Abstract: A package and method of packaging a surgical implant or surgical instrument are described. The package comprises a container and a holder having a recess arranged to receive a portion of a surgical implant or instrument, or a component coupled to the surgical implant or instrument. The holder is arranged to be at least partially received within the container. The holder has a first configuration in which the mouth of the recess is arranged to partially surround a portion of an implant or instrument, or a component coupled to the surgical implant or instrument, such that the recess grips the implant or instrument in position spaced apart from the container when the holder is at least partially received in the container. The holder also has a second configuration in which the mouth of the recess opens to release the implant or instrument.

Abstract: An outer package for a medicament is provided. The outer package has a front face, a back face, a first side, a second side, a top, and a bottom. The outer package has an interior and an exterior, the interior containing an inner package containing a medicament. The top is provided at an angle with respect to the front face of the package when the package is sealed, and has an opening suitable for extending a portion of the inner package therethrough when the package is sealed.

Abstract: The disclosure pertains to a vessel for holding replacement heart valves and associated positioning and installation apparatus which is configured and adapted to contain a biocidal sterilization fluid during and following exposure of a delivery system for the replacement heart valve to sterilization by ionizing radiation and methods of use therefor. The vessel includes a shield which limits exposure of biologically derived material therein to radiation. The vessel also provides a storage and shipping container for the replacement heart valve in which the biologically derived material is maintained in a sterile fluid environment.

Abstract: The invention relates to a medical clip carrier device for retention and/or mounting of at least one medical clip, in particular a ligature clip, comprising at least one clip receptacle in which a clip is retainable in a mounted position, and a securing device with at least one securing member for detachably securing a clip in the at least one clip receptacle. The clip receptacle comprises an insertion opening for insertion of a clip into the clip receptacle and removal of the clip therefrom. The at least one securing member is constructed in the form of a retaining projection which protrudes at least partially into the insertion opening.

Abstract: Packaging for prosthetic heart valves including an assembly for securely retaining a heart valve within a sterile jar and facilitating retrieval therefrom. The assembly includes a packaging sleeve that fits closely within the jar and has a clip structure for securing a valve holder. A delivery handle on the end of a shaft couples with the valve holder while the packaging sleeve engages the jar to prevent rotation. The assembly of the packaging sleeve, valve, and holder can then easily be removed from the jar.

Abstract: Compositions that include antimicrobial agents and biodegradable delivery vehicles adapted to enter a cell and release the antimicrobial agents in the cell as they biodegrades. Also provided are compositions that include first and second delivery vehicles including first and second antimicrobial agents, wherein the first delivery vehicles are adapted to release the first antimicrobial agents at a rate that differs from that at which the second delivery vehicles release the second antimicrobial agents, articles of manufacture that include one or more biodegradable delivery vehicles, and methods of making and using the compositions to treat intracellular and/or extracellular infections are disclosed.

Abstract: Methods and packages for storing film strips while reducing or eliminating stress cracking during storage, including use of packages having an inner surface made from polymeric materials exhibiting various physical properties and including films and pouches that are annealed.

Abstract: An implant storage and insertion system for a shape memory orthopedic implant allows the implant to be constrained in a deformed state, protected, insulated, held for insertion, and properly positioned in bone. The implant storage and insertion system includes a restraining block having an impact surface. The restraining block engages an implant at a first end, and further a medical instrument engages the restraining block and positions the restraining block at a bone such that the impact surface may be impacted to insert a second end of the implant into the bone.

Abstract: The present invention concerns an attachable membrane device for providing a piercable liquid barrier membrane to the surface of a pierceable fluid container, such as an infusion bag. The attachable membrane device have a fastening part comprising a fastening surface adapted to be attached to the surface of the pierceable fluid container and thereby provide a liquid tight seal between the fastening surface and the surface of the pierceable fluid container. Additionally, the attachable membrane device is further provided with a barrier membrane part, adapted to provide a liquid tight seal after penetration by a piercing member. Connection means is arranged to the attachable membrane device. The invention simplifies the injection or withdrawal of a fluid in a pierceable fluid container.

