With Deflection Patents (Class 209/210)
  • Patent number: 10629833
    Abstract: Provided herein are flashing ratchets that produce transport based on the oscillating application of regularly-spaced, asymmetric potentials. In particular, devices are provided that transport electrons without the requirement of an overall source-drain bias favoring electron transport.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: April 21, 2020
    Assignee: Northwestern University
    Inventors: Ofer Kedem, Bryan Lau, Emily A. Weiss
  • Patent number: 10618046
    Abstract: The combined value of integrating optical forces and electrokinetics allows for the pooled separation vectors of each to be applied, providing for separation based on combinations of features such as size, shape, refractive index, charge, charge distribution, charge mobility, permittivity, and deformability. The interplay of these separation vectors allow for the selective manipulation of analytes with a finer degree of variation. Embodiments include methods of method of separating particles in a microfluidic channel using a device comprising a microfluidic channel, a source of laser light focused by an optic into the microfluidic channel, and a source of electrical field operationally connected to the microfluidic channel via electrodes so that the laser light and the electrical field to act jointly on the particles in the microfluidic channel. Other devices and methods are disclosed.
    Type: Grant
    Filed: May 23, 2018
    Date of Patent: April 14, 2020
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Sean J. Hart, Sarah J. R. Staton, Alexander V. Terray, Gregory E. Collins
  • Patent number: 9914139
    Abstract: 1. A hydrocyclone for separating a fiber suspension into a heavy fraction and including a distribution head for supplying a fluid to the separation chamber, which distribution head is situated centrally in the separation chamber relatively close to the other end. The distribution head has at least one outlet passage designed for spraying a fluid jet, the fluid jet having a flow component in the direction towards the other end of the separation chamber, and the fluid jet having another flow component directed towards the one end.
    Type: Grant
    Filed: November 6, 2015
    Date of Patent: March 13, 2018
    Assignee: GL&V Luxembourg S.a.r.l.
    Inventors: Valentina Kucher, Gunnar Liliengren, Jan Backman
  • Patent number: 9101664
    Abstract: We describe methods for synthesis and formulations of stable elastomeric negative acoustic contrast particles with controllable compressibility and density. These elastomeric negative acoustic contrast particles have a density/compressibility ratio that is less than that of water and therefore exhibit negative acoustic contrast under acoustic radiation exposure. This negative acoustic contrast allows our elastomeric negative acoustic contrast particles to be acoustically manipulated (e.g. separated) differently from other components (e.g. cells) within an aqueous solution. This disclosure also describes methods for biofunctionalization of the elastomeric negative acoustic contrast particles and as an example their use as platforms for bioassays.
    Type: Grant
    Filed: May 11, 2010
    Date of Patent: August 11, 2015
    Inventors: Gabriel Lopez, Gregory Kaduchak
  • Patent number: 8783467
    Abstract: The disclosure relates to obstacle array devices (also known as bump array devices) for separating populations of particles by size. Improvements over previous obstacle array devices are realized by causing the fluid velocity profile across gaps between obstacles to be asymmetrical with respect to the plane that bisects the gap and is parallel to the direction of bulk fluid flow. Such asymmetry can be achieved by selecting the shape(s) of the obstacles bounding the gap such that the portions of the obstacles upstream from, downstream from or bridging the narrowest portion of the gap are asymmetrical with respect to that plane. Improvements are also realized by using obstacles that have sharp edges bounding the gaps. Other improvements are realized by selecting obstacle shapes such that the critical particle dimensions defined by the gaps in two different fluid flow directions differ.
