Abstract: The present invention relates to an apparatus and to a method for filling a solution bag for dialysis with a liquid, wherein the apparatus comprises a needle for introduction into a filling line or filling opening of the bag, wherein the needle is a double wall needle having a preferably thermally conductive outer wall and having an inner wall, with a thermal insulation being present between the outer wall and the inner wall; and with a heating element being provided that is configured to heat the outer side of the outer wall to a temperature above the temperature of the inner side of the inner wall.

Abstract: An on-body injector system includes a drug container assembly including a container, a seal member, and a sealing interface between the seal member and the container. The container includes an opening and the seal member at least partially covers the opening in the container. A fluid pathway assembly is coupled to the drug container assembly and includes a needle that is movable between a storage position, in which a point of the needle is spaced from the seal member, and a delivery position, in which the point of the needle is disposed at least partially through the seal member. A radiation generator is configured to emit rays of radiation to sterilize and/or disinfect the sealing interface. A barrier is disposed adjacent to the sealing interface and has an opening. At least a portion of the drug container assembly is positioned adjacent to the opening in the barrier.

Abstract: An on-body injector system includes a drug container assembly including a container, a seal member, and a sealing interface between the seal member and the container. The container includes an opening and the seal member at least partially covers the opening in the container. A fluid pathway assembly is coupled to the drug container assembly and includes a needle that is movable between a storage position, in which a point of the needle is spaced from the seal member, and a delivery position, in which the point of the needle is disposed at least partially through the seal member. A radiation generator is configured to emit rays of radiation to sterilize and/or disinfect the sealing interface. A barrier is disposed adjacent to the sealing interface and has an opening. At least a portion of the drug container assembly is positioned adjacent to the opening in the barrier.

Abstract: A syringe adapter includes a housing having a first end and a second end positioned opposite the first end, with the housing including a connector body positioned at the first end of the housing and configured to be secured to a syringe barrel, a cannula positioned within the housing, with the cannula defining a transfer opening and a valve opening, a seal arrangement positioned within the housing and movable within the housing, and an aspiration assembly comprising an aspiration housing defining an aspiration opening, a filter received by the aspiration housing, and one-way valve received by the aspiration housing, where the valve opening of the cannula is positioned within the aspiration housing, and where air is configured to flow into the filter via the aspiration opening, into the one-way valve, and into the valve opening of the cannula.

Abstract: A securing device for securing an infusion appliance to an infusion container includes a first fastening element, which is designed in such a way that it is connectable to a fastening region of the infusion container, and a second fastening element, which is arranged at a distance from the first fastening element and which is designed in such a way that it is connectable to a fastening region of the infusion appliance. At least one connection element connects the first fastening element and the second fastening element to each other. The securing device can be used for medical infusion and transfusion arrangements.

Abstract: In certain embodiments, a vial adaptor comprises a housing configured to couple the adaptor with a vial, an access channel, a regulator channel, and a regulator assembly. The access channel is configured to facilitate withdrawal of fluid from the vial when the adaptor is coupled to the vial. The regulator channel is configured to facilitate a flow of a regulating fluid from the regulator assembly to compensate for changes in volume of a medical fluid in the vial. The regulator assembly can include a valve configured to transition between a closed configuration and an opened configuration.

Abstract: A method and apparatus for a connection interface between a reservoir or syringe, infusion set tubing, and an infusion pump is provided. The reservoir, a base and a cap are connected to form an integrated unit that is capable of being inserted and secured in an infusion pump housing. The cap and the infusion pump are each provided with at least one sensor or at least one detectable feature, arranged to interact with at least one corresponding detectable feature or sensor on the other of the cap and infusion pump device, to detect one or more of the presence, position or other characteristic of the cap when the cap is aligned or coupled with the infusion pump housing. The detectable feature and sensor may be magnetic, RF, mechanical, optical or any combination.

Abstract: Methods and devices for transferring materials between containers are discussed. One such connector includes: a base; a first elongate structure having first and second ends, the first elongate structure extending from a first side of the base at the first end to the second end distal the base, the second end forming a first opening sized and configured to receive a first container; a duct extending through the base and having a first tip skirted on one or more sides by the first elongate structure; a first guard positioned within the first elongate structure, wherein the first guard comprises a first surface, and the first surface is located further away from the base than the first tip. When the first container is moved into the first opening, the first surface moves toward the base, and the first tip enters the first container, creating a fluid path for the first container.

