Abstract: A system for sterilizing a drug delivery device includes a drug delivery device having a first self-healing seal configured to seal a fluid reservoir disposed within the drug delivery device. A sealable container is configured to receive the drug delivery device therein. The sealable container has a base portion and a cover portion. The cover portion has a second self-healing seal positioned to align with the first self-healing seal when the drug delivery device is disposed within the sealable container. A fill port includes a fill path, the fill path being configured to pass through the first and second self-healing seals to fluidly couple the fill port to the reservoir of the drug delivery device. Other systems, methods, and devices of sterilization are also disclosed.

Abstract: A method of securing a portable electronic device with a touchscreen interface for use in a sterile environment comprises providing a sterilizable enclosure and providing a transfer device. The transfer device has an upper wall and a lower wall defining a passage. The enclosure provides a frame and a base movable between open and closed positions. The enclosure is held open with the transfer device. The electronic device is inserted through the passage and into the enclosure. One of the transfer device and the enclosure is moved away from the other.

Abstract: A system and method for improving installation of a prosthesis. Devices include prosthesis installation tools, prosthesis assembly tools, site preparation systems, and improved power tools used in implant site preparation.

Abstract: A foldable sleeve for retaining a surgical instrument is presented. The foldable sleeve includes a first panel having a first set of lock tabs, a second panel hingedly connected to the first panel, the second panel having a first pair of openings and a second pair of openings, and a third panel hingedly connected to the second panel, the third panel having a second set of lock tabs. The first panel and the third panel are each selectively movable over a portion of the second panel to retain the surgical instrument within the foldable sleeve.

Abstract: A system for organizing tools including a board and one or more holders. The board has a plurality of holes formed on the top surface, the plurality of holes are arranged in rows and columns at predetermined intervals, where the holes in each row and column are aligned with holes in adjacent rows and columns. The one or more holders each have a top portion and a bottom portion, where the top portion secures one end of a tool and the bottom portion has a hole dimensioned to align with the plurality of holes on the board. One or more screws secure the one or more holders to the board, where the one or more screws pass through the hole on the holder and into one of the plurality of holes on the board.

Abstract: The invention relates to a method for tempering a plurality of capillaries, which are arranged on a carrier, wherein the carrier having a length, width and height receives the capillaries along the width of the carrier. The carrier has a recess in order to receive a tempering element so that the capillaries may be tempered in their central region by means of contact with the tempering element. According to the invention, the ends of the capillaries filled with samples are unsealed during tempering.

Abstract: Microbiota restoration therapy compositions and methods for manufacturing, processing, and/or delivering microbiota restoration therapy compositions are disclosed. An example method for manufacturing a microbiota restoration therapy composition may include collecting a human fecal sample and adding a diluent to the human fecal sample to form a diluted sample. The diluent may include a cryoprotectant. The method may also include mixing the diluted sample with a mixing apparatus and filtering the diluted sample. Filtering may form a filtrate. The method may also include transferring the filtrate to a sample bag and sealing the sample bag.

Abstract: A bone staple insertion tool for inserting a bone staple into a patient includes a body having a proximal portion, a distal surface and a fulcrum. The body defines a longitudinal axis and the fulcrum is positioned on the distal surface. The distal surface has a first end and a second end. A bone staple mount is fixed to the body and extends from the body proximate the first end. A force applicator is movably attached to the body. The force applicator has a gripping portion and a staple pin portion. The staple pin portion is positioned proximate the second end. The force applicator is configured to receive the bone staple. Upon actuation of the gripping portion, the staple pin portion bends the inter-axis of the bone staple across the fulcrum to an expanded state, wherein the first and second legs are positioned substantially parallel to the longitudinal axis.

Abstract: The inventive subject matter is directed to compositions and methods for ready-to-inject norepinephrine compositions with improved stability. Most preferably, compositions presented herein are substantially antioxidant free and exhibit less than 10% isomerization of R-norepinephrine and exhibit less than 5% degradation of total norepinephrine.