    Type: Grant
    Filed: December 7, 2012
    Date of Patent: July 22, 2014
    Assignee: The Trustees of Princeton University
    Inventors: Kevin Loutherback, James C. Sturm, Robert Austin, Keith Morton, Jason Puchalla
  • Patent number: 8779382
    Abstract: This invention relates to the reduction of charged particle loss by radially introducing sheath air from the porous wall. The corona-wire unipolar aerosol charger of the present invention includes a charging chamber, at least one aerosol inlet channel, a corona wire, an annular sheath air inlet opening, a porous tube defining a charging chamber, an annular sheath air outlet opening, and an aerosol outlet channel. The sheath air inlet opening is for radially introducing a sheath air flow into the charging chamber. The charged particles will not deposit on the wall surface of the charger if the radial velocity of the introduced sheath air at the wall is higher or comparable to the electrostatic velocity of charged particles. The dilution effect of charged particle due to the use of clean air can be further minimized by redirecting the excess clean air to the outside of the charger.
    Type: Grant
    Filed: May 16, 2013
    Date of Patent: July 15, 2014
    Assignee: National Chiao Tung University
    Inventors: Chuen-Jinn Tsai, Chih-Liang Chien, Virat Wattanamekhinkul
  • Patent number: 8657120
    Abstract: Trapping structures are provided for particle separation devices that make use of traveling wave fluid flow. These trapping structures are operative to capture and collect separated particles and present them for extraction. The extraction can be accomplished in conventional manners, such as through the use of suitable sized pipettes.
    Type: Grant
    Filed: November 30, 2006
    Date of Patent: February 25, 2014
    Assignee: Palo Alto Research Center Incorporated
    Inventors: Meng H. Lean, Jeonggi Seo
  • Patent number: 8579117
    Abstract: The disclosure relates to obstacle array devices (also known as bump array devices) for separating populations of particles by size. Improvements over previous obstacle array devices are realized by causing the fluid velocity profile across gaps between obstacles to be asymmetrical with respect to the plane that bisects the gap and is parallel to the direction of bulk fluid flow. Such asymmetry can be achieved by selecting the shape(s) of the obstacles bounding the gap such that the portions of the obstacles upstream from, downstream from, or bridging the narrowest portion of the gap are asymmetrical with respect to that plane. Improvements are also realized by using obstacles that have sharp edges bounding the gaps. Other improvements are realized by selecting obstacle shapes such that the critical particle dimensions defined by the gaps in two different fluid flow directions differ.
    Type: Grant
    Filed: July 24, 2009
    Date of Patent: November 12, 2013
    Assignee: The Trustees of Princeton University
    Inventors: Kevin Loutherback, James C. Sturm, Robert Austin, Keith Morton, Jason Puchalla
  • Publication number: 20130213861
    Abstract: A radial opposed migration classifier is provided for separating particles in a sample, introducing and removing the particles into and out of the classifier at the same potential. A sample passes through a classification channel having two circular walls. The sample is introduced and exits the classifier through the same plane as the first wall, which is at a different potential from the second wall. A cross-flow fluid enters the classification channel through one of the walls. The cross-flow fluid flows at a first velocity and exits in a first direction through the other wall. An imposed field is applied on the particles in a second direction counter to the first direction of the cross-flow. This causes the particles of a desired size and/or charge to migrate at a second velocity opposite and/or equal to a first velocity of the cross-flow. The particles that travel through the channel are discharged.
    Type: Application
    Filed: February 15, 2013
    Publication date: August 22, 2013
    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventor: California Institute of Technology
  • Publication number: 20130213860
    Abstract: A method is provided for changing a property of a sample. A sample, comprising particles suspended within a sample fluid, is introduced into a channel which comprises two walls that are permeable to a flow of fluid. A cross-flow is introduced at a predetermined temperature and of a predetermined chemical composition into the channel through a wall. This cross-flow flows at a first velocity and exits in a first direction through the other wall. An imposed field is applied on the particles in a second direction counter to the first direction of the cross-flow. The imposed field causes the particles to migrate at a second velocity opposite and/or equal to the first velocity of the cross-flow. Particles that are approximately balanced by the first and second velocities travel through the channel and are discharged in a fluid of predetermined chemical composition and at the predetermined temperature of the cross-flow.
