Patents by Inventor Zhihao Hu

Zhihao Hu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170327799
    Abstract: Genetically engineered cells and microorganisms are provided that produce fatty alcohols from the fatty acid biosynthetic pathway, as well as methods of their use.
    Type: Application
    Filed: June 9, 2017
    Publication date: November 16, 2017
    Applicant: REG Life Sciences LLC
    Inventors: Zhihao Hu, Fernando Valle
  • Publication number: 20170292121
    Abstract: The present invention relates to novel mutant thioesterase enzymes and naturally-occurring equivalents thereof, compositions made from such enzymes and uses of thioesterase enzymes. In particular, the present invention provides mutant thioesterase enzymes that have altered properties, for example, altered substrate specificity, altered activity, altered selectivity, and/or altered proportional yields in the product mixtures. The present invention also provides polynucleotides encoding such mutant thioesterase enzymes, and vectors and host cells comprising such polynucleotides. The invention further provides for novel uses of thioesterases in the production of various fatty acid derivatives, which are useful as, or as components of, industrial chemicals and fuels.
    Type: Application
    Filed: February 22, 2017
    Publication date: October 12, 2017
    Inventors: Louis HOM, Na TRINH, Murtaza ALIBHAI, Zhihao HU, Eli GROBAN, Vikranth Arlagadda, Elizabeth CLARKE
  • Publication number: 20170275651
    Abstract: Compositions and methods for production of fatty alcohols using recombinant microorganisms are provided as well as fatty alcohol compositions produced by such methods.
    Type: Application
    Filed: March 7, 2017
    Publication date: September 28, 2017
    Inventors: Jay D. Keasling, Zhihao Hu, Chris Somerville, George Church, David Berry, Lisa C. Friedman, Andreas Schirmer, Shane Brubaker, Stephen B. DEL CARDAYRE
  • Patent number: 9758769
    Abstract: The disclosure relates to variant carboxylic acid reductase (CAR) enzymes for the improved production of fatty alcohols in recombinant host cells.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: September 12, 2017
    Assignee: REG LIFE SCIENCES, LLC
    Inventors: Derek L. Greenfield, Elizabeth Clarke, Eli Groban, Vikranth Arlagadda, Sungwon Lee, Xuezhi Li, Zhihao Hu, Baolong Zhu
  • Publication number: 20170204436
    Abstract: The disclosure relates to fatty diols and recombinant microorganisms for producing them. More particularly, the disclosure relates to recombinant microorganisms engineered to produce fatty diols via fermentation. Further encompassed is a process that uses the microorganisms to produce fatty diols from a simple carbon source.
    Type: Application
    Filed: July 17, 2015
    Publication date: July 20, 2017
    Inventors: Andreas W. Schirmer, Noah HELMAN, Haibo Wang, Zhihao Hu, Vikranth Arlagadda, Alma Itzel RAMOS-SOLIS, Elizabeth Clarke
  • Publication number: 20170130211
    Abstract: The present disclosure provides compositions and methods for using hydrogenotrophic microorganisms capable of biologically utilizing or converting H2 and CO and/or CO2 gas into high-value molecules and biological material, such as essential amino acids (e.g., lysine, threonine, methionine) and animal feed.
    Type: Application
    Filed: January 2, 2015
    Publication date: May 11, 2017
    Inventors: Jill Bradshaw, Zhihao Hu, Jay Kouba
  • Publication number: 20170102710
    Abstract: The present disclosure provides a vacuum cleaning robot with vision navigation function and navigation method thereof The vacuum cleaning robot comprises a cleaning body and a vision navigation controller. The cleaning body comprises a sense unit, a drive unit, and a drive control unit. The vision navigation controller comprises a vision capture unit, a storage unit, and a path navigation control unit. The vision capture unit is configured to capture the related vision information, and the related vision information constitutes the map information comprising the partial map and the global map of the current room; the path navigation control unit is configured to make a path navigation instruction according to the vision information, the map information, and the sense information; and the drive control unit is configured to control the drive unit according to the path navigation instruction.
    Type: Application
    Filed: October 13, 2015
    Publication date: April 13, 2017
    Applicant: LOOQ SYSTEM, INC.