Abstract: A conjunctival cover including an annular generally curved shell having a conjunctival portion structured to conform to and overly at least part of the conjunctiva of an eye. The annular generally partially spherical shell defines a generally central opening. The central opening is sized to leave a cornea of the eye substantially or partially uncovered when the conjunctival cover is applied to the eye.

Abstract: A method of packaging a surgical implant is provided. The method includes receiving a portion of the surgical implant or a component coupled to the surgical implant at least partially within a recess of an implant holder. The recess includes a plurality of lobe shapes adapted to engage the implant or component. The recess only receives a top portion of the surgical implant or component couple to the surgical implant. The holder is inserted into a container. The holder has a first configuration in which the mouth of the recess is arranged to partially surround a portion of an implant or a component coupled to an implant. When the holder is at least partially received in the container, the recess grips the implant in a position spaced apart from the container. The holder also has a second configuration in which the mouth of the recess opens to release the implant.

Abstract: An enclosure for a portable electronic device includes a frame, a base, and a unitary seal. The frame includes a frame periphery edge and defines a window. A glass panel is attached to the frame adjacent the window, positioned to abut a touchscreen interface of the electronic device. The base comprises a base periphery edge. The base and the frame cooperatively define a closed position of the enclosure for securing the portable electronic device therein. The seal comprises a seal periphery edge, and is fixed to one of the base and the frame and positioned to be engaged by the other in the closed position. The seal periphery edge, the frame periphery edge and the base periphery edge are aligned in the closed position. The seal defines a boundary between a touch zone outside of the seal and a no-touch zone inside of the seal.

Abstract: A medical solution packaging assembly comprising a medical solution container that houses a medical solution comprising a semi-permeable material including one or more surface that is at least partially permeable to air molecules and has low permeability to vapor molecules of the medical solution, wherein the medical solution container is configured to inflate beyond its original volume. The assembly further comprising a packaging comprising one or more surface within which the solution container resides; a compressing mechanism configured to apply external force onto at least one surface of the medical solution container or limit the volume to which the medical solution container inflates, wherein a volume of air ingress from an external environment of the medical solution container is less than that which would occur without the compressing mechanism.

Abstract: The present invention relates generally to methods of sterilizing elastomeric articles in a manner that prevents and/or reduces degradation to the articles, particularly degradation that may be caused and/or accelerated by sterilization techniques such as gamma irradiation, x-ray irradiation, and electron-beam processing. The methods include packaging the elastomeric articles in order to improve their resistance to degradation. In certain aspects of the invention, packaged elastomeric articles, optionally containing one or more antidegradants, such as antioxidant and/or antiozonant compounds, are also provided. The methods of providing degradation-resistant elastomeric articles in accordance with the present invention may also be used to reduce the occurrence of cracking and discoloration in elastomeric articles, regardless of whether they are subjected to sterilization.

Abstract: A containment assembly for enclosing a medication container may comprise a first housing portion or interface portion having a proximal end and a distal end. The interface portion may include a housing wall which defines a channel spanning from the proximal end to the distal end. The channel may be open at the proximal and distal end. The containment assembly may further comprise only two pierceable septa configured to form a barrier to the channel. The containment assembly may further comprise a variable-volume housing portion having a variable volume chamber. The variable-volume portion chamber of the variable-volume housing portion may be in fluid communication with the distal end of the channel.

Abstract: Disclosed is a vapor-tight container comprising a container body having a first extension formed to extend outwards along a rim of a sidewall thereof and a locking protrusion bent downwards from an end of the first extension, and a container lid configured to cover an upper portion of the container body so that the inside of the container body is sealed.

Abstract: The present invention relates to a packaging method for increasing the shelf life of fungal spores and to the packaging that contains such spores. The packaging method comprises the steps of pre-drying the spores to a water activity range viable for the fungus of interest, followed by packing of the spores into gas- and water-vapor-impermeable packaging by means of the use of sachets, thereby providing an atmosphere of low relative humidity and low oxygen content, followed by keeping of the spores in the packaging for a certain period of time at the temperature suitable for the spores prior to the exposure thereof to high temperatures.