    Type: Application
    Filed: February 15, 2013
    Publication date: August 22, 2013
    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventor: CALIFORNIA INSTITUTE OF TECHNOLOGY
  • Patent number: 8397918
    Abstract: A separator for separating a first component and a second component from within a mixed fluid includes a plurality of discs, a separator chamber, and a disc rotator. The discs are spaced apart along a disc axis The separator chamber encircles the plurality of discs. The disc rotator rotates the plurality of discs about the disc axis relative to the separator chamber. The separator chamber includes a chamber inlet that receives the mixed fluid, a first outlet, and a second outlet. The disc rotator rotates the plurality of discs about the disc axis so that the mixed fluid is spun around the separator chamber about the disc axis to separate the heavier second component from the first component. The first component is directed out of the separator through the first outlet and the second component is directed out of separator through the second outlet.
    Type: Grant
    Filed: September 26, 2009
    Date of Patent: March 19, 2013
    Inventor: Keith A. Langenbeck
  • Patent number: 8276760
    Abstract: An improved technique for particle separation is provided. A serpentine structure is utilized in a continuous fluid flow environment to allow for suitable separation of particles to occur in a manner that does not require external application of forces to initiate the separation. The geometry of the serpentine structure and associated forces generated in connection with fluid flow therein suffice.
    Type: Grant
    Filed: November 30, 2006
    Date of Patent: October 2, 2012
    Assignee: Palo Alto Research Center Incorporated
    Inventors: Meng H. Lean, Ashutosh Kole, Jeonggi Seo
  • Publication number: 20110284673
    Abstract: A device is disclosed for removing slag from a coal gasification reactor and to a slag water bath enclosed by the reaction vessel. The slag is discharged by means of a lock-type transfer vessel arranged downstream of the slag bath. The lock-type transfer vessel comprises one upper and one lower cylindrical section, the upper cylindrical section having a diameter larger than that of the lower cylindrical section and both sections being connected with each other via a tapered section which preferably is conical and the angle of the cone being similar to that of the angle of repose of the slag. Also disclosed is a process for removing slag from a coal gasification reactor and a slag water bath housed by the reaction vessel. The device permits a discharge of slag in a lock-type transfer vessel and precludes formation of slag incrustations in the lock-type transfer vessel.
    Type: Application
    Filed: January 14, 2011
    Publication date: November 24, 2011
    Applicant: UHDE GMBH
    Inventor: CHRISTOPH HANROTT
  • Patent number: 7897026
    Abstract: A fluid particle-separating device includes a sorting, first and second diverting channels, a detector, a microprocessor, first and second actuators, and first and second sieving valves. The sorting channel receives fluid containing first and second particles. The first and second diverting channels guide the first and second particles. The detector recognizes the sizes and numbers of the first and second particles and outputs first and second recognition signals. The microprocessor receives the first and second recognition signals and outputs first and second control signals. The first and second sieving valves respectively inside the first and second diverting channels allow the particles to pass through or not. The first actuator receives the first control signal and controls the deformation of the second sieving valve to block the first particle. The second actuator receives the second control signal and controls the deformation of the first sieving valve to block the second particle.
    Type: Grant
    Filed: July 31, 2007
    Date of Patent: March 1, 2011
    Assignee: Raydium Semiconductor Corporation
    Inventors: Chung-Cheng Chou, Wai William Wang
  • Publication number: 20110024335
    Abstract: An apparatus for acoustic concentration of particles in a fluid flow includes a substantially acoustically transparent membrane and a vibration generator that define a fluid flow path therebetween. The fluid flow path is in fluid communication with a fluid source and a fluid outlet and the vibration generator is disposed adjacent the fluid flow path and is capable of producing an acoustic field in the fluid flow path. The acoustic field produces at least one pressure minima in the fluid flow path at a predetermined location within the fluid flow path and forces predetermined particles in the fluid flow path to the at least one pressure minima.
