Abstract: Described here are stimulation systems and methods for stimulating one or more anatomical targets in a patient for treatment conditions such as dry eye. The stimulation system may include a controller and a microstimulator. The components of the controller and microstimulator may be implemented in a single unit or in separate devices. When implemented separately, the controller and microstimulator may communicate wirelessly or via a wired connection. The microstimulator may generate pulses from a signal received from the controller and apply the signal via one or more electrodes to an anatomical target. In some variations, the microstimulator may include a passive generation circuit configured to generate a pulse based on a signal received from the controller.

Abstract: A surgical instrument includes a catheter, a distal segment, a needle, and a tracking sensor. The catheter is configured to be inserted into an anatomical passageway of a patient and includes a catheter lumen. The distal segment includes a port that communicates with the catheter lumen. The needle is slidably disposed within the catheter lumen and is translatable relative to the catheter between a retracted position and an extended position. A needle distal end is configured to extend through the port when the needle is in the extended position. The tracking sensor is coupled to the needle and is configured to generate a signal corresponding to a location of the needle distal end within the patient.

Abstract: The present disclosure relates to real-time in vivo spectrophotometric analysis of skin tissue. In some implementations, the spectrophotometry is implemented using a wireless microchip with at least one sensor implanted beneath the skin of an individual. The absorption of light at different wavelengths by the skin tissue is correlated to various skin states, revealing transient conditions or pathologies in real time. An external interrogation device is positioned on or adjacent to the surface of the skin and includes one or more energy sources for emitting light of different wavelengths. The external device may provide signals for wirelessly powering the implanted microchip, as well as have communication capabilities for receiving wireless transmissions from the implanted microchip. The sensors on the implantable microchip can be used to measure light intensity attenuated by the skin tissue between the light sources and the sensors.

Abstract: A breast implant system comprises at least one casing with a flexible outer shape for implantation in a patient's body so as to form part of a breast implant and further comprises at least one first element contained in the casing and optionally at least one second element also contained in the casing. The first and second elements are either displaceable within the casing and/or their volume can be changed in order to change the shape and/or size of the breast implant. A reservoir comprising a lubricating fluid is connected to the casing so as to allow lubricating fluid to be supplied to and removed from the casing in order to reduce surface friction between adjacent elements and/or between the casing and the elements before the shape of the breast implant is changed.

Abstract: An implant (1) to be used for the occlusion of bifurcation aneurysms, with the implant (1) having an expanded state in which it is implanted in the blood vessel (Z) and a contracted state in which it is movable through the blood vessel (Z) and a proximal fixing section (3) a distal section (5) where the implant (1) is radially widened relative to the fixing section (3) and which is intended for placement in or in front of the aneurysm (A), and a transition section (4) located between the fixing section (3) and the distal section (5), wherein the implant (1). The implant is composed of interconnected or intersecting filaments (10) originating from the fixing section (3) or distal section (5) which meet centrally in the transition section (4), wherein the filaments (10) in the transition section (4) at least to some extent pass through a sleeve (7).

Abstract: Methods of manufacturing a 3D micro-scale structure. A 2D net including a plurality of panels and a plurality of hinges is provided. The panels are arranged in a pattern. The hinges interconnect immediately adjacent ones of the panels within the pattern. An energy source remote from the 2D net is powered to deliver energy to the 2D net. The delivered energy triggers the 2D net to self-fold into a 3D micro-scale structure. The delivered energy creates an eddy current within at least one component of the 2D net, with the eddy current generating heat sufficient to melt at least one of the hinges. The melting hinge causes the corresponding panels to fold or pivot relative to one another. In some embodiments, the energy source is a microwave energy source. In other embodiments, the energy source delivers a magnetic field.

Abstract: A pacemaker defibrillator system implantable in the intercostal space of a mammalian patient is configured with sensors to sense electrical, mechanical and blood flow activity of the heart from the base to the apex, and the patient position, and to generate corresponding signals responsive to the sensed cardiac situation, as well as to provide instantaneous display of the cardiac situation and the system operational situation using an LCD and multicolor LEDs generating signals which can be seen through the skin of the patient. The system includes at least two flexible electrical generators contoured to conform to the anatomy of the intercostal space and embedded with electrodes for measuring electrical activity, as well as echocardiographic piezoelectric electrodes for measuring mechanical activity of the heart and Doppler blood flow.

