Abstract: A control circuit for an isolated power supply is disclosed, the control circuit includes a secondary-side drive signal generator, a secondary-side transistor switch turn-off detector and a primary-side control signal generator. The primary-side control signal generator is configured to: determine a second turn-on instant referring to an turn-off instant of the secondary-side synchronous rectification transistor from the turn-off acknowledgement signal; determine a first turn-on instant referring to a supposed turn-on instant for the primary-side transistor switch from the feedback signal of the output voltage of the isolated power supply; and determine the turn-on instant for the primary-side transistor switch from the second turn-on instant or the first turn-on instant whichever is later, and responsively generate the primary-side transistor switch control signal.

Abstract: A control method and control circuit for a switched-mode power supply (SMPS) and a control chip are disclosed. The SMPS is switched between different operating modes based on different levels of its output voltage. When the output voltage is lower than a first reference and the difference between it and the first reference exceeds a threshold, an operating frequency of a power transistor and output voltage are controlled to satisfy a proportional relationship defined by an associated slope. When the output voltage is lower than the first reference and the difference between it and the first reference is below the threshold, the power transistor is controlled to operate at a fixed frequency. When the output voltage is higher than the first reference, the power transistor is controlled to operate at a variable frequency.

Abstract: The present disclosure provides a coal bump control method for sectional hydraulic fracturing regions of a near vertical ultra thick coal seam. The method includes: deepening a main shaft from a mining level to a fracturing level; excavating a cross-hole from a roof rock layer of a coal seam at the fracturing level to enter a coal seam being mined, and excavating a roadway along the strike of the coal seam; and drilling hydraulic fracturing boreholes in a dedicated fracturing roadway along an inclination angle of the coal seam to the coal seam above the roadway, wherein the length of the borehole makes the borehole in communication with a goaf, and the spacing of the boreholes along the strike and the sectional spacing of the boreholes in an inclination direction are designed according to the parameters of fracturing equipments and the fracturing length.

Abstract: RNAi agents for inhibiting the expression of the alpha-1 antitrypsin (AAT) gene, compositions including AAT RNAi agents, and methods of use are described. Also disclosed are pharmaceutical compositions including one or more AAT RNAi agents together with one or more excipients capable of delivering the RNAi agent(s) to a liver cell in vivo. Delivery of the AAT RNAi agent(s) to liver cells in vivo inhibits AAT gene expression and treats diseases associated with AAT deficiency such as chronic hepatitis, cirrhosis, hepatocellular carcinoma, transaminitis, cholestasis, fibrosis, and fulminant hepatic failure.

Abstract: This application relates to the field of image processing, and provides a point light source image detection method and an electronic device. The method includes: obtaining to-be-tested images, and determining pixel brightnesses of the to-be-tested images; determining low-brightness pixels and high-brightness pixels in the images based on the pixel brightnesses; filtering, based on the low-brightness pixels, out an image that does not meet a preset dark environment requirement, and filtering, based on the high-brightness pixels, out an image that does not meet a preset point light source size; and determining, based on a result of the filtering, whether a to-be-tested image is a point light source image. Pixels in images are classified into low-brightness pixels and high-brightness pixels. For the low-brightness pixels, the images are screened based on a preset dark environment requirement, so that the selected point light source images meet the preset dark environment requirement.

Abstract: A method for preparing a shell-bionic ceramic tool and a shell-bionic ceramic tool, wherein the shell-bionic ceramic tool includes alternating stacks of ceramic powders with different components, pressing a ceramic green body using a cold briquetting method, carrying out pre-pressing once using a graphite indenter on a working surface thereof after each layer of the ceramic powder being loaded, and pressing a last layer using a graphite rod, and then pressing a whole ceramic green body with a certain pressure to promote a bonding of the layers of ceramic powder, which in turn gives a complex shape to an interface between the layers, increases a bonding area between the layers, and plays the role of hindering crack expansion, extending the crack expansion path, and improving the bonding strength of the interface; after then, hot-pressed sintering is used to densify the ceramic green body to obtain the shell-bionic ceramic tool.