Abstract: A vial access device includes an outer housing defining an annular space and an inner space, an inner housing, and a connector configured to engage a mating connector with the connector having a body defining a central passageway and a flange that extends radially outward from the body. The flange and the housing defining a filter space that is in fluid communication with the annular space. A pressure equalization system is positioned within the annular space of the outer housing. The device also includes a vial connection element configured to be secured to a vial and having a body and a spike member extending from the body. The spike member defining a fluid passageway and a vent passageway with the fluid passageway in fluid communication with the central passageway of the connector and the vent passageway in fluid communication with the filter space and the annular space.

Abstract: A liquid reservoir unit includes a reservoir portion, an outflow portion disposed at a position near a first end of the reservoir portion, and an inflow portion disposed at a position near the first end of the reservoir portion. The outflow portion includes an outflow opening opened to an interior of the reservoir portion, and the inflow portion includes an inflow opening opened to the interior of the reservoir portion. The outflow opening and the inflow opening are located at different positions in a width direction which is a lengthwise direction of the reservoir portion when the reservoir portion is viewed from the first end, and also located at different positions in a depth direction from the first end toward a second end on the opposite side to the first end.

Abstract: To provide a protector that is detachable with one hand and that eliminates the need of re-gripping a medical needle to perform puncture; and a medical needle assembly constituted by a combination of the protector and a medical needle. A protector 1 is a protector that is detachably fitted and attached to a medical needle 2. When a proximal end portion of the protector 1 is pressed in a state in which the protector 1 is attached to the medical needle 2, the fitted state thereof is thereby released, and the protector 1 is detached from the medical needle 2.

Abstract: A device for the inflation of an inflatable life vest, notable in that it includes a storage casing containing at least two cartridges of pressurized gas which are arranged side-by-side and touching one another to form a row, and a release casing comprising at least one striker device that makes it possible, in the event of activation, to puncture each of the said cartridges simultaneously or in succession to release the gas they contain in gaseous form to the outside of the inflation device through at least one orifice made on the release casing, the said storage and release casings being in the overall shape of a flattened hollow parallelepiped and joined together removably and in a manner that is gastight with respect to the gas contained in the said cartridges.

Abstract: A filling aid device for filling a reservoir. The device includes a cover portion comprising a septum window; a slider beam comprising a septum cover; and a first filling aid tab attached to the slider beam, the first filling aid tab in slidable relation to the cover from a first position to a second position, wherein when the filling aid device is in an unlocked position, the septum cover is located below the septum window, wherein when the first filling aid tab is moved from the first position to the second position, the septum cover is moved from below the septum window, and the filling aid device is in the locked position.

Abstract: A drug mixing system including at least one receptacle port adaptor adapted to be inserted into a port of a fluid receptacle, at least one syringe adaptor adapted to be attached to a syringe and to the at least one receptacle port adaptor and at least one vial adaptor adapted for connection to a vial containing a drug and adapted for connection to the at least one syringe adaptor, the system being characterized in that at least one of the receptacle port adaptor, the at least one syringe adaptor and the at least one vial adaptor being vented to the atmosphere in a manner which prevents release to the atmosphere of possibly harmful contents of the vial in a liquid, solid or gaseous form.

Abstract: A system includes a vial stabilizer base having a first body and a plurality of fingers projecting from the first body, with the plurality of fingers being annularly disposed about the first body, and a vial adapter having a second body and a plurality of arms projecting from the second body. The second body defines a passageway. The plurality of fingers of the vial stabilizer base defines a socket having a first seat configured to receive a vial and a second seat configured to receive the vial adapter.

Abstract: The present disclosure relates to medical vials pre-attached with a vial adapter assembly for the transfer of gases/liquids/fluid or other substances to/from medical vials.

Abstract: An adapter (14) for transferring a substance from a first container (10) into a second container, having a circumferential wall (47) suitable for housing the first container, along which a cannula body (64) extends and by which said cannula body is coaxially surrounded at least in part, said adapter also comprising a hollow cylindrical section (26) connected to the cannula body and connectable to the second container. The cannula body extends with the longitudinal axis thereof perpendicular to one side of a wall (24) running transversely with respect to the circumferential wall and the hollow cylindrical section extends with the longitudinal axis perpendicular to the other side of the wall. The adapter (14) has a cup-shaped outer body (18) having an outer circumferential wall (32) and the wall (24), running transversely to the longitudinal axis of the outer body, which has an insert (46) having the circumferential wall (47).

