Patents by Inventor Zhihao Hu

Zhihao Hu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10961553
    Abstract: Methods and compositions, including nucleotide sequences, amino acid sequences, and host cells, for producing fatty alcohols are described.
    Type: Grant
    Filed: February 5, 2018
    Date of Patent: March 30, 2021
    Assignee: Genomatica, Inc.
    Inventors: Zhihao Hu, Vikranth Arlagadda
  • Publication number: 20210071207
    Abstract: The disclosure relates to fatty diols and recombinant microorganisms for producing them. More particularly, the disclosure relates to recombinant microorganisms engineered to produce fatty diols via fermentation. Further encompassed is a process that uses the microorganisms to produce fatty diols from a simple carbon source.
    Type: Application
    Filed: June 1, 2020
    Publication date: March 11, 2021
    Applicant: Genomatica, Inc.
    Inventors: Andreas W. Schirmer, Noah HELMAN, Haibo Wang, Zhihao Hu, Vikranth Arlagadda, Alma Itzel RAMOS-SOLIS, Elizabeth Clarke
  • Publication number: 20210071212
    Abstract: The disclosure relates to omega-hydroxylated fatty acid derivatives and methods of producing them. Herein, the disclosure encompasses a novel and environmentally friendly production method that provides omega-hydroxylated fatty acid derivatives at high purity and yield. Further encompassed are recombinant microorganisms that produce omega-hydroxylated fatty acid derivatives through selective fermentation.
    Type: Application
    Filed: June 29, 2020
    Publication date: March 11, 2021
    Applicant: Genomatica, Inc.
    Inventors: Andreas W. Schirmer, Haibo Wang, Stephen B. Del Cardayre, Zhihao Hu, Louis G. Hom, Baolong Zhu, Cindy Chang, Emanuela E. Popova
  • Patent number: 10844406
    Abstract: Compositions and methods for production of fatty alcohols using recombinant microorganisms are provided as well as fatty alcohol compositions produced by such methods.
    Type: Grant
    Filed: March 7, 2017
    Date of Patent: November 24, 2020
    Assignee: Genomatica, Inc.
    Inventors: Jay D. Keasling, Zhihao Hu, Chris Somerville, George Church, David Berry, Lisa C. Friedman, Andreas Schirmer, Shane Brubaker, Stephen B. Del Cardayre
  • Publication number: 20200364882
    Abstract: A method for target tracking includes: determining predicted target position information of at least one first target object and predicted blocking object position information of a respective blocking object according to a historical image frame; determining historical target appearance feature sequence of first target object and historical blocking object appearance feature sequence of blocking object according to historical image frame sequence; determining current target position information and current target appearance feature of second target object according to current image frame; determining target similarity information according to predicted target position information, historical target appearance feature sequence, current target position information and current target appearance feature; determining blocking object similarity information according to predicted blocking object position information, historical blocking object appearance feature sequence, current target position information and curr
    Type: Application
    Filed: August 6, 2020
    Publication date: November 19, 2020
    Inventors: Weitao FENG, Zhihao HU, Wei WU
  • Patent number: 10711288
    Abstract: The disclosure relates to omega-hydroxylated fatty acid derivatives and methods of producing them. Herein, the disclosure encompasses a novel and environmentally friendly production method that provides omega-hydroxylated fatty acid derivatives at high purity and yield. Further encompassed are recombinant microorganisms that produce omega-hydroxylated fatty acid derivatives through selective fermentation.
    Type: Grant
    Filed: June 16, 2014
    Date of Patent: July 14, 2020
    Assignee: GENOMATICA, INC.
    Inventors: Andreas W. Schirmer, Haibo Wang, Stephen B. Del Cardayre, Zhihao Hu, Louis G. Hom, Baolong Zhu, Cindy Chang, Emanuela E. Popova
  • Patent number: 10676763
    Abstract: The disclosure relates to fatty diols and recombinant microorganisms for producing them. More particularly, the disclosure relates to recombinant microorganisms engineered to produce fatty diols via fermentation. Further encompassed is a process that uses the microorganisms to produce fatty diols from a simple carbon source.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: June 9, 2020
    Assignee: GENOMATICA, INC.