Abstract: A pharmacy bottle system includes a bottle and a ring. The bottle is formed as a single piece of molded plastic material and includes a body and a neck. The body defines an interior cavity. The interior cavity extends from a first end to a second end of the interior cavity. The body includes a spine portion covering the first end of the interior cavity. The spine portion defines a spine width measured from a front to a back of spine portion. The neck extends from the second end of the interior cavity and has an opening therethrough providing access to the interior cavity. The ring is secured about the neck of the bottle. The ring defines a ring width measured between a front and a back of the ring. The ring width is larger than the spine width. The neck extends above a top surface of the ring.

Abstract: A stable transmucosal composition consisting essentially of naltrexone hydrochloride in water is provided. The composition is surprisingly stable at room temperature and can be used for simple, rapid and effective opioid overdose rescue.

Abstract: A pouch for retaining an endoscope during and after a decontamination process includes a first pouch side, a second pouch side attached to the first pouch side to form the pouch that is configured to retain the endoscope, and a port member coupled to the second pouch side. The second pouch side is securable to the first pouch side to seal the endoscope within the pouch. The second pouch side is configured to permit passage of a decontaminating substance. The port member is coupled to the second pouch side and includes an external interface configured to be connected to a device that provides the decontaminating substance for passage through the port member into an interior of the pouch.

Abstract: The invention relates to a support (1) for receiving at least one surgical object, in particular at least one bone screw (2), in a receiving position (A). Said support (1) comprises at least one supporting surface (3) which is designed and arranged in such a manner that a supporting area (5) of the object can be brought into contact with the supporting surface (3) in the receiving position (A). Said object can be removed from the receiving position (A) in the direction of removal (E). The direction of removal (E) extends at an angle of a maximum 45°, preferably a maximum 20°, more particularly essentially parallel to a longitudinal axis (L) of the object housed in the receiving position (A). Said support (1) comprises at least one mounting surface (4) that can be moved in relation to the base body (23) and which is designed and arranged in such a manner that the object can be maintained by means of the mounting surface (4) in the receiving position (A), in particular in a clamped manner.

Abstract: Internally pierced formed blisters containing fluid compositions for use in devices to produce a spray or mist delivery of the compositions include internal piercing nozzles that can have significantly reduced channel volume to increase pressure of the fluid forced through the nozzle and provide finer control of spray geometry. The piercing nozzles are configured to deliver the contents of the blister to the central nervous system through the nasal olfactory epithelium.

Abstract: A sterilizer having a cassette for holding metal instruments or medical devices. The cassette includes a metallic container that defines a sterilization chamber. The container has at least one outer surface. A plurality of spaced-apart, elongated rails extend along the at least one outer surface of the container. Each of the rails includes a free, longitudinal edge wherein the edges of the rails lie in a first plane. An insulating shell encases the metallic container and the plurality of rails. An outer surface of the insulating shell lies in the first plane. A receiving unit includes a housing having an outer surface and an inner surface. The inner surface engages the edges of the rails and the outer surface of the insulating shell when the cassette is disposed within the inner housing. A plurality of spaced-apart elongated ribs extends along the outer surface of the housing.

Abstract: The present invention relates to combination products including bioactive glass and collagen as well as kits comprising the same.

Abstract: A container storing an anesthetic is disclosed. The container is sealed by a closure and stores a liquid anesthetic solution. The anesthetic is from 0.1% to 10% by weight of the liquid anesthetic solution. The container is made of a material that is inert to the anesthetic and the closure is made of siliconized rubber or a metal. A concentration of the anesthetic in a liquid anesthetic solution stored in the container following a predetermined time period is at least 93% of a concentration of the anesthetic in a liquid anesthetic solution before the liquid anesthetic solution is stored in the container.

Abstract: A therapeutic rinse for treating a sore throat. The therapeutic rinse may be stored in a self-heating container that is capable of reaching a temperature of at least 130 degrees Fahrenheit when activated. The therapeutic rinse includes a liquid composition having sodium chloride, water, and a variety of vitamins, minerals and herbs stored in the reservoir of the self-heating container. An antibiotic may also be included in the therapeutic rinse. Before use, the therapeutic rinse may be heated.

