operations of a battery, without employing dedicated equipment for estimating the condition of the battery. A battery management device according to the present invention identifies a first period and a subsequent second period in a rest period after a battery finishes discharging or charging, and uses an output voltage difference in the second period to estimate the condition of the battery (see FIG. 1).

Abstract: Crystals of the compound represented by formula (1), a method for the production thereof, and a method for producing an antibody-drug conjugate using the crystals.

Abstract: A valve spring includes a nitrided layer, and a core portion that is further inward than the nitrided layer. A chemical composition of the core portion consists of, in mass %, C: 0.53 to 0.59%, Si: 2.51 to 2.90%, Mn: 0.70 to 0.85%, P: 0.020% or less, S: 0.020% or less, Cr: 1.40 to 1.70%, Mo: 0.17 to 0.53%, V: 0.23 to 0.33%, Ca: 0.0001 to 0.0050%, Cu: 0.050% or less, Ni: 0.050% or less, Al: 0.0050% or less, Ti: 0.050% or less, and N: 0.0070% or less, with the balance being Fe and impurities. In the core portion, a number density of V-based precipitates having a maximum diameter ranging from 2 to 10 nm is 500 to 8000 per ?m2, and in the core portion, a numerical proportion of Ca sulfides with respect to a total number of oxide-based inclusions and sulfide-based inclusions is 0.20% or less.

Abstract: This invention provides an antitumor drug delivery formulation for treating a subject having a tumor more highly expressing a TUG1 gene than normal tissues or preventing the subject from tumor metastasis, comprising a polymeric micelle comprising a nucleic acid that suppresses high expression of the TUG1 gene as an active ingredient, wherein the polymeric micelle comprises a block copolymer having a cationic poly(amino acid) segment and a hydrophilic polymer chain segment and the nucleic acid, and wherein the nucleic acid is bound to a cationic group of the cationic poly(amino acid) segment to form a complex and/or the nucleic acid is incorporated in the micelle or attached into the micelle; and the polymeric micelle accumulates in the tumor.

Abstract: The present invention comprises: a spool (10); a clamper (22); a torch electrode (31); a high-voltage power source circuit (30); a non-bonding detection circuit (40); a first changeover switch (50) switching a connection between the spool (10) and the high-voltage power source circuit (30) or the non-bonding detection circuit (40); and a relay (53) turning on/off a connection between the clamper (22) and a spool side of the first changeover switch (50), and comprises a control part (60) that sets the first changeover switch (50) to the high-voltage power source circuit side and turns off the relay (53) to generate electric discharge, and that sets the first changeover switch (50) to the non-bonding detection circuit side and turns on the relay (53) to perform non-bonding detection. Due to this configuration, electric corrosion of a wire clamper can be suppressed and non-bonding detection can be carried out with a simple configuration.

Abstract: The present invention comprises: a spool (10); a damper (22); a torch electrode (31); a high-voltage power source circuit (30); a non-bonding detection circuit (40); a first changeover switch (50) switching a connection between the spool (10) and the high-voltage power source circuit (30) or the non-bonding detection circuit (40); and a relay (53) turning on/off a connection between the damper (22) and a spool side of the first changeover switch (50), and comprises a control part (60) that sets the first changeover switch (50) to the high-voltage power source circuit side and turns off the relay (53) to generate electric discharge, and that sets the first changeover switch (50) to the non-bonding detection circuit side and turns on the relay (53) to perform non-bonding detection. Due to this configuration, electric corrosion of a wire damper can be suppressed and non-bonding detection can be carried out with a simple configuration.

Abstract: This invention provides a composition and a method for treating or preventing a subject having a tumor that more highly expresses a TUG1 gene than in normal tissues (e.g., brain tumor, breast cancer, colon cancer, prostate cancer, liver cancer, lung cancer, leukemia, or lymphoma), which composition comprises, as an active ingredient, a nucleic acid that inhibits the high expression of the TUG1 gene in tumor stem cells.

