Abstract: The invention relates to an atomizing plug assembly and an atomizer formed thereby. The atomizing plug assembly comprises a containing part and an atomizing part. The containing part has a containing body. The containing body defines a containing space for containing a liquid to be atomized and has an aerosol opening which communicates with the containing space. The atomizing part is integrated with or detachably connected with the containing part and has a vibrating member and a nozzle plate. The vibrating member has an atomizing electrical connecting portion, where the vibrating member is electrically connected, and a pin element electrically connected with the atomizing electrical connecting portion. The nozzle plate is located corresponding to the aerosol opening. The atomizer is formed by electrically connecting the atomizing plug assembly to a base.

Abstract: The combination of: a) an apparatus with a main body and an operating assembly on the main body configured to cause fluid from a supply to be processed so as to become entrained in air in a surrounding atmosphere, wherein the main body has an elongate finger having a length and a free end; and b) a container defining a receptacle for a supply of fluid. The container has an entry opening that is dimensioned to allow the elongate finger on the main body to be directed, free end first, through the entry opening to allow a portion of the length of the elongate finger to be immersed in a supply of fluid in the receptacle. Structure cooperates between the apparatus and container to support the main body and container in an operative relationship.

Abstract: A vertical chemical vapor deposition (CVD) reactor and a method for synthesizing metal oxide impregnated carbon nanotubes. The CVD reactor includes a preheating zone portion and a reaction zone portion, and preferably an additional cooling zone portion and a product collector. The method includes (a) subjecting a liquid reactant solution comprising an organic solvent, a metallocene, and a metal alkoxide to atomization in the presence of a gas flow comprising a carrier gas and a support gas to form an atomized mixture, and (b) heating the atomized mixture to a temperature of 200° C.-1400° C., wherein the heating forms a metal oxide and at least one carbon source compound, wherein the metallocene catalyzes the formation of carbon nanotubes from the at least one carbon source compound and the metal oxide is incorporated into or on a surface of the carbon nanotubes to form the metal oxide impregnated carbon nanotubes.

Abstract: A drug solution tank of the present invention is a drug solution tank for an ultrasonic inhaler, including a drug solution reservoir portion having an upper edge that surrounds an opening and a bottom portion formed so as to protrude downward, a flange portion formed so as to extend outward from the upper edge of the drug solution reservoir portion, and a leg portion that is continuous with the outer perimeter or lower surface of the flange portion, is formed so as to surround the drug solution reservoir portion, and extends downward past the bottom portion of the drug solution reservoir portion.

Abstract: Disclosed herein are formulations of pirfenidone or pyridone analog compounds for aerosolization and use of such formulations for aerosol administration of pirfenidone or pyridone analog compounds for the prevention or treatment of various fibrotic and inflammatory diseases, including disease associated with the lung, heart, kidney, liver, eye and central nervous system. In some embodiments, pirfenidone or pyridone analog compound formulations and delivery options described herein allow for efficacious local delivery of pirfenidone or pyridone analog compound. Compositions include all formulations, kits, and device combinations described herein. Methods include inhalation procedures, indications and manufacturing processes for production and use of the compositions described.

Abstract: A nebulization structure includes a driving element, a structure plate and a nebulization plate. The structure plate is installed on a side of the driving element, and the structure plate is substantially in a circular disc shape and has a plurality of through holes, and at least one rib is formed between adjacent through holes to define a water guide passage. The nebulization plate is clamped between the driving element and the structure plate and made of a polymer material to overcome the problems of having easy metal fatigue and embrittlement of the nebulization plate made of metal, and being corroded by corrosive liquids.

Abstract: Methods, systems, and devices are provided for generating a mist. In one embodiment, a fluid delivery device is provided that includes a housing, a fluid vaporizer disposed within the housing and configured to receive fluid and to produce an aerosol mist of liquid particles from the fluid, and a pump configured to accelerate the aerosol mist produced by the fluid vaporizer. Methods are provided for producing a mist, and the methods can include delivering a fluid to a fluid vaporizer that generates a first mist. The fluid vaporizer delivers the mist to a pump that generates a second mist from the first mist.