Abstract: A method and apparatus for a connection interface between a reservoir or syringe, infusion set tubing, and an infusion pump is provided. The reservoir, a base and a cap are connected to form an integrated unit that is capable of being inserted and secured in an infusion pump housing. The cap and the infusion pump are each provided with at least one sensor or at least one detectable feature, arranged to interact with at least one corresponding detectable feature or sensor on the other of the cap and infusion pump device, to detect one or more of the presence, position or other characteristic of the cap when the cap is aligned or coupled with the infusion pump housing. The detectable feature and sensor may be magnetic, RF, mechanical, optical or any combination.

Abstract: A method and apparatus for a connection interface between a reservoir or syringe, infusion set tubing, and an infusion pump is provided. The reservoir, a base and a cap are connected to form an integrated unit that is capable of being inserted and secured in an infusion pump housing. The cap and the infusion pump are each provided with at least one sensor or at least one detectable feature, arranged to interact with at least one corresponding detectable feature or sensor on the other of the cap and infusion pump device, to detect one or more of the presence, position or other characteristic of the cap when the cap is aligned or coupled with the infusion pump housing. The detectable feature and sensor may be magnetic, RF, mechanical, optical or any combination.

Abstract: A rectangular or square fluid container having a baffle assembly configured to fit inside an interior volume within the fluid container. The fluid container is capable of being pressurized and has a number of valves or ports on a top wall thereof, which valves or ports allow for the fluid container to be filled with a fluid, for the fluid container to be pressurized, and for the removal of fluid from the fluid container.

Abstract: A fluid transfer device comprising a first reservoir (1) having a predetermined sub-ambient pressure and volume and a presealed opening (1a), a second reservoir (2) containing a predetermined volume of a fluid (M) and having a presealed opening (2a), and a chamber (3) having an internal space (6) and an inlet (4) to the space (6) adapted to be connected to the opening (2a) of the second reservoir (2) and an outlet (5) from the space (6) adapted to be connected to the opening (1a) of the first reservoir (1).

Abstract: A drug container connector (1) is provided with a puncture needle (20) capable of puncturing a plug (186) that seals a mouth (183) of a container (180); and a cover (90) that covers an opening, on a tip side, of a flow channel (21) formed in the puncture needle (20). The puncture needle (20) is configured to penetrate the cover (90) and puncture the plug (186). The puncture needle (20) is provided on a connector main body (10). The cover (90) is held by a slider (50). The slider (90) is movable with respect to the connector main body (10) in a longitudinal direction of the puncture needle (20). The slider (50) is provided with claws (66, 76) capable of engaging with a flange (182) at the mouth of the container (180).

Abstract: Described in detail herein is cooler apparatus. The cooler can include an outer shell and an inner shell. The outer shell can include a top face, a bottom face, a front surface, back surface a first side and a second side. The top face can be secured to the cooler using a zipper. The top face can provide access the inner shell. One or more bottle openers can be affixed to the front surface of the outer shell. The front surface can further include an enclosure accessible using a zipper. The bottom side can be compressible in response to receiving pressure. One or more straps can be affixed to either the first side, second side or back surface of the cooler. The inner shell can form a volume to store physical objects. The cooler can be a backpack, tote or a 24-pack cooler.

Abstract: According to embodiments described in the specification, a chemical process includes the steps of reacting a chemical reaction fluid including a solvent, 1,2-biaryl gem-dibromocyclopropane or 1,2-biphenyl-gem-dibromocyclopropane, and a metal salt including a silver tetrafluoroborate salt at low temperatures to make 1-phenyl-2-bromo indenes in a vessel that is capable of being closed.

Abstract: A machine (1) for preparing aromatic beverages by means of extraction of a respective substance, such as espresso coffee and similar, that comprises at least one extraction device (3) adapted for extracting an single dose of said substance provided in a package (2), for example in the form of a substantially rigid capsule or substantially flexible pod, and a previous opening disposition (5) disposed upstream of the extraction device (3) and adapted to provide passageways (53) in the single dose packages (2) before the latter are supplied to the extraction device (3). A process for preparing beverages with anticipated opening of a package (2) by means of the previous opening disposition (5) disposed upstream of the extraction device (3).