    Inventors: Zhihao HU, Yongtao CHEN
  • Publication number: 20170096688
    Abstract: The invention relates to the use of EntD polypeptides, polynucleotides encoding the same, and homologues thereof to enhance the production of fatty aldehydes and fatty alcohols in a host cell.
    Type: Application
    Filed: May 16, 2016
    Publication date: April 6, 2017
    Inventors: Zhihao HU, Derek L. GREENFIELD, Vikranth Arlagadda
  • Patent number: 9598706
    Abstract: Compositions and methods for production of fatty alcohols using recombinant microorganisms are provided as well as fatty alcohol compositions produced by such methods.
    Type: Grant
    Filed: April 25, 2013
    Date of Patent: March 21, 2017
    Assignee: REG LIFE SCIENCES, LLC
    Inventors: Jay D. Keasling, Zhihao Hu, Chris Somerville, George Church, David Berry, Lisa C. Friedman, Andreas Schirmer, Shane Brubaker, Stephen B. Del Cardayre
  • Patent number: 9587231
    Abstract: The present invention relates to novel mutant thioesterase enzymes and naturally-occurring equivalents thereof, compositions made from such enzymes and uses of thioesterase enzymes. In particular, the present invention provides mutant thioesterase enzymes that have altered properties, for example, altered substrate specificity, altered activity, altered selectivity, and/or altered proportional yields in the product mixtures. The present invention also provides polynucleotides encoding such mutant thioesterase enzymes, and vectors and host cells comprising such polynucleotides. The invention further provides for novel uses of thioesterases in the production of various fatty acid derivatives, which are useful as, or as components of, industrial chemicals and fuels.
    Type: Grant
    Filed: August 14, 2015
    Date of Patent: March 7, 2017
    Assignee: REG LIFE SCIENCES, LLC
    Inventors: Louis Hom, Na Trinh, Murtaza Alibhai, Zhihao Hu, Eli Groban, Vikranth Arlagadda, Elizabeth Clarke
  • Publication number: 20160362710
    Abstract: Disclosed herein are various embodiments regarding the production of fatty acid methyl esters. Disclosed herein are various embodiments regarding the use of methanol compositions for the production of fatty esters.
    Type: Application
    Filed: January 16, 2015
    Publication date: December 15, 2016
    Applicant: REG LIFE SCIENCES, LLC
    Inventors: Grace J. LEE, Zhihao HU
  • Publication number: 20160324498
    Abstract: An on-line energy coincidence method for an all-digital PET system, comprising: a detection module conducting information collection on a scintillation pulse, forming a single event data frame and sending it to an upper computer; the upper computer conducting two-bit position distribution statistics on an incident gamma photon event and conducting position spectrum partition; performing statistics on an energy distribution spectrum of each crystal bar, to acquire an energy correction value; the detection module uploading a crystal bar partition data table and an energy peak correction data table; starting information collection of on-line energy correction; when an event is coming, according to a two-dimensional coordinate thereof, from the crystal partition table, searching for a crystal bar number corresponding thereto, and searching for an energy correction value from the energy correction table; and sending data passing the energy coincidence to the upper computer.
    Type: Application
    Filed: November 14, 2013
    Publication date: November 10, 2016
    Inventors: Qingguo Xie, Xiaoke Wu, Jun Zhu, Ming Niu, Zhihao Hu, Luyao Wang
  • Publication number: 20160326499
    Abstract: The disclosure relates to variant carboxylic acid reductase (CAR) enzymes for the improved production of fatty alcohols in recombinant host cells.
    Type: Application
    Filed: May 13, 2016
    Publication date: November 10, 2016
    Applicant: Reg Life Sciences, LLC
    Inventors: Derek L. GREENFIELD, Elizabeth CLARKE, Eli GROBAN, Vikranth Arlagadda, Sungwon LEE, Xuezhi LI, Zhihao Hu, Baolong ZHU
  • Publication number: 20160208295
    Abstract: Disclosed herein are various embodiments regarding the production of fatty acid methyl esters. Disclosed herein are various embodiments regarding the use of methanol compositions for the production of fatty esters.