Abstract: Inhalation delivery of aerosols containing small particles from a device that forms drug containing aerosols for use in inhalation therapy. A device for delivering drug containing aerosols for inhalation therapy is provided. The device includes a housing and an airway that has a gas/vapor mixing airway. The airway further includes a subassembly, which has a metallic substrate coated on its surface with a composition comprising a drug.

Abstract: A portable ultrasonic cosmetic applicator for spraying lip gloss, eye shadow, blush, tanning solutions, moisturizing agents, and sterilants onto the body or face. Useful for wound healing, makeup artists in the movie industry, beauty salons, and for personal use. The applicator is small and lightweight thus making it easy to use without the use of external air pressure more commonly used with airbrush spraying equipment of this type. Noisy compressors, pressurized cylinders and air lines are all eliminated. The amount of unused solutions are reduced due to its ability to produce a smaller and more uniform droplet size which, in turn, produces a fine misty spray unlike some of the more traditional applicators. Due to its lack of complexity and awkwardness, the user is able to apply liquid in a simple and graceful manner.

Abstract: A respiratory therapy apparatus that introduces water into the pressurized air delivered to a user during various positive airway pressure therapies and corresponding methods. The respiratory therapy apparatus may be configured to administer one or more positive airway pressure therapies, including: continuous positive airway pressure therapy (CPAP), hi-level positive airway pressure therapy (BPAP), auto positive airway pressure therapy (autoPAP), proportional positive airway pressure therapy (PPAP), and/or other positive airway pressure therapies. The respiratory therapy apparatus may include a user interface that defines an interface passage to communicate pressurized air to the user for inhalation and a humidifier that introduces water into the pressurized air generally at the interface passage. Methods may include introducing water into the interface passage at one or more humidifier ports disposed about the interface passage.

Abstract: A mass spectrometry method includes a step of atomizing liquid including a sample using an ultrasonic transducer; a step of transferring the atomized liquid; a step of generating ions from the transferred liquid using a DART ion source; and a step of analyzing a mass spectrometry by introducing the generated ions into a mass spectrometer.

Abstract: An aerosol generation system (and method) comprises an aerosol generating device (1) for generating an aerosol output (2) and controller (12) for controlling the generating device (1) using a generator drive signal. An aerosol density detector (6,9) is used. A time delay measurement device (13) is adapted to derive a timing measurement based on the generator drive signal and the aerosol density detector output, wherein the timing measurement and the aerosol density are combined to derive an aerosol output rate.

Abstract: There is provided a control unit for controlling the operation of a nebulizer, the nebulizer comprising a reservoir chamber for storing a liquid to be nebulised, an actuator, and a nebulizing element comprising a plurality of nozzles arranged to nebulize the liquid upon operation of the actuator; wherein the control unit is configured to obtain an indication of the size of the nozzles in the nebulizing element; and control the operation of the actuator based on the obtained indication to provide nebulised liquid at a required output rate and/or with droplets of a required size.

Abstract: Methods and devices for stimulating nerves are disclosed. In one embodiment adapted for stimulating excitable tissue, the invention includes drive circuitry, an acoustic transducer and a pair of electrodes.

Abstract: A humidifier assembly for a CPAP includes a base housing with a gas inlet configured to receive respiratory gas from the CPAP unit. The base housing includes a first connecting device located at a sidewall of the base housing and configured to directly, removably connect the base housing to the CPAP unit. The base housing also includes a second connecting device configured to be coupled to an air delivery hose. The humidifier assembly further includes a liquid storage container that is removably received in the base housing. The liquid storage container includes a liquid storage space configured to store liquid and a humidifying region configured to receive the respiratory gas from the gas feed opening and receive a partial amount of the liquid stored in the liquid storage space to enrich the respiratory gas with moisture.

Abstract: A pressure support device includes a humidification system (10) to control the humidity of a pressurized flow of breathable gas generated by the pressure support device. The humidification system includes a liquid storage chamber (32) and a humidification chamber (34). When in an operational orientation, liquid travels from the liquid storage chamber to the humidification chamber through a serpentine feed path (38) due to gravity. The serpentine shape of feed path halts the flow of liquid responsive to the device being tilted out of an operational orientation.