Abstract: An image generation system implements a multi-branch GAN to generate images that each express visually similar content in a different modality. A generator portion of the multi-branch GAN includes multiple branches that are each tasked with generating one of the different modalities. A discriminator portion of the multi-branch GAN includes multiple fidelity discriminators, one for each of the generator branches, and a consistency discriminator, which constrains the outputs generated by the different generator branches to appear visually similar to one another. During training, outputs from each of the fidelity discriminators and the consistency discriminator are used to compute a non-saturating GAN loss. The non-saturating GAN loss is used to refine parameters of the multi-branch GAN during training until model convergence. The trained multi-branch GAN generates multiple images from a single input, where each of the multiple images depicts visually similar content expressed in a different modality.

Abstract: A continuously variable transmission with both equal-difference output and equal-ratio output includes an input mechanism, a hydraulic transmission mechanism, a planetary-gear-set convergence mechanism, an equal-difference output mechanism, an equal-ratio output mechanism, a clutch assembly, and a brake. The clutch assembly connects an output end of the input mechanism to an input end of the hydraulic transmission mechanism and the planetary-gear-set convergence mechanism and connects an output end of the hydraulic transmission mechanism to the planetary-gear-set convergence mechanism. The clutch assembly connects the planetary-gear-set convergence mechanism to the equal-difference output mechanism and the equal-ratio output mechanism. The clutch assembly connects the equal-ratio output mechanism to the equal-difference output mechanism.

Abstract: A chainsaw includes a chain, a liquid pump assembly, a motor, and a controller. The chain is used for implementing a cutting operation. The liquid pump assembly includes a liquid pump and a motor. The liquid pump is used for releasing a liquid for lubricating or cooling the chain. The motor is used for at least driving the liquid pump to operate. The controller is electrically connected to at least the motor. The controller is configured to, when the liquid pump is in the jammed state, control the liquid pump assembly to enter a throttling mode in which a supplied amount of the liquid is reduced, and when the liquid pump exits the jammed state, control the liquid pump assembly to exit the throttling mode. Technical solutions provided by the present application can determine and release the jammed state of the chainsaw.

Abstract: A continuously variable transmission with both equal-difference output and equal-ratio output includes an input mechanism, a hydraulic transmission mechanism, a planetary-gear-set convergence mechanism, an equal-difference output mechanism, an equal-ratio output mechanism, a clutch assembly, and a brake. The clutch assembly connects an output end of the input mechanism to an input end of the hydraulic transmission mechanism and the planetary-gear-set convergence mechanism and connects an output end of the hydraulic transmission mechanism to the planetary-gear-set convergence mechanism. The clutch assembly connects the planetary-gear-set convergence mechanism to the equal-difference output mechanism and the equal-ratio output mechanism. The clutch assembly connects the equal-ratio output mechanism to the equal-difference output mechanism.

Abstract: The present invention relates to transdermal delivery systems, methods and kits that include an agent to penetrate the basement membrane, a membrane of the skin previously known to be difficult to penetrate. In particular, the formulation includes a basement membrane disruptor that reversibly denatures the basement membrane of the skin. The formulation of the present invention further includes having at least one penetration agent, at least one vaso-modulator, and at least one active ingredient. In an embodiment, the penetration agent includes a solvent, a lipophilic agent, a hydrophilic agent, wherein the basement membrane disruptor, the vaso-modulator, and the active ingredient pass through the stratum corneum and epidermis. The basement membrane disruptor allows the vaso-modulator and the active ingredient pass through the basement membrane to dermis. The active ingredient, once at the dermis, is delivered locally to the tissue or systemically to the blood stream.

Abstract: A hydrogel for cell-laden bioprinting, bioink, and a preparation method and an application thereof, relates to the technical field of biomedical polymer hydrogels. The hydrogel for cell-laden bioprinting is polymer gel formed by adding a cell-specific material into a matrix of alginate and gelatin and crosslinking and curing, wherein the cell-specific material is polypeptide selected according to different laden cells. The structures printed using the hydrogel may have the advantages such as adjustable mechanical properties, adjustable porosity, high biocompatibility, high printing accuracy, and high customizability, which may widely support the printing of human tissues and organs such as spinal cord, cartilage, and heart, and has good prospects for applications in tissue repair, organ transplantation and so on.