Abstract: A bottle connector for use in a medical fluid transfer arrangement, the bottle connector having an axial direction and a radial direction and comprising a first part and a second part, the first part comprising a hollow piercing member comprising an inner gas channel and extending in the axial direction beyond the end of the first part. The second part comprises a bottle coupling member, for coupling the bottle connector to a medical bottle. The first and second parts are pre-connected and are concentrically arranged with respect to each other and the bottle connector has a transport configuration with a first, maximum length in which the piercing member is completely located within the bottle connector, and a fluid transfer configuration with a second, minimum length.

Abstract: A configuration of a liquid ejecting head enables a stable, continuous ink supply with the off-carriage method, even if a force operates in the direction of joint needle insertion and removal. To this end, a joint opening that accepts insertion of a joint needle on a printing apparatus side is placed at a position closer to a joint face between an ejecting head and a sub tank unit than a positioning opening that engages with a positioning member on the printing apparatus side. Consequently, even if external force is produced due to coupling, the force exerted on the joint face that is a weak portion of an inkjet head may be minimized.

Abstract: Vials for loading a fluid system are provided. The illustrative vials are configured to minimize air bubbles from being transferred into the fluid system. Certain vial embodiments are provided with filters to allow microbes to pass into the fluidic system, while retaining larger particulate matter.

Abstract: A syringe adapter includes a housing having a first end and a second end with the first end configured to be secured to a first container, a cannula having a first end and a second end with the second end positioned within the housing, and a collet having a first end and a second end with at least a portion of the collet received within the housing. The collet includes a body defining a passageway, a seal member received by the passageway, and an arcuate, resilient locking member connected to the body of the collet. The collet is movable from a first position where the locking member is open to receive a mating connector to a second position where radially outward movement of the locking member is restricted.

Abstract: A needle-less vial assembly that includes a substance transfer assembly configured to telescopically engage with a vial neck of a vial. A first portion of the substance transfer assembly is configured to sealingly engage with an interior wall of the vial neck, where the first portion includes a first inlet configured to receive a substance from the vial. A second portion of the substance transfer assembly is configured to matingly engage with a syringe, and includes an outlet configured to dispense the substance to the syringe. A channel is defined through the first portion and the second portion, thereby enabling fluid communication of the substance from the vial to the syringe via the first inlet and the outlet.

Abstract: A syringe adapter is used for connecting a dosing syringe to a container in order to take up a fluid. The syringe adapter has a fluid delivery channel for creating a flow connection between the inside of the container and the inside of the dosing syringe. At least one ventilation channel of the syringe adapter is used for creating an air connection between the inside of the container and the container surroundings. In at least one of the channels a non-return valve is arranged, which allows the passage of media in an open position and in a closed position closes the channel. This results in a syringe adapter which has improved handing and in particular provides sufficient dosing precision.

Abstract: An integrated liquid injection evaporation container that includes a container body provided with a space for storing a liquid, a seal gasket configured to seal the container body from an upper end portion is provided on an upper portion of the container body, a press cap configured to press the seal gasket tight on the container body. A first injection hole configured to inject a fluid is provided on an upper end of the container body, and a second injection hole corresponding to the first injection hole is provided on the press cap. Use of the first injection hole, the second injection hole, and the seal gasket provides convenient liquid injection without contamination, and simple mechanical liquid injection.

Abstract: Dual vial adapter assemblage modified including a drug vial adapter having a female connector fitted with a normally closed needlefree swabable self-sealing access valve, a liquid vial adapter with a male connector and a manually operable flow control arrangement. The flow control arrangement has three operative positions including an initial extended set-up position, an intermediate compacted flow communication position and a final detachment position for separating the drug vial adapter and the liquid vial adapter. The liquid vial adapter and the drug vial adapter are engaged in the initial extended set-up position and the intermediate compacted flow communication position. The self-sealing access valve is closed in the initial extended set-up position and compressed open in the intermediate compacted flow communication position.

Abstract: Improved fitment assemblies for headspace gas removal. In one configuration, a fitment assembly includes a fitment defining a fluid pathway between an interior and an exterior of a container, the fitment including a tubular body having an upper neck portion and a lower neck portion, the lower neck portion depending from the upper neck, the upper neck portion including a proximal end defining a proximal opening. The lower neck portion including a distal end defining a distal opening, the tubular body defining a central bore that passes therethrough, the central bore being concentric about a central axis and passing through the proximal opening and the distal opening a flange for coupling with a container, the flange extending radially outward at a junction with the upper neck portion and the lower neck portion, wherein the lower neck portion is configured to extend into the interior of the container.

