Abstract: A microfluidic chip for culturing and real-time monitoring of multicellular tissues and use method thereof. The chip comprises a glass substrate layer, and a PDMS microchannel layer located on the glass substrate layer, wherein the glass substrate layer comprises a glass substrate, and a plurality of microelectrodes thereon; the PDMS microchannel comprises a plurality of independent microfluidic channels; the microelectrodes on the glass substrate are in one-to-one correspondence with the microfluidic channels in the PDMS microchannel layer; and the microelectrodes are electrically connected to an external circuit. The use method comprises: cell capture, cell or tissue culture, electrical impedance spectroscopy detection, and tissue release.

Abstract: A formulation and method for delivery of bioactive substances when applied to, or within, the skin or other exterior region of a mammal. for example, a patient, includes a vasoactive agent; an osmolyte; and an active ingredient. The formulation is sufficiently hygroscopic so as to create a condition of hypertonicity when absorbed by the skin. When the formulation is applied to the skin, the vasoactive agent can be delivered to the dermis so as to contact the vasculature of a patient.

Abstract: The present disclosure relates to a circular transposon compound, wherein the circular transposon compound includes a Tn5 transposase and an insert DNA; and the insert DNA contains transposon end sequences, two tag sequences, and a DNA sequence containing an enzymecutting site. The present disclosure further relates to an application of the circular transposon in DNA library construction. In the present disclosure, the method of constructing a DNA library by using the circular transposon compound has simple and convenient operations and high library construction efficiency, wherein the whole process of the library construction can be completed in only 80 minutes, and the required DNA amount is significantly reduced, with 1-50 ng of target DNAs being sufficient for the library construction, thereby promoting the wide application of the next-generation sequencing technology in the life science research and precise medical enterprise, which has great and profound significance.

Abstract: The invention provides a topical formulation for treating pain comprising a nonsteroidal anti-inflammatory agent or a Cox-2 inhibitor and a gabapentin family member.

Abstract: The present invention relates to transdermal delivery systems, methods and kits that include an agent to penetrate the basement membrane, a membrane of the skin previously known to be difficult to penetrate. In particular, the formulation includes a basement membrane disruptor that reversibly denatures the basement membrane of the skin. The formulation of the present invention further includes having at least one penetration agent, at least one vaso-modulator, and at least one active ingredient. In an embodiment, the penetration agent includes a solvent, a lipophilic agent, a hydrophilic agent, wherein the basement membrane disruptor, the vaso-modulator, and the active ingredient pass through the stratum corneum and epidermis. The basement membrane disruptor allows the vaso-modulator and the active ingredient pass through the basement membrane to dermis. The active ingredient, once at the dermis, is delivered locally to the tissue or systemically to the blood stream.

Abstract: A formulation and method for delivery of bioactive substances when applied to, or within, the skin or other exterior region of a mammal. for example, a patient, includes a vasoactive agent; an osmolyte; and an active ingredient. The formulation is sufficiently hygroscopic so as to create a condition of hypertonicity when absorbed by the skin. When the formulation is applied to the skin, the vasoactive agent can be delivered to the dermis so as to contact the vasculature of a patient.

Abstract: Set forth herein is a preparation of ibuprofen (2-(4-isobutylphenyl) propionic acid) in the free acid form that is suitable for topical administration. The topical ibuprofen formulation is prepared by dissolving the free acid form of ibuprofen, or preparing a homogeneous suspension of the free acid form of ibuprofen, in the presence of a pharmaceutically acceptable solvent so as to produce a topical drug formulation compatible with the penetration of 2-(4-isobutylphenyl) propionic acid through the skin tissue. Topical formulations of ibuprofen can be based on a pharmaceutically acceptable solvent such as, e.g., a pyrrolidone solvent or dimethylacetamide.

Abstract: A system, method and computer program product to refine an original complex CFG into a simpler CFG showing interesting paths and reducing interfering paths with dynamic input for the state of program. The method receives/encodes dynamic user input in the form of annotations which encodes user's special interests or knowledge of the program at run time, e.g., some assumptions of any variables appeared, which can be equations of variable and value or relationships between variables. The method then simplifies all the branching points in a generated AST (Abstract Syntax Tree) whenever possible by querying a SMT (Satisfiability Modulo Theories) solver with branching condition and the user annotations and by evaluating immediate values of expressions or eliminate unreachable parts in the CFG. Finally, the method generates a simplified CFG by simplified AST. This can assist a programmer to understand the code and facilitates correlating different basic blocks under a same scenario.

Abstract: A reusable casting head device comprises a casting head control mechanism, a casting head mechanism and a temperature control mechanism. A gate of the casting head is sealed by the gate holder to allow that initially heated molten aluminum is rapidly heated in the casting head, thus improving efficiency; the casting head made of beryllium copper is heated and maintained by the high-frequency heating ring, thus providing a high accuracy of temperature measurement and control; and the rotating cylinder, the positioning cylinder and the reverse rotating cylinder are employed for procedure operation to intelligentize the casting operation, thus providing low production cost.

