Means For Supplying, Or Permitting Inhalation Of, Separate Streams Of Treating Agent/respiratory Gas Mixture Through Nasal Passages Patents (Class 128/203.22)
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Publication number: 20140150789Abstract: The present invention generally relates to, amongst other things, systems, devices, materials, and methods that can improve the accuracy and/or precision of nitric oxide therapy by, for example, reducing the dilution of inhaled nitric oxide (NO). As described herein, NO dilution can occur because of various factors. To reduce the dilution of an intended NO dose, various exemplary nasal cannulas, pneumatic configurations, methods of manufacturing, and methods of use, etc. are disclosed.Type: ApplicationFiled: December 4, 2013Publication date: June 5, 2014Applicant: INO Therapeutics LLCInventors: Craig Flanagan, Simon Freed, John Klaus, Thomas Kohlmann, Martin D. Meglasson, Manesh Naidu, Parag Shah
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Publication number: 20140144442Abstract: A delivery device for and method of providing for delivery of substance to the central nervous system (CNS) of a subject, the delivery device comprising: a nosepiece unit for insertion into a nasal airway of a subject and comprising an outlet unit which includes a nozzle for delivering substance into the nasal airway of the subject; and a substance supply unit which is operable to deliver a dose of substance to the nozzle; wherein the delivery device is configured such that at least 30% of the dose as initially deposited in the nasal airway is deposited in an upper posterior region of the nasal airway, thereby providing a CNS concentration of the substance, and hence CNS effect, which is significantly greater than that which would be predicted from a counterpart blood plasma concentration of the substance.Type: ApplicationFiled: January 29, 2014Publication date: May 29, 2014Applicant: OptiNose ASInventors: Per Gisle Djupesland, Peter Roderick Hafner
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Publication number: 20140083424Abstract: A nozzle for use in delivering a mixture of aerosol propellant and drug formulation. The nozzle includes a drug product inlet configured to receive a mixture of aerosolized propellant and an intranasal dosage form. The inlet is disposed at the proximal end. A nozzle body is secured to the drug product inlet. Two or more channels are disposed within the body. Two or more orifice apertures are disposed at the distal end of the nozzle.Type: ApplicationFiled: November 8, 2013Publication date: March 27, 2014Applicant: Impel NeuroPharma Inc.Inventors: John D. Hoekman, Michael Hite, Alan Brunelle, Joel Relethford
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Publication number: 20140060536Abstract: A nasal delivery device and a method of delivering substance to a nasal airway of a subject can be used for mass treatment, especially mass vaccination. The delivery device can include an interface unit, as a replaceable unit, having at least one nosepiece unit for fitting to a respective nostril of a subject, a nozzle from which substance is in use delivered, and at least one delivery unit having a substance supply unit for delivering substance to the nozzle of the at least one nosepiece unit. The delivery device can also include an actuation unit for actuating the at least one delivery unit of the interface unit.Type: ApplicationFiled: March 5, 2013Publication date: March 6, 2014Applicant: OPTINOSE ASInventor: Per Gisle Djupesland
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Patent number: 8616203Abstract: A patient interface for communicating fluids to and/or from a patient's nasal cavity and/or oral cavity is disclosed. In addition, a patient interface for fluid and physiological function monitoring proximate to the patient's nasal cavity and/or oral cavity is disclosed. An apnea monitor and a method for monitoring apnea are also disclosed.Type: GrantFiled: April 20, 2012Date of Patent: December 31, 2013Assignee: Ric Investments, LLCInventors: Michael B. Jaffe, Ivan Bustamante, Kimberly A. Golden, Randall J. Terry, Patrick Tuxbury, John A. Triunfo, Jr., Anthony T. Pierry, Gregory Kenny, Anthony Pannozzo, John Depiano, Julia Rose Anderson, Eric Hyman, Deirdre McKeown
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Patent number: 8609043Abstract: The present invention relates to the use of a container, made of an inorganic additive containing plastic material, for reducing physical/chemical interaction between the container and an oil, fat and/or wax containing formulation contained therein.Type: GrantFiled: August 6, 2012Date of Patent: December 17, 2013Assignee: M & P Patent AktiengesellschaftInventor: Claudia Mattern
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Patent number: 8590530Abstract: A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a container-receiving unit comprising a container chamber for receiving a substance-containing container which contains substance to be delivered to the nasal cavity of the subject, the container chamber including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the container chamber; a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the container chamber and through which the subject in use exhales, such as to entrain substance from the container and deliver the same through the nosepiece; and moisture-mitigation means for mitigating an effect of moisture in an exhaled breath on the entrainment of substance from the container.Type: GrantFiled: May 14, 2012Date of Patent: November 26, 2013Assignee: OptiNose ASInventors: Per Gisle Djupesland, Roderick Peter Hafner, Colin David Sheldrake