Abstract: This invention provides a method of sterilizing an S-nitrosothiol, for example S-nitrosoglutathione, without reduction of purity by more than about 5.0% through degradation. The invention allows sterile S-nitrosothiol or a sterile pharmaceutical pre-composition comprising S-nitrosothiol, wherein the S-nitrosothiol is in dry solid form, to be produced. The sterile pharmaceutical pre-composition is mixed with one or more diluents, excipients, carriers, additional active agents, or any combination thereof, for example sterile saline, to prepare a pharmaceutical composition of S-nitrosothiol for use.

Abstract: The invention provides a two-part package and method of use for a pre-attached medical implant and delivery tool system. The package includes a wet compartment and a dry compartment and allows a pre-attached implant and delivery tool system to be at least partially stored immersed in a fluid in the wet compartment and at least partially stored in the dry compartment. In one embodiment the implant comprises a replacement heart valve, and the heart valve is stored inside the wet compartment while the heart valve delivery tool remains dry in the dry compartment.

Abstract: A method produces labels having multiple sheets glued together in a first surface region of the basic label and lying loosely on top of each other in a second surface region. After printing an anti-adhesion layer in first surface regions and a frame region, webs are applied and printed to produce lowermost label sheets. An anti-adhesion layer is printed onto the last web in third surface regions lying between the first and/or second surface regions and the frame region. After punching the material web between the third surface regions and the first and/or second surface regions, an outermost web is applied and printed. By punching a frame through all webs, a lattice take-off is severed, simultaneously forming an outermost sheet section in each third surface region projecting laterally beyond the lowermost label sheets.

Abstract: A blood filtering device has a tubular housing with a tubular section and tubular housing volume. A filtration section with a filter medium separating a raw side from a clean side is arranged in the tubular housing. The filtration section is movable along the tubular section and movably sealed relative to the tubular housing. The filtration section separates the tubular housing volume into variable first and second tubular housing volumes. A first communication path extends between raw side and first tubular housing volume. A second communication path exits between raw side and second tubular housing volume. When moving the filtration section, blood in the first tubular housing volume flows through the first communication path to the raw side; blood plasma passes through the filter medium to the clean side; residual blood flows through the second communication path into the variable second tubular housing volume.

Abstract: A method and device for high-pressure, high-temperature steam sterilization of endoscopes includes pressure resistant fittings to attach a steam generator to the ports of an endoscope. The method and device allows for high-pressure, high-temperature steam to circulate throughout the endoscope, exposing various surfaces to steam for sterilization. The method and device also allows for high-pressure, high-temperature steam to circulate selectively through the channels of the endoscope, selectively sterilizing the channels and allowing for use of this method with current high-level disinfection methods. The method and device also allows for movement of the scope elevator channel during the sterilization process, allowing for steam to reach the crevices around the elevator and other moving parts of an endoscope.

Abstract: Multi-monodose containers are described including a row of at least two vials, a first vial connected to an adjacent second vial through an articulating joint, the articulating joint sufficiently flexible to reversibly mate a planar outer surface of the first vial with a planar outer surface of the adjacent second vial; wherein the row of the at least two vials is configured to form a first rectangular packing cross-sectional area in an expanded configuration and configured to form a second rectangular packing cross-sectional area in a folded configuration, the second rectangular packing cross-sectional area smaller than the first rectangular packing cross-sectional area.

Abstract: A medical assembly, preferably a sterilized one, includes a medical article (5) and a package containing the article, the package including a hollow support element (2) inside which the article (5) is free, a first protective element (3), called a stopper, which can be coupled to the support element (2) of the article, such that the support element (2) has a grip part (20) that protrudes from the stopper (3), and a second hollow protective element (4), called a cover. The cover can be coupled to the stopper (3) in such a way as to delimit, in cooperation with the stopper (3), a chamber (8) inside which there extends the grip part (20) of the support element, and, in the state when the cover is coupled to the stopper, a part of the stopper (3) protrudes from the cover (4).