    Inventors: Andreas W. Schirmer, Noah Helman, Haibo Wang, Zhihao Hu, Vikranth Arlagadda, Alma Itzel Ramos-Solis, Elizabeth Clarke
  • Publication number: 20200140910
    Abstract: The present invention provides a recombinant microorganism for producing citicoline and a method for producing citicoline by using the recombinant microorganism, wherein genes for degradation and utilization of citicoline, choline, and phosphocholine are knocked out, In addition, a pyrimidine nucleoside synthesis pathway is genetically engineered to remove feedback inhibition to the synthesis pathway. A yield of more than 20 g/L of citicoline can be obtained with recombinant strains in a 5-liter fermenter by means of a biological fermentation method, achieving industrial mass production with low citicoline production costs and less pollution; therefore, the method is a simple, environmentally friendly and has a relatively high promotion and application value.
    Type: Application
    Filed: January 7, 2020
    Publication date: May 7, 2020
    Inventors: Junjun Jiang, Junying Fan, Feng Tian, Xintong Wang, Kailin Zhang, Zhihao Hu
  • Publication number: 20200109374
    Abstract: The disclosure relates to variant carboxylic acid reductase (CAR) enzymes for the improved production of fatty alcohols in recombinant host cells.
    Type: Application
    Filed: May 16, 2019
    Publication date: April 9, 2020
    Inventors: Derek L. Greenfield, Elizabeth J. Clarke, Eli S. Groban, Vikranth Arlagadda, Sungwon Lee, Xuezhi Li, Zhihao Hu, Baolong Zhu
  • Publication number: 20190194630
    Abstract: The present disclosure provides compositions and methods for using hydrogenotrophic microorganisms capable of biologically utilizing or converting H2 and CO and/or CO2 gas into high-value molecules and biological material, such as essential amino acids (e.g., lysine, threonine, methionine) and animal feed.
    Type: Application
    Filed: February 13, 2019
    Publication date: June 27, 2019
    Inventors: Jill Bradshaw, Zhihao Hu, Jay Kouba
  • Patent number: 10301603
    Abstract: The disclosure relates to variant carboxylic acid reductase (CAR) enzymes for the improved production of fatty alcohols in recombinant host cells.
    Type: Grant
    Filed: September 5, 2017
    Date of Patent: May 28, 2019
    Assignee: Reg Life Sciences, LLC
    Inventors: Derek L. Greenfield, Elizabeth J. Clarke, Eli S. Groban, Vikranth Arlagadda, Sungwon Lee, Xuezhi Li, Zhihao Hu, Baolong Zhu
  • Publication number: 20190093089
    Abstract: The present invention relates to novel mutant thioesterase enzymes and naturally-occurring equivalents thereof, compositions made from such enzymes and uses of thioesterase enzymes. In particular, the present invention provides mutant thioesterase enzymes that have altered properties, for example, altered substrate specificity, altered activity, altered selectivity, and/or altered proportional yields in the product mixtures. The present invention also provides polynucleotides encoding such mutant thioesterase enzymes, and vectors and host cells comprising such polynucleotides. The invention further provides for novel uses of thioesterases in the production of various fatty acid derivatives, which are useful as, or as components of, industrial chemicals and fuels.
    Type: Application
    Filed: April 20, 2018
    Publication date: March 28, 2019
    Inventors: Louis HOM, Na TRINH, Murtaza ALIBHAI, Zhihao HU, Eli GROBAN, Vikranth Arlagadda, Elizabeth CLARKE
  • Publication number: 20190031594
    Abstract: Genetically engineered cells and microorganisms are provided that produce products from the fatty acid biosynthetic pathway (fatty acid derivatives), as well as methods of their use. The products are particularly useful as biofuels.
    Type: Application
    Filed: April 16, 2018
    Publication date: January 31, 2019
    Applicant: REG Life Sciences, LLC
    Inventors: Zhihao Hu, Fernando Valle
  • Publication number: 20190017081
    Abstract: Methods and compositions, including nucleotide sequences, amino acid sequences, and host cells, for producing fatty alcohols are described.