Abstract: A mist generator device includes a mist generation unit that generates mist from a liquid. A mist flow passage is connected to the mist generation unit. The mist from the mist generation unit flows through the mist flow passage. A tubular mist nozzle releases the mist, which is supplied from the mist generation through the mist flow passage, out of the mist generator device. The mist nozzle includes a mist entrance, a mist exit, and an inner constriction located at an inner side of the mist nozzle. The inner constriction includes a step that decreases an inner diameter of the mist nozzle from the mist entrance toward the mist exit.

Abstract: A recovery and collection assembly for an atomized material inhalation device is provided. The recovery and collection assembly includes an outer tubular housing and an input tube. The outer tubular housing includes a sidewall defining an outer chamber, an upper end piece attached to an upper end of the sidewall, and a lower end piece attached to a lower end of the sidewall. The lower end piece has at least one air flow opening allowing fluid communication between an interior of the outer chamber and an atmosphere surrounding the outer tubular housing. The input tube extends through the lower end piece and has a first end in fluid communication with the atomized material inhalation device. The input tube also has a second end disposed in an upper half of the outer chamber and in fluid communication with the outer chamber and defines an inner chamber.

Abstract: Methods and devices for stimulating nerves are disclosed. In one embodiment adapted for stimulating excitable tissue, the invention includes drive circuitry, an acoustic transducer and a pair of electrodes.

Abstract: A dental ultrasonic drug delivery system capable of accurately cleaning the inside of root canals and killing bacteria in dentin tubules is provided. The dental ultrasonic drug delivery system delivers a drug to a target using an ultrasonic delivery device 800 . The drug is delivered in a mixed state with nanobubbles. A dental therapeutic probe for applying ultrasound is attached to the ultrasonic delivery device 800 . The dental therapeutic probe is selected from: (1) a root canal insertion probe 100 which is configured to be inserted into a root canal and causes ultrasound to propagate in the root canal; (2) a dental caries therapeutic probe which causes ultrasound to propagate in a dental caries portion; (3) a periodontal disease therapeutic probe which applies ultrasound to a periodontal disease portion; and (4) a hyperesthesia therapeutic probe which applies ultrasound to hyperesthesia portion.

Abstract: The present application relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. The method involves: (a) heating a substrate coated with a composition of a drug to form a vapor, wherein the coated composition is in the form of a film less than 10? thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another aspect, a method of forming an aerosol for use in inhalation therapy is provided, wherein the method involves: (a) heating a substrate coated with a composition of a drug to form a vapor in less than 100 milliseconds, wherein the vapor has a mass greater than 0.1 mg; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy.

Abstract: In a known device for sterilization by ultraviolet radiation, a UV radiator (4) is arranged in a housing (2) made of metal or plastic, which has a radiation outlet window (3) for the emission of UV radiation. The radiation outlet window is covered by a polymer film (7) transparent to ultraviolet radiation. Proceeding from this background, in order to provide a reliable and operationally safe device for sterilization, it is proposed that the housing (2) have a gas inlet (22) for introduction of a cooling gas stream as well as a gas outlet (23) for discharging the cooling gas stream, and that the gas outlet (23) be connected to a measuring sensor (17; 18, 20, 21) for measuring the pressure, mass flow rate, and/or volumetric flow rate of the discharged cooling gas stream.

Abstract: A dispenser head for a fluid dispenser device, the head including a hollow body (30, 130, 230) that defines a fluid passage between an inlet orifice (32, 132, 232) and a spray orifice (31, 131, 231); vibration generator means (40, 140, 240) being arranged in said passage upstream from said spray orifice (31, 131, 231), said vibration generator means (40, 140, 240) being actuated while fluid is passing so as to spray said fluid finely through said spray orifice (31, 131, 231).

Abstract: Embodiments of the present invention relate to a method and apparatus for supplying a fluid, including but not limited to oxygen and/or medications to a non-human animal in a configuration that does not require a human to hold a component on the animal.

Abstract: A portable ultrasonic cosmetic applicator for spraying makeup/sterilants onto the body or face. Eliminates the use of noisy compressors, pressurized cylinders and air lines. Characterized by a small, lightweight device without the use of cumbersome attachments or pumps. Produces a fine misty spray that is easily applied with a smaller and more uniform droplet size than commonly used spray equipment or hand applicators, thus reducing the amount of unused cosmetics.