Abstract: A container storing an anesthetic is disclosed. The container is sealed by a closure and stores a liquid anesthetic solution. The anesthetic is from 0.1% to 10% by weight of the liquid anesthetic solution. The container is made of a material that is inert to the anesthetic and the closure is made of siliconized rubber or a metal. A concentration of the anesthetic in a liquid anesthetic solution stored in the container following a predetermined time period is at least 93% of a concentration of the anesthetic in a liquid anesthetic solution before the liquid anesthetic solution is stored in the container.

Abstract: An array of absorbent article packages for multiple baby stages of development displayed via a merchandise display system may comprise multiple packages. Each package may comprise articles having absorbent article configurations appropriate for the stage of development of an infant, newborn, or toddler. Each package may also comprise indicia representative of the appropriate stage of development of the infant, newborn, or toddler. And, absorbent article configurations may differ between packages having overlapping size ranges.

Abstract: Endosseous implant to be applied to a human or animal bone, wherein the surface of the implant is made from titanium or a titanium alloy, said implant having a smooth or rough surface texture, which is characterized in that said surface has been treated with at least one selected organic phosphonate compound or a pharmaceutically acceptable salt or ester or an amide thereof; process for producing said implants.

Abstract: A single use rigid package containing pharmaceutical compositions which protects tablets, capsules, soft shell pills against hard transporting conditions and undesired rupture. The package comprises at least four sections made from a single sheet foldable into a folded configuration. At least two sections are carrier sections pivotally connected to each other and each comprising cavities for housing pharmaceutical compositions. Two sections are end sections not comprising cavities, the end sections being foldable to adjacent and at least partly covering the carrier sections when the sheet is folded so as to protect the carrier sections. The package allows for personal transportation, e.g. in a pocket, and it is easy and convenient to open for people of all levels of ability and dexterity. Its design allows for transport as standard mail withstanding temperature fluctuation, vibrations and shocks, mechanical pressure and variation in atmospheric pressure which may occur during transport.

Abstract: A unit dose container for holding a single dose of a given liquid, the container comprising: a chamber (8) in which, in use, the given liquid is stored, the chamber having a wall through which, in use, the liquid is to be supplied; a release mechanism (7), at least part of which is internal to, or forms part of the wall of the chamber, the release mechanism being movable relative to the chamber between first and second positions; and means for allowing the release mechanism (7) to move from the first to the second positions, thereby opening a passage through the wall so that the liquid can exit the chamber (8), the means including at least one flexible wall portion.

Abstract: A device for controlling the dehydration operation during a freeze-drying treatment comprises a freeze-drying chamber (1) connected to a vacuum line, and a gas analyzer, for analyzing the gases contained in the chamber. The gas analyzer comprises a gas ionization system (8) comprising a plasma source (13) in contact with the gases, which plasma source is combined with a generator (15) capable of generating a plasma from said gases, and a system for analyzing the ionized gases, comprising a radiation sensor (17) located close to the plasma generation zone and connected to an apparatus (18) for analyzing the change in the radiative spectrum emitted by the plasma. According to the invention, the device includes a means (16) for repeatedly turning the plasma source (13) on and off. The device may further include an optical port (25) placed between the gas ionization system (8) and the freeze-drying chamber (1).

Abstract: The present invention is a packaged system that includes a housing to protect a treatment device mounted on a distal portion of a catheter. The housing holds the device suspended such that there is little or no contact between the housing and the device, protecting the device from physical damage and also from exchange of chemical components between the device and the packaging materials, which can occur when a device remains in contact with packaging materials over an extended period of time. A port in the housing allows a controlled environment, for example a vacuum, to be maintained within the housing. A hollow stylet inserted into the distal end of the catheter before the catheter is placed in the housing precludes compression of the catheter and provides an injection port through which the catheter may be flushed with a fluid prior to use, eliminating the need for a separate flushing cannula.

Abstract: A medicine dispensing record system that joins with a medicine container and records and displays content and administration information about a medicine to ensure the proper administration of the medicine. The medicine information that is recorded may be erased and updated when a subsequent dose of medicine is administered. The medicine dispensing system includes an identification portion that affixes to the medicine container and includes a dry-erase surface that provides a receptive and erasable surface for a user to record and review information about a last medicine dose with information such as: time and/or date the last dose was administered, amount of medicine administered, current daily intake amount, contents of the medicine container, scheduled administration of the medicine, and warnings about the medicine. The information displayed on the surface is constantly revised with each subsequent dosage of the medicine with an attached dry-erase marker.

