Dental mouthpiece

- ORTHODONTICELL, INC.

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Description

FIG. 1 is a top perspective view of a dental mouthpiece showing our new design;

FIG. 2 is a top view of the dental mouthpiece shown in FIG. 1;

FIG. 3 is a bottom view of the dental mouthpiece shown in FIG. 1;

FIG. 4 is a right side view of the dental mouthpiece shown in FIG. 1;

FIG. 5 is a left side view of the dental mouthpiece shown in FIG. 1;

FIG. 6 is a back view of the dental mouthpiece; and,

FIG. 7 is a front view of the dental mouthpiece shown in FIG. 1.

The broken-line disclosure is understood to represent portions of the article in which the claimed design is embodied, but which form no part of the claimed design.

Claims

The ornamental design for a dental mouthpiece, as shown and described.

Referenced Cited
U.S. Patent Documents
D263073 February 16, 1982 Jonkers
D273893 May 15, 1984 Weitzman
4622952 November 18, 1986 Gordon
4976733 December 11, 1990 Girardot
5211622 May 18, 1993 Liboff et al.
5543318 August 6, 1996 Smith et al.
5693029 December 2, 1997 Leonhardt
5713917 February 3, 1998 Leonhardt et al.
5725377 March 10, 1998 Lemler et al.
5817139 October 6, 1998 Kasano
5957949 September 28, 1999 Leonhardt et al.
6344052 February 5, 2002 Greenan et al.
6618625 September 9, 2003 Silverstone
6957106 October 18, 2005 Schuler et al.
6988004 January 17, 2006 Kanno et al.
7029276 April 18, 2006 Mao
7136699 November 14, 2006 Palti
7341062 March 11, 2008 Chachques et al.
7483749 January 27, 2009 Leonhardt et al.
7686799 March 30, 2010 Leonhardt et al.
7881784 February 1, 2011 Pasricha et al.
8133267 March 13, 2012 Leonhardt et al.
8166976 May 1, 2012 Webster et al.
8226407 July 24, 2012 Hanewinkel et al.
8465533 June 18, 2013 Palti
8534289 September 17, 2013 Hernandez
8639361 January 28, 2014 Nathanson
8646455 February 11, 2014 Webster
8656930 February 25, 2014 Schuler et al.
8660669 February 25, 2014 Nemeh et al.
8738144 May 27, 2014 Schneider
8909346 December 9, 2014 Chalmers
8945104 February 3, 2015 Boone et al.
9032964 May 19, 2015 Schuler et al.
9533170 January 3, 2017 Dye et al.
9545331 January 17, 2017 Ingemarsson-Matzen
D778449 February 7, 2017 Ingemarsson-Matzen
9656096 May 23, 2017 Pilla
9662184 May 30, 2017 Lowe
9687383 June 27, 2017 Ingemarsson-Matzen
D832447 October 30, 2018 Wiffen
10543119 January 28, 2020 Ingemarsson-Matzen
D881399 April 14, 2020 Ingemarsson-Matzen
20020143373 October 3, 2002 Courtnage et al.
20030032998 February 13, 2003 Altman
20030220556 November 27, 2003 Porat et al.
20040010231 January 15, 2004 Leonhardt et al.
20040115587 June 17, 2004 Breining et al.
20040147906 July 29, 2004 Voyiazis et al.
20040236238 November 25, 2004 Schuler et al.
20050171578 August 4, 2005 Leonhardt
20060030908 February 9, 2006 Powell et al.
20060100553 May 11, 2006 Lodin
20070167984 July 19, 2007 Kieval et al.
20070190028 August 16, 2007 Qu et al.
20070265680 November 15, 2007 Liu et al.
20080227046 September 18, 2008 Lowe et al.
20080243060 October 2, 2008 Hartmann et al.
20100082027 April 1, 2010 Chalmers
20100184183 July 22, 2010 Schussler et al.
20120156648 June 21, 2012 Kaufman et al.
20130253413 September 26, 2013 Levine et al.
20140023983 January 23, 2014 Lowe et al.
20140214115 July 31, 2014 Greiner et al.
20140214116 July 31, 2014 Peterson et al.
20140214124 July 31, 2014 Greiner et al.
20140214144 July 31, 2014 Peterson et al.
20170028184 February 2, 2017 Godden et al.
20170036032 February 9, 2017 Schuler et al.
20170112983 April 27, 2017 Thorne et al.
20170266371 September 21, 2017 Leonhardt et al.
20170274206 September 28, 2017 Leonhardt
20180064935 March 8, 2018 Leonhardt et al.
20180071135 March 15, 2018 Ingemarsson-Matzen
20190015661 January 17, 2019 Leonhardt et al.
20190022389 January 24, 2019 Leonhardt
20190022396 January 24, 2019 Leonhardt
20200030136 January 30, 2020 Hernandez
20200330753 October 22, 2020 Leonhardt et al.
Foreign Patent Documents
2685161 October 2007 CA
0603451 June 1994 EP
2013-034881 February 2013 JP
10-2007-0010908 January 2007 KR
10-0726825 June 2007 KR
2006/116728 November 2006 WO
2007/146187 December 2007 WO
2008/145724 December 2008 WO
2009/021535 February 2009 WO
2011/016629 February 2011 WO
Other references
  • Harkins et al., “Chitosan-Cellulose Composite for Wound Dressing Material. Part 2. Antimicrobial Activity, Blood Absorption Ability, and Biocompatibility,” Journal of Biomedical Materials Research Part B, Applied biomaterials, vol. 102, (2014), 1199-1206.
  • Hart, K. “Rankl and Osteoprotegerin Levels in Response to Orthodontic Forces” (2012). Theses and Dissertations (ETD). Paper 107. http://dx.doi.org/10.21007/etd.cghs.2012.0127.
  • Healthcmi, “Acupuncture Combats Hypertension In University of California Research,” Available online at <https://www.healthcmi.com/Acupuncture-Continuing-Education-News/1688-acupuncture-c . . . >, (2016), 9 pages.
  • Healthcmi, “Acupuncture Controls Hypertension In Groundbreaking Trial,” Available online at <https://www.healthcmi.com/Acupuncture-Continuing-Education-News/1804-acupuncture-c . . . >, (2017), 9 pages.
  • Healthcmi, “UC Irvine—Acupuncture Reduces Hypertension Confirmed,” Available Online at <https://www.healthcmi.com/Acupuncture-Continuing-Education-News/1792-uc-irvine-acup . . . >, (2017), 6 pages.
  • Heart Valve Calcifications-Focused Ultrasound TherapyFocused Ultrasound Therapy; Research Paper Last Updated: Jan. 28, 2020, The Focused Ultrasound Foundation Newsletter (5 pages).
  • Hearts build new muscle with this simple protein patch, jacobsschool.ucsd.edu/news/news_releases/release.sfe?id=1813 (Sep. 16, 2015).
  • Hoffmann, “Regeneration of the gastric mucosa and its glands from stem cells”, Curr Med Chem, 15(29):3133-44 (2008).
  • Holding et al. “The correlation of Rank, Rankl and TNFa expression with bone loss volume and polyethylene wear debris around hip implants” Biomaterials 27(30):5212-9—Nov. 2006.
  • Holen et al. “Role of Osteoprotegerin (OPG) in Cancer” Clin Sci (Lond). Mar. 2006; 110(3):279-91. doi: 10.1042/CS20050175.
  • Hopkins Medicine “Overview of Pacemakers and Implantable Cardioverter Defibrillators (ICDs),” hopkinsmedicine.org/healthlibrary/conditions/cardiovascular_diseases/ )verview of pacemakers and implantable cardioverter defibrillators icds 85,P00234/, last visited Sep. 12, 2018.