Abstract: A dispensing device includes a container with a receiving space containing a dispensable medium extractable via a dispensing element. A control body (19) with a connecting body (11) is longitudinally displaceable in a housing part (9), from an inactive base position to an active extraction position by a rotational movement. A media-carrying connection is created between the receiving space and the dispensing element. A control part of the control body (19) can be attached to a control path (54) of the connecting body (11). When the control body (19) moves rotationally relative to the housing part (9), each control part follows the rotational movement in an axially unchanged manner and brings the connecting body from the base position to an extraction position via each associable control path (54) of the connecting body (11). The control path comprises a slope.

Abstract: An adapter assembly for establishing bidirectional fluid connection between a cartridge and a vial includes a housing having an open first end adapted to engage the cartridge and a second open end adapted to engage the vial. The adapter includes a needle assembly having a first tip and a second tip, with the needle assembly disposed within the housing and at least partially supported by a needle holder. The needle assembly is movable relative to the housing from an initial position in which the first and second tip are isolated from the cartridge and vial, to an end of use position, in which first tip is engaged with the vial and the second tip is engaged with the cartridge, establishing fluid communication therebetween. The needle assembly is maintained in the initial position by a locking structure which is released by rotationally advancing the needle holder relative to the housing.

Abstract: A safety needle assembly of an infusion set for infusing fluids into a subcutaneously implanted access port is disclosed. The needle assembly is configured to prevent fluid/vapor escape therefrom so as to reduce or prevent fluid exposure to a clinician using the needle assembly. In one embodiment, the needle assembly comprises a handle portion including a needle extending therefrom, the needle defining a lumen for passage of a fluid therethrough. The needle assembly also includes a safety assembly defining a needle hole through which the needle initially extends. The safety assembly is selectively and axially slidable along the needle in order to shield a distal tip of the needle and prevent user contact therewith. A fluid isolation component is included in the safety assembly for isolating fluid escape from the needle to prevent exposure to a clinician.

Abstract: Device for preparing a liquid beverage from a cartridge, comprising a supply unit (2) for supplying injection fluid to the cartridge (10), a cartridge holder (6) configured to accept and support a cartridge; the said cartridge holder being detachable from the device and complementary insertion means (7) are configured to allow the cartridge holder to be inserted from its detached position into the supply unit (2). The injection means (5) are provided and form part of the supply unit. The injection means are able to move into engagement with the cartridge and relative to the injection unit. Sealing means (16) are also provided in association with the injection means in order to provide sealing locally between the said injection means and the cartridge.

Abstract: A Microplate comprising a plurality of wells (2) is arranged in a two-dimensional array, wherein each well (2) is inclined or pivotably mounted in the microplate (1) so that the wells (2) align with the direction of a centrifugal force during centrifuging of the microplate (1).

Abstract: A connector device for connecting two containers with first and second members slidably displaceable in regard to each other along an axis between a first and a second position is presented. The first member comprises a needle parallel to the axis so that the first container's septum is penetrated by one end of the needle when the first container is introduced into the first member. The second member comprises a coupling to the second container. The other needle end penetrates the second container's septum when the members are in the second position establishing a connection between the two containers. The first member comprises a coupling to the second container coupled to the second member. The first member can couple to the second container when the two members are in the second position and cannot couple to the second container when the two members are in the first position.

Abstract: A system includes a vial stabilizer base having a first body and a plurality of fingers projecting from the first body, with the plurality of fingers being annularly disposed about the first body, and a vial adapter having a second body and a plurality of arms projecting from the second body. The second body defines a passageway. The plurality of fingers of the vial stabilizer base defines a socket having a first seat configured to receive a vial and a second seat configured to receive the vial adapter.

Abstract: An apparatus for filling a device having a penetrable septum and a sealed chamber. The apparatus includes a filling member engageable with the penetrable septum to penetrate the septum, port(s), and a closure. The closure and filling member are movable between (i) a first position wherein the closure closes the port(s), and (ii) a second position opening the port(s). The filling member and/or septum is movable relative to the other between (i) a first position wherein the filling member is spaced from the septum, and (ii) a second position wherein the filling member is penetrated through the septum and in communication with the sealed chamber. A locking device is movable between (i) a locked position locking the closure and/or filling member in the first position, and (ii) an unlocked position allowing movement of the closure and/or filling member relative to the other and into the second position.