Abstract: A computer-implemented method includes preprocessing, by a compiler, a plurality of macros in a computer program. Preprocessing a macro includes identifying a compile time condition associated with the macro. Preprocessing the macro further includes determining a current value of the compile time condition at the time of compiling a computer instruction and a previous value of the compile time condition. Preprocessing the macro further includes determining a set of computer instructions enclosed by the macro. The method further includes storing a macro information record that includes the compile time condition, the current value and the previous value of the compile time condition, and an identification of the set of computer instructions enclosed by the macro.

Abstract: A multi-subgraph matching method and apparatus, and a device are provided. After receiving a plurality of query graphs, the multi-subgraph matching apparatus groups the plurality of query graphs based on a hash value of each query graph, to generate a plurality of groups of query graphs. A plurality of query graphs whose hash values fall within a same value range belong to a same group. Then, the multi-subgraph matching apparatus respectively matches the plurality of groups of query graphs with a data graph in parallel, to obtain matching results. The matching results are matching results between the plurality of query graphs and the data graph. According to the multi-subgraph matching method in this application, grouping efficiency can be increased, and subgraph matching efficiency can be effectively increased.

Abstract: Provided herein are N-acetylgalactosamine (GalNAc)-derived compounds, modified oligonucleotides, and methods of modulating protein function and treating diseases, disorders, and symptoms in a subject.

Abstract: Isolated power supply control circuits, isolated power supply and control method thereof are disclosed, the control circuit for controlling an isolated power supply includes a secondary-side control signal generator and a primary-side control signal generator. The secondary-side control signal generator produces a secondary-side transistor switch control signal containing information about a turn-off instant of a secondary-side synchronous rectification transistor, which serves as a second turn-on instant. The primary-side control signal generator derives, from a feedback signal, a supposed turn-on instant for a primary-side transistor switch, which serves as a first turn-on instant. The primary side turn-on signal generator further derives a turn-on instant for the primary-side transistor switch from the second or first turn-on instant whichever is later and responsively generates a primary-side transistor switch control signal.

Abstract: An instruction scheduling method and an instruction scheduling system for a reconfigurable array processor. The method includes: determining whether a fan-out of a vertex in a data flow graph (DFG) is less than an actual interconnection number of a processing unit in a reconfigurable array; establishing a corresponding relationship between the vertex and a correlation operator of the processing unit; introducing a register to a directed edge, acquiring a retiming value of each vertex; arranging instructions in such a manner that retiming values of the instruction vertexes are in ascending order, and acquiring transmission time and scheduling order of the instructions; folding the DFG, placing an instruction to an instruction vertex; inserting a register and acquiring a current DFG; and acquiring a common maximum subset of the current DFG and the reconfigurable array by a maximum clique algorithm, and distributing the instructions.

Abstract: Synthetic ?v?6 integrin ligands of Formula I having serum stability and affinity for integrin ?v?6, which is a receptor expressed in a variety of cell types, are described. The described ligands are useful for delivering cargo molecules, such as RNAi agents or other oligonucleotide-based compounds, to cells that express integrin ?v?6, and thereby facilitating the uptake of the cargo molecules into these cells. Compositions that include ?v?6 integrin ligands and methods of use are also described.

Abstract: The production of a porous copper-zinc structure includes providing copper ink, creating a 3D model of the porous copper-zinc structure, 3D printing the copper ink into a porous copper lattice structure using the 3D model, heat treatment of the porous copper lattice structure producing a heat treated porous copper lattice structure, surface modification of the heat treated porous copper lattice structure by nanowires growth on the heat treated porous copper lattice structure producing a heat treated porous copper lattice structure with nanowires, and electrodeposition of zinc onto the heat treated porous copper lattice structure with nanowires to produce the porous copper-zinc structure.

Abstract: An alumina-based ceramic tool material with low thermal expansion and a preparation process thereof, accordingly, the ceramic tool material may have both the high hardness of alumina ceramics after the hot pressing sintering, and reduces the thermal expansion coefficient of the overall ceramic material by adding the Sc2W3O12 as the negative thermal expansion phase, which improves the thermal shock resistance of ceramic tools in high-speed cutting engineering and meets the requirements of large temperature range during the machining of nickel-based superalloys. Moreover, the composite material does not use metal binder and has strong thermal stability even in the high-speed machining under extreme heat-force-chemistry coupling, so it has a high machining compatibility for nickel-based superalloys.