Abstract: This invention provides an antitumor drug delivery formulation for treating a subject having a tumor more highly expressing a TUG1 gene than normal tissues or preventing the subject from tumor metastasis, comprising a polymeric micelle comprising a nucleic acid that suppresses high expression of the TUG1 gene as an active ingredient, wherein the polymeric micelle comprises a block copolymer having a cationic poly(amino acid) segment and a hydrophilic polymer chain segment and the nucleic acid, and wherein the nucleic acid is bound to a cationic group of the cationic poly(amino acid) segment to form a complex and/or the nucleic acid is incorporated in the micelle or attached into the micelle; and the polymeric micelle accumulates in the tumor.

Abstract: This invention provides a composition and a method for treating or preventing a subject having a tumor that more highly expresses a TUG1 gene than in normal tissues (e.g., brain tumor, breast cancer, colon cancer, prostate cancer, liver cancer, lung cancer, leukemia, or lymphoma), which composition comprises, as an active ingredient, a nucleic acid that inhibits the high expression of the TUG1 gene in tumor stem cells.

Abstract: A bicycle driving device including a shaft rotatably mounted on a part of a body frame; two crank arms perpendicularly disposed at both ends of the shaft so as to be symmetrical with each other at 180° with respect to a center of the shaft as a base point; a pedal attached to a tip of the crank arm; a gear mounted at one end of the shaft, which is provided with a chain; and balance weights disposed in a predetermined plane parallel to a surface formed by a rotary motion of the crank arm for generating kinetic energy equivalent to the kinetic energy generated by rotary motion of the crank arm and the pedal, wherein each mount position of those balance weights is set to be adjustable in an arc with a predetermined radius with respect to an axial center of the shaft.

Abstract: A composite material includes: carbon fibers having an average fiber length of more than about 10 mm and about 100 mm or less; and a thermoplastic resin. The carbon fibers are substantially two-dimensionally-randomly oriented. The composite material includes a carbon fiber bundle (A) in a ratio of about 30 volume % or more and less than about 90 volume % to a total volume of the carbon fibers, the carbon fiber bundle (A) including the carbon fibers of a critical single fiber number defined by formula (1) or more. An average number (N) of the carbon fibers in the carbon fiber bundle (A) satisfies formula (2). Critical single fiber number=600/D??(1) 6×104/D2<N<2×105/D2??(2) D is an average fiber diameter (?m) of the carbon fibers.

Abstract: [Object] To provide a full float type crankshaft device for bicycle which allows a sub-assembly formed by integrating crankshafts to be mounted on a body side. [Constitution] The crankshaft device includes a shaft 1 provided at a center of a cylindrical hanger member 9, having cranks attached to both end portions, which is configured to have bearings 3,3 provided at inner sides where the cranks are attached, a housing 2 configured at an outer diameter side of the shaft 1 to support the shaft 1 via the bearings 3, and clamp nuts 5 each with a cup-like shape as a whole, which are attached to both end portions of the housing 2 having O-rings 6 as rubber elastic elements interposed between both end portions.

Abstract: A composite material includes: carbon fibers having an average fiber length of more than about 10 mm and about 100 mm or less; and a thermoplastic resin. The carbon fibers are substantially two-dimensionally-randomly oriented. The composite material includes a carbon fiber bundle (A) in a ratio of more than 0 volume % and less than about 30 volume % to a total volume of the carbon fibers, the carbon fiber bundle (A) including the carbon fibers of a critical single fiber number defined by formula (1) or more. An average number (N) of the carbon fibers in the carbon fiber bundle (A) satisfies formula (2). Critical single fiber number=600/D??(1) 1.0×104/D2<N<2.5×104/D2??(2) D is an average fiber diameter (?m) of the carbon fibers.

Abstract: A hub device for a bicycle includes a hub case which is attached to a center of a wheel for receiving a load exerted from a rim to which a tire is fitted, and formed to have each inner diameter of both end portions larger than a diameter of a center portion, a sleeve with plural slits in a circumferential direction and a cylindrical shape integrally attached to the hub case at the inner diameter side, which serves to transfer the load exerted to the hub case to a shaft, a bearing for receiving the load exerted to the sleeve and rotatably supporting a whole structure of the wheel, a shaft for rotatably supporting the whole structure of the wheel via the bearing, and spherical washers attached to both end portions of the shaft.