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Patent number: 8555878Abstract: A delivery device (20, 22) for and a method of delivering a substance to the nasal airway (1) of a subject, in particular the posterior region of the nasal airway, the delivery device comprising: a closure unit for causing the closure of the oropharyngeal velum of the subject; and a delivery unit for delivering a gas flow entraining a substance to one of the nostrils of the subject at such a driving pressure as to flow around the posterior margin of the nasal septum and out of the other nostril of the subject, wherein the delivery unit comprises a nosepiece (30, 40, 58, 82, 102, 132) which includes an outlet through which the gas flow is in use delivered to the one nostril and a sealing member for sealing the one nostril to the outlet such as in use to prevent the escape of the gas flow through the one nostril.Type: GrantFiled: June 2, 2006Date of Patent: October 15, 2013Assignee: OptiNose ASInventor: Per Gisle Djupesland
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Patent number: 8555877Abstract: A delivery device (20, 22) for and a method of delivering a substance to the nasal airway (1) of a subject, in particular the posterior region of the nasal airway, the delivery device comprising: a closure unit for causing the closure of the oropharyngeal velum of the subject; and a delivery unit for delivering a gas flow entraining a substance to one of the nostrils of the subject at such a driving pressure as to flow around the posterior margin of the nasal septum and out of the other nostril of the subject, wherein the delivery unit comprises a nosepiece (30, 40, 58, 82, 102, 132) which includes an outlet through which the gas flow is in use delivered to the one nostril and a sealing member for sealing the one nostril to the outlet such as in use to prevent the escape of the gas flow through the one nostril.Type: GrantFiled: June 2, 2006Date of Patent: October 15, 2013Assignee: OptiNose ASInventor: Per Gisle Djupesland
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Patent number: 8551454Abstract: Disclosed herein are vials and devices containing a ketorolac solution for intranasal administration and a head space comprising no more than about 10% v/v oxygen and which vials and devices are stored in an oxygen-impermeable pouch. Also disclosed are processes for preparing the vials and devices.Type: GrantFiled: March 11, 2010Date of Patent: October 8, 2013Assignee: Luitpold Pharmaceuticals, Inc.Inventors: Roger Whiting, Ramachandran Thirucote
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Patent number: 8511312Abstract: A respiratory auxiliary device includes a first conduit provided with a pair of nasal prongs and having two opposite end portions, two second conduits connected fluidly and respectively to the end portions, and a pressure-measuring pipe adapted for connection with a pressure-measuring device. One of the second conduits is adapted for discharging air exhaled by a patient. The other one of the second conduits is adapted to be connected to an air supply device. The pressure-measuring pipe is disposed within said one of the second conduits, and has one end extending into the first conduit in proximity to the nasal prongs.Type: GrantFiled: June 29, 2009Date of Patent: August 20, 2013Assignee: Galemed CorporationInventors: Gary C. J. Lee, Shu-Ping Zou, Yi-He Lee
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Patent number: 8464711Abstract: Apparatus, methods, and kits for treating symptoms associated with common ailments, such as headaches, rhinitis, asthma, epilepsy, nervous disorders and the like, are provided. The apparatus comprises dispensers for carbon dioxide and other therapeutic gases. The methods comprise delivering small volumes of these gases to patients in a manner where the gas infuses into a body region in order to bathe the mucous membranes therein. It has been found that even very short exposure of patients to small volumes and high concentrations of such gases can provide significant relief from symptoms.Type: GrantFiled: November 1, 2010Date of Patent: June 18, 2013Assignee: Capnia, Inc.Inventors: Ned S. Rasor, Julia S. Rasor
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Publication number: 20130109992Abstract: A surgical mask for use in dental procedures, and oral or facial surgery, formed of a continuous sheet of flexible material comprising a nose-conforming shell incorporating adhesive material for sealing and for maintaining position on the patient during the dental or surgical procedure. The mask forms an encasement for input/output manifolds, and terminates in flexible flange at the columella-labial junction; the mask includes a manifold for receiving and directing N2O/O2 into the nasal vault of the patient, and for the removal of exhalant and the scavenging of gases from the work area.Type: ApplicationFiled: July 7, 2011Publication date: May 2, 2013Inventor: Robert F. Guyette