Abstract: The present invention relates to improved manually openable packages which include a rigid or semi-rigid tray having a single thermoplastic overwrap comprising a polymeric laminate surrounding the tray and having a front panel and an opposing back panel. The inventive packages also include a continuous seal circumscribing a recessed cavity of the tray which comprises a heat seal formed by heat sealing a portion of the front panel to the peripheral flange of the tray.

Abstract: A method of packaging pre-filled medical devices is disclosed. The method comprises producing a packaging having a front panel and a back panel defining a compartment capable of holding one or more medical devices wherein at least one of the front panel or top panel has a portion containing a gas permeable material while the remaining portion of the pouch is gas impermeable. This gas permeable material allows gas to pass through the material and contact the one or more articles contained within the compartment or allows gas to pass through the gas permeable material from the inside of the compartment to the outside of the container. Upon completion of sterilization, the pouch is sealed and the gas permeable portion is cut away leaving the sterilized medical device enclosed in a completely gas impermeable pouch.

Abstract: A method and a machine for realizing containers, including at least steps of impressing a shape in relief on a sheet of deformable material, enveloping the sheet about itself and reciprocally joining lateral flaps thereof in order to form a tubular blank, and closing a bottom end of the tubular blank.

Abstract: A sterilizable enclosure for securing a portable electronic device having a touchscreen and for preventing ingress and egress of contaminants to and from the secured device, comprising a frame with a frame periphery edge, the frame defining a window with a transparent panel adjacent the window arranged to abut the touchscreen. A base coupled to the frame comprises a base periphery edge and cooperates with the frame to define a closed position in which the device is secured between the base and the frame. A seal comprising a seal periphery edge is attached to at least one of the base and the frame and is arranged to be engaged between the base and the frame when the enclosure is closed to prevent ingress and egress of contaminants to and from the secured device with the seal periphery edge adjacent to the frame periphery edge and base periphery edge.

Abstract: An end effector for a surgical fastening device is provided. The end effector includes a body defining a longitudinal axis, one or more fasteners, an anvil, and a pusher. Each fastener has an unformed configuration and a formed configuration. Each fastener includes first and second arms that extend in opposite directions. The first arm has first and second elbow segments. The first elbow segment is configured to bend as the fastener is formed. The second elbow segment is configured to remain unbent as the fastener is formed. The pusher is configured to advance the fastener distally through the body and into engagement with the anvil to form the fastener against the anvil.

Abstract: A containment vessel for storing and rinsing a medical implant coupled to a delivery system having an outer sheath may include a hollow element having a wall, a proximal end, a distal end, and a lumen extending between the proximal end and the distal end, the lumen of the hollow element being configured and adapted to contain a medical implant in a partially-deployed configuration during storage and rinsing of the medical implant and a proximal end cap including a secondary proximal end cap removably secured to the proximal end cap and configured to reversibly seal the proximal end cap to the outer sheath, thereby establishing a closed fluid connection between the lumen of the hollow element and a lumen of the outer sheath. The proximal end cap may include a sheathing guide configured and adapted to direct the medical implant into the lumen of the outer sheath.

Abstract: An apparatus for at least one of storage, treatment, assessment and transport of an organ or tissue includes a cooling container configured to cool the organ or tissue, a perfusion circuit configured to perfuse the organ or tissue, and a sample compartment for holding a biological sample. Preferred apparatus has a first internal compartment under a first cover (lid) of the apparatus that includes the coolant container and the sample compartment. The apparatus can include a second internal compartment under a second cover (lid) of the apparatus, the second internal compartment including at least part of the perfusion circuit and a sample compartment.

Abstract: A rack assembly and a dishwasher having the same, the rack assembly includes a basket in which a plurality of holes are formed; and a loading plate that is disposed to be separable from the basket and to be deformable so that loading plate and the materials to be washed placed thereon are removable from the basket. Through this configuration, loading and unloading of the materials to be washed can be easily performed.