    Type: Application
    Filed: January 16, 2015
    Publication date: July 21, 2016
    Applicant: REG LIFE SCIENCES, LLC
    Inventors: Grace J. LEE, Zhihao HU
  • Patent number: 9340801
    Abstract: The disclosure relates to variant carboxylic acid reductase (CAR) enzymes for the improved production of fatty alcohols in recombinant host cells.
    Type: Grant
    Filed: April 2, 2013
    Date of Patent: May 17, 2016
    Assignee: REG LIFE SCIENCES, LLC
    Inventors: Derek L. Greenfield, Elizabeth J. Clarke, Eli S. Groban, Vikranth Arlagadda, Sungwon Lee, Xuezhi Li, Zhihao Hu, Baolong Zhu
  • Publication number: 20160130616
    Abstract: The disclosure relates to omega-hydroxylated fatty acid derivatives and methods of producing them. Herein, the disclosure encompasses a novel and environmentally friendly production method that provides omega-hydroxylated fatty acid derivatives at high purity and yield. Further encompassed are recombinant microorganisms that produce omega-hydroxylated fatty acid derivatives through selective fermentation.
    Type: Application
    Filed: June 16, 2014
    Publication date: May 12, 2016
    Inventors: Andreas W. Schirmer, Haibo Wang, Stephen B. DEL CARDAYRE, Zhihao Hu, Louis G. Hom, Baolong Zhu, Cindy Chang, Emanuela E. Popova
  • Publication number: 20160102327
    Abstract: Methods and compositions, including nucleotide sequences, amino acid sequences, and host cells, for producing fatty alcohols are described.
    Type: Application
    Filed: May 22, 2015
    Publication date: April 14, 2016
    Applicant: REG LIFE SCIENCES, LLC
    Inventors: Zhihao HU, Vikranth ARLAGADDA
  • Publication number: 20160046914
    Abstract: The present invention relates to novel mutant thioesterase enzymes and naturally-occurring equivalents thereof, compositions made from such enzymes and uses of thioesterase enzymes. In particular, the present invention provides mutant thioesterase enzymes that have altered properties, for example, altered substrate specificity, altered activity, altered selectivity, and/or altered proportional yields in the product mixtures. The present invention also provides polynucleotides encoding such mutant thioesterase enzymes, and vectors and host cells comprising such polynucleotides. The invention further provides for novel uses of thioesterases in the production of various fatty acid derivatives, which are useful as, or as components of, industrial chemicals and fuels.
    Type: Application
    Filed: August 14, 2015
    Publication date: February 18, 2016
    Inventors: Louis HOM, Na TRINH, Murtaza ALIBHAI, Zhihao HU, Eli GROBAN, Vikranth Arlagadda, Elizabeth CLARKE
  • Publication number: 20160032328
    Abstract: The invention relates to the use of EntD polypeptides, polynucleotides encoding the same, and homologues thereof to enhance the production of fatty aldehydes and fatty alcohols in a host cell.
    Type: Application
    Filed: February 13, 2014
    Publication date: February 4, 2016
    Applicant: REG Life Sciences, LLC
    Inventors: Zhihao HU, Derek L. GREENFIELD, Vikranth ARLAGADDA
  • Patent number: 9175234
    Abstract: The present invention relates to novel mutant thioesterase enzymes and naturally-occurring equivalents thereof, compositions made from such enzymes and uses of thioesterase enzymes. In particular, the present invention provides mutant thioesterase enzymes that have altered properties, for example, altered substrate specificity, altered activity, altered selectivity, and/or altered proportional yields in the product mixtures. The present invention also provides polynucleotides encoding such mutant thioesterase enzymes, and vectors and host cells comprising such polynucleotides. The invention further provides for novel uses of thioesterases in the production of various fatty acid derivatives, which are useful as, or as components of, industrial chemicals and fuels.
    Type: Grant
    Filed: December 23, 2009
    Date of Patent: November 3, 2015
    Assignee: REG Life Sciences, LLC
    Inventors: Louis Hom, Na Trinh, Murtaza Alibhai, Zhihao Hu, Eli Groban, Vikranth Arlagadda, Elizabeth Clarke