Abstract: A composite material includes: carbon fibers having an average fiber length of more than about 10 mm and about 100 mm or less; and a thermoplastic resin. The carbon fibers are substantially two-dimensionally-randomly oriented. The composite material includes a carbon fiber bundle (A) in a ratio of more than 0 volume % and less than about 30 volume % to a total volume of the carbon fibers, the carbon fiber bundle (A) including the carbon fibers of a critical single fiber number defined by formula (1) or more. An average number (N) of the carbon fibers in the carbon fiber bundle (A) satisfies formula (2). Critical single fiber number=600/D??(1) 1.0×104/D2<N<2.5×104/D2??(2) D is an average fiber diameter (?m) of the carbon fibers.

Abstract: A composite material includes: carbon fibers having an average fiber length of more than about 10 mm and about 100 mm or less; and a thermoplastic resin. The carbon fibers are substantially two-dimensionally-randomly oriented. The composite material includes a carbon fiber bundle (A) in a ratio of about 30 volume % or more and less than about 90 volume % to a total volume of the carbon fibers, the carbon fiber bundle (A) including the carbon fibers of a critical single fiber number defined by formula (1) or more. An average number (N) of the carbon fibers in the carbon fiber bundle (A) satisfies formula (2). Critical single fiber number=600/D??(1) 6×104/D2<N<2×105/D2??(2) D is an average fiber diameter (?m) of the carbon fibers.

Abstract: The present invention relates to a shaped product being excellent in isotropy constituted by a fiber-reinforced composite material in which discontinuous reinforcing fibers are isotropic in a plane and are two-dimensionally oriented in the thermoplastic resin, the reinforcing fibers contained in the shaped product includes a reinforcing fiber bundle (A) constituted by the reinforcing fibers of the critical single fiber number defined by formula (1) or more, a ratio of the reinforcing fiber bundle (A) to the total amount of the reinforcing fibers in the shaped product is 20 vol % or more and less than 90 vol %, and the average number (N) of the reinforcing fibers in the reinforcing fiber bundle (A) satisfies formula (2): Critical single fiber number=600/D??(1) 0.7×104/D2<N<1×105/D2??(2) wherein D is an average fiber diameter (?m) of the reinforcing fibers.

Abstract: An ultrasonic horn used in, for instance, a wire bonding apparatus and formed with mounting flanges, including a slit and a cross-sectional shape varying portion; the slit being on the central axis in the horn's longitudinal direction and extending fore and aft relative to the center of the mounting flanges, the length of the slit(s) being equal to or greater than the width direction of a flange region that is between the opposing flanges, and at least a part of the cross-sectional shape varying portion being on the outer surface of the horn at a slit region in which the slit is formed. The stress center point in the cross-section of the ultrasonic horn at the flange region is positioned more to the inside than a straight line joining the stress center points in the cross-sections of the ultrasonic horn at the front and rear end portions of the slit.

Abstract: An ultrasonic horn used in, for instance, a wire bonding apparatus and formed with mounting flanges, including a slit and a cross-sectional shape varying portion; the slit being on the central axis in the horn's longitudinal direction and extending fore and aft relative to the center of the mounting flanges, the length of the slit(s) being equal to or greater than the width direction of a flange region that is between the opposing flanges, and at least a part of the cross-sectional shape varying portion being on the outer surface of the horn at a slit region in which the slit is formed. The stress center point in the cross-section of the ultrasonic horn at the flange region is positioned more to the inside than a straight line joining the stress center points in the cross-sections of the ultrasonic horn at the front and rear end portions of the slit.

Abstract: An ultrasonic horn used in, for instance, a wire bonding apparatus and formed with mounting flanges, including a slit and a cross-sectional shape varying portion; the slit being on the central axis in the horn's longitudinal direction and extending fore and aft relative to the center of the mounting flanges, the length of the slit(s) being equal to or greater than the width direction of a flange region that is between the opposing flanges, and at least a part of the cross-sectional shape varying portion being on the outer surface of the horn at a slit region in which the slit is formed. The stress center point in the cross-section of the ultrasonic horn at the flange region is positioned more to the inside than a straight line joining the stress center points in the cross-sections of the ultrasonic horn at the front and rear end portions of the slit.