  • https://www.dicardiology.com/content/bioleonhardt-unveils-stem-pump Jan. 28, 2014.
  • Hu et al. “Klotho Deficiency Causes Vascular Calcification in Chronic Kidney Disease” J Am Soc Nephrol. Jan. 2011; 22(1): 124-136.
  • Hu et al. “Exosomes derived from human adipose mesenchymal stem cells accelerates cutaneous wound healing via optimizing the characteristics of fibroblasts”, Nature Scientific Reports, vol. 6, Article No. 32993 (2016).
  • Hu Klein, “Vagus Nerve Stimulation: A new approach to reduce heart failure” Cardiology Journal (2010).
  • Huang et al. “Myocardial transfection of hypoxia-inducible factor-1a and co-transplantation of mesenchymal stem cells enhance cardiac repair in rats with experimental myocardial infarction”, Stem Cell Research & Therapy 5:22 (2014) DOI: 10.1186/scrt410.
  • Hudson Et Al. “Local delivery of recombinant osteoprotegerin enhances postorthodontic tooth stability” Calcif Tissue Int Apr. 2012; 90(4):330-42. doi: 10.1007/S00223-012-9579-4.
  • Hy et al., “Insulin-like growth factor 1 and hair growth,” Dermatol Online J,; 5(2):1 (Nov. 1999).
  • Iglesias-Linares Et Al. “The use of gene therapy vs. corticotomy surgery in accelerating orthodontic tooth movement.” Orthod Craniofac Res. Aug. 2011; 14(3):138-48. doi: 10.1111/j.1601-6343.2011.01519.x.
  • Infante et al. “RANKL/RANK/OPG system beyond bone remodeling: involvement in breast cancer and clinical perspectives” Journal of Experimental & Clinical Cancer Research (2019) 38:12. https://doi.org/10.1186/s13046-018-1001-2.
  • Interesting study about prolactin, VEGF and angiogenic inhibition, http://www.regrowth.com/hair-loss-forums/topic/interesting-study-about-prolactin-vegf-and-angiogenic-inhibition/ (Nov. 2006).
  • Kaur et al. “Electrically conductive polymers and composites for biomedical applications”, RSC Adv., 2015,5,37553-37567 DOI: 10.1039/C5RA01851J.
  • Keles et al. “Inhibition of tooth movement by osteoprotegerin vs. pamidronate under conditions of constant orthodontic force”, Eur J Oral Sci. Apr. 2007;115(2):131-6.
  • Keunen et al. “Anti-VEGF treatment reduces blood supply and increases tumor cell invasion in glioblastoma,” Proc. Natl. Acad. Sci. U. S. A. Mar. 1, 2011; 108(9): 3749-3754, published online Feb. 14, 2011; doi: 10.1073/pnas.1014480108.
  • Khan et al. “Accelerating Tooth Movement: What Options We Have?” J Dent Health Oral Disord Ther 2016, 5(7):00181.
  • Kido et al. “Hypoxia-Inducible Factor 1-Alpha Reduces Infarction and Attenuates Progression of Cardiac Dysfunction After Myocardial Infarction in the Mouse” JACC, vol. 46, Issue 11, Dec. 6, 2005, pp. 2116-2124. https://doi.org/10.1016/j.jacc.2005.08.045.
  • Kim Et Al., “Effect of Electrical Energy on the Efficacy of Biofilm Treatment Using the Bioelectric Effect,” NPJ Biofilms and Microbiomes, vol. 1, (2015), Article 15016, 8 pages.
  • Kim et al., The effects of electrical current from a micro-electrical device on tooth movement, http://e-kjo.org/search.php?where=aview&id=10.4041/kjod.2008.38.5.337& . . . visited Aug. 2, 2017.
  • King et al. “Mechanical Decalcification of the Aortic Valve” 272 The Annals of Thoracic Surgery vol. 42 No. 3 Sep. 1986 (pp. 269-272).
  • Kinney et al., “High Intensity Focused Electromagnetic Therapy Evaluated by Magnetic Resonance Imaging: Safety and Efficacy Study of a Dual Tissue Effect Based Non-Invasive Abdominal Body Shaping,” Lasers in Surgery and Medicine, vol. 51, (2019), pp. 40-46.
  • Kondo et al.. “Types of tooth movement, bodily or tipping, do not affect the displacement of the tooth's center of resistance but do affect the alveolar bone resorption” Angle Orthod Jul. 2017; 87(4):563-569.
  • Kose et al. “Citric acid as a decalcifying agent for the excised calcified human heart valves” Anadolu Kardiyol Derg 2008; 8: 94-8 (Eng Abstract).
  • Krishnan et al. (eds.), “Biological Mechanisms of Tooth Movement”, John Wiley & Sons 2015 (10 pages).
  • Lamoureux et al. “Therapeutic Relevance of Osteoprotegerin Gene Therapy in Osteosarcoma: Blockade of the Vicious Cycle between Tumor Cell Proliferation and Bone Resorption” Cancer Res 1 2007 67(15):7308-7318; DOI: 10.1158/0008-5472.CAN-06-4130.
  • Alghatrif et al. “The Conundrum of Arterial Stiffness, Elevated blood pressure, and Aging” Curr Hypertens Rep. Feb. 2015; 17(2): 12. doi: 10.1007/s11906-014-0523-z.
  • Almpani et al., “Nonsurgical Methods for the Acceleration of the Orthodontic Tooth Movement”, Tooth Movement. Fronl Oral Biol., vol. 18, pp. 80-91 (Karger, Basel, CH 2016) (DOI:10.1159/000382048), Published online: Nov. 24, 2015.
  • Andersson et al. “Drinking, antidiuresis and milk ejection from electrical stimulation within the hypothalamus of the goat,” Acta Physiol Scand. Dec. 31, 1955; 35(2):191-201; DOI: 10.1111/j.1748-1716.1955 tb01277.x.
  • Ando et al.“ RANKL/RANK/OPG: key therapeutic target in bone oncology” Curr Drug Discov Technol. Sep. 2008; 5(3): 263-268.
  • Aronowitz et al. “Mechanical versus enzymatic isolation of stromal vascular fraction cells from adipose tissue” SpringerPlus (2015) 4:713 DOI 10.1186/S40064-015-1509-2.
  • Atkinson et al. “Bioelectric Properties of the Tooth” 1969 vol. 48 issue: 5, pp. 789-794.
  • Aubert et al. “A new ultrasonic process for a renewal of aortic valve decalcification” Cardiovascular Ultrasound 2006, 4:2 doi:10:1186/1476-7120-4-2.
  • Aydin Et Al., “Focusing of Electromagnetic Waves by a Left-Handed Metamaterial Flat Lens,” vol. 13, (2005), pp. 8753-8759.
  • Back et al. “Endogenous Calcification Inhibitors in the Prevention of Vascular Calcification: A Consensus Statement From the COST Action EuroSoftCalcNet” Frontiers in Cardiovascular Medicine | www.frontiersin.org, Jan. 2019 | vol. 5 | Article 196.
  • Banerjee, P. “Electrical muscle stimulation for chronic heart failure: an alternative tool for exercise training?” Curr Heart Fail Rep., 7(2):52-8. doi: 10.1007/s11897-010-0013-9 (Jun. 2010).
  • Bang et al., “Attenuation of Hypertension by C-Fiber Stimulation of the Human Median Nerve and the Concept-Based Novel Device,” Scientific Reports, vol. 8, (2018), 12 pages.
  • Barbault et al., Amplitude-modulated electromagnetic fields for the treatment of cancer: Discovery of tumor-specific frequencies and assessment of a novel therapeutic approach, Journal of Experimental & Clinical Cancer Research, Apr. 14, 2009, vol. 28, No. 51, doi:10.1186/1756-9966-28-51, 10 pages.