Abstract: Packaging for prosthetic heart valves including an assembly for stabilizing dry prosthetic tissue implants such as heart valves during storage. The packaging assembly includes a primary sterile barrier that permits gas sterilization of the tissue implant, and a secondary sterile barrier that prevents oxidation of the implant during storage. Tissue heart valves are placed inside an inner tray and sealed with a gas-permeable lid. The inner tray is placed within an outer sterile barrier and the assembly is sterilized. The outer sterile barrier may include a double seal so that a first gas-permeable seal can be closed for sterilization, after which a second gas-impermeable seal is closed to seal out any further oxygen contact with the tissue implant. Alternatively, the inner tray is placed within a sterile pouch and the assembly gas-sterilized, and then the entire assembly is placed within another pouch that provides an impermeable barrier.

Abstract: A pack module includes a number of absorbent articles and at least one belt to which the absorbent articles can be releasably attached. The belt when placed in the pack module constitutes a gripping device which is intended to act on at least one of the articles and, at least partially, remove at least one absorbent article from the pack module when the gripping device is used. Removal of firmly compressed absorbent articles from a pack module without using additional material in the pack module is thus possible.

Abstract: The medical container includes a container body having a proximal end opening, a proximal-end edge portion surrounding the proximal end opening, a plug body sealing a mouth section; a bag body including an edge portion fixed in a fluid-tight manner to the proximal-end edge portion, and a flexible reversing part surrounded by the edge portion. In a first state, the reversing part expands toward a distal end side and in a second state the reversing part expands toward a proximal end side. The medical container further includes a protection cover which can take a proximal end side mounting state in which the protection cover is mounted on the container body so as to cover the proximal end opening, and a distal end side mounting state in which the protection cover is mounted on the container body so as to cover the mouth section.

Abstract: A system includes a first sterile medical device container. The first sterile medical device container is transparent to radiofrequency (RF) signals in a particular frequency range. The system also includes a sterile medical device within the first sterile medical device container. The sterile medical device is capable of radiofrequency communication through the first sterile medical device container using the particular frequency range. The system further includes a second container fully enclosing the first sterile medical device container and the sterile medical device, the second container including RF shielding material that is substantially opaque to the RF signals in the particular frequency range.

Abstract: The invention refers to a new system for packaging pharmaceutical compositions comprising active principles that may be administered intravenously, in particular it concerns a system for packaging in bottles which makes it possible to ensure the complete transfer of the content of the bottle into the liquid for intravenous infusion and at the same time prevent any accidental contact with the active principle by the health-care personnel preparing said intravenous infusion, and a complete kit for intravenous administration.

Abstract: The present invention provides an aqueous pharmaceutical composition comprising the fusion protein whose amino acid sequence is set forth as SEQ ID No:1 and an aqueous solution comprising 40 to 60 mM sodium phosphate. The present invention further provides a lyophilized pharmaceutical composition, an reconstituted solution, a sealed package comprising the lyophilized pharmaceutical composition, and a vial comprising the lyophilized pharmaceutical or the reconstituted solution. The present invention also provides a method of producing the lyophilized pharmaceutical composition and the sealed package. The present invention also provides a method of treating a human having cocaine seeking behavior, and methods of using the aqueous pharmaceutical composition and lyophilized pharmaceutical composition.

Abstract: In the case of a package (1) for single-dose films (2) containing active substances, comprising an upper packaging material element (3) and a lower packaging material element (4) which are connected together by a peripheral seal area or respectively sealing seam (5) such that a cavity (6) for holding the film (2) is formed, said cavity being enclosed on all sides, wherein the upper packaging material element (3) and the lower packaging material element (4) each have at least one cut (7, 8) in the region of the seal area or respectively, the sealing seam (5), said cuts being congruent, and at least one cut (7, 8) is crossed by a folding or bending line (10), the folding or bending line (10) is formed in a weakened manner.

Abstract: The present invention related to the use of a pharmaceutical composition which is essentially free of pharmaceutically active ingredients for the treatment of human skin, especially in the treatment of rosacea, acne, atopic dermatitis, contact dermatitis, perioral dermatitis, psoriasis or neurodermitis, as well as for prophylactic and/or cosmetic purposes.