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Patent number: 8408211Abstract: A method of intercepting controlled quantities of air exhaled from at least one of two nostrils on an individual's nose to permit inhalation of the intercepted air, including the steps of: providing an air flow intercepting apparatus; and placing the air flow intercepting apparatus in an operative position relative to the individual's nostrils so that as the individual inhales and exhales during repeating breathing cycles: a) a first quantity of exhaled air flows past the air flow intercepting apparatus; and b) a second quantity of exhaled air impinges upon the air flow intercepting apparatus so as to at least one of: i) stagnate; and ii) be redirected by the air flow intercepting apparatus so that at least a portion of the second quantity of exhaled air is drawn into the individual's nostrils as the individual inhales.Type: GrantFiled: December 11, 2009Date of Patent: April 2, 2013Inventor: Ruthanna DeJule
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Patent number: 8327844Abstract: A delivery device (20, 22) for and a method of delivering a substance to the nasal airway (1) of a subject, in particular the posterior region of the nasal airway, the delivery device comprising: a closure unit for causing the closure of the oropharyngeal velum of the subject; and a delivery unit for delivering a gas flow entraining a substance to one of the nostrils of the subject at such a driving pressure as to flow around the posterior margin of the nasal septum and out of the other nostril of the subject, wherein the delivery unit comprises a nosepiece (30, 40, 58, 82, 102, 132) which includes an outlet through which the gas flow is in use delivered to the one nostril and a sealing member for sealing the one nostril to the outlet such as in use to prevent the escape of the gas flow through the one nostril.Type: GrantFiled: March 30, 2004Date of Patent: December 11, 2012Assignee: OptiNose ASInventor: Per Gisle Djupesland
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Patent number: 8277781Abstract: Disclosed herein are devices and processes for preparing a vial for an intranasal administration of a medicament where the vial comprises reduced oxygen content.Type: GrantFiled: March 13, 2009Date of Patent: October 2, 2012Assignee: Luitpold Pharmaceuticals, Inc.Inventors: Roger Whiting, Ramachandran Thirucote
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Patent number: 8251058Abstract: Various embodiments of the invention may provide a breathing and/or anesthetic unit that is portable, compact, inexpensive, and convenient, and which may expedite medical procedures by allowing a health care provider to quickly sedate a patient. Such a unit may be ideal for minor medical procedures needing mild or moderate analgesia/sedation (e.g., <30 minutes) in various fields. Such a unit may include (i) a handheld gas supply container including a therapeutic amount of anesthetic gas; (ii) a mask; (iii) a single-use, uninterruptable flow coupler to couple the mask to the supply container; and (iv) a handheld, self-contained, recovery gas container, including a negative pressure, coupled to the mask.Type: GrantFiled: September 29, 2009Date of Patent: August 28, 2012Inventor: Erin Bird
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Patent number: 8251061Abstract: A gas therapy system involves sensing the blood gas concentration of the patient and adapting a gas therapy based on the sensed gas concentration. Disordered breathing may be detected bases on blood gas concentration, and gas or cardiac electrical therapy may be adapted to treat the detected disordered breathing. One or more of sensing the blood gas concentration, detecting disordered breathing, or adapting the therapy may be performed at least in part implantably. The gas therapy is delivered to the patient through an external respiratory device, such as a positive airway pressure device.Type: GrantFiled: August 30, 2004Date of Patent: August 28, 2012Assignee: Cardiac Pacemakers, Inc.Inventors: Kent Lee, Jesse W. Hartley, Jeffrey E. Stahmann, Quan Ni
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Patent number: 8191552Abstract: A method and apparatus for nasal drug delivery comprises a first tube in fluid communication with a means for generating a negative pressure and a second tube in fluid communication with an aerosol. The first tube is contacted with one nostril, the said second tube is contacted with the other nostril, and a negative pressure is applied to the first tube, producing a negative pressure within a nasal cavity and causing the aerosol to be drawn into the nasal passages and to deposit on an internal nasal surface.Type: GrantFiled: November 13, 2009Date of Patent: June 5, 2012Assignees: CFD Research Corporation, Centers For Disease Control and PreventionInventors: Andrzej Przekwas, Vincent Harrand, Mark Papania