Abstract: A dual-opening carton has a front, rear, and opposing side panels. A flap extends over the top of the carton, allowing the top to be opened and re-closed. A score line extends around the carton to facilitate the removal of a top portion of the carton. The score line has segments extending along the front panel, the rear panel, and rear portions of the side panels that have a relatively low cut length to land length ratios that maintain relatively high structural integrity. The score line also has segments extending along the front of the side panels have a relatively high cut length to land length ratio to facilitate tear propagation. The score line extending along the side panels is angled so that a pull force vector removing the top portion of the carton runs along a plane generally parallel to the score line.

Abstract: An easy open packaging pouch, including a packaging film, with a bonded peripheral edge section that has been formed by superimposing the packaging film such that two bonding layers are facing one another such that the peripheral edge of the packaging film is bonded. The package is designed to tear open from a notch formed in the peripheral edge, and a content is placed such that a tear starting from the starting point will intersect the content during opening. Opening includes tearing along a tear line that advances diagonally, with respect to the content, from the notch. Once the tear reaches the content, the tear diverges in two directions; one continuing in a substantially unchanged direction, and the other inflecting along the content. Opening will expose an end portion of the content.

Abstract: A thermally shrinkable wrapper, in particular for use in sterilization processes, includes a first layer of a thermally shrinkable film in the form of a continuous band having a pre-determined width and at least approximately parallel longitudinal edges that define a longitudinal direction of the wrapper. A second layer of a thermally shrinkable film in the form of a continuous band having a pre-determined width and at least approximately parallel longitudinal edges, is placed over said first layer so that the longitudinal edges of the first and said second layer are at least approximately aligned with respect to each other. A pair of bearing bands provided by a thermally non-shrinkable material are embedded and welded between the first layer and the second layer in the area of their aligned longitudinal edges.

Abstract: A packaging for sterile products, comprising a tray and a hood made from cellular plastic material comprising at least two covering sheets held at a distance from one another by a plurality of spacers having cells longitudinally parallel to each other, the tray and the hood comprising a base and sidewalls cut from a plate of said material and with at least one of said sidewalls having double thickness and being formed by folding two panels of the plate around the folding lines perpendicular to the direction of said spacers. The interior covering sheets are perforated to allow the passage of a sterilizing gas through said covering sheet, the perforations allowing the passage of the gas but preventing the passage of dust, wide cut-outs traversing at least the other covering sheet of the plate in order to ensure communication of said cells with the outside and being provided along the folding lines of said panels.

Abstract: A method of protecting an in-vivo sensor includes forming a sensing surface on a surface of the in-vivo sensor, the sensing surface including a functionalized monolayer that will bind to an analyte of interest; and coating the sensing surface of the sensor with a bioabsorbable polymeric coating including a bioabsorbable polymer; wherein the bioabsorbable polymeric coating is configured to protect the in-vivo sensor until needed for implantation.

Abstract: A tampon disposal device includes a tubular stiffener, and a membrane conforming to the stiffener with an opening on one end and an enclosure opposite the opening. The membrane is folded inside the stiffener into a first layer attached to the stiffener; and second and third layers that form a lip surrounding the stiffener near a stiffener rim. The second layer folds over the rim, reversing direction to become the third layer lip portion. The third layer continues inside the stiffener. A weak adhesive attaches the lip to the outside stiffener. Another adhesive attaches the first layer to the second layer inside the stiffener. When a hand grasps a tampon string with the membrane and pulls on the string, the first adhesive allows the lip to separate and be pulled into the stiffener together with the tampon. Pushing inwardly on the stiffener seals the tampon inside the membrane.

Abstract: The present invention is generally related to an apparatus and method for sanitizing a continuous positive airway pressure (CPAP) device, in particular the invention relates to a system, method and device that attach to a CPAP device and sanitizes all of the parts of the CPAP device, including the inner areas of the hose, reservoir and face mask most prone for bacteria buildup. The device has an ozone operating system and one or more ozone distribution lines that distributes ozone to a CPAP device and a non-permeable bag for sanitizing a CPAP mask.

Abstract: The present invention relates to a urinary catheter and collection bag that can be provided without additional packaging.

