Abstract: Provided are a bifunctional molecule capable of binding to human transforming growth factor ? (TGF?) and human programmed death-ligand 1 (PD-L1), a pharmaceutical composition comprising the same, and use thereof treating cancer. The bifunctional molecule has high affinity for PD-L1, can significantly promote the secretion of IL-2 and IFN-?, enhances T cell immune responses, and can block TGF? with high specificity, and thus can be used for treating cancer. Also provided is a monoclonal antibody or an antigen-binding fragment thereof binding to human PD-L1.

Abstract: A semiconductor structure includes a substrate, first and second transistors, first and second fuses, a contact structure, and a dielectric layer. The substrate has first and second device regions, and a fuse region. The first and second transistors are respectively above the first and second device regions. The first fuse is electrically connected to the first transistor and includes a first fuse active region having first and second portions. The second fuse is electrically connected to the second transistor and includes a second fuse active region having third and fourth portions. The contact structure interconnects the second portion and the third portion, wherein the first portion and the fourth portion are on opposite sides of the contact structure. The dielectric layer is between the contact structure and the fuse region of the substrate.

Abstract: The disclosure herein describes using a transcript generation model for generating a transcript from a multi-speaker audio stream. Audio data including overlapping speech of a plurality of speakers is obtained and a set of frame embeddings are generated from audio data frames of the obtained audio data using an audio data encoder. A set of words and channel change (CC) symbols are generated from the set of frame embeddings using a transcript generation model. The CC symbols are included between pairs of adjacent words that are spoken by different people at the same time. The set of words and CC symbols are transformed into a plurality of transcript lines, wherein words of the set of words are sorted into transcript lines based on the CC symbols, and a multi-speaker transcript is generated based on the plurality of transcript lines. The inclusion of CC symbols by the model enables efficient, accurate multi-speaker transcription.

Abstract: A soft-switching power converter includes a main switch, an energy-releasing switch, and an inductive coupled unit. The main switch is a controllable switch. The energy-releasing switch is coupled to the main switch. The inductive coupled unit is coupled to the main switch and the energy-releasing switch. The inductive coupled unit includes a first inductance, a second inductance coupled to the first inductance, and an auxiliary switch unit. The auxiliary switch unit is coupled to the second inductance to form a closed loop. The main switch and the energy-releasing switch are alternately turned on and turned off. The auxiliary switch unit is controlled to start turning on before the main switch is turned on so as to provide at least one current path.

Abstract: This application provides techniques of generating interactive videos. The techniques comprise obtaining an original video, creating an interactive track for the original video to obtain an initial video, and adding an interactive component to the interactive track; and generating an interactive video by rendering at least one interactive video frame and other video frames of the initial video based on the interactive component. In this way, an interactive video with an interactive capability can be generated without additionally adding a data channel to implement an interaction function, thereby reducing processing load of a terminal and reducing resource consumption of the terminal.

Abstract: A computer system obtains an image of a scene captured by a camera and identifies a two-dimensional (2D) pose of the person in the image. The 2D pose includes a plurality of 2D joint positions in the image. The 2D pose is converted to a three-dimensional (3D) pose of the person including a plurality of 3D joint positions. The computer system determines a rotation angle of each joint relative to a T-pose of the person based on the plurality of 3D joint positions. The rotation angle of each joint is applied to a skeleton template of the avatar. The computer system renders the skeleton template of the avatar having the rotation angle for each joint.

Abstract: The present disclosure provides a device including a first conductive line and a second conductive line. The first conductive line includes a first segment that extends along a first direction and has a first side forming a first angle smaller than the right angle with the first direction. The second conductive line includes a first segment deviating from the first direction with the first angle. The first segment of the second conductive line is separated from the first side of the first segment of the first conductive line by a first distance greater than or equal to a first design rule distance.

Abstract: A soft-switching power converter includes a main switch, an energy-releasing switch, and an inductive coupled unit. The main switch is a controllable switch. The energy-releasing switch is coupled to the main switch. The inductive coupled unit is coupled to the main switch and the energy-releasing switch. The inductive coupled unit includes a first inductance, a second inductance coupled to the first inductance, and an auxiliary switch unit. The auxiliary switch unit is coupled to the second inductance to form a closed loop. The main switch and the energy-releasing switch are alternately turned on and turned off. The auxiliary switch unit is controlled to start turning on before the main switch is turned on so as to provide at least one current path.

Abstract: The present disclosure relates to a wide-range perpendicular sensitive magnetic sensor and the method for manufacturing the same, the magnetic sensor includes a substrate, a plurality of magnetic tunnel junctions, a plurality of magnetic flux regulators, a first output port and a second output port.

Abstract: The present disclosure relates to a wide-range perpendicular sensitive magnetic sensor and the method for manufacturing the same, the magnetic sensor includes a substrate, a plurality of magnetic tunnel junctions, a plurality of magnetic flux regulators, a first output port and a second output port.

Abstract: A current sensor includes: four first uniaxial TMR chips and at least two second uniaxial TMR chips, each first uniaxial TMR chip and each second uniaxial TMR chip being located on the same virtual ring, wherein magnetic sensitive directions of the four first uniaxial TMR chips are perpendicular to a radius of the virtual ring, magnetic sensitive directions of two adjacent first uniaxial TMR chips are perpendicular to each other, magnetic sensitive directions of the two second uniaxial TMR chips are parallel to the radius of the virtual ring and opposite to each other, and the two second uniaxial TMR chips respectively have the same positions as two first uniaxial TMR chips; each first uniaxial TMR chip and each second uniaxial TMR chip are configured to collect a magnetic induction intensity, the magnetic induction intensity is configured to calculate a target current value of a to-be-measured wire.