Abstract: An aseptic fluid connector having a male connector and a female connector engageable to aseptically transfer fluid therethrough. The male connector includes a closure and a piercing member comprising a hollow shaft for receiving fluid therein, a tip, and at least one port in fluid communication with the interior of the hollow shaft for passage of the fluid therethrough. The closure and/or the shaft is movable between (i) a first position wherein the closure closes the port(s), and (ii) a second position opening the port(s). The female connector includes a pierceable septum. The male and female connector are engageable such that the piercing member pierces the pierceable septum. Only when the pierceable member has fully penetrated the pierceable septum can the closure and/or the shaft move from the first position, to the second position to aseptically transfer fluid therethrough.

Abstract: A refillable fluid container for a fluid dispenser is provided. The refillable fluid dispenser includes a body, an output port and a dispensing mechanism. The body includes at least one wall that defines a reservoir for storing fluid therein. The output port is in fluid communication with the reservoir. The dispensing mechanism is associated with the output port. The dispensing mechanism is selectively operable between a closed position and an opened position. A fluid dispenser is also provided.

Abstract: A puncturing device for pressurized containers comprises an elongated housing member defining an elongated cavity with openings at first and second ends thereof for receiving an inverted pressurized container at the first end, the housing member including an attachment member for securing the second end of the housing member to a collection receptacle. A non-sparking puncturing member, is mounted within the housing member for piercing a nozzle-end of the pressurized container at its domed top. A counter records each action of the puncture pin. Gases and residual contents are released into the receptacle through the hollow core of the puncture pin. An auxiliary support member is mounted on the housing member for stabilizing relative movement between the housing member and the receptacle. A force-applying apparatus is mounted on the housing member for forcing the pressurized container onto the puncture pin.

Abstract: Provided is a pressure equalizing device for facilitating drug reconstitution in a closed system. The pressure equalizing device includes a container for attachment to a receptacle, to permit pressure equalization between the container and the receptacle. The container includes a first chamber and a second chamber. The device further includes a vent channel extending between the first chamber and a distal opening of the vent channel. In accordance with the invention, when the receptacle is connected to the pressure equalizing device, the vent channel establishes direct fluid communication between the first chamber and the receptacle. Additionally, a longitudinal axis of the pressure equalizing device is configured to be aligned with or parallel to a longitudinal axis of the receptacle when the pressure equalizing device is attached to the receptacle.

Abstract: The single-use valve to be installed on a line for transporting a fluid includes a tubular body, which is intended to be placed on the line and contains a mobile element that is able to take up two positions in the tubular body. Each position allows the fluid to pass through the tubular body or not, one being a standby position, while the other is an active position. Inside the tubular body, a driver able to move the mobile element such that the mobile element passes from its standby position to the active position. The driver includes a pretensioned elastic device. Outside the tubular body, a device for maintaining the pretension connects to a controller able to deactivate the device for maintaining the tension.

Abstract: The invention relates to an adapter (1) for a transfer device (20) for a fluid, for the connection of a container (17) containing the fluid, wherein the container (17) is closed by a pierceable closure element (18), and the adapter (1) has an attachment (4) which can be fitted sealingly, in an attachment direction, onto a container mouth closed by the closure element. A penetration element (6) is mounted on the attachment (4) in such a way that the penetration element (6) is movable, with the aid of guide means, between a rest position (R) and a withdrawal position (E), wherein the penetration element (6) has a hollow needle (9) with which the closure element (18) can be pierced in the withdrawal position (E).

Abstract: A pierce and fill connector cap for a vial sealed by an elastomeric septum includes a vial collar and a needle holder. The vial collar body defines a collar aperture to be positioned in overlying registry with the septum of the vial, and the needle holder includes a needle holder body providing a means for holding an elongate needle in registry with the collar aperture. The needle holder body being moveable with respect to said vial collar between a first position spaced from the vial collar and a second position proximate the vial collar, such that a needle held by the needle holder will puncture through the vial septum.

Abstract: There is provided a plug member that is detachably mounted to a liquid inlet to close the liquid inlet. The plug member comprises a sealing part configured to close the liquid inlet, such that at least part of the sealing part is inserted in the liquid inlet; and a cover part arranged around at least part of circumference of the sealing part.