Abstract: The present disclosure provides an arctigenin liquid nano-preparation and a preparation method thereof, and relates to the technical field of pharmaceutical preparation. In the present disclosure, arctigenin is prepared into a liquid nano-preparation, having advantages of distribution of a droplet diameter on nanoscale, significantly increased specific surface area, rapid absorption, and high bioavailability. Meanwhile, nano-preparation entered the body can be captured by wandering leucocytes, and a medicament is delivered to inflammatory lesions through chemiotaxis, thereby conferring a targeted drug delivery feature on the arctigenin and making a therapy more targeted. Moreover, in the present disclosure, the arctigenin is dissolved in an oil phase, and the oil phase is dissolved in water by emulsification to further make the arctigenin dissolve in the water and increase water solubility of the arctigenin.

Abstract: The present disclosure provides CRISPR-Cas effector polypeptides that exhibit enhanced gene editing and/or trans cleavage activity, compared to a wild-type CasPhi polypeptide. The present disclosure provides systems and kits comprising such CRISPR-Cas effector polypeptides. The present disclosure provides methods, including gene editing and diagnostic methods, using a CRISPR-Cas effector polypeptide of the present disclosure.

Abstract: A displaying base plate and a manufacturing method thereof, and a displaying device. The displaying base plate includes a substrate, and a first electrode layer disposed on one side of the substrate, wherein the first electrode layer includes a first electrode pattern; a first planarization layer disposed on one side of the first electrode layer that is away from the substrate, wherein the first planarization layer is provided with a through hole, and the through hole penetrates the first planarization layer, to expose the first electrode pattern; and a second electrode layer, a second planarization layer and a third electrode layer that are disposed in stack on one side of the first planarization layer that is away from the substrate, wherein the second electrode layer is disposed closer to the substrate, the second electrode layer is connected to the first electrode pattern and the third electrode layer.

Abstract: The present disclosure provides an apparatus and a method for hydrate-based wastewater treatment and cold storage. The apparatus for hydrate-based wastewater treatment and cold storage includes a water chilling unit, a hydrate-based cold storage tank, an airflow disturbance device, a water layer positioning system, a spraying system, a suction filtration system, a heat exchange system, and a system monitoring device. The water chilling unit provides a secondary refrigerant at a low temperature. The secondary refrigerant flows through an evaporator coil in the hydrate-based cold storage tank for heat exchange. The airflow disturbance device induces hydrate nucleation. The water layer positioning system positions a contact surface between a water layer and a hydrate former after hydrate decomposition to facilitate drawing and separation of the treated upper water layer. The spraying system and the suction filtration system enhance the solid-liquid separation efficiency to improve the removal rate of pollutants.

Abstract: The embodiment of the present disclosure discloses a method, an electronic device, and a storage medium for a ship route optimization. The method for the ship route optimization considers a dynamic feature of a multi-functional emergency rescue ship and an interference effect caused by an airflow, uses a movement model with kinematics non-holonomic constraints, such as a ship total cost assessment function to simulate the movement of the ship, and based on a sparrow search algorithm, learns how to apply the algorithm to a route plan of the emergency rescue ship. The method can improve the ship route optimization algorithm, improve an accuracy and practical applicability of a calculated plan. The method can effectively and accurately locate obstacles and hidden reefs, and consider effects of an airflow and a non-holonomic constraint effect, so as to make the route planning of the ship more efficient and intelligent.

Abstract: Various embodiments are disclosed for providing machine learning routines with peripheral device data to infer driver activity and location. Peripheral device data may be collected on a peripheral device having a machine learning routine executing thereon to infer driver activity and perform improved estimation of driver location. Using driver activity and location estimation, contextually relevant delivery workflow assistance may be automatically provided to a delivery driver or other individual without requiring manual input, thereby improving driver safety and operational efficiency.

Abstract: A charging system includes at least one first charging device and at least one second charging device that are cascaded. The first charging device includes at least one first accommodation portion for mounting a first energy storage device and a connecting port for connecting the second charging device or the first charging device. The second charging device includes at least one second accommodation portion for mounting a second energy storage device and a connecting port for connecting the first charging device or the second charging device. The first accommodation portion and the second accommodation portion have different shapes or dimensions.

Abstract: Provided are an organic electroluminescent device and a use thereof. The organic electroluminescent device comprises a metal complex having particular spectral characteristics (that is, satisfying requirements on D and AR), and the metal complex can better approach the commercially pursued BT.2020 luminescence. Compared with a metal complex that does not satisfy the requirements on D and AR, the metal complex is applied to the organic electroluminescent device to make the obtained organic electroluminescent device have higher device efficiency and more saturated green light emission, can better satisfy the BT.2020 luminescence requirement of the market, and can still maintain high device performance, especially device efficiency, when approaching the BT.2020 luminescence, and the metal complex basically reaches maximum efficiency of the device. The organic electroluminescent device comprising the preceding metal complex has a broad commercial application prospect and can achieve more saturated luminescence.