  • Barker et al., “A Formidable Foe is Sabotaging Your Results: What You Should Know About Biofilms and Wound Healing,” Plastic and Reconstructive Surgery, vol. 139, (2017), pp. 1184e-1194e.
  • Beebe et al. “Bioelectric Applications for Treatment of Melanoma,” Cancers (Basel). Sep. 2010; 2(3): 1731-1770, published online Sep. 27, 2010; doi: 10.3390/cancers20317.
  • Berman “Suzanne Somers' Experimental Breast Reconstruction” Medpage Today, Feb. 7, 2012, www.medpagetoday.com > blogs > celebritydiagnosis.
  • Bl et al. “Key Triggers of Osteoclast-Related Diseases and Available Strategies for Targeted Therapies: A Review” Front Med (Lausanne). 2017; 4: 234. doi: 0.3389/fmed.2017.00234.
  • Borden et al., “Electric Current-Induced Detachment of Staphylococcus epidermidis Biofilms from Surgical Stainless Steel,” Applied and Environmental Microbiology, vol. 70, (2004), pp. 6871-6874.
  • Boyle “Wound-Treating Jelly Regenerates Fresh, Scar-Free Skin”, Popular Science, (Dec. 15, 2011), “New material developed for accelerated skin regeneration in major wounds”, Science Highlight, (National Institute of Biomedical 11 Imaging and Bioengineering, Dec. 17, 2015).
  • Bradshaw et al. “Designer self-assembling hydrogel scaffolds can impact skin cell proliferation and migration” Nature Scientific Reports, vol. 4, Article No. 6903 (2014).
  • Brooks et al. “Bioelectric impedance predicts total body water, blood pressure, and heart rate during hemodialysis in children and adolescents” J. Ren Nutr., 18(3):304-311 (May 2008); doi: 10.1053/j.jrn.2007.11.008.
  • Buckle et al. “Soluble Rank Ligand Produced by Myeloma Cells Causes Generalised Bone Loss in Multiple Myeloma” PLoS One. 2012; 7(8): e41127. doi: 10.1371/journal.pone.0041127 PMCID: PMC3430669.
  • Cai et al., “Intermedin Inhibits Vascular Calcification by Increasing the Level of Matrix (Gamma)-Carboxyglutamic Acid Protein,” Cardiovascular Research, vol. 85, (2010), p. 864 873.
  • CalXStars Business Accelerator, Inc.—Website—Justia Patents—Mar. 15, 2017—US Patent Application for Stimulator, Pump & Composition Patent Application (Application #20170266371) https://protect-us.mimecast.com/s/tSaBCxkVlwuDr61CvMWbF?domain=patents.justia.com.
  • Campbell et ali. “Electrical stimulation to optimize cardioprotective exosomes from cardiac stem cells” Med Hypotheses Mar. 2016; 88:6-9. doi: 10.1016/j.mehy 2015.12 022. Epub Jan. 11, 2016.
  • Canty et al., “Antibiotics Enhance Prevention and Eradication Efficacy of Cathodic-Voltage-Controlled Electrical Stimulation against Titanium-Associated Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa Biofilms,” mSphere, vol. 4, (May/Jun. 2019), e00178-19, 14 pages.
  • Caubet et al., “A Radio Frequency Electric Current Enhances Antibiotic Efficacy Against Bacterial Biofilms,” Antimicrobial Agents and Chemotherapy, vol. 48, (2004), vol. 4662-4664.
  • Cerrada et al. “Hypoxia-Inducible Factor 1 Alpha Contributes to Cardiac Healing in Mesenchymal Stem Cells-Mediated Cardiac Repair,” Stem Cells and Development, 22(3): 501-511 (2013).
  • Cervera “The interplay between genetic and bioelectrical signaling permits a spatial regionalisation of membrane potentials in model multicellular ensembles,” Nature, Scientific Reports, Oct. 12, 2016 vol. 6, Article No. 35201 (2016).
  • Chang et al. “Pulsed electromagnetic fields stimulation affects osteoclast formation by modulation of osteoprotegerin, RANK ligand and macrophage colony-stimulating factor”, Journal of Orthopaedic Research, 23 (2005) 1308-1314.
  • Chang et al. Effect of Pulse-Burst Electromagnetic Field Stimulation on Osteoblast Cell Activities; Bioelectromagnetics 25:457-465 (2004).
  • Chemet & Levin, “Transmembrane voltage potential is an essential cellular parameter for the detection and control of tumor development in a Xenopus model,” Dis. Models & Meeh. 6, pp. 595-607 (2013); doi:10.1242/dmm.010835.
  • Chen et al. “Secreted Klotho Attenuates Inflammation-Associated Aortic Valve Fibrosis in Senescence-Accelerated Mice P1” Hypertension. 2018;71:877-885. DOI: 10.1161/HYPERTENSIONAHA.117.10560.) Downloaded from http://ahajournals.org by on Apr. 24, 2020 (9 pages).
  • Chen et al., “Deficiency in the Anti-Aging Gene Klotho Promotes Aortic Valve Fibrosis Through AMPK(Alpha)-Mediated Activation of RUNX2,” Aging Cell, vol. 15, (Oct. 2016), pp. 853-860.
  • Chen et al., “Regenerative Hair Waves in Aging Mice and Extra-Follicular Modulators Follistatin, Dkk1, and Sfrp4,” Journal of Investigative Dermatology, Aug. 2014, vol. 134, Issue 8, pp. 2086-2096.
  • Chen et al., “The Role and Mechanism of (Alpha)-Klotho in the Calcification of Rat Aortic Vascular Smooth Muscle Cells,” BioMed Research International, vol. 2015, (2015), 7 pages.
  • Chen et al., “The Strategy to Prevent and Regress the Vascular Calcification in Dialysis Patients,” BioMed Research International, vol. 2017, (2017), 11 pages.
  • Chen et al., Efficacy and Safety of Acupuncture for Essential Hypertension: A Meta-Analysis, Medical Science Monitor, vol. 24, (2018), pp. 2946-2969.
  • Chiang et al., “Silver-Palladium Surfaces Inhibit Biofilm Formation,” Applied and Environmental Microbiology, vol. 75, (2009), pp. 1674-1678.
  • Christouls et al. “Pathogenesis and Management of Myeloma Bone Disease” Expert Rev Hematol. 2009; 2(4):385-398.
  • Ciria et al., Antitumor effectiveness of different amounts of electrical charge in Ehrlich and fibrosarcoma Sa-37 tumors, BMC Cancer, Nov. 26, 2004, 10 pages, vol. 4, No. 87.
  • Collette et al., “Measurement of the local aortic stiffness by a non-invasive bioelectrical impedance technique,” in Medical & Biological Engineering, vol. 49, No. 4, Feb. 2011, pp. 431-439, Available online at <https://www.ncbi.nlm.nih.gov/pubmed/21286830>, 1 page (Abstract Only).
  • Collins “Bioelectric Signals Can Be Used to Detect Early Cancer,” Tufts News, http://now.tufts.edu/news-releases/bioelectric-signals-used-detect-early-cancer (Feb. 1, 2013).
  • Columbia “Implant Procedure Concepts—Pacemaker, ICD and CRT Overview,” columbia.edu/itc/hs/medical/hickey/docs/Pacemaker,%20ICD%20and%20CRT%200verview%20022007.pdf, last risited Sep. 12, 2018.
  • Stoodley et al., “Influence of Electric Fields and pH on Biofilm Structure as Related to the Bioelectric Effect,” Antimicrobial Agents and Chemotherapy, vol. 41, (1997), pp. 1876-1879.