Abstract: The present application discloses and claims an individually packaged, absorbent article of enhanced length, and including at least two sets of wings, which article is folded into a compact package form, and which package in being unfolded by a consumer, results in less operation steps by the consumer for donning of the article, and for disposal of the package.

Abstract: The multi-panel sterilization assembly includes a barrier panel formed of permeable material having barrier properties, side wings that can include grip portions for folding or unfolding the barrier panel; and a fold protection panel. The assembly has at least one pull tab attached to an end of the barrier panel to aid in unfolding the assembly after sterilization. At least one wing and/or pull tab is held in place against the barrier panel during manufacturing with a transient adhesive that loses strength such that the wing or pull tab is easily pulled off the barrier panel after sterilization.

Abstract: A peritoneal dialysis system includes (i) a reusable fill container; (ii) a reusable drain container; and (iii) a reusable continuous ambulatory peritoneal dialysis (“CAPD”) set configured and arranged to be fluidly connected to at least one of the reusable fill container or the reusable drain container.

Abstract: An absorbent article includes a body side liner, a back sheet, an absorbent body positioned between the body side liner and the back sheet, and a distribution layer positioned between the absorbent body and the back sheet. The absorbent body defines a first opening having an opening length that is at least 50% the absorbent body length. The first opening has a median anterior portion width that is greater than a median central portion width that is greater than a median posterior portion width. The first opening includes a well, a channel, and a taper. The well transitions into the channel via a first convex transition and a concave transition. The channel transitions into the taper via a second convex transition.

Abstract: A method is disclosed for state sensing and controlling of a multi-state drug delivery device. In some embodiments a power switch is reused as a state sensor. Optionally the state sensor may be toggled by user actions and/or the movements of parts of the device, for example needle and/or a protective element. Optionally, drug discharge and/or status indication is controlled in accordance with sensor output. In some embodiments control is by means of a processor. Alternatively or additionally, control is by means of simple physical circuits.

Abstract: Non-durable self-supporting flexible containers with easily variable sizing. Line ups of flexible containers have similar sizes, shapes, and constructions, but hold differing amounts of fluent product at unexpected fill heights.

Abstract: Provided is a packaging bag which can prevent the entry of water between a handle and a body, as well as can maintain proper degrees of easy-opening properties and bag-break strength. A packaging bag includes an easy-peel seal. The seal includes first regions in which multiple belt-shaped seals are spaced from each other in the width direction and second regions in which a single belt-shaped seal is disposed. The first regions and second regions are alternately disposed adjacent to each other in the length direction of the belt-shaped seals. The single belt-shaped seal in each second region has a wide width so that the multiple belt-shaped seals in the adjacent first regions can be connected to the single belt-shaped seal.

Abstract: A product dispensing system and a method of queuing usage of products. In one form, a plurality of layers of products, each having multiple items in separate packages, is provided, each layer having a carrier with the separate packages being secured to and extending from the carrier. The layers are assembled in a stacked orientation behind a front layer with layers behind the front layer being at least partially concealed and inaccessible. Products are used one layer at a time, and when the separate packages from the front layer are removed, the packages of the next-succeeding layer are exposed for use. In another form of the invention, the packages for each layer are secured to and extend in series from the carrier for each layer, with a first package secured to the carrier for the layer, and each succeeding package being secured to the next preceding package.

Abstract: The present invention relates to a therapeutic method for the treatment of cancer that comprises the use of a combination of inotuzumab ozogamicin (CMC-544) and temsirolimus. The enhanced antitumor of the combination therapy is particularly useful for patient population that are recalcitrant to inotuzumab ozogamicin or temsirolimus therapy, relapse after treatment with inotuzumab ozogamicin or temsirolimus or where enhanced antitumor effect reduces toxicities associated with treatment using inotuzumab ozogamicin or temsirolimus.

Abstract: The invention relates to a storage case comprising two parts, each with an outer side and an inner side, where a side area on each part may comprise a connecting element for hinged connection with the other part, where at least one of the two parts on the outer side comprises a circumferential frame connectable with the part and with a central aperture and where further a display element is positioned on the outer side of the at least one part and interlocked between the outer side and the frame connectable to the part.