Abstract: Methods and formulations for removing a tattoo by using a cell disrupter in combination with a vasodilator, and optionally one or more of an osmotic modifying agent, a chelation agent, and an occlusive modifying agent. Embodiments optionally further include using one or more of an antibiotic, anesthetic, penetration enhancer, excipient, carrier and vehicle.

Abstract: The present disclosure provides a light state regulation controller, control system and control method. The controller comprises a peak current comparator, a PWM controller, a power switch, a state detector and a state machine. The peak current comparator produces a PWM turn-off signal according to a comparison result between a peak current sampling signal and a reference voltage. The PWM controller outputs a PWM control signal and the reference voltage under the control of the PWM turn-off signal and a state control signal, wherein the state control signal controls the state of the PWM control signal. The state detector detects a state change in the PWM control signal or an equivalent signal for the PWM control signal, and outputs a state input signal. The state machine produces a plurality of states according to the state input signal, and outputs the state control signal reflecting the plurality of states.

Abstract: The present disclosure provides a light state regulation controller, control system and control method. The controller comprises a peak current comparator, a PWM controller, a power switch, a state detector and a state machine. The peak current comparator produces a PWM turn-off signal according to a comparison result between a peak current sampling signal and a reference voltage. The PWM controller outputs a PWM control signal and the reference voltage under the control of the PWM turn-off signal and a state control signal, wherein the state control signal controls the state of the PWM control signal. The state detector detects a state change in the PWM control signal or an equivalent signal for the PWM control signal, and outputs a state input signal. The state machine produces a plurality of states according to the state input signal, and outputs the state control signal reflecting the plurality of states.

Abstract: A method for filtering out nodes associated with hierarchical data structures is provided. The method may include generating node controllers on the hierarchical data structures. The method may include determining whether user actions are received on a first node controller, a second node controller, and a third node controller associated with the generated plurality of node controllers. The method may include filtering node levels associated with hierarchical data structures, and presenting the hierarchical data structures without the filtered out node levels. The method may include filtering out sibling nodes associated with the hierarchical data structures, and presenting the hierarchical data structures without the filtered out sibling nodes. The may further include reverse-collapsing first node levels and filtering out second node levels based on the reverse-collapsed first node levels, and presenting the hierarchical data structures without the filtered out second node levels.

Abstract: A method for filtering out nodes associated with hierarchical data structures is provided. The method may include generating node controllers on the hierarchical data structures. The method may include determining whether user actions are received on a first node controller, a second node controller, and a third node controller associated with the generated plurality of node controllers. The method may include filtering node levels associated with hierarchical data structures, and presenting the hierarchical data structures without the filtered out node levels. The method may include filtering out sibling nodes associated with the hierarchical data structures, and presenting the hierarchical data structures without the filtered out sibling nodes. The may further include reverse-collapsing first node levels and filtering out second node levels based on the reverse-collapsed first node levels, and presenting the hierarchical data structures without the filtered out second node levels.

Abstract: The present invention is directed to novel compounds of Formula I. The compounds of the present invention are potent tyrosine kinase modulators, and are suitable for the treatment and prevention of diseases and conditions related to abnormal activities of tyrosine kinase receptors.

Abstract: The invention provides a topical formulation for treating pain comprising a nonsteroidal anti-inflammatory agent or a Cox-2 inhibitor and a gabapentin family member.

Abstract: A software protection system includes a user terminal and a server. According to an authorization request from the user terminal as to target software, the server generates an encrypted authorization file and an executable file of the target software. When the executable file is to be run at a terminal, a determination is made as to whether the physical information of the terminal and information as to the target software are same as that in the encrypted authorization file. When the information are same, the running of the executable file is permitted. The disclosure further provides a software protection method.

Abstract: A system, method and computer program product to refine an original complex CFG into a simpler CFG showing interesting paths and reducing interfering paths with dynamic input for the state of program. The method receives/encodes dynamic user input in the form of annotations which encodes user's special interests or knowledge of the program at run time, e.g., some assumptions of any variables appeared, which can be equations of variable and value or relationships between variables. The method then simplifies all the branching points in a generated AST (Abstract Syntax Tree) whenever possible by querying a SMT (Satisfiability Modulo Theories) solver with branching condition and the user annotations and by evaluating immediate values of expressions or eliminate unreachable parts in the CFG. Finally, the method generates a simplified CFG by simplified AST. This can assist a programmer to understand the code and facilitates correlating different basic blocks under a same scenario.

Abstract: The present invention is directed to novel compounds of Formula I. The compounds of the present invention are potent tyrosine kinase modulators, and are suitable for the treatment and prevention of diseases and conditions related to abnormal activities of tyrosine kinase receptors.

Abstract: A reusable casting head device comprises a casting head control mechanism, a casting head mechanism and a temperature control mechanism. A gate of the casting head is sealed by the gate holder to allow that initially heated molten aluminum is rapidly heated in the casting head, thus improving efficiency; the casting head made of beryllium copper is heated and maintained by the high-frequency heating ring, thus providing a high accuracy of temperature measurement and control; and the rotating cylinder, the positioning cylinder and the reverse rotating cylinder are employed for procedure operation to intelligentize the casting operation, thus providing low production cost.