Abstract: The present invention is directed to an adherent resorbable matrix for use in surgical applications. The adherent resorbable matrix includes a biocompatible adherent material including chitosan.

Abstract: A skin rejuvenation resurfacing apparatus comprising an oscillating, reciprocating high speed, needle-based device and its related procedure for inducing mechanical trauma to an area of the skin to be treated.

Abstract: In various embodiments methods are provided for delivering an agent of interest (e.g., protein, antibody, nucleic acid) into cells. In certain embodiments the method comprises contacting the cells with anisotropic magnetic particles in the presence of the agent; and applying a substantially uniform magnetic field to said magnetic particles where movement of said particles induced by said magnetic field introduces transient openings into said cell facilitating entry of said agent of interest into said cells.

Abstract: A magnetic field sensor for determining a position of a magnet, the position identified by one or more position variables can include: one or more magnetic field sensing element operable to generate one or more magnetic field measurements of the magnet and an associated one or more measured magnetic field variable values; a first module for identifying calculated magnetic field variable values associated with a plurality of positions of the magnet; a second module operable to perform an optimization process to determine a value of a distance function, the distance function using the one or more measured magnetic field variable values and the calculated magnetic field variable values; and a third module operable to determine the position of the magnet by associating the value of the distance function with corresponding values of the one or more position variables. A complimentary method can be used in the magnetic field sensor.

Abstract: A method includes providing an indwelling tool having a magnetic body at the inside of a luminal organ by inserting the tool into a working channel inserted from a natural opening of a living body to the luminal organ, in a manner such that an axis along a length of the magnetic body is arranged substantially parallel to a length direction of the working channel; disposing the tool in a vicinity of a diseased part of the luminal organ; applying a magnetic field to the magnetic body by using a magnetic field generating device provided at the outside of the luminal organ, so as to attract the magnetic body and make a side face of the magnetic body along the axis thereof push against a tissue in the vicinity of the diseased part; and lifting a tissue around a position of the tool, which includes the diseased part, by applying a magnetic force to the magnetic body by using the magnetic field generating device.

Abstract: Instrumentation for percutaneous delivery of blood filtration devices to atrial appendages includes a curved access sheath and a delivery tube. A compressed filter device attached to a tether wire is loaded in the delivery tube. The access sheath and the delivery tube can be mechanically locked and moved together to place the device in a suitable deployment position. The device is deployed by expelling it from the delivery tube either by retracting the delivery tube over the tether wire, or by moving the tether wire forward through the delivery tube. A filter membrane in the deployed device extends across the appendage ostium to filter blood flow through the ostium. The filter membrane is configured to present a flat surface to atrial blood flow past the ostium.

Abstract: A guidance device includes: a magnetic field generation unit configured to generate the magnetic field; a movement mechanism configured to move the magnetic field generation unit in a vertical direction; a rotation mechanism configured to rotate the magnetic field generation unit in a vertical plane including a magnetization direction of the magnetic field generation unit; an input unit configured to input first operation information for changing posture of a capsule medical device; and a control unit configured to: cause the rotation mechanism to rotate the magnetic field generation unit to change the posture of the capsule medical device based on the first operation information; and control the movement mechanism to change a distance between the magnetic field generation unit and the capsule medical device to correct a magnetic attracting force in a vertical direction of the capsule medical device.

Abstract: A mammary implant and method of making are provided herein. The implant includes an outer shell configured to retain fluid therein, an injection element coupled to the outer shell and adapted to receive therethrough an injection device for injecting fluid into the outer shell, and an injection marker zone made of a material having ultrasonically detectable markers incorporated therein. The markers are a plurality of microcavities that are located relative to the injection element so that, when ultrasonically detected, such detection indicates a location of the injection element.

Abstract: Continuum robots and similar devices and methods and systems for controlling such devices are provided. The devices can include rods comprising strips, that are pre-curved, or both. Also provided is a system and method for modeling and controlling the configuration and operation of such devices.

Abstract: Embodiments of the invention provide devices, systems, and methods that precisely identify a minimum of one predetermined spot which is hidden under a skin. The system comprises a locator device and corresponding implanted target device. The port locator device preferably comprises one magnet with north and south magnetic pole, a body and a suspending component. The body may utilize specific geometry which improves accuracy. The implanted target device may include at least one magnet and at least one target or a plurality of targets and at least one magnet. Various configurations can be provided that precisely identify a single spot or a plurality of spots which are hidden under a skin.