Abstract: A package for a flat medical implant includes a flexible outer component, such as Tyvek®, including a first panel and a second panel foldable over said first panel for closing the package, and an inner component, such as paper, mechanically interlocked with the flexible outer component. A flat medical implant is held by the inner component. While the outer and inner components remains mechanically interconnected to one another, the upper ends of the first and second panels of the outer component are peelable away from one another for opening the package and accessing the flat medical implant at an upper end of the package.

Abstract: A medical container includes: a container body, a mouth section through which liquid can enter and exit, a proximal-end opening, and a proximal-end edge portion surrounding the proximal-end opening; a plug body that seals the mouth section; a bag body having a bag-like shape and including an edge portion that is tightly fixed to the proximal-end edge portion and seals the proximal-end opening, and a reversing part which is surrounded by the edge portion, has flexibility, and is reversed inside/outside; and a space surrounded by the container body, the plug body and the bag body. The reversing part is reversed inside/outside when the liquid enters and exits the space through the mouth section, whereby the reversing part can take a first state in which the reversing part expands toward a distal end side, and a second state in which the reversing part expands toward the proximal end side.

Abstract: The present invention relates to Pharmaceutical compositions comprising an antibody specifically binding to human proprotein convertase subtilisin/kexin type 9 (PCSK9), to methods for treating diseases or conditions in which proprotein convertase subtilisin/kexin type 9 (PCSK9) expression or activity causes an impact by administration of PCSK9-specific antibodies or antigen-binding fragments thereof and preferably by additional administration of an inhibitor of 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-CoA reductase). The present invention further relates to PCSK9-specific antibodies or antigen-binding fragments thereof for use in the treatment of diseases or conditions in which PCSK9 expression or activity causes an impact.

Abstract: The invention relates to a medical sterile packaging, which defines a receiving space for at least one implant, which is formed for temporary or permanent insertion in a human or animal body, which receiving space is closed in a sterile and germ-proof manner in a storage disposition of the sterile packaging for the sterile packaging of the at least one implant, wherein the sterile packaging is produced from one or more cleanable and sterilisable materials.

Abstract: To provide a medical tray which can be made more compact upon discarding, the medical tray has a bottom portion, a side wall provided along an outer periphery of the bottom portion, and a pair of side wall deformation guiding portions provided at opposing positions of the side wall for guiding the side wall when the side wall is deformed into a convex state toward the bottom portion.

Abstract: Disclosed is a surgical glove that alleviates the biasing force associated with bending or abducting the hand and fingers when wearing a surgical glove.

Abstract: The embodiments described herein relate to chemically and mechanically durable glass compositions and glass articles formed from the same. In another embodiment, a glass composition may include from about 70 mol. % to about 80 mol. % SiO2; from about 3 mol. % to about 13 mol. % alkaline earth oxide; X mol. % Al2O3; and Y mol. % alkali oxide. The alkali oxide may include Na2O in an amount greater than about 8 mol. %. A ratio of Y:X may be greater than 1 and the glass composition may be free of boron and compounds of boron. In some embodiments, the glass composition may also be free of phosphorous and compounds of phosphorous. Glass articles formed from the glass composition may have at least a class S3 acid resistance according to DIN 12116, at least a class A2 base resistance according to ISO 695, and a type HGA1 hydrolytic resistance according to ISO 720.

Abstract: A brachytherapy packaging system is disclosed including an inner tray containing a plurality of recesses, each recess for holding a strand of linked radiological seeds separated by spacers. An inner tray cover may also contain a plurality of recesses that coincide with the recesses of the inner tray when placed over the inner tray. The inner tray and inner tray cover may be supported by and enclosed in a container made out of a metal such as pewter. A retainer may also be supportable on the top of the container, shaped for holding a forceps or tweezers. An outer tray may be used for supporting and enclosing the container and optional retainer. The outer tray may be sealed with a removable sheet adhesively attached to a rim of the outer tray. Different configurations of the inner tray and inner tray cover may be used for different packaging configurations.