  • Sultana et al., “Electrochemical Biofilm Control: A Review,” Biofouling, vol. 31, (2015), pp. 745-758.
  • Sutherland et al. “Prolonged electrical stimulation of the nipples evokes intermittent milk ejection in the anaesthetised lactating rat,” Exp Brain Res. 1987;66(1):29-34.
  • Szkotak et al., “Differential Gene Expression to Investigate the Effects of Low-Level Electrochemical Currents on Bacillus subtilis,” AMB Express, vol. 1, (Nov. 2011), 12 pages.
  • Tajima et al. “HIF-1alpha is necessary to support gluconeogenesis during liver regeneration” Biochem Biophys Res Commun. Oct. 2, 2009; 387(4):789-94. doi: 10.1016/j.bbrc.2009.07.115. Epub Jul. 28, 2009.
  • Tamaki et al., “Cardiomyocyte Formation by Skeletal Muscle-Derived Multi-Myogenic Stem Cells after Transplantation into Infarcted Myocardium”, PLoS ONE 3(3): e1789. doi:10.1371/journal pone.0001789 (Mar. 2008).
  • Tan et al. “Bioelectric Perturbations in Orthodontic tooth movement” 2010 Journal of Dental Sciences & Research 1:1: pp. 41-49.
  • Tan et al., “Acupuncture Therapy for Essential Hypertension: a Network Meta-Analysis,” Annals of Translational Medicine, vol. 7, (2019), pp. 1-12.
  • Tavlasoglu et al. “Is partial decalcification of posterior mitral annular bed logical in all mitral valve replacement procedures?” European Journal of Cardio-Thoracic Surgery 43 (2013) 449-450.
  • Thattaliyath et al. “Modified Skeletal Myoblast Therapy For Cardiac Failure Using AAV SDF-1,” Proc. Inti. Soc. Mag. Reson. Med. 16, p. 579 (2008).
  • Tokyo Medical and Dental University “Rankl expressed by osteocytes has an important role in orthodontic tooth movement” Science Daily Oct. 20, 2017.
  • Totsugawa, et al. “Ultrasonic annular debridement in minimally invasive aortic valve replacement” Gen Thorac Cardiovasc Surg. Jan. 2020;68(1):81-83 doi: 10.1007/s11748-019-01158-8. Epub Jun. 15, 2019 (Abstract Only).
  • Trafton, Anne, “A Noninvasive Method for Deep Brain Stimulation,” MIT News Office, (available at http://news.mit.edu/2017/noninvasive-method-deep-brain-stimulation-0601), (Jun. 1, 2017), 3 pages.
  • Ucirvine, “Electroacupuncture for Hypertension in Women: The Susan Samueli Center for Integrative Medicine at UC Irvine is Recruiting Patients for a Study”, Principle Investigators: Dr. Stephanie Tjen-a-Looi and Dr. Shaista Malik, MOD# 20266, HS# 1999-2222, (2017), 1 page.
  • Ueland et al. “Inflammatory cytokines as biomarkers in heart failure,” Clinica Chimica Acta, vol. 443, Mar. 30, 2015, pp. 71-77; doi.org/10.1016/j.cca.2014.09.001.
  • Valvublator Heart Valve Regeneration, accessed Apr. 24, 2020 https://valvublator.com (6 pages).
  • Van Dam et al. “RANK/RANKL signaling inhibition may improve the effectiveness of checkpoint blockade in cancer treatment” Critical Reviews in Oncology/Hematology vol. 133, Jan. 2019, pp. 85-91.
  • Verna et al. “The rate and the type of orthodontic tooth movement is influenced by bone turnover in a rat model” European Journal of Orthodontics 22 (2000) 343-352.
  • Vilela-Martin et al., “Effects of Transcutaneous Electrical Nerve Stimulation (TENS) on Arterial Stiffness and Blood Pressure in Resistant Hypertensive Individuals: Study Protocol for a Randomized Controlled Trial,” Trials, vol. 17, (2016), pp. 1-13.
  • Vinod Krishnan, Ze'ev Davidovitch (eds.), Biological Mechanisms of Tooth Movement, (John Wiley & Sons 2015 (10 Pages).
  • Wagenseil et al., “Elastin in large artery stiffness and hypertension,” Journal of Cardiovascular Translational Research, vol. 5, No. 3, 2012, pp. 264-273, Available online at <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383658/ >, 21, pages.
  • Walsh & Choi “Biology of the Rank* Ran* OPG System in Immunity, Bone, and Beyond”, Front Immunol. 2014; 5:511.
  • Wang et al. “Local and sustained miRNA delivery from an injectable hydrogel promotes cardiomyocyte proliferation and functional regeneration after ischemic injury”, Nat Biomed Eng. 2017; 1: 983-992, doi: 10.1038/S41551-017-0157-y.
  • Wang et al., “Controlling Streptococcus Mutans and Staphylococcus aureus Biofilms With Direct Current and Chlorhexidine,” AMB Express, vol. 7, (Nov. 2017), 9 pages.
  • Warner “Inflammation Adds to Blood Pressure Risks, High Blood Pressure and C-Reactive Protein May Trigger Heart Attack, Stroke” Art. WebMD Health News (2003) 2 pages.
  • Wei et al., “Epicardial FSTL1 reconstitution regenerates the adult mammalian heart,” Nature 525: 479-485 (Sep. 24, 2015).
  • Welch “RGS2 Proteins Regulate Blood Pressure” JASN Nov. 2010, 21 (11) 1809-1810.
  • Wellman et al., “Bacterial Biofilms and the Bioelectric Effect,” Antimicrobial Agents and Chemotherapy, vol. 40, (1996), pp. 2012-2014.
  • Wong et al., “Dual Functional Polyelectrolyte Multilayer Coatings for Implants: Permanent Microbicidal Base With Controlled Release of Therapeutic Agents,” Journal of the American Chemical Society, vol. 132, (2010), p. 17840-17848.
  • Wu et al., “Vascular Calcification: an Update on Mechanisms and Challenges in Treatment,” Calcified Tissue International, vol. 93, (Oct. 2013), pp. 365-373.
  • Xiong Et Al. “Current understanding of neuroinflammation after traumatic brain injury and cell-based therapeutic opportunities” Chin J Traumatol. Jun. 2018; 21(3): 137-151. doi: 10.1016/j.cjtee.2018.02.003.
  • Yamaguchi, “RANK/RANKL/OPG during orthodontic tooth movement”, Orthod Craniofac Res. May 2009; 12(2):113-9. doi: 10.1111/j.1601-6343.2009.01444.x.
  • Yamakazi et al., “Hair cycle-dependent expression of hepatocyte growth factor (HGF) activator, other proteinases, and proteinase inhibitors correlates with the expression of HGF in rat hair follicles”, J Investig Dermatol Symp Proc., 4 (3):312-5 (Dec. 1999).
  • Yang “Effect RANKL Produced by Periodontal Ligament Cells on Orthodontic Tooth Movement” (2016) Dental Theses. Paper 13.
  • Yang et al., “Acupuncture for hypertension,” Cochrane Database of Systematic Reviews, Available Online at <https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD008821.pub2/full >, (2018), 4 pages.
  • Yang Lei, “Mechanisms and Reversal of Elastin Specific Medial Arterial Calcification” (2014). All Dissertations, Paper 1307, (available at https://tigerprints.clemson.edu/all_dissertations/1307), 214 pages.
  • Yarbrough Et Al., “Specific Binding and Mineralization of Calcified Surfaces by Small Peptides,” Calcified Tissue International, vol. 86, (2010), pp. 58-66.
  • Yu et al. “Association between inflammation and systolic blood pressure in RA compared to patients without RA” Arthritis Research & Therapy vol. 20, Article No. 107 (2018).