Abstract: In accordance with non-limiting examples, a nebulizer includes a main body comprising an air channel section and further comprising a mixing chamber and a venturi positioned to be placed within the patient's oral cavity and configured to receive medicine and air and mix the medicine and air within the mixing chamber and receive the air flow through the venturi and cause the medicine entering the mixing chamber to be atomized by the action of air flowing through the venturi. An air flow sensor is associated with the main body and configured to measure the air flow created by the patient's one of at least inhaling and exhaling air.

Abstract: Atomizer for a ventilation machine with a ventilator, including a body with a first connection for connecting the atomizer to a ventilator and a second connection for connecting the atomizer to a line leading to a patient, wherein the body forms a flow channel from the first connection to the second connection; and an atomizing device for atomizing a fluid; wherein the atomizing device is disposed between the first connection and the second connection in the flow channel and adapted so that the fluid can be atomized substantially parallel to, and preferably in, the flow direction from the first connection to the second connection.

Abstract: There is provided a nebulizer (2), comprising a first plate (20) configured to hold a transducer (14); a second plate (22) having an aperture therein, the first plate being positioned on a first side of the second plate such that the transducer is adjacent the aperture; and a third plate (24) configured to hold a mesh plate through which liquid can pass to form droplets, the third plate being positioned on a second side of the second plate opposite the first side such that the mesh plate (16) is adjacent the aperture, with the aperture, transducer and mesh plate forming a cavity for holding liquid to be nebulized. A method for manufacturing such a nebulizer is also provided.

Abstract: A liquid spray device includes a container defining a reception space for receiving a liquid medicine therein, having a discharge outlet for discharging the liquid medicine to an exterior of the container; a spray module disposed in the discharge outlet, and connected electrically to a driving source such that the liquid medicine forcefully collides against the discharge outlet due to ultrasonic oscillation of the spray module and spraying out a plurality of mist droplets; and a particle sorter disposed downstream to a discharging direction of the liquid medicine, spaced from the spray module at a predetermined distance to permit once against collision of the liquid medicine during the discharging operation such that the mist droplets are sprayed out through the particle sorter in terms of a plurality of micro-mist droplets along the discharging direction.

Abstract: An aerosol generating device includes a membrane for atomizing a liquid; an actuating device, which is coupled to the membrane so that this membrane is set in oscillatory motion when activated by electric signals; and a flexible substrate, which has electric lines for supplying electric signals to the actuating device and is designed for fastening the aerosol generating device to a fastening area of an inhalation therapy unit, and on which the membrane and the actuating device are held.

Abstract: A photo-resist (21) is applied in a pattern of vertical columns having the dimensions of holes or pores of the aperture plate to be produced. This mask pattern provides the apertures which define the aerosol particle size, having up to 2500 holes per square mm. There is electro-deposition of metal (22) into the spaces around the columns (21). There is further application of a second photo-resist mask (25) of much larger (wider and taller) columns, encompassing the area of a number of first columns (21). The hole diameter in the second plating layer is chosen according to a desired flow rate.

Abstract: An aerosolization system includes a container that is configured to deliver a unit dosage of a liquid when squeezed a single time. The system also includes an aerosolizer that is constructed of a housing defining a mouthpiece, and an aerosol generator disposed in the housing. The aerosol generator includes a vibratable membrane having a front face and a rear face, and a vibratable element used to vibrate the membrane. Further, the housing includes an opening that is adapted to receive a unit dosage of the liquid from the container. The opening provides a liquid path to the rear face of the vibratable membrane.

Abstract: A nebulizer includes a piezoelectric transducer for aerosolizing a drug solution in a disposable cup module disposed above the transducer. Acoustic waves generated by the transducer propagate sequentially through transmitting medium, a first barrier, coupling medium, and a second barrier that forms part of the cup module, and into the interior of the cup module. The transducer at least partially comprises silver. The silver fluidly contacts the transmitting medium to discourage bacteria growth in the transmitting medium. The device includes electronics components that drive the transducer and measure an electrical characteristic associated with the transducer during operation. The electronics components measures changes in the electrical characteristic to determine when the drug solution level falls below a predetermined threshold, and deactivates the device accordingly.