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Patent number: 8181646Abstract: An aerosol inhalation system includes a first conduit member for delivering medication in the form of aerosol particles to a patient. The system also includes a first device in fluid communication with the first holding chamber for producing the aerosol particles and being sealingly yet releasably received within an adapter that forms an entrance into a first holding chamber. The adapter has a compressible material disposed thereon which is at least partially compressed by insertion of the first device to form the seal between the first device and the adapter, thereby creating a closed system that is therefore capable of delivering a fixed concentration of the medication to the patient due to a valve of the valve mechanism being closed when the patient inhales and the medication is delivered to the patient.Type: GrantFiled: December 14, 2010Date of Patent: May 22, 2012Assignee: Aeon Research and Technology, Inc.Inventors: Sunil Kumar Dhuper, Herbert Fred D'Alo
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Patent number: 8161971Abstract: A patient interface for communicating fluids to and/or from a patient's nasal cavity and/or oral cavity is disclosed. In addition, a patient interface for fluid and physiological function monitoring proximate to the patient's nasal cavity and/or oral cavity is disclosed. An apnea monitor and a method for monitoring apnea are also disclosed.Type: GrantFiled: August 1, 2007Date of Patent: April 24, 2012Assignee: Ric Investments, LLCInventors: Michael B. Jaffe, Ivan Bustamante, Kimberly A. Golden, Randall J. Terry, Patrick Tuxbury, John A. Triunfo, Jr., Anthony T. Pierry, Gregory Kenny, Anthony Pannozzo, John DePiano, Julia Rose Anderson, Eric Hyman, Deirdre McKeown
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Patent number: 8146589Abstract: A nasal delivery device (11) for delivering substance to a nasal airway (1) of a subject, comprising: first and second nosepiece units (17, 19), each including a nosepiece (21, 23) for fitting to respective nostrils of a subject; at least one substance supply unit (13, 15) for supplying substance for delivery to the nasal airway (1) of the subject; and a valve unit (35, 37) for selectively fluidly connecting the at least one substance supply unit (13, 15) alternately to respective ones of the nosepiece units (17, 19).Type: GrantFiled: March 28, 2003Date of Patent: April 3, 2012Assignee: OptiNose ASInventor: Per Gisle Djupesland
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Patent number: 8096301Abstract: The present invention relates to a device for delivering a supply of gases to a patient. The device includes a patient interface and connecting member. The connecting member is preferably a L-shaped swivelled connector that is capable of being fixed into one of two positions, a first position where the connector is freely rotatable within the patient interface, and a second position where an interference between the interface and connector prevents the free rotation of the connector within the patient interface. The present invention further relates to a connector that has outlet means, which includes at least one outlet vent and a funnel, which in use directs and passes a substantial portion gases expired from the patient through the outlet vent or vents.Type: GrantFiled: December 4, 2009Date of Patent: January 17, 2012Assignee: Fisher & Paykel Healthcare LimitedInventors: Nicholas Charles Alan Smith, Lewis George Gradon, Alastair Edwin McAuley, Christopher Earl Nightingale, Ivan Milivojevic
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Patent number: 8025050Abstract: A nebulizer and cartridge structure thereof for use in a nebulization apparatus comprises a first cartridge accommodation space and a second cartridge accommodation space. The first cartridge accommodation space includes at least one connection bottom, and the second cartridge accommodation space includes at least one connection side. Moreover, the second cartridge accommodation space is disposed under a lower connection position of the first cartridge accommodation space. The connection bottom is connected to the connection side to form an included angle that can be a lead angle. The lead angle further includes a fillet angle or a chamfering angle. Accordingly, the nebulizer and the cartridge structure can efficiently reduce the residues of liquid medicament.Type: GrantFiled: November 13, 2006Date of Patent: September 27, 2011Assignee: Health & Life Co., Ltd.Inventors: Shan-Yi Yu, Han-Chang Liu
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Patent number: 7987850Abstract: An infant nasal interface prong device for use with an nCPAP system. The device includes first and second nasal prongs and a base. Each prong includes a bellows segment, a tip, and a lumen. The tip extends from the bellows segment to a tip end and is adapted for insertion with an infant's naris. The lumen extends through the tip and the bellows segment. In an undeflected state, a central axis of the lumen along the bellows segment is transversely offset from the lumen axis at the tip end. The base is connected to each of the nasal prongs and is adapted for coupling to a CPAP generator. The bellows segment renders the corresponding prong highly flexible relative to the base. The offset positioning of the tip end promotes desired positioning of the base/CPAP generator, relative to the patient and more closely conforms to the expected nasal anatomy.Type: GrantFiled: January 5, 2010Date of Patent: August 2, 2011Assignee: CareFusion 2200, Inc.Inventors: Chris Zollinger, Brian Pierro