    Type: Application
    Filed: October 12, 2010
    Publication date: February 3, 2011
    Applicant: LOS ALAMOS NATIONAL SECURITY, LLC
    Inventors: Michael D. Ward, Gregory Kaduchak
  • Patent number: 7837040
    Abstract: An apparatus for acoustic concentration of particles in a fluid flow includes a substantially acoustically transparent membrane and a vibration generator that define a fluid flow path therebetween. The fluid flow path is in fluid communication with a fluid source and a fluid outlet and the vibration generator is disposed adjacent the fluid flow path and is capable of producing an acoustic field in the fluid flow path. The acoustic field produces at least one pressure minima in the fluid flow path at a predetermined location within the fluid flow path and forces predetermined particles in the fluid flow path to the at least one pressure minima.
    Type: Grant
    Filed: April 9, 2007
    Date of Patent: November 23, 2010
    Assignee: Los Alamos National Security, LLC
    Inventors: Michael D. Ward, Gregory Kaduchak
  • Publication number: 20100032350
    Abstract: A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises a bubble valve for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing the pressure pulse. The particle sorting system may include a plurality of closely coupled sorting modules which are combined to further increase the sorting rate. The particle sorting system may comprise a multi-stage sorting device for serially sorting streams of particles, in order to decrease the error rate.
    Type: Application
    Filed: July 8, 2009
    Publication date: February 11, 2010
    Applicant: CYTONOME/ST, LLC
    Inventors: Manish DESHPANDE, John R. GILBERT
  • Patent number: 7627627
    Abstract: A method for controlling command message flow in a network including a server and a client. A command window, comprising a maximum number of command messages that may be outstanding at the server, is included in messages sent from the server to the client. The value of the command window at the server is modified in accordance with available server resources for receiving command messages. When there are insufficient resources at the server to process one of the command messages delivered to the server, then a pause message is sent to the client indicating which said command message cannot be received; indicia is stored that indicates the command message initially discarded; and subsequent said command messages delivered to the server are discarded until an initially discarded said command message is again delivered to the server.
    Type: Grant
    Filed: April 30, 2004
    Date of Patent: December 1, 2009
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Richard Perham Helliwell, Richard Fitzhugh Wrenn, Edward A. Gardner
  • Patent number: 7582482
    Abstract: Apparatus and method for treating a liquid sample stream including at least one analyte ion species and matrix ion species of opposite charge to said one analyte ion species. The liquid sample stream flows through a treatment channel. A carrier liquid stream including a matrix ion species capture material flows substantially parallel to the sample stream in the treatment channel forms a liquid interface between them. The matrix ion species diffuses through the interface to contact and become bound by the capture material in said carrier liquid.
    Type: Grant
    Filed: August 28, 2003
    Date of Patent: September 1, 2009
    Assignee: Dionex Corporation
    Inventors: Parnendu K. Dasgupta, Petr Kuban, Jordan M. Berg
  • Publication number: 20090101547
    Abstract: A device for performing the manipulation of particles suspended in a fluid is disclosed. The device comprises a duct for the flow of a fluid in which particles are suspended, an acoustic transducer, and a reflector for establishing an acoustic standing wave field across the width of the duct. It has been unexpectedly found that optimum performance of the device occurs when the spacing between the transducer and a reflector is 300 microns or less. The device seeks to overcome prior engineering difficulties that prevented one from observing the individual particle bands or separating the individual particle bands from the duct.
    Type: Application
    Filed: September 15, 2006
    Publication date: April 23, 2009
    Applicant: Protasis Corporation
    Inventors: Joseph Cefai, David Anthony Barrow, William Terence Coakley, Jeremy John Hawkes
  • Patent number: 7472794
    Abstract: A system, method and apparatus employing the laminar nature of fluid flows in microfluidic flow devices in separating, sorting or filtering colloidal and/or cellular particles from a suspension in a microfluidic flow device is disclosed. The microfluidic flow device provides for separating a particle within a suspension flow in a microfluidic flow chamber. The chamber includes a microfluidic channel comprising at least one inlet port for receiving a suspension flow under laminar conditions, a first outlet port and a second outlet port. The chamber further includes an interface for translating a particle within the channel. The first outlet port receives a first portion of the suspension exiting the said channel and the second outlet port receives the particle in a second portion of the suspension exiting the channel.