Abstract: A charging system includes at least one first charging device and at least one second charging device that are cascaded. The first charging device includes at least one first accommodation portion for mounting a first energy storage device and a connecting port for connecting the second charging device or the first charging device. The second charging device includes at least one second accommodation portion for mounting a second energy storage device and a connecting port for connecting the first charging device or the second charging device. The first accommodation portion and the second accommodation portion have different shapes or dimensions.

Abstract: Disclosed are an aromatic amine derivative and an organic electroluminescent device including the same. A fluorenyl/silafluorenyl group having an ortho-substituted group is introduced into the structure of the aromatic amine derivative. The aromatic amine derivative may be used as a light-emitting material in a light-emitting layer of an organic electroluminescent device. These novel compounds can provide better device performance.

Abstract: Embodiments are directed to a composite binary decomposition network. An embodiment of a computer-readable storage medium includes executable computer program instructions for transforming a pre-trained first neural network into a binary neural network by processing layers of the first neural network in a composite binary decomposition process, where the first neural network having floating point values representing weights of various layers of the first neural network. The composite binary decomposition process includes a composite operation to expand real matrices or tensors into a plurality of binary matrices or tensors, and a decompose operation to decompose one or more binary matrices or tensors of the plurality of binary matrices or tensors into multiple lower rank binary matrices or tensors.

Abstract: The present disclosure relates to a spike event decision-making device, method, chip, and electronic device to eliminate inherent delays of an output spike event of the neuromorphic chip when reading decisions. The spike event decision-making device includes a first counting module configured to count a number of input spike events of the spiking neural network, a second counting module configured to count some or all of the output spike events of the spiking neural network; and a decision-making module configured to generate a decision-making result according to numbers of spike events fired by neurons in an output layer of the spiking neural network when the number counted by the first counting module reaches a first predetermined value, or when the total count counted by the second counting module reaches a second predetermined value.

Abstract: The present disclosure relates to a thermoplastic pulverulent composition comprising (a) at least one silica particle treated with alkoxysilane; and (b) at least one thermoplastic polymer. The present disclosure also relates to a 3D-printed object formed from the thermoplastic pulverulent composition and a process of forming the 3D-printed object. The thermoplastic pulverulent composition shows good powder flowability and the printed object obtained from said thermoplastic pulverulent composition surprisingly shows high elongation at break, high impact strength, good toughness and low surface roughness.

Abstract: A method, system, and non-transitory computer readable medium for predicting cell viability of a cell culture in a bioreactor during a biomolecule manufacturing process are disclosed. In various embodiments, at least three manufacturing process parameters related to the process for manufacturing molecules are input into a machine learning model that is trained to predict cell viabilities. The trained machine learning model may then analyze the at least three manufacturing process parameters to generate an indicator of cell viability of the cell culture.

Abstract: A method, system, and non-transitory computer readable medium for predicting a glycan distribution of one or more glycans attached to molecules during a biomolecules manufacturing process are disclosed. In various embodiments, at least three manufacturing process parameters related to the process for manufacturing the molecules are input into a probabilistic graphical model that is trained to predict glycan distribution. The trained probabilistic graphical model may then analyze the at least three manufacturing process parameters to predict the distribution of the glycans that are attached to the molecules.

Abstract: The disclosure is directed towards the real-time detection and mitigation of security threats to a domain name system (DNS) for a communication network. A graph-theoretic method is applied to detect compromised DNS assets (e.g., DNS servers and web servers that DNS servers map domain names to). A graph is generated from domain name resolution (DNR) transactions. The nodes of the graph represent the DNS assets and edges between the nodes represent the DNR transactions. The graph is analyzed to detect features that signal compromised assets. The detection of such features serves to act as a binary classifier for the represented assets. The binary classifier acts to classify each node as non-compromised or compromised. The analysis is guided by supervised and/or unsupervised machine learning methods. Once the assets are classified, DNR transactions are analyzed in real-time. If the transaction involves a compromised asset, an intervention is performed that mitigates the threat.

Abstract: Provided are a display substrate and a detection method therefor, and a display apparatus. Compensation sub-circuits that are in one-to-one correspondence with each stage of a shift register are arranged in a gate driving circuit, and a first capacitor in each compensation sub-circuit is thus charged under the control of a detection input circuit when each stage of the shift register outputs a signal stage by stage; and an output control circuit is used to disconnect the compensation sub-circuit from a pull-up node of the corresponding stage of the shift register. The triggering of each stage of the shift register is stopped after each stage of the shift register (CR(n)) completes outputting, and the output control circuit provides a signal of a first power voltage end to the pull-up node of the corresponding stage of the shift register under the control of a second control end and the first capacitor.

Abstract: In response to receiving a request for an identity key from a first entity, an identity key for the first entity is generated. A first request from the first entity to replicate a set of data is received. The generated identity key for the first entity is added to the metadata of the set of data requested to be replicated. A determination is made whether a replication rule exists for the first entity. In response to determining that a replication rule exists for the first entity, the set of data is replicated according to the replication rule for the first entity.