Abstract: The invention relates to a method for preparing an anti-counterfeiting modal fiber, including: mixing a pulp stock solution with a cellulose catalyst, alkalizing, aging, sulfonating, and then dissolving the pulp stock solution in an alkaline solution to obtain a treatment solution; mixing the treatment solution with multiple amino acid-metal chelates, filtering, defoaming and ripening to obtain a spinning stock solution; and mixing the spinning stock solution with a spinning bath additive, and wet spinning, followed by drafting, defoaming, desulfurizing, water washing, and other post-treatments, to obtain an anti-counterfeiting modal fiber, wherein the amino acid metal-chelates account for 0.5%-1.5% by weight of the spinning stock solution. Amino acid-metal chelates are used to anti-counterfeit and encrypt the modal fibers, and the anti-counterfeiting and encrypting is involved in the spinning stock solution of modal fibers.

Abstract: A semiconductor device includes first and second gate structures, a metallization layer, and first and second tie-off contacts. The first and second gate structures extend substantially along a first direction and are aligned with each other substantially along the first direction. The metallization layer includes a Vdd line, a Vss line, metal lines between the Vdd line and the Vss line and extending substantially along a second direction different from the first direction. The first tie-off contact overlaps an intersection of the first gate structure and a first one of the Vdd line and the Vss line from a top view. The second tie-off contact overlaps an intersection of the second gate structure and a first one of the metal lines from the top view, wherein said first one of the metal lines is adjacent to a second one of the Vdd line and the Vss line.

Abstract: A method and a sensor for detecting L-cystine are disclosed. The method is implemented by assembling a sodium 3,3?-dithiodipropane sulfonate (SPS) membrane on a surface of Au membrane layer of an Au electrode and using an extended gate of field effect transistor (FET) and in-situ signal amplification of the FET to detect L-cystine sensitively. The polyanion of the SPS membrane adsorbs and binds a positively charged target L-cystine through electrostatic interaction, thus forming an electric double layer structure to generate a membrane potential identifying a monovalent organic ammonium ion. The sensor includes the FET, wherein a gate-extended gold electrode is arranged on the FET, and the SPS membrane is assembled on the surface of the Au membrane layer of the gate-extended gold electrode. The sensor has an excellent Nernst response to L-cystine.

Abstract: A method includes creating a layout design of the integrated circuit after determining a difference between the poly extension effect of a p-type transistor and the poly extension effect of an n-type transistor. Creating the layout design includes forming first-type active zone patterns, forming second-type active zone patterns, generating a gate-strip pattern, and positioning the gate-strip pattern over the first-type active zone patterns and the second-type active zone patterns. Creating the layout design also includes determining whether to generate one or more poly cut patterns that intersect the gate-strip, based on the difference between the poly extension effect of a p-type transistor and the poly extension effect of an n-type transistor.

Abstract: The present disclosure relates to a thermoplastic pulverulent composition comprising (a) at least one silica particle treated with alkoxysilane; and (b) at least one thermoplastic polymer. The present disclosure also relates to a 3D-printed object formed from the thermoplastic pulverulent composition and a process of forming the 3D-printed object. The thermoplastic pulverulent composition shows good powder flowability and the printed object obtained from said thermoplastic pulverulent composition surprisingly shows high elongation at break, high impact strength, good toughness and low surface roughness.

Abstract: A semiconductor structure includes a substrate, an anti-fuse, first and second transistors, a contact structure, and a dielectric layer. The substrate includes a well region and first and second conductivity type doped regions in the well region, in which the second conductivity type doped region surrounds the first conductivity type doped region and includes a first portion and a second portion perpendicular to the first portion in a top view. The anti-fuse is in an anti-fuse region of the first conductivity type doped region. The first and second transistors are in the well region. The anti-fuse is disposed between the first and second transistors, and the anti-fuse is electrically connected to the first and second transistors. The contact structure is above the anti-fuse. The dielectric layer is between the contact structure and the anti-fuse region of the first conductivity type doped region.

Abstract: A method for human body model reconstruction and a reconstruction system are disclosed. The method includes acquiring a target image, and acquiring a segmented image by segmenting the target image based on an object to be reconstructed in the target image, the target image being one front image of the object; acquiring an initial estimate shape and a part of texture information of the object respectively, according to the segmented image; determining an initial 3D model of the object through the initial estimate shape, the initial 3D model being a 3D model without texture; acquiring complete texture information of the object according to the part of texture information and a texture generation model; and generating a 3D reconstruction model of the object based on the initial 3D model and the complete texture information, the 3D reconstruction model being a 3D model with texture.

Abstract: The present disclosure relates to an AC/DC closed-loop current sensor, including a magnetism gathering iron core, a TMR chip, a signal processing circuit, a signal generator, and a feedback coil. The TMR chip is arranged at an air gap of the magnetism gathering iron core and connected to the signal processing circuit. The signal processing circuit is connected to the signal generator. The feedback coil is wound around the magnetism gathering iron core and connected to the signal generator. The signal processing circuit is configured to select from the induced signal of the TMR chip and make an amplification to obtain a current signal component and send the current signal component to the signal generator. The signal generator is configured to adjust a current output to the feedback coil based on the current signal component, and output a measurement result of the selected current signal component.