    Type: Grant
    Filed: February 14, 2007
    Date of Patent: January 6, 2009
    Assignee: Colorado School of Mines
    Inventors: John Oakey, David W. M. Marr
  • Patent number: 7428971
    Abstract: The present invention provides a fine-particle sorting technique that uses optical pressure (optical force) and that can be applied in place of heretofore known cell sorting techniques; and a fine-particle recovering technique therefor. The fine-particle recovering method of the present invention comprises directing a laser beam toward a flow path of fine particles in such a manner that the laser beam crosses the flow direction of the fine particles to thereby deflect the direction of movement of the fine particles to be recovered, in the direction of convergence of the laser beam. The sorting method of the present invention comprises performing flow cytometric sorting of fine particles according to the above recovering method of the present invention.
    Type: Grant
    Filed: October 31, 2003
    Date of Patent: September 30, 2008
    Assignee: Techno Network Shikoku Co., Ltd.
    Inventors: Ken Hirano, Yoshinobu Baba
  • Patent number: 7404490
    Abstract: The present invention relates to an improved apparatus and method for assembly for a cylindrical split-flow thin separation channel that is capable of continuously separating particles of interest from a suspension flowing through the channel. The apparatus provides better precision in the separation process by providing better flow characteristics at the inlet, outlet, and in the zone of separation. Splitter surfaces are provided that match the calculated theoretical Inlet Splitter Surface (ISS) and Outlet Splitter Surface (OSS). A flow distributor diverts the inlet carrier flow into a stable, circumferentially uniform, laminar annular flow. The design enables manufacturing and assembly methods to ensure precise alignment of the components to further improve the flow profiles within the separation channel and to ensure repeatability device-to-device.
    Type: Grant
    Filed: June 15, 2005
    Date of Patent: July 29, 2008
    Assignee: SHOT, Inc.
    Inventors: David J. Kennedy, Eric W. Taylor, John C. Vellinger
  • Publication number: 20080128332
    Abstract: Trapping structures are provided for particle separation devices that make use of traveling wave fluid flow. These trapping structures are operative to capture and collect separated particles and present them for extraction. The extraction can be accomplished in conventional manners, such as through the use of suitable sized pipettes.
    Type: Application
    Filed: November 30, 2006
    Publication date: June 5, 2008
    Inventors: Meng H. Lean, Jeonggi Seo
  • Patent number: 7351327
    Abstract: A process for concurrently fractionating and treating a full range naphtha stream. The full boiling range naphtha stream is first subjected to simultaneous thioetherification and splitting into a light boiling range naphtha, an intermediate boiling range naphtha and a heavy boiling range naphtha. The intermediate boiling range naphtha containing thiophene and thiophene boiling range mercaptans is passed on to a polishing hydrodesulfurization reactor where a low sulfur, low olefin gas oil is concurrently fed to the polishing reactor to insure that a liquid phase is present.
    Type: Grant
    Filed: April 7, 2004
    Date of Patent: April 1, 2008
    Assignee: Catalytic Distillation Technologies
    Inventors: Gary G. Podrebarac, Willibrord A. Groten, Lawrence A. Smith, Jr.
  • Publication number: 20070284291
    Abstract: A method for selective separation of particles from a particle-containing material includes preparing a slurry of the particle-containing material and a dispersant, passing the slurry through a hydraulic classifier in a first direction, establishing a particle flow in a direction that is different from the first direction, and recovering particles having a mean particle size of about 2-7 ?m. The flow of particles defines a cross-current flow relative to the slurry feed direction. The method further includes providing the classifier with an interior divider assembly defining at least one inclined channel. The divider assembly typically includes a plurality of substantially parallel dividers separating the classifier into multiple channels having a substantially equal internal volume. A hydraulic classifier for separating particles having a mean particle size of from about 2-7 ?m in accordance with the present method is provided also.