  • Zalavras, Charalampos G. “CORR Insights(Registered): Cathodic Voltage-Controlled Electrical Stimulation Plus Prolonged Vancomycin Reduce Bacterial Burden of a Titanium Implant-associated Infection in a Rodent Model,” Clinical Orthopaedics and Related Research, vol. 474, (2016), pp. 1676-1678.
  • Zaniboni et al. “Do electrical current and laser therapies improve bone remodeling during an orthodontic treatment with corticotomy?” Clin Oral Invest 23, 4083-4097 (2019). https://doi.org/10.1007/s00784-019-02845-9.
  • Zdzisinska et al. “RANK/RANKL i OPG w szpiczaku plazmocytowym [The role of RANK/RANKL and OPG in multiple myeloma]” Postepy Hig Med Dosw (Online). 2006; 60:471-482 (Abstract Only).
  • Zhang et al. “Exosomes derived from human embryonic mesenchymal stem cells promote osteochondral regeneration”, Osteoarthritis and Cartilage, vol. 24, Issue 12, Dec. 2016, pp. 2135-2140.
  • Zhang et al., “Comparison of arterial stiffness in non-hypertensive and hypertensive population of various age groups,” Jan. 24, 2018, 2 pages (Abstract Only).
  • Zhang et al., “Highly Stable and Reusable Imprinted Artificial Antibody Used for in Situ Detection and Disinfection of Pathogens,” Chemical Science, vol. 6, (2015), pp. 2822-2826.
  • Zhao et al. “Local osteoprotegerin gene transfer inhibits relapse of orthodontic tooth movement.” Am J Orthod Dentofacial Orthop. Jan. 2012; 141(1):30-40. doi: 10.1016/j.ajodo.2011.06.035.
  • Zupan et al. “The relationship between osteoclastogenic and anti-osteoclastogenic pro-inflammatory cytokines differs in human osteoporotic and osteoarthritic bone tissues,” Journal of Biomedical Science, 2012, 19:28 (DOI: 10.1186/1423-0127-19-28).
  • Landau et al. “Review: Proposed Methods to Improve the Survival of Adipose Tissue in Autologous Fat Grafting” Plast Reconstr Surg Glob Open. 2018;6(8):e1870. Published Aug. 3, 2018. doi:10.1097/GOX.0000000000001870.
  • Lanzetto et al. “Fundamental principles of an anti-VEGF treatment regimen: optimal application of intravitreal anti-vascular endothelial growth factor therapy of macular diseases,” Graefes Arch. Clin. Exp. Ophthalmol. 2017;255(7): 1259-1273 (published online May 19, 2017); doi: 10.1007/s00417-017-3647-4.
  • Lasserre et al., “Influence of Low Direct Electric Currents and Chlorhexidine Upon Human Dental Biofilms,” Clinical and Experimental Dental Research, vol. 2, (Jul. 2016), pp. 146-154.
  • Lasserre et al., “Oral Microbes, Biofilms and Their Role in Periodontal and Peri-Implant Diseases,” Materials, vol. 11, (Sep. 2018), Article 1802, 17 pages.
  • Lee et al. “Hepatocyte growth factor (HGF) activator expressed in hair follicles is involved in in vitro HGF-dependent hair follicle elongation,” J. Dermatol. Sci., 25(2):156-63 (Feb. 2001).
  • Lee et al., “Targeted Release of Tobramycin From a pH-Responsive Grafted Bilayer Challenged With S. Aureus,” Biomacromolecules, vol. 16, (2015), pp. 650-659.
  • Lei et al., “Efficacy of Reversal of Aortic Calcification by Chelating Agents,” Calcified Tissue International, vol. 93, (Nov. 2013), 15 pages.
  • Leibrock et al., “NH4CI Treatment Prevents Tissue Calcification in Klotho Deficiency,” Journal of the American Society of Nephrology, vol. 26, (2015), pp. 2423-2433.
  • Leonhardt “Leonhardt Adds HIF-1 Alpha To Estate of Bioelectric Controlled Release Regenerative Proteins” Press Release, Published Jun. 13, 2017.
  • Leonhardt, “Leonhardt Ventures Files Patent for Heart Valve Regeneration,” (available at https://bioleonhardt.com/leonhardt-ventures-files-patent-for-heart-valve-regeneration/), (Mar. 20, 2018), 6 pages.
  • Leonhardt, H.—Leonhardt Announces Vibrational Energy Device For Preventing Blood Clots Provisional Patent Application and License Agreements, (available at https://leonhardtventures.com/leonhardt-announces-vibrational-energy-device-preventing-blood-clots-provisional-patent-application-license-agreements/), (Jul. 5, 2017), 5 pages.
  • Leonhardt, Leonhardt Announces Vibrational Energy Device For Preventing Blood Clots Provisional Patent Application and License Agreements, (available at https://leonhardtventures.com/leonhardt-announces-vibrational-energy-device-preventing-blood-clots-provisional-patent-application-license-agreements/), (Jul. 5, 2017), 5 pages.
  • Leonhardt's Launchpads Announces Filing of Patent for Bioelectric Stimulation Controlled Klotho Expression—Powerful Anti-aging and Regeneration Promoting Protein, by Api Podder, Published: Mar. 13, 2019, available online at <https://mysocialgoodnews.com/leonhardts-launchpads-announces-filing-of-patent-for-bioelectric-stimulation-controlled-klotho-expression-powerful-anti-aging-and-regeneration-promoting-protein/.
  • Li et al., “Exogenous IGF-1 promotes hair growth by stimulating cell proliferation and down regulating TGF-(Beta)1 in C57BL/6 mice in vivo” Growth Hormone & IGF Research, vol. 24, Issues 2-3, pp. 89-94 (Apr.-Jun. 2014).
  • Li et al., “Long-Lasting Reduction of Blood Pressure by Electroacupuncture in Patients with Hypertension: Randomized Controlled Trial,” Medical Acupuncture, vol. 27, No. 4, (2015), pp. 253-266.
  • Li et al., “Repetitive Electroacupuncture Attenuates Cold-Induced Hypertension through Enkephalin in the Rostral Ventral Lateral Medulla,” Scientific Reports, vol. 6, (2016), 10 pages.
  • Li et al., “The Mechanism of Acupuncture in Treating Essential Hypertension: A Narrative Review,” International Journal of Hypertension, vol. 2019, (2019), Article ID 8676490, 10 pages.
  • Meadows et al. “Anti-VEGF Therapies in the Clinic,” Cold Spring Harb. Perspect. Med. Oct. 2012; 2(10): a006577: doi: 10.1101/cshperspect.a006577.
  • Miles et al. “Assessment of the changes in arch perimeter and irregularity in the mandibular arch during initial alignment with the AcceleDent Aura appliance vs no appliance in adolescents: A single-blind randomized clinical trial”, Dec. 2016, vol. 150, Issue 6 American Journal of Orthodontics and Dentofacial Orthopedics (9 pages).
  • Mishra “Angiogenic neovessels promote tissue hypoxia,” Proc. Natl. Acad. Sci. U. S. A. Sep. 20, 2016; 113(38): 10458-10460, published online Sep. 13, 2016; doi: 10.1073/pnas.1612427113.
  • Moe, “Klotho: A Master Regulator of Cardiovascular Disease?,” Circulation, vol. 125, (2012), pp. 2181-2183.
  • Mosteiro et al. “Tissue damage and senescence provide critical signals for cellular reprogramming in vivo.” Science, 2016; 354 (6315): aaf4445 DOI: 10.1126/science.aaf4445.
  • Niiranen et al., “Relative Contributions of Arterial Stiffness and Hypertension to Cardiovascular Disease: The Framingham Heart Study,” Journal of the American Heart Association, vol. 5, No. 11, 2016, 8 pages.