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Patent number: 7975690Abstract: The present invention relates to a nasal delivery device for and a method of delivering a substance, in particular one of a liquid, as a suspension or solution, or a powder containing a medicament, especially systemic or topical pharmaceuticals, or a vaccine to the nasal airway of a subject.Type: GrantFiled: June 12, 2002Date of Patent: July 12, 2011Assignee: OptiNose ASInventor: Per Gisle Djupesland
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Patent number: 7958890Abstract: A dry powder inhaler has a dispersion chamber containing beads. A dose of dry powder is released into the chamber, or into an inlet tangentially joining into the chamber. As the patient inhales on a nosepiece or mouthpiece, air moves circularly through the dispersion chamber to drive the beads. The beads roll, bounce, and collide repeatedly with the drug particles on the chamber surfaces or on the beads. The smaller active drug particles are separated from larger carrier particles and from each other, and a powder aerosol is created and inhaled by the patient. The beads are preferably lightweight, so that they can be rapidly accelerated and moved, even with nominal inspiration. The flow resistance of the inhaler is also reduced via the beads, allowing greater airflow and powder dispersion, without any increased effort by the patient.Type: GrantFiled: December 4, 2008Date of Patent: June 14, 2011Assignee: Quadrant Technologies LimitedInventors: Andrew W. Gieschen, Michael Ligotke, Jeffrey Chen, Charles F. Ganem, Bernard Greenspan
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Patent number: 7934498Abstract: A device and method for facilitating the delivery of medication/humidity to a patient without breaking a ventilator circuit that contains a two-position flow control valve in the circuit, so as to permit manual switching from a first position in which humidified air/oxygen will be supplied to a patient and a second position in which atomized medication will be supplied to the patient.Type: GrantFiled: November 13, 2006Date of Patent: May 3, 2011Inventor: Robert Heidelberger
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Patent number: 7921846Abstract: A heat and moisture exchanger for both conducting a stream of air produced by a ventilator to a moisturizing medium and internally bypassing the moisturizing medium if aerosolized medication is introduced into the stream includes a housing having a ventilator-side port coupled to an outlet of a ventilator and a source of aerosolized medication. The housing has a patient-side port for coupling to a patient to provide ventilation including either air or air carrying aerosolized medication. A first path conducts air from the ventilator-side port through the moisturizing medium and the patient-side port, and a second path conducts air carrying aerosolized medication from the ventilator-side port directly to the patient-side port. A two-way valve mechanism in the housing selectively couples the ventilator-side port into fluid communication with one or the other of the first and second paths.Type: GrantFiled: February 1, 2008Date of Patent: April 12, 2011Assignee: Thayer Medical CorporationInventors: Gregory S. Marler, David T. Sladek
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Patent number: 7861717Abstract: The invention relates to a gas-supply system for patients receiving artificial respiration or breathing spontaneously, in which one or several gases (for example NO, oxygen) are added to the respiration gas at varying proportions (continuously or intermittently) by means of a control device (program control, sensor control or combined program/sensor control). This gas-supply system allows for adaptive dosing of the gas to suit individual patients.Type: GrantFiled: December 16, 2003Date of Patent: January 4, 2011Assignee: INO Therapeutics GmbHInventor: Christian Krebs
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Patent number: 7856979Abstract: Described herein are nasal respiratory devices and methods for treating a variety of medical diseases including snoring and sleep apnea through the use of such devices. In general, these devices include an airflow resistor, such as a flap valve and a holdfast for securing the device in communication with the subject's nasal cavity. The devices may be configured to include leak paths to regulate the expiratory pressure when worn by a subject. Methods for using these devices may include securing a device over or at least partially within (or both of) a subject's nasal cavities.Type: GrantFiled: May 22, 2007Date of Patent: December 28, 2010Assignee: Ventus Medical, Inc.Inventors: Rajiv Doshi, Ryan Kendall Pierce, Bryan Loomas