Abstract: A nebulizer includes a medicament storage module and a nebulizing unit. The medicament storage module includes an inclined bottom wall, a tubular sidewall, and a guiding part. The inclined bottom wall is inclined at an inclination angle. The tubular sidewall is connected with a periphery of the inclined bottom wall. A storage chamber is defined by the inclined bottom wall and the tubular sidewall collaboratively, and a liquid medicament is accommodated within the storage chamber. The tubular sidewall has an outlet, and the inclined bottom wall is extended downwardly to the outlet. The guiding part is arranged around a junction between the inclined bottom wall and the tubular sidewall. The nebulizing unit is disposed on the medicament storage module and aligned with the outlet. The liquid medicament outputted from the outlet is nebulized into a plurality of mist droplets by the nebulizing unit.

Abstract: A drug package comprising a plurality of drug vials containing drugs for delivery to a patient in a drug delivery device; and a data carrier including drug treatment information for use by the drug delivery apparatus.

Abstract: Methods, compositions, and medical device systems relating to treating exercise-induced pulmonary hemorrhage (EIPH) and nasopharyngeal cicatrix (NC) in a mammal. For example, one method comprises administering through inhalation a composition comprising a physiologically acceptable carrier and an effective amount of each of one or more stem cell derived factors. Exemplary stem cell derived factors include, but are not limited to, growth factors, chemokines, and cytokines. The mammal may be a horse, dog, camel, or Homo sapiens.

Abstract: An aerosolization system includes a squeezable container having a resilient container body. The container is configured to deliver a unit dosage of a liquid when squeezed a single time. The system also includes an aerosolizer that is constructed of a housing defining a mouthpiece, and an aerosol generator disposed in the housing. The aerosol generator includes a vibratable membrane having a front face and a rear face, and a vibratable element used to vibrate the membrane. Further, the housing includes an opening that is adapted to receive a unit dosage of the liquid from the container. The opening provides a liquid path to the rear face of the vibratable membrane.

Abstract: There is provided a method of determining whether a first type of liquid is being used in a nebulizer, the method comprising obtaining a measurement of the time taken by the nebulizer to nebulize a specified volume of liquid that was held therein, comparing the time taken to nebulize the specified volume of liquid to an estimated value for the time required to nebulize the same volume of the first type of liquid, and determining whether the liquid nebulized by the nebulizer was the first type of liquid based on the comparison.

Abstract: A nebulizer device including a mesh aerosol generator combined with an inhalation chamber formed with three openings and a single one-way expiratory valve, a first opening being connected to the patient and used for the transport and administration of the particles from the device to the patient, the said first opening being placed upstream of the aerosol generator, a second opening placed upstream of the device aerosol generator allowing the passage of air from the outside of the chamber to the inside of the inhalation chamber, and allowing the complete ventilation of the inside of the inhalation chamber, a third opening, placed downstream of the aerosol generator and upstream of the said first opening, provided with a single one-way expiratory valve allowing the exhalation of the air from the patient through this third opening, the said third opening being closed by means of the one-way expiratory valve during the inhalation phases and open during the exhalation phases, and whereby the resistance of the sai

Abstract: A method of safely delivering an ophthalmic fluid to an eye, the method including targeting the eye with an ophthalmic fluid misting device and activating an ultrasonic generator to deliver the ophthalmic fluid from the ophthalmic fluid misting device across a space between the misting device and the eye. The method further including maintaining a momentum of the ophthalmic fluid that is insufficient to trigger at least one of the ocular blink reflex and the lacrimation reflex of the eye.

Abstract: An alpha1-proteinase inhibitor delays the onset or progression of pulmonary exacerbations. In addition, methods delay the onset or diminish the progression of pulmonary exacerbations by the administration of inhaled alpha1-proteinase inhibitor.

Abstract: A pharmaceutical aerosol is disclosed which is suitable for delivering an active compound to the mucosa of the nose, the osteomeatal complex or a paranasal sinus. The pressure of the aerosol is not constant, but pulsates at a frequency from about 10 to 90 Hz. The aerosol is further characterised in that it exhibits a low effective flow rate of less than about 5 litres per minute. The aerosol is, inter alia, suitable for the prevention, management, or treatment of a disease, symptom, or condition affecting the nose or the paranasal sinuses, such as acute and chronic sinusitis.