    Type: Application
    Filed: February 5, 2018
    Publication date: January 17, 2019
    Inventors: Zhihao Hu, Vikranth Arlagadda
  • Patent number: 10149657
    Abstract: An on-line energy coincidence method for an all-digital PET system, comprising: a detection module conducting information collection on a scintillation pulse, forming a single event data frame and sending it to an upper computer; the upper computer conducting two-bit position distribution statistics on an incident gamma photon event and conducting position spectrum partition; performing statistics on an energy distribution spectrum of each crystal bar, so as to acquire an energy correction value; the detection module uploading a crystal bar partition data table and an energy peak correction data table; starting information collection of on-line energy correction; when an event is coming, according to a two-dimensional coordinate thereof, from the crystal partition table, searching for a crystal bar number corresponding thereto, and searching for an energy correction value from the energy correction table; and sending data passing the energy coincidence to the upper computer.
    Type: Grant
    Filed: November 14, 2013
    Date of Patent: December 11, 2018
    Assignee: Raycan Technology Co., Ltd. (Suzhou)
    Inventors: Qingguo Xie, Xiaoke Wu, Jun Zhu, Ming Niu, Zhihao Hu, Luyao Wang
  • Patent number: 10017455
    Abstract: Genetically engineered cells and microorganisms are provided that produce fatty alcohols from the fatty acid biosynthetic pathway, as well as methods of their use.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: July 10, 2018
    Assignee: REG Life Sciences, LLC
    Inventors: Zhihao Hu, Fernando Valle
  • Publication number: 20180135028
    Abstract: The disclosure relates to variant carboxylic acid reductase (CAR) enzymes for the improved production of fatty alcohols in recombinant host cells.
    Type: Application
    Filed: September 5, 2017
    Publication date: May 17, 2018
    Inventors: Derek L. GREENFIELD, Elizabeth J. CLARKE, Eli S. GROBAN, Vikranth Arlagadda, Sungwon LEE, Xuezhi LI, Zhihao Hu, Baolong ZHU
  • Patent number: 9951322
    Abstract: The present invention relates to novel mutant thioesterase enzymes and naturally-occurring equivalents thereof, compositions made from such enzymes and uses of thioesterase enzymes. In particular, the present invention provides mutant thioesterase enzymes that have altered properties, for example, altered substrate specificity, altered activity, altered selectivity, and/or altered proportional yields in the product mixtures. The present invention also provides polynucleotides encoding such mutant thioesterase enzymes, and vectors and host cells comprising such polynucleotides. The invention further provides for novel uses of thioesterases in the production of various fatty acid derivatives, which are useful as, or as components of, industrial chemicals and fuels.
    Type: Grant
    Filed: February 22, 2017
    Date of Patent: April 24, 2018
    Assignee: REG Life Sciences, LLC
    Inventors: Louis Hom, Na Trinh, Murtaza Alibhai, Zhihao Hu, Eli Groban, Vikranth Arlagadda, Elizabeth Clarke
  • Patent number: 9890401
    Abstract: Methods and compositions, including nucleotide sequences, amino acid sequences, and host cells, for producing fatty alcohols are described.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: February 13, 2018
    Assignee: REG LIFE SCIENCES, LLC
    Inventors: Zhihao Hu, Vikranth Arlagadda
  • Publication number: 20180010137
    Abstract: The invention relates to compositions and methods, including polynucleotide sequences, amino acid sequences, recombinant host cells and recombinant host cell cultures engineered to produce fatty acid derivative compositions comprising fatty acids, fatty alcohols, fatty aldehydes, fatty esters, alkanes, terminal olefins, internal olefins or ketones. The fatty acid derivative composition is produced extracellularly with a higher titer, yield or productivity than the corresponding wild type or non-engineered host cell.
    Type: Application
    Filed: July 14, 2017
    Publication date: January 11, 2018
    Inventors: Derek L. GREENFIELD, Andreas W. Schirmer, Elizabeth J. CLARKE, Eli S. GROBAN, Bernardo M. Da Costa, Zhihao Hu, Kevin Holden, Noah Helman