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Patent number: 7849851Abstract: A nebulizer having an insertable container and a monitoring device for counting actuations of the nebulizer is proposed. The monitoring device is mounted in a detachable housing part and directly detects movements of container during a nebulizing process, an air supply current in the region of a mouthpiece, and/or the production of aerosol, in order to detect this as the actual dispensing of fluid and actuation of the nebulizer, while preferably the time of actuation of the nebulizer is additionally detected and stored. This allows better monitoring and guidance for the user.Type: GrantFiled: February 24, 2005Date of Patent: December 14, 2010Assignee: Boehringer Ingelheim International GmbHInventors: Bernd Zierenberg, Klaus Noehl, Johannes Geser, Gilbert Wuttke, Stefan Kaulmann, Hubert Kunze, Andreas Fiol
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Patent number: 7845347Abstract: Apparatus, methods, and kits for treating symptoms associated with common ailments, such as headaches, rhinitis, asthma, epilepsy, nervous disorders and the like, are provided. The apparatus comprises dispensers for carbon dioxide and other therapeutic gases. The methods comprise delivering small volumes of these gases to patients in a manner where the gas infuses into a body region in order to bathe the mucous membranes therein. It has been found that even very short exposure of patients to small volumes and high concentrations of such gases can provide significant relief from symptoms.Type: GrantFiled: July 10, 2006Date of Patent: December 7, 2010Assignee: Capnia, Inc.Inventors: Ned S. Rasor, Julia S. Rasor
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Patent number: 7845348Abstract: Apparatus, methods, and kits for treating symptoms associated with common ailments, such as headaches, rhinitis, asthma, epilepsy, nervous disorders and the like, are provided. The apparatus comprises dispensers for carbon dioxide and other therapeutic gases. The methods comprise delivering small volumes of these gases to patients in a manner where the gas infuses into a body region in order to bathe the mucous membranes therein. It has been found that even very short exposure of patients to small volumes and high concentrations of such gases can provide significant relief from symptoms.Type: GrantFiled: July 10, 2006Date of Patent: December 7, 2010Assignee: Capnia, Inc.Inventors: Ned S. Rasor, Julia S. Rasor
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Patent number: 7841337Abstract: A breath-actuated nasal delivery device, comprising: a mouthpiece through which a user in use exhales to actuate the delivery device; a nosepiece for fitting to a nostril of the user through which a substance is in use delivered; a substance supply unit actuatable to deliver a dose of a substance through the nosepiece; a loading unit operable to load the substance supply unit with an actuation force; and a release mechanism for enabling actuation of the substance supply unit in response to exhalation by the user through the mouthpiece; wherein the release mechanism comprises a locking unit which is movable: between a locking configuration in which the substance supply unit is locked in a non-actuated position when loaded by the loading unit and a release configuration in which the substance supply unit is actuatable by the loading unit, and a trigger member for releasing the locking unit from the locking configuration to the release configuration in response to exhalation by the user through the mouthpiece anType: GrantFiled: September 6, 2002Date of Patent: November 30, 2010Assignee: Optinose ASInventor: Per Gisle Djupesland
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Patent number: 7836883Abstract: Apparatus, methods, and kits for treating symptoms associated with common ailments, such as headaches, rhinitis, asthma, epilepsy, nervous disorders and the like, are provided. The apparatus comprises dispensers for carbon dioxide and other therapeutic gases. The methods comprise delivering small volumes of these gases to patients in a manner where the gas infuses into a body region in order to bathe the mucous membranes therein. It has been found that even very short exposure of patients to small volumes and high concentrations of such gases can provide significant relief from symptoms.Type: GrantFiled: July 10, 2006Date of Patent: November 23, 2010Assignee: Capnia, Inc.Inventors: Ned S. Rasor, Julia S. Rasor
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Patent number: 7832400Abstract: A nasal cannula comprising a hollow main body having opposed first and second openings formed therein and the main body defining an internal chamber. A partition divides the internal chamber into first and second flow compartments. A flow passageway of a first nasal prong communicates with the first compartment and a flow passageway of the first mouth piece communicates with the first compartment to define a first flow passageway which communicates with both a first nostril and a mouth of the patient. A flow passageway of a second nasal prong communicates with the second compartment and a flow passageway of the second mouth piece communicates with the first compartment to define a second flow passageway which communicates with both a second nostril and the mouth of the patient.Type: GrantFiled: December 13, 2004Date of Patent: November 16, 2010Assignee: Salter LabsInventors: James N. Curti, Peter W. Salter