Abstract: Provided in accordance with the present disclosure are systems for identifying a position of target tissue relative to surgical tools using a structured light detector. An exemplary system includes antennas configured to interact with a marker placed proximate target tissue inside a patient's body, a structured light pattern source, a structured light detector, a display device, and a computing device configured to receive data from the antennas indicating interacting with the marker, determine a distance between the antennas and the marker, cause the structured light pattern source to project and detect a pattern onto the antennas. The instructions may further cause the computing device to determine, a pose of the antennas, determine, based on the determined distance between the antennas and the marker, and the determined pose of the antennas, a position of the marker relative to the antennas, and display the position of the marker relative to the antennas.

Abstract: A surgical or laparoscopic method of treating obesity of a patient using a device adapted to stretch a portion of the stomach wall of said patient. The method comprising the steps of: cutting a hole in the abdominal wall of said patient, dissecting an area around the stomach, placing said device in contact with the stomach, and fixating, direct or indirect, through invagination of the stomach wall, said device to the stomach wall such that said device can stretch a portion of said stomach wall.

Abstract: An ischemic stroke device includes a telescoping member, a first or proximal expandable member connected to the telescoping support member, and a second or distal expandable member connected to the first expandable member. A proximal portion of the first expandable member is attached to a distal end of an outer shaft of the telescoping support member, and a distal end of the first expandable member is attached to a distal portion of an inner core wire of the telescoping support member. The proximal end of the second expandable member is permanently joined to the distal end of the inner core wire. The first expandable member everts to cover the second expandable member that is used to capture an obstruction or clot, prior to pulling the obstruction or clot into a catheter for removal from a patient's vasculature.

Abstract: A method at a computer system includes obtaining an electronic document comprising document elements, and injecting into the document in association with one of the document elements one or more hotspot attributes, the hotspot attributes defining attributes of a hotspot that is displayable in conjunction with the document element when the document is displayed, the hotspot attributes being associated with predefined physical gestures and respective document actions; such that the hotspot, when displayed as part of a displayed document, indicates that a viewer of the displayed document can interact with the displayed document using the predefined physical gestures (i) performed at a position that overlap a displayed version of the document in a field of view of a camera system and (ii) captured by the camera system, wherein a physical gesture results in a respective document action being performed on the displayed document.

Abstract: A medical system comprises a probe comprising a terminal distal end. The system further comprises a first coil in the probe and comprises a guide instrument including a terminal distal end and defining a lumen sized to guide the probe. The probe can be inserted through the lumen to reach a worksite. At the worksite, the terminal distal end of the probe is configured to reach at least the terminal distal end of the guide instrument. The system further comprises a sensor embedded in a wall of the guide instrument and comprises processing hardware configured to receive a first induced signal from the first coil and to receive from the sensor an indication of a pointing direction of the guide instrument. The processing hardware is configured to use the first induced signal and the indication of the pointing direction to determine a roll angle of the probe.

Abstract: An apparatus and a method for determining the position of a medical instrument, particularly for the purpose of medical navigation. In order to use a simple system to provide a relatively inexpensive technique for determining positional information, the position and/or orientation of the medical instrument is determined by ascertaining the same on the basis of position finding operations. Electromagnetic fields are first measured and the results of relative field strength measurements are taken as a basis for ascertaining the direction of a line from a transmitter to a receiver. After this direction information is known, it is used to determine the positional information of the medical instrument.

Abstract: A closing system for a bag. The closing system comprises a first plate and a second plate. The closing system further comprises a plurality of constriction rods extending between the first plate and the second plate. The constriction rods present a constriction area configured to receive a portion of the bag. Each of the first plate and the second plate is configured to rotate. Rotation of the plates is configured to shift the constriction rods so as to reduce a size of the constriction area.

Abstract: A flexible probe has an assembly in its distal end that includes a transmitter and a receiver that receives signals from the transmitter for sensing a position of the receiver relative to the transmitter. A pair of flat spring coils disposed between the transmitter and the receiver deform in response to pressure exerted on the distal tip when the distal tip engages a wall of a body cavity.

Abstract: An apparatus for inserting an electrode structure into nerve in tissue of a living body includes a nerve fixing part which fixes the nerve such that at least part of the nerve is hung thereon, and an electrode structure ejector on which the electrode structure is mounted, and which moves the electrode structure in insertion direction to insert the electrode structure into the fixed part of the nerve, wherein the nerve fixing part and the electrode structure ejector are disposed on the same axis.