Abstract: An inhalation device having a base unit, a mouthpiece, and an aerosol head is provided. The base unit has an air inlet, an air outlet opening, a groove for receiving the mouthpiece, and key lock member(s). The mouthpiece has two segments: a first segment which is insertable into the groove of the base unit and has an air inlet opening and a lateral opening for receiving an aerosol generator and a second segment with an aerosol outlet. The aerosol head has an aerosol generator, a liquid reservoir, and key lock member(s) complementary to those of the base unit. The base unit, mouthpiece and aerosol head are connectible with one another such that when engaging the members of the key lock with the complementary members, the aerosol generator is inserted into the lateral opening of the mouthpiece.

Abstract: The invention provides an inhalation device for enabling a user to inhale at a desired inspiratory flow rate and/or pressure, comprising a feedback system configured to indicate to a user by means of a signal during an inhalation manoeuvre whether an inhalation parameter, such as the inspiratory flow rate, is within a predefined target range. The signal may be an optical or a non-optical signal, such as a light signal, an acoustic signal, or a tactile signal.

Abstract: A nebulizer assembly configured for removable attachment to an ultrasonic actuator includes a base plate portion, a porous mesh member, and a cover member. The base plate portion includes an opening extending therethrough, and is substantially rigid such that ultrasonic vibrations from the ultrasonic actuator may be transmitted through the base plate portion to the porous mesh member to vibrate the porous mesh member. The porous mesh member is configured for passage therethrough of a nebulized fluid, and is disposed in the opening of the base plate portion proximate a fluid emission side of the nebulizer assembly. The cover member is disposed on a second side of the nebulizer assembly opposite the fluid emission side. The cover member covers the opening and defines a cavity between the cover member and the porous mesh member. The cavity is configured to retain a fluid to be nebulized.

Abstract: There is provided a method of operating a nebulizer, the method comprising controlling an actuator in the nebulizer to operate in a pulsed operation mode; measuring the sound produced by the nebulizer during operation; and using the measurement of the sound as an indication of the performance of the nebulizer. A control unit for a nebulizer that is configured to perform this method is also described.

Abstract: A drug delivery apparatus includes a mouthpiece portion having an internal conduit for delivering an aerosol including the drug to the patient. The internal conduit has an inlet end and a mouthpiece end that is structured to be received in the patient's mouth. The mouthpiece portion is structured to operate at a substantially fixed inhalation flow rate when the patient inhales through the mouthpiece end. The apparatus further includes an aerosol generator for generating the aerosol from a drug supply and injecting the aerosol into a first region within the mouthpiece portion located between an outlet of the aerosol generator and the inlet end of the conduit. The mouthpiece portion also includes a flow accelerating mechanism that causes a localized flow rate at the first region to be greater than the inhalation flow rate. A method is also provided that increases the local flow rate within the mouthpiece portion.

Abstract: A pharmaceutical aerosol is disclosed which is suitable for delivering an active compound to the mucosa of the nose, the osteomeatal complex or a paranasal sinus. The pressure of the aerosol is not constant, but pulsates at a frequency from about 10 to 90 Hz. The aerosol is further characterized in that it exhibits a low effective flow rate of less than about 5 liters per minute. The aerosol is, inter alia, suitable for the prevention, management, or treatment of a disease, symptom, or condition affecting the nose or the paranasal sinuses, such as acute and chronic sinusitis.

Abstract: A method and a composition for treatment of pulmonary bacterial infections caused by gram-negative bacteria suitable for treatment of infection caused by Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Pseudomonas aeruginosa, Haemophilus influenzae, Proteus mirabilis, Enterobacter species, Serratia marcescens as well as those caused by Burkholderia cepacia, Stenotrophomonas maltophilia, Alcaligenes xylosoxidans, and multidrug resistant Pseudomonas aeruginosa, using a concentrated formulation of aztreonam lysinate delivered as an aerosol or dry powder formulation.

Abstract: A combined medication and training mask for an animal includes a body, a mask module and a plenum module. A cavity is provided in a terminal end of the mask module. A nebulizer is received in that cavity.