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Patent number: 7827986Abstract: Apparatus, methods, and kits for treating symptoms associated with common ailments, such as headaches, rhinitis, asthma, epilepsy, nervous disorders and the like, are provided. The apparatus comprises dispensers for carbon dioxide and other therapeutic gases. The methods comprise delivering small volumes of these gases to patients in a manner where the gas infuses into a body region in order to bathe the mucous membranes therein. It has been found that even very short exposure of patients to small volumes and high concentrations of such gases can provide significant relief from symptoms.Type: GrantFiled: September 21, 2006Date of Patent: November 9, 2010Assignee: Capnia, Inc.Inventors: Ned S. Rasor, Julia S. Rasor
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Patent number: 7810495Abstract: A blister pack for use with inhalation therapy inhalers comprises an elongate bottom element having an overlying top element defining a plurality of spaced top crowned areas containing powder or liquid medications or drugs.Type: GrantFiled: June 19, 2006Date of Patent: October 12, 2010Assignee: Microdose Therapeutx, Inc.Inventor: Anand V. Gumaste
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Patent number: 7753991Abstract: A water transport assembly, is provided including a housing having a first chamber therein, which is accessible through an opening in the housing. The housing additionally includes a sample inlet port and a sample outlet port, both of which are in fluid communication with the first chamber. A flat ion exchange membrane is attached to the housing in a plane over the opening in the housing, to seal the opening in a vapor tight seal. Water will pass through the membrane based upon the vapor pressure on each side of the membrane, to either dry or humidify sample passing through the first chamber. When the flat ion exchange membrane is a flat, thin ion exchange membrane it is preferable that the thin ion exchange membrane have a thickness of between about 0.1 and about 3.0 mils.Type: GrantFiled: June 21, 2005Date of Patent: July 13, 2010Assignee: Kertzman Systems, Inc.Inventor: Jack Kertzman
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Publication number: 20100147298Abstract: A fluid delivery device for being secured on an infant pacifier comprises a fluid delivery nozzle configured to direct fluid toward an infant's nares and a nozzle support member secured to the fluid delivery nozzle and configured for being secured on the mouth shield of the pacifier.Type: ApplicationFiled: December 11, 2009Publication date: June 17, 2010Applicant: A PLUS MEDICALInventors: Thomas C. Loescher, Dennis L. Fitzwater
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Patent number: 7708014Abstract: An inhalation device for transpulmonary administration comprises: a chamber (16) for containing a pharmaceutical composition which is pulverized into fine particles by an air-generated impact for dispersal in air; an air inlet flow path (2) for introducing to the chamber (16) outside air to apply the air-generated impact to the pharmaceutical composition and for injecting the outside air toward the pharmaceutical composition; an inhalation flow path (1) for inhaling the pulverized pharmaceutical composition; a housing (9) for accommodating the chamber (16), the air inlet flow path (2), and the inhalation flow path (1); a mouthpiece (10) provided at one end of the housing (9), the mouthpiece (9) being provided with a mouth-side flow path (11) which communicates with the inhalation flow path (1), and an auxiliary flow path (12).Type: GrantFiled: December 12, 2003Date of Patent: May 4, 2010Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Chikamasa Yamashita, Hitoshi Matsushita, Shigeru Ibaragi, Akitsuna Akagi
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Patent number: 7640934Abstract: An infant nasal interface prong device for use with an nCPAP system. The device includes first and second nasal prongs and a base. Each prong includes a bellows segment, a tip, and a lumen. The tip extends from the bellows segment to a tip end and is adapted for insertion with an infant's naris. The lumen extends through the tip and the bellows segment. In an undeflected state, a central axis of the lumen along the bellows segment is transversely offset from the lumen axis at the tip end. The base is connected to each of the nasal prongs and is adapted for coupling to a CPAP generator. The bellows segment renders the corresponding prong highly flexible relative to the base. The offset positioning of the tip end promotes desired positioning of the base/CPAP generator, relative to the patient and more closely conforms to the expected nasal anatomy.Type: GrantFiled: December 2, 2005Date of Patent: January 5, 2010Assignee: CareFusion 2200, Inc.Inventors: Chris Zollinger, Brian Pierro
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Patent number: 7559327Abstract: A ventilation interface device is disclosed that may include a hollow cannula, at least one nasal insert and at least one exhaust port or may include a mask designed to cover a user's nose, mouth or both nose and mouth. The at least one nasal insert may be formed so as to fit in any size nares of any user and may be detachable. Additionally, the at least one exhaust port may be in any of a variety of orientations and, in some embodiments, contain sealable ports.Type: GrantFiled: May 31, 2005Date of Patent: July 14, 2009Assignee: Respcare, Inc.Inventor: Shara Hernandez