  • Nimeri et al. “Acceleration of tooth movement during orthodontic treatment—a frontier in Orthodontics”, Prog Orthod 2013; 14:42; DOI: 10.1186/2196-1042-14-42.
  • Nodzo et al., “Cathodic Electrical Stimulation Combined With Vancomycin Enhances Treatment of Methicillin-Resistant Staphylococcus aureus Implant-Associated Infections,” Clinical Orthopaedics and Related Research, vol. 473, (2015), pp. 2856-2864.
  • Nodzo et al., “Cathodic Voltage-Controlled Electrical Stimulation Plus Prolonged Vancomycin Reduce Bacterial Burden of a Titanium Implant-associated Infection in a Rodent Model,” Clinical Orthopaedics and Related Research, vol. 474, (2016), 1668-1675.
  • Nordstorm “Electrical Stimulation Blood Pressure Treatment Devices Market to Set Astonishing Growth by 2026” Art. Apr. 4, 2019 Gator Ledger.
  • Norton et al. “Bioelectric Perturbations of Bone: Research Directions and Clinical Applications” Angle Orthod (1984) 54 (1): 73-87.
  • Novack “Inflammatory osteoclasts, a different breed of bone eaters?” Arthritis Rheumatol. Dec. 2016; 68(12): 2834-2836. doi: 10.1002/art.39835.
  • Novickij et al., “Induction of Different Sensitization Patterns of MRSA to Antibiotics Using Electroporation,” Molecules, vol. 23,(2018), Article 1799, 10 pages.
  • O'Neill et al., “Recent Progress in the Treatment of Vascular Calcification,” Kidney International, vol. 78, (Dec. 2010), pp. 1232-1239.
  • Oranger et al. “Cellular Mechanisms of Multiple Myeloma Bone Disease” Clinical and Developmental Immunology vol. 2013, Article ID 289458, 11 pages http://dx.doi.org/10.1155/2013/289458.
  • Otero et al. “Expression and Presence of OPG and RANKL mRNA and Protein in Human Periodontal Ligament with Orthodontic Force”, Gene-Regulation-and-Systems-Biology, 2016, 10, 15-20.
  • Oyajobi “Multiple myeloma/hypercalcemia” Arthritis Research & Therapy vol. 9, Article No. S4 (2007).
  • Palza et al., “Electroactive Smart Polymers for Biomedical Applications,” Materials, vol. 12, (2019), 24 pages.
  • Park et al. “Effects of SM-215 on Hair Growth by Hair Follicle Stimulation”, Indian Journal of Science and Technology, vol. 8(25), DOI: 10.17485/ijst/2015/v8i25/80263, (Oct. 2015).
  • Park, Alice “Shrinking Stem Cells Are the Real Reason for Hair Loss” Time, (Feb. 5, 2016).
  • Paulus “Cytokines and heart failure,” Heart Fail. Monit. 2000; 1(2):50-6.
  • Pierce et al. “Collection and characterization of amniotic fluid from scheduled C-section deliveries,” Cell Tissue Bank, DOI 10.1007/s10561-016-9572-7 (Springer, 2012) and is available from Irvine Scientific.
  • Plumbingtoday, “How to Remove Hard, White Mineral Deposits from Faucets/Showerheads,” (available at https://plumbingtoday.biz/blog/how-to-remove-hard-white-mineral-deposits-from-faucets-showerheads), (Jul. 11, 2016), 4 pages.
  • Pozo et al., “Bioelectric Effect and Bacterial Biofilms. A Systematic Review,” The International Journal of Artificial Organs, vol. 31, (2008), pp. 786-795.
  • Pozo et al., “Effect of Electrical Current on the Activities of Antimicrobial Agents Against Pseudomonas Aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis Biofilms,” Antimicrobial Agents and Chemotherapy, vol. 53, (2009), pp. 35-40.
  • Pozo et al., “Prevention of Staphylococcus epidermidis Biofilm Formation Using Electrical Current,” Journal of Applied Biomaterials & Functional Materials, vol. 12, (2014), pp. 81-83.
  • Pozo et al., “The Electricidal Effect: Reduction of Staphylococcus and Pseudomonas Biofilms by Prolonged Exposure to Low-Intensity Electrical Current,” Antimicrobial Agents and Chemotherapy, vol. 53, (2009), pp. 41-45.
  • Price et al. “Mitral Valve Repair is Feasible Following Extensive Decalcification and Reconstruction of the Atrioventricular Groove” J Heart Valve Dis. Jan. 2015;24(1):46-52 (Abstract Only).
  • Prochazka et al. “Therapeutic Potential of Adipose-Derived Therapeutic Factor Concentrate for Treating Critical Limb Ischemia,” Cell Transplantation, 25(9), pp. 1623-1633(11) (2016).
  • Prochazka et al., “Cocktail of Factors from Fat-derived Stem Cells Shows Promise for Critical Limb Ischemia” http://www.sciencenewsline.com/news/2016012204520017.html (Jan. 21, 2016).
  • Pupo et al., Electrotherapy on Cancer: Experiment and Mathematical Modeling, Current Cancer Treatment—Novel Beyond Conventional Approaches, Prof. Oner Ozdemir (Ed.) ISBN: 978-953-307-397-2, InTech, Available from: http://www.intechopen.com/books/current-cancer-treatment-novel-beyond-conventional-approaches/electrotherapy-on-cancer-experiment-and-mathematical-modeling, 2011.
  • Puro et al “Bioelectric impact of pathological angiogenesis on vascular function,” PNAS Aug. 30, 2016 113(35) 9934-9939; published ahead of print Aug. 22, 2016 https://doi.org/10.1073/pnas.1604757113.
  • Rachner et al. “Prognostic Value of RANKL/OPG Serum Levels and Disseminated Tumor Cells in Nonmetastatic Breast Cancer” Clin Cancer Res Feb. 15, 2019 (25) (4) 1369-1378; DOI: 10.1158/1078-0432.CCR-18-2482.
  • Raje et al. “Role of the RANK/RANKL Pathway in Multiple Myeloma” Clin Cancer Res 2019 25(1):12-20; DOI: 10.1158/1078-0432.CCR-18-1537.
  • Ren et al., “Efficient Eradication of Mature Pseudomonas Aeruginosa Biofilm via Controlled Delivery of Nitric Oxide Combined with Antimicrobial Peptide and Antibiotics,” Frontiers in Microbiology, vol. 7, Article 1260, (Aug. 2016), 8 pages.
  • Reversing Age-Related Hair Loss and Restoring Healthy Hair Growth in Men and Women https://nutritionreview.org/2015/08/reversing-age-related-hair-loss-and-restoring-healthy-hair-growth-in-men-and-women/ (Aug. 24, 2015).
  • RFA (radiofrequency ablation), Swedish Medical Imaging, 2 pages, author unknown, undated.
  • Sabbah “Electrical vagus nerve stimulation for the treatment of chronic heart failure”, Cleve Clin J Med, 78 Suppl 1: S24-9. doi: 10.3949/ccjm.78.s1.04 (Aug. 2011).
  • Sabino-Carvalho et al., “Non-invasive Vagus Nerve Stimulation Acutely Improves Blood Pressure Control in a Placebo Controlled Study,” The FASEB Journal, vol. 31, 2017, available online at <https://www.fasebj.org/doi/abs/10.1096/fasebj.31.1_supplement.848.8 >, 2 pages) Abstract Only.
  • Sahmeddini et al., “Electro-Acupuncture Stimulation at Acupoints Reduced the Severity of Hypotension During Anesthesia in Patients Undergoing Liver Transplantation,” Journal of Acupuncture and Meridian Studies, vol. 5, Issue 1, (2012), pp. 11-14.