Abstract: A packaged, sterilized intraocular lens prepared by a process comprising providing a hydrophobic acrylic, or low water acrylic, intraocular lens and positioning the acrylic lens in a lens enclosure with an aqueous solution to provide a lens package. The lens package is then heated to a temperature sufficient for sterilization, however, the heating of the lens package must begin before the acrylic lens reaches an equilibrated, hydrated state following contact of the lens with the aqueous solution. The resulting sterilized acrylic intraocular lens will have less than sixty percent of total volume of disc-like features, or less than forty percent of total volume of water vacuoles, after 60 days following sterilization compared to an acrylic lens of the same composition, which was sterilized under the same conditions, but in an equilibrated, hydrated state.

Abstract: A packaging structure (100) for a patch includes a first and second base materials (120, 130) which have a peripheral edge part laminated with each other, and the patch is included therein. The first and second base materials (120, 130) have a first to forth sides (121 to 124, 131-134). At least one of the first and second base materials (120, 130) has a first to third opening parts (125 to 127, 135 to 137). The first to third opening parts (125 to 127, 135 to 137) guides so as to open toward the inner peripheral edge (120c1, 120c2, 120c4, 130c1, 130c2, 130c4) of the sealing part (120c, 130c).

Abstract: The present disclosure concerns a package for an ostomy sealing member for sealing around a stoma in relation to an ostomy appliance, said sealing member comprising a hypoallergenic, mouldable adhesive material, said sealing member having an annular periphery and an opening therein for receiving a stoma, wherein the opening is non-concentric with the periphery.

Abstract: A modular medical instrument sterilization container and related methods are disclosed. The container includes a base and a plurality of sidewalls, each being substantially planar and having a consistently repeated cross-section. A plurality of corner posts having a uniform, consistent cross-section is connected between the plurality of sidewalls. A plurality of bottom edge rails having a uniform, consistent cross-section is connected between a sidewall and the base. A plurality of top edge rails having a uniform, consistent cross-section is connected to the sidewall. A plurality of junction connectors are connected between one of the plurality of corner posts and at least one of: two of the bottom edge rails and two of the top edge rails.

Abstract: A method is provided for maintaining the disinfection of medical equipment, in particular medical endoscopes (10), following processing. The method comprises placing the disinfected equipment (10) in a sealed chamber (12), and subsequently reducing the pressure within the sealed chamber (12) to cause evaporation of residual moisture. Gas scavenger sachets (21) are also provided within the sealed chamber (12) to remove atmospheric oxygen, thus causing a further reduction in the chamber pressure. The method may optionally include a further step of charging the sealed chamber (12) with a disinfectant gas or vapor. The processed medical equipment (10) is then maintained at the desired level of disinfection within the controlled biostatic environment in the sealed chamber (12).

Abstract: Individually packaged topical formulations comprising about 0.25 to about 6% w/w of glycopyrrolate for the treatment of hyperhidrosis, wherein said wipe is contained within a pouch resistant to leakage. The formulations may further comprise ethanol, a buffering agent and water. In addition, the formulations may further comprise a polymer system comprising a hydrophobic polymer in combination with a hydrophilic polymer.

Abstract: Method for the production of a fibrinogen solution from an aqueous solution that contains functionally intact fibrinogen and is contaminated with profibrin and/or fibrin monomers and/or fibrin monomer complexes and/or fibrin split products, characterized in that the contaminations are precipitated using a non-denaturing precipitating agent at a temperature ranging from ?4° to +4° and calcium ion activity not exceeding that of a 1,000 ?M CaCl2 solution and are separated from the solution by means of filtering or centrifugation process.

Abstract: The invention relates to a kit for preserving a biological product including a three-dimensional bag (1) intended for holding said biological product, said bag (1) having a substantially constant three-dimensional geometry during the use thereof, as well as a casing (2) intended for packing said bag, said casing (2) including a cavity (3) arranged such as to receive said bag (1), said cavity (3) having a substantially constant three-dimensional geometry during the use thereof, and a slot (4) being provided along one edge of said cavity such as to enable said bag (1) to be inserted in said cavity (3), a front strip (5) and a rear strip (6) extending on the outside away from said slot (4), said strips being intended for being combined with one another in order to provide an airtight seal of said cavity (3) of the casing (2).