Abstract: Systems and methods are provided for identifying or locating a tag within a patient's body that include a probe that transmits synchronized electromagnetic signals, e.g., RF energy, and optical signals, e.g., infrared light pulses into the patient's body, whereupon the tag converts the optical signals into electrical energy to open and close a switch in the tag to modulate signals, e.g., backscatter signals, transmitted by the tag in response to the electromagnetic signals. For example, the tag may include photodiodes coupled to the switch that transforms the optical signals to alternately short the antenna to modulate the backscatter signals. Alternatively, the tag may include a smart circuit that harvests electrical energy from the optical signals to power the smart circuit and/or modulate the backscatter signals, e.g., to include data related to the tag and/or alternate the tag between an information mode and a distance mode.

Abstract: Various embodiments of wirelessly detectable objects to be used in medical procedures are provided. Such may employ ionizing radiation hard wireless radio frequency identification (RFID) transponders, other wireless transponders and/or integrated circuits, and attachment structures, all of which retain structural and functional integrity when exposed to standard sterilization dosages of ionizing radiation. Additionally or alternatively, the wireless radio frequency identification (RFID) transponders, other wireless transponders and/or integrated circuits, and attachment structures, may retain structural and functional integrity when exposed to standard sterilization temperatures and/or pressures.

Abstract: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.

Abstract: A sensor insertion assembly comprising a sensor cartridge having an insertion needle and a sensor within a sterile capsule. The sensor insertion assembly further comprises an inserter comprising a chamber for receiving the sensor cartridge, wherein the inserter further comprises an insertion mechanism operable for actuating the insertion needle for inserting the sensor into a subject. The sensor cartridge is removable from the chamber. The sensor cartridge is operable for shielding the insertion needle upon removal of the sensor cartridge from the chamber.

Abstract: Devices, systems and methods for microelectronic animal identification are disclosed. The microelectronic animal identification device includes an inserter configured to releasably holding the microelectronic chip at a distal end of the inserter, and an actuator configured to release the microelectronic chip from the inserter when the distal end of the inserter is inserted into a substrate of an animal body part. The microelectronic animal identification system includes a microelectronic chip and delivery system, a pigment marking device, a media transfer assembly for producing a pigment mark, a tissue sample device, and a data management system providing traceability of the animal and the materials used.

Abstract: A method of deploying a prosthesis within a native mitral valve is disclosed. The expandable frame preferably includes about twelve proximal anchors, wherein the proximal anchors have free ends positioned radially outwardly from the frame in an expanded configuration. The expandable frame preferably includes about twelve distal anchors, wherein the distal anchors also have a free ends positioned radially outwardly from the frame and extend toward a proximal end when the frame is in the expanded configuration. A valve body is supported within the frame for preventing blood flow in one direction. The expandable frame is radially expanded during deployment, which causes the free ends of the proximal and distal anchors to move closer together. In the expanded configuration, the proximal anchors are positioned on an inflow side of the native mitral valve and the distal anchors are positioned on an outflow side of the native mitral valve.

Abstract: Disclosed herein is a customized ossicular prosthesis suitable for treatment of conductive hearing loss due to ossicular chain defects, and a method and system for manufacturing the same. Medical imaging equipment can detect specifically designated landmarks in normal human middle ear ossicles, including significant anatomic differences in those structures. Those anatomic features are used to generate a customized ossicular prosthesis specifically configured for a particular patient's anatomy using 3D printing techniques and devices.

Abstract: There is provided a treatment method that is capable of reducing burden on a patient when a medical sheet is indwelled in the body of the patient. A treatment method includes an introduction of introducing a catheter, which has stored a medical sheet (e.g., a myocardial cell sheet), to a heart inside a living body, and an indwelling step of drawing the myocardial cell sheet from the catheter and indwelling the myocardial cell sheet in the heart.

Abstract: A system for tracking a tracking element inside a body is provided. It includes a first tracking system, which includes a first tracking sensor for detecting the current position of a tracking element inside a body relative to a nominal position with respect to the first tracking sensor, and a second tracking system, which includes a second tracking sensor for determining the position of the first tracking sensor of the first tracking system relative to the second tracking sensor, and a control unit. The first tracking sensor is movable, and the control unit is configured to deliver a correction signal indicating a deviation of the current position of the tracking element relative to a nominal position with reference to the first tracking sensor. Further, a respective tracking method is provided.