  • Sahoo and Losardo, “Exosomes and Cardiac Repair After Myocardial Infarction”, Circulation Research, 114:333-344 (Jan. 16, 2014).
  • Salcedo et al., “Low current electrical stimulation upregulates cytokine expression in the anal sphincter,” Int. J. Colorectal Dis., Feb. 2012;27(2):221-5. doi: 10.1007/s00384-011-1324-3. Epub (Oct. 2011).
  • Sandvik et al., “Direct Electric Current Treatment under Physiologic Saline Conditions Kills Staphylococcus epidermidis Biofilms via Electrolytic Generation of Hypochlorous Acid,” PloS one, vol. 8, (Feb. 2013), e55118, 14 pages.
  • Schardong et al., “Intradialytic neuromuscular electrical stimulation reduces DNA damage in chronic kidney failure patients: a randomized controlled trial,” Biomarkers, vol. 23, Issue 5, 2018, pp. 1-11.
  • Schimmel et al. “Neuroinflammation in traumatic brain injury: A chronic response to an acute injury” Brain Circ, 2017, 3(3):135-142.
  • Schmidt-Malan et al., “Activity of Fixed Direct Electrical Current in Experimental Staphylococcus aureus Foreign-Body Osteomyelitis,” Diagnostic Microbiology and Infectious Disease, vol. 93, (2019), pp. 92-95.
  • Seifi & Jeszri “Correlation of bone resorption induced by orthodontic tooth movement and expression of RANKL in rats”, Dental Journal, vol. 26, No. 4 (2009).
  • Sethi et al. “Aortic stiffness: pathophysiology, clinical implications, and approach to treatment” Integr Blood Press Control. 2014; 7: 29-34.
  • Shahid et al., “Rhinosinusitis in Children,” ISRN Otolaryngology, vol. 2012, Article ID 851831, (Dec. 2012), 11 pages.
  • Shirtliff et al., “Assessment of the Ability of the Bioelectric Effect to Eliminate Mixed-Species Biofilms,” Applied and Environmental Microbiology, vol. 71, (2005), pp. 6379-6382.
  • Shoji-Matsunaga et al. “Osteocyte regulation of orthodontic force-mediated tooth movement via RANKL expression.” Scientific Reports, 7: 8753, published online Aug. 18, 2017, DOI:10.1038/s41598-017-09326-7.
  • Showkatbakhsh et al. “Effect of Intra-Canal Direct Current Electric Stimulation on Orthodontic Tooth Movement: An Experimental Study in Canines” Journal of Dental School 2016; 34(3): 157-67.
  • Showkatbakhsh et al. “The effect of pulsed electromagnetic fields on the acceleration of tooth movement.” World J Orthod. 2010 Winter;11(4):e52-6.
  • Signature Orthodontics “Accelerated Tooth Movement”, http://www.sigortho.com/accelerated-tooth-movement, visited Mar. 15, 2017.
  • Silvers et al. “The Bioelectric Code: Reprogramming Cancer and Aging from the Interface of Mechanical and Chemical Microenvironments,” Front. Cell Dev. Biol., Mar. 6, 2018; doi.org/10.3389/fcell.2018.00021.
  • Sisay et al. “The RANK/RANKL/OPG system in tumorigenesis and metastasis of cancer stem cell: potential targets for anticancer therapy” Onco Targets Ther. 2017; 10: 3801-3810.
  • Somayaji et al., “In Vitro Scanning Electron Microscopic Study on the Effect of Doxycycline and Vancomycin on Enterococcal Induced Biofilm,” Iranian Endodontic Journal, vol. 5, (2010), pp. 53-58.
  • Souli et al., “Effects of Slime Produced by Clinical Isolates of Coagulase-Negative Staphylococci on Activities of Various Antimicrobial Agents,” Antimicrobial Agents and Chemotherapy, vol. 42, (Apr. 1998), pp. 939-941.
  • Spadari et al.. Electrical stimulation enhances tissue reorganization during orthodontic tooth movement in rats; Clinical Oral Investigations, Jan. 2017, vol. 21, Issue 1, pp. 111-120, Abstract.
  • Spiridonov et al. “Effect of Transcutaneous Electrical Stimulation of Nerves on Blood Pressure and Blood Content of Neuropeptide CGRP and Nitric Oxide in Hypertensive Rats with Metabolic Disturbances” Bull Exp Biol Med (Feb. 2019) 166: 436-437.
  • Stein et al., “The effect of transcutaneous electrical nerve stimulation on blood pressure,” Blood Pressure, vol. 22, Issue 3, 2013, available online at < https://www.tandfonline.com/doi/full/10.3109/08037051.2012.722271 >, 5 pages.
  • Stenn et al., “Bioengineering the Hair Follicle,” Organogenesis, 3(1): 6-13 (Jan.-Mar. 2007).
  • Stewart et al., “Electrolytic Generation of Oxygen Partially Explains Electrical Enhancement of Tobramycin Efficacy Against Pseudomonas Aeruginosa Biofilm,” Antimicrobial Agents and Chemotherapy, vol. 43, (1999), pp. 292-296.
  • Control of pelage hair follicle development and cycling by complex interactions between follistatin and activin, FASEB J (Jan. 2, 2003).
  • Corrigan et al. “Neurogenic inflammation after traumatic brain injury and its potentiation of classical inflammation”, Journal of Neuroinflammation, 2016, 13:264; doi://doi.org/10.1186/s12974-016-0738-9.
  • Costerton et al., “Mechanism of Electrical Enhancement of Efficacy of Antibiotics in Killing Biofilm Bacteria,” Antimicrobial Agents and Chemotherapy, vol. 38, (1994), pp. 2803-2809.
  • Costerton et al., “The Application of Biofilm Science to the Study and Control of Chronic Bacterial Infections,” The Journal of Clinical Investigation, vol. 112, (2003), pp. 1466-1477.
  • Cowburn et al. “HIF isoforms in the skin differentially regulate systemic arterial pressure” Proc Natl Acad Sci U S A. Oct. 22, 2013; 110(43): 17570-17575.
  • Cross et al. “Milk Ejection following Electrical Stimulation of the Pituitary Stalk in Rabbits,” Nature 166, 994-995 (Dec. 9, 1950); doi:10.1038/166994b0 (Abstract Only).
  • D'Apuzzo et al. “Biomarkers of Periodontal Tissue Remodeling during Orthodontic Tooth Movement in Mice and Men: Overview and Clinical Relevance”, The Scientific World Journal, vol. 2013 (2013), Article ID 105873, 8 pages, http://dx.doi.org/10.1155/2013/105873.
  • Dai et al. “Nanosecond Pulsed Electric Fields Enhance the Anti-tumour Effects of the mTOR Inhibitor Everolimus against Melanoma,” Scientific Reports vol. 7, Article No. 39597 (2017).
  • Delcaru et al., “Microbial Biofilms in Urinary Tract Infections and Prostatitis: Etiology, Pathogenicity, and Combating strategies,” Pathogens, vol. 5, (2016), 12 pages.
  • Deswal et al. “Cytokines and Cytokine Receptors in Advanced Heart Failure An Analysis of the Cytokine Database from the Vesnarinone Trial (VEST),” Circulation. 2001;103:2055-2059;://doi.org/10.1161/01.CIR.103.16.2055.
  • Dibart et al. “Tissue response during Piezocision-assisted tooth movement: a histological study in rats”, Eur J Orthod (2014) 36 (4): 457-464; DOI: https://doi.org/10.1093/ejo/cjt079.
  • Dietrich et al. “Decalcification of the mitral annulus: surgical experience in 81 patients” Thorac Cardiovasc Surg. Oct. 2006;54(7):464-7 (Abstract Only).