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Publication number: 20090159081Abstract: Discharge device for nasal application of medicaments. The invention relates to a discharge device (10) for nasal application of medicaments, with a main body (A) having a contact surface (10b) which, during use, is vertically oriented and is directed toward the face of the user, and with a nosepiece (70) which is arranged in a fixed position with respect to the main body (A) and is designed to be inserted into a nostril of the user, which nosepiece (70) is provided on an upper edge area of the contact surface (10b), protrudes from the contact surface (10b) and has a discharge opening (72). Use as a discharge device that counteracts incorrect use.Type: ApplicationFiled: December 10, 2008Publication date: June 25, 2009Inventor: Peter Stadelhofer
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Patent number: 7540284Abstract: An aerosolization device comprises a chamber adapted to contain a powder pharmaceutical formulation, a lid at least partially covering the chamber, at least one piercing element forcible through the lid to provide access to the powder pharmaceutical formulation, and a shapeable surface extending from the chamber, the shapeable surface being adapted to undergo a shape change to form a conduit. The powder pharmaceutical formulation may be extracted from the chamber by a user inhaling through the conduit. In another version, the lid is removable from the chamber without the need for a piercing element.Type: GrantFiled: June 19, 2002Date of Patent: June 2, 2009Assignee: Novartis Pharma AGInventors: John S. Patton, Michael T. Newhouse
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Publication number: 20090101146Abstract: A nasal delivery device and a method of delivering substance to a nasal airway of a subject can be used for mass treatment, especially mass vaccination. The delivery device can include an interface unit, as a replaceable unit, having at least one nosepiece unit for fitting to a respective nostril of a subject, a nozzle from which substance is in use delivered, and at least one delivery unit having a substance supply unit for delivering substance to the nozzle of the at least one nosepiece unit. The delivery device can also include an actuation unit for actuating the at least one delivery unit of the interface unit.Type: ApplicationFiled: December 19, 2008Publication date: April 23, 2009Inventor: Per Gisle Djupesland
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Patent number: 7513252Abstract: Method and device for scavenging tainted escape gas at a location proximate the patient's mouth (24) before that gas diffuses into, or otherwise reaches the personal breathing space (32, 35) of attending health care providers (38, 39). The scavenging device (50) includes, but is not limited to a suction arrangement (52) suspendable from a patient's nasal mask (40) used for administering gaseous analgesia or anesthetic such as nitrous oxide to the patient (20). A suction inlet (54) is positionable proximate the patient's mouth (24) and an exhaust outlet (56) is provided that is interconnectable with a vacuum source (46).Type: GrantFiled: October 12, 2004Date of Patent: April 7, 2009Inventor: Hakan Berg
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Patent number: 7481218Abstract: A nasal delivery device and a method of delivering substance to a nasal airway of a subject can be used for mass treatment, especially mass vaccination. The delivery device includes an interface unit, as a replaceable unit, having at least one nosepiece unit for fitting to a respective nostril of a subject, a nozzle from which substance is in use delivered, and at least one delivery unit having a substance supply unit for delivering substance to the nozzle of the at least one nosepiece unit. The delivery device also includes an actuation unit for actuating the at least one delivery unit of the interface unit.Type: GrantFiled: July 2, 2003Date of Patent: January 27, 2009Assignee: Optinose ASInventor: Per Glsle Djupesland
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Patent number: RE41298Abstract: The present invention relates to a device for delivering a supply of gases to a patient. The device includes a patient interface and connecting member. The connecting member is preferably a L-shaped swivelled connector that is capable of being fixed into one of two positions, a first position where the connector is freely rotatable within the patient interface, and a second position where an interference between the interface and connector prevents the free rotation of the connector within the patient interface. The present invention further relates to a connector that has outlet means, which includes at least one outlet vent and a funnel, which in use directs and passes a substantial portion gases expired from the patient through the outlet vent or vents.Type: GrantFiled: October 10, 2007Date of Patent: May 4, 2010Assignee: Fisher & Paykel Healthcare LimitedInventors: Nicholas Charles Alan Smith, Alastair Edwin McAuley, Chris Earl Nightingale, Ivan Milivojevic, Lewis George Gradon