Abstract: A navigation and monitoring system to track positions of surgical components during surgery of a patient. Some embodiments include a power source to emit a tracking signal during surgery of the patient, a first sensor mounted to a region of the patient to respond to the emitted tracking signal, and a control unit to track a position of the region relative to a fixed region of the patient as the region moves with respect to the fixed region, based on the response of the first sensor. The system can calibrate and register a movable reference point of the patient relative to a fixed reference point, and can maintain that reference point when the movable reference point moves in space during a surgical process.

Abstract: Detecting spatial location and rotation (pitch, roll and yaw) of an implantable programmable valve device having a direction of flow of fluid therethrough. A permanent-magnet rotor disk associated with the valve has magnets arranged in a ring. A single position within the ring represents a moveable reference marker position. Also included in the valve is a first fixed, stationary, non-moveable magnet disposed a predetermined distance relative to the moveable reference marker position. A magnetoresistive sensor array produces the asymmetric magnetic field pattern including a moveable reference marker corresponding to the moveable reference marker position in the ring and a first fixed reference marker corresponding to the first fixed, stationary, non-moveable magnet. An indicator device determines spatial location based only on the moveable reference marker and yaw based on the moveable reference marker relative to the first fixed reference marker.

Abstract: A luminal access device is provided that includes a luminal graft attached to a patient lumen. A percutaneous access device (PAD) is coupled to the luminal graft and adapted to stabilize a conduit in fluid communication with the luminal graft and an external medical device. A portion of said PAD adapted to be external to the patient and seal around said conduit. Infectious agent penetration at an insertion site of the PAD is reduced by providing a porous inner sleeve fluidly connected to a conduit. A vacuum or hydrodynamic source is fluidly connected to the conduit to create a fluid draw from the subject tissue through the inner sleeve to the conduit. The conduit is readily formed to have a bore and an outer conduit surface, the outer conduit surface being optionally nanotextured. The conduit bore is adapted to accommodate a medical appliance.

Abstract: An intraocular implant device for restoring, augmenting, or improving vision of a user, the implant including an intraocular implant body shaped for positioning inside a lens chamber of an eye, the body having an anterior side facing the cornea of the eye, and a posterior side facing the retina of the eye; a photoelectric sensor disposed on the anterior side of the body; wherein the photoelectric sensor is operable to receive incident light through the cornea and to convert the received light into electrical energy for use with one or more circuit components disposed on the body, and wherein the photoelectric sensor is nearly simultaneously operable to convert the received light into image data. The ocular implant device may include a projector for projecting the image data onto the retina of a user. The ocular implant may include a wireless receiver for receiving image data transmissions from an external source.

Abstract: An intraocular implant device is operable in augmented reality and virtual reality configurations. The intraocular implant device includes an intraocular implant body shaped for positioning inside a lens chamber in an eye. The intraocular implant body has an anterior side facing the cornea of the eye and a posterior side facing the retina of the eye. A photoelectric sensor is disposed on the anterior side of the intraocular implant body. The photoelectric sensor is operable to receive natural, optimized or enhanced incident light through the cornea and to convert the received light into electrical energy for use with one or more circuit components disposed on the intraocular implant body.

Abstract: The present disclosure provides systems and methods for retrieving an implantable device. An implantable device includes a casing, and a marker coupled to the casing, wherein the marker includes a detectable material encased in a biocompatible material, and wherein the marker facilitates accurately locating and retrieving the implantable device after implantation in a patient.

Abstract: Embodiments provide focused wireless charging method and apparatus based on radio frequency receiving and phase compensation retransmission. The method is based on the reciprocity principle, making each charging signal transmitted by the external charging system could stack in-phase when arriving at the embedded rechargeable battery, realizing wireless near field focusing in any given area in an unknown complex inhomogeneous propagation environment and a high charging efficiency. The focused wireless charging technology based on radio frequency receiving and phase compensation retransmission in embodiments could realize in-phase stacking and precise focus of each wireless charging signal of the external system on the embedded batteries to be charged automatically under different propagation environment, different environment medium, and possible random offset of the rechargeable battery.