  • Dong-Hwan Kim et al., The effects of electrical current from a micro-electrical device on tooth movement, Korean Orthod., Oct. 2008, 38(5):337-346.
  • Ehrlich Et Al., “Engineering Approaches for the Detection and Control of Orthopaedic Biofilm Infections,” Clinical Orthopaedics and Related Research, vol. 437, (2005), pp. 59-66.
  • El-Bialy Et Al. “Effect of Low Intensity Pulsed Ultrasound (LIPUS) on Tooth Movement and Root Resorption: A Prospective Multi-Center Randomized Controlled Trial” J. Clin. Med. 2020, 9, 804; doi:10.3390/jcm9030804.
  • Electric Tumor Treatment Fields, No. 0827 Policy, http://www.aetna.com/cpb/medical/data/800_899/0827.html (Nov. 18, 2016).
  • Electrical brain stimulation could support stroke recovery https://www.sciencedaily.com/releases/2016/03/160316151108.htm (Mar. 16, 2016).
  • Eurekalert, UCI Study Finds Acupuncture Lowers Hypertension by Activating Natural Opioids, Available Online at < https://www.eurekalert.org/pub_releases/2016-10/uoc-usf103116.php >, (2016), 2 pages.
  • Fan et al., “A Review on the Nonpharmacological Therapy of Traditional Chinese Medicine with Antihypertensive Effects,” Evidence-Based Complementary and Alternative Medicine, vol. 2019, (2019), Article ID 1317842, 7 pages.
  • Fatemi et al. “Imaging elastic properties of biological tissues by low-frequency harmonic vibration” Proceedings of the IEEE, 91(10):1503-1519 (Oct. 2003).
  • FDA Approves Algovita Spinal Cord Stimulation System from Greatbatch, http://www.odtmag.com/contents/view_breaking-news/2015-12-02/fda-approves-algovita-spinal-cord-stimulation-system-from-greatbatch (Dec. 2, 2015).
  • Ferris, “Battle against baldness turns to stem cells” http://www.cnbc.com/2015/01/29/studies-indicate-its-possible-to-use-stem-cells-to-cure-baldness.html (Jan. 29, 2015).
  • Ferrucci, D. A. “Introduction to This is Watson,” in IBM Journal of Research and Development, vol. 56, No. 3.4, pp. 1:1-1:15, May-Jun. 2012. DOI: 10.1147/JRD.2012.2184356.
  • Fili et al. “Therapeutic implications of osteoprotegerin” Cancer Cell International vol. 9, Article No. 26 (2009).
  • Flachskampf et al., “Randomized Trial of Acupuncture to Lower Blood Pressure,” Circulation, vol. 115, (2007), pp. 3121-3129.
  • Fonseca et al. “Electrical stimulation: Complementary therapy to improve the performance of grafts in bone defects?” Journal of Biomedical Materials Research Part B: Applied Biomaterials 2018 vol. 000b, Issue 0.
  • Froughreyhani et al., “Effect of Electric Currents on Antibacterial Effect of Chlorhexidine Against Entrococcus Faecalis Biofilm: An in Vitro Study,” Journal of Clinical and Experimental Dentistry, vol. 10, (Dec. 2018), pp. e1223-e1229.
  • Fukuoka and Suga, “Hair Regeneration Treatment Using Adipose-Derived Stem Cell Conditioned Medium: Follow-up With Trichograms” Eplasty, 15:e10 (Mar. 2015).
  • Fukuoka et al. “Hair Regeneration Treatment Using Adipose-Derived Stem Cell Conditioned Medium: Follow-up With Trichograms” Eplasty, 15:e10 (Mar. 2015).
  • Fukuoka et al., “The Latest Advance in Hair Regeneration Therapy Using Proteins Secreted by Adipose-Derived Stem Cells” The American Journal of Cosmetic Surgery, 29(4):273-282 (2012).
  • Gavira et al. “Repeated implantation of skeletal myoblast in a swine model of chronic myocardial infarction,” Eur. Heart J., 31(8): 1013-1021. doi: 10.1093/eurheartj/ehp342 (2010).
  • Giganti et al. “Changes in serum levels of TNF-alpha, IL-6, OPG, Rankl and their correlation with radiographic and clinical assessment in fragility fractures and high energy fractures”, J Biol Regul Homeost Agents, Oct.-Dec. 2012;26(4):671-80.
  • Giladi et al., “Microbial Growth Inhibition by Alternating Electric Fields,” Antimicrobial Agents and Chemotherapy, vol. 52, (2008), pp. 3517-3522.
  • Golberg et al., “Eradication of Multidrug-Resistant A. Baumannii in Bum Wounds by Antiseptic Pulsed Electric Field,” Technology, vol. 2, (2014), pp. 153-160.
  • Golberg et al., “Eradication of Multidrug-Resistant A. Baumannii in Burn Wounds by Antiseptic Pulsed Electric Field,” Technology, vol. 2, (2014), pp. 153-160.
  • Golberg et al., “Pulsed Electric Fields For Burn Wound Disinfection in a Murine Model,” Journal of Burn Care & Research, vol. 36, (2015), pp. 7-13.
  • Goranov et al. “Bone Lesions in Multiple Myeloma—The OPG/RANK—ligand System” Folia Med (Plovdiv). 2004; 46(3): 5-11 (Abstract Only).
  • Goswami et al. “Osteoprotegerin rich tumor microenvironment: implications in breast cancer” Oncotarget. Jul. 5, 2016; 7(27): 42777-42791.
  • Grad, D., “Electrical Scalp Device Can Slow Progression of Deadly Brain Tumors”, New York Times, https://www.nytimes.com/2014/11/16/health/electrical-scalp-device-can-slow-progression-of-deadly-brain-tumors.html?_r=0 (Nov. 15, 2014).
  • Greenwald “Pulse pressure and arterial elasticity” QJM: An International Journal of Medicine, vol. 95, Issue 2, 2002, pp. 107-112.
  • Guimarães-Camboa et al. “Redox Paradox: Can Hypoxia Heal Ischemic Hearts?” Cell, 39(4):392-394, (Nov. 21, 2016) DOI: http://dx.doi.org/10.1016/j.devcel.2016.11.007.
  • Gullestad Et Al. “Inflammatory cytokines in heart failure: mediators and markers,” Cardiology. 2012;122(1):23-35. doi: 10.1159/000338166. Epub Jun. 12, 2012.
  • Gurbax et al. “Accelerated Orthodontic Tooth Movement: A Review” mod Res Dent. 1(2). MRD.000508. 2017. DOI: 10.31031/MRD.2017.01.000508.
  • Hamman, R. “Modulation Of RANKL and Osteoprotegerin in Adolescents Using Orthodontic Forces”, Masters Thesis, University of Tennessee (2010).
  • Hamzelou Et Al. “Cancer reversed in frogs by hacking cells' electricity with light,” New Scientist This Week, Mar. 16, 2016.
  • Hari et al., “Application of Bioelectric Effect to Reduce the Antibiotic Resistance of Subgingival Plaque Biofilm: An in Vitro Study,” Journal of Indian Society of Periodontology, vol. 22, (2018), pp. 133-139.
Patent History
Patent number: D957646
Type: Grant
Filed: May 3, 2021
Date of Patent: Jul 12, 2022
Assignee: ORTHODONTICELL, INC. (Salt Lake City, UT)
Inventors: Howard J. Leonhardt (Corona Del Mar, CA), John Joseph Marchetto (Weston, FL), Alex Richardson (Thousand Oaks, CA)
Primary Examiner: Wan Laymon
Application Number: 29/782,021
Classifications
Current U.S. Class: Mold, Model Or Form (48) (D24/181)