Abstract: A valve clamp for treating the cardiac valve regurgitation. The valve clamp includes a first clamp part, a second clamp part, and a connecting part. The first clamp part has the first clamping arms. The second clamp part has a corresponding number of second clamping arms. The first clamping arm and the second clamping arm can clip an object therebetween through the interaction force generated by closing and pushing against each other. Moreover, the valve clamp can also include a closed ring, which is sleeved outside the periphery of the first clamp part and the periphery of the second clamp part, such that the clamping arms can close as needed, and the clamping is tighter. The valve clamp has the advantages of a minimally invasive implantation, a simple manufacture, a low difficulty of operation, good effects, etc.

Abstract: The invention relates to an inspection system adapted for determining a state and/or content of a wafer or reticle container or at least a part of a wafer or reticle container, comprising a detection device or a multitude of detection devices (102, 104, 152, 154, 156, 158, 160, 164) adapted to receive detection data from a surface and/or interior of the wafer or reticle container or the part of a wafer or reticle container indicative of the state and/or content of the wafer or reticle container or the part of a wafer or reticle container.

Abstract: A flexible catheter includes an elongated body, and a sensor. The elongated body has proximal and distal end portions and defines a working channel therethrough. The sensor is disposed in the distal end portion of the elongated body and is adapted for detecting the position of a distal end of the elongated body within the anatomy of a patient. The sensor is formed from a wire that forms a first layer of wraps about the distal end portion of the elongated body and that includes first and second leads that form a twisted pair proximal to the first layer of wraps. The twisted pair of the first and second leads extends to the proximal end portion of the elongated body.

Abstract: The present invention provides systems and methods for accurately delivering embolic coils within a body lumen of a patient, as well as recapturing deployed embolic coils for removal or repositioning. In various embodiments, an embolic coil delivery system may include an elongate sheath with a lumen extending therethrough. An elongate shaft may be slidably disposed within the sheath. The shaft may comprise a split-distal end that defines an aperture. The split-distal end may be moveable between a contracted configuration and an expanded configuration. An embolic coil may include a proximal ball-tip that may be reversibly disposed within the aperture of the split-distal end.

Abstract: A system for determining a location of an electrode of a medical device (e.g., a catheter) in a body of a patient includes a localization block for producing an uncompensated electrode location, a motion compensation block for producing a compensation signal (i.e., for respiration, cardiac, etc.), and a mechanism for subtracting the compensation signal from the uncompensated electrode location. The result is a corrected electrode location substantially free of respiration and cardiac artifacts. The motion compensation block includes a dynamic adaptation feature which accounts for changes in a patient's respiration patterns as well as intentional movements of the medical device to different locations within the patient's body. The system further includes an automatic compensation gain control which suppresses compensation when certain conditions, such as noise or sudden patch impedance changes, are detected.

Abstract: A bone screw comprising a shaft, in which the shaft comprises a bore that is configured to fit a magnet. In addition, a bone plate comprising apertures that can fit the bone screw. The bone plate may be fastened to bone using the bone screws, and the bone screws may be oriented to generate attractive or repulsive forces. Further, a disc-shaped housing that comprises a magnet.

Abstract: An absorbable vascular filter is disclosed for deployment within a vessel for temporary filtering of body fluids. A preferred embodiment is the placement of such absorbable vascular filter within the inferior vena cava (IVC) to filter emboli for the prevention of pulmonary embolism for a limited duration in time. Once protection from PE is complete, the filter is biodegraded according to a planned schedule determined by the absorption properties of the filter components. Hence the temporary absorbable vascular filter obviates the long term complications of permanent IVC filters such as increased deep vein thrombosis, neighboring organ puncture from filter fracture and embolization while also circumventing the removal requirement of metal retrievable IVC filters.

Abstract: A double-joint sickle knife for an endoscopy therapy includes a knife head, a knife base, a knife body, an outer sheath, a guide wire, a handle and a sliding rod. The knife head is connected with one end of the knife base by a transverse joint, and the other end of the knife base is connected with a head end of the knife body by a longitudinal joint. The outer sheath is sleeved on the outside of the knife body and capable of sliding along the knife body. The tail end of the knife body is connected with one end of the handle, and a sliding rod for adjusting the transverse joint is arranged on the handle. The guide wire is electric conductive. One end of the guide wire is connected with the knife head, and passes through the knife base, the knife body, the handle and the sliding rod successively. The other end of the guide wire is connected with the power port.