    Type: Application
    Filed: June 13, 2006
    Publication date: December 13, 2007
    Inventors: Thomas L. Robl, John Groppo
  • Patent number: 7259344
    Abstract: A method is described that comprises sorting carbon nanotubes (CNTs) within a fluidic flow for a targeted subset of the CNTs. The sorting comprises attracting at least a portion of the CNTs within the fluidic flow in a direction of increasing intensity of an electric field component of a substantially stationary beam of light. The electric field component has a frequency that is less than one or more resonant frequencies of the CNTs within the portion.
    Type: Grant
    Filed: October 1, 2004
    Date of Patent: August 21, 2007
    Assignee: Intel Corporation
    Inventors: Yuegang Zhang, Herman A. Lopez, Shida Tan
  • Patent number: 6994219
    Abstract: A particulate feed comprising a first particle type and a second particle type is separated by providing a separation apparatus having a separation vessel having a top and a bottom, and wherein the separation vessel includes inwardly sloping side walls. A magnet structure has a first pole positioned exterior of and adjacent to each of the side walls of the separation vessel, and a second pole positioned above the separation vessel. A mixture of the particulate feed and a ferrofluid is introduced into the separation vessel, and the particulate feed is separated into a first particle fraction comprising a majority of the first particle type, which sinks in the separation vessel, and a second particle fraction comprising a majority of the second particle type which floats in the separation vessel.
    Type: Grant
    Filed: January 26, 2004
    Date of Patent: February 7, 2006
    Assignee: General Electric Company
    Inventors: Paul Gregory Roth, Richard Frederick Halter
  • Patent number: 6994218
    Abstract: An apparatus for sorting cells includes a cell alignment portion applying a process to a cell-suspending fluid with a great number of cells and arraying the cells with a spacing between each cell, a cell information detecting portion detecting information on the cells, a cell sorting portion for sorting the cells based upon the information detected by the cell information detecting portion, a first passage of the cell alignment portion so as to let the cell-suspending fluid flow, and a second passage of the cell alignment portion, intersecting with the first passage so as to communicate therewith, letting a splitting fluid flow so as to split the flow of the cell-suspending fluid in the first passage and forming a great number of small cell-containing liquid drops.
    Type: Grant
    Filed: March 28, 2003
    Date of Patent: February 7, 2006
    Assignee: Aisin Seiki Kabushiki Kaisha
    Inventors: Takashi Kawano, Takahiro Yamada
  • Patent number: 6905029
    Abstract: A method, system, apparatus, and article of manufacture provide a cross-flow migration classifier capable of separating particles. The classifier provides a channel through which a sample, having one or more particles, passes in a first direction, wherein the channel comprises two or more walls that are permeable to a flow of fluid. A cross-flow enters the channel through one of the permeable walls and exits through another of the permeable walls. An imposed field is applied in a second direction that is counter to the cross-flow and having an orthogonal component to the first direction. The imposed field causes one or more of the particles to migrate at a first velocity opposite and/or equal to a second velocity of the cross-flow. The particles that migrate opposite to the cross-flow are continuously discharged from the cross-flow migration classifier.
    Type: Grant
    Filed: August 29, 2003
    Date of Patent: June 14, 2005
    Assignee: California Institute of Technology
    Inventor: Richard C. Flagan
  • Patent number: 6902650
    Abstract: The present invention provides a method making stratified paper by redistributing the pulp suspension inside the headbox nozzle using acoustic radiation waves. Acoustic radiation forces fractionate fibers based on fiber radius. The acoustic radiation waves separate the fibers by pushing the coarse and longer fibers to the inner area while fines and smaller fibers remain in the outer area. This has a similar effect of multi-layer stratification headbox, and provides paper with a smoother surface.
    Type: Grant
    Filed: November 3, 2003
    Date of Patent: June 7, 2005
    Assignee: International Paper Company
    Inventors: Chang Shin Park, Hanjian Xu
  • Patent number: 6868971
    Abstract: A separator for separating solids and other objects (debris) from a liquid, and having a separator body (2) through which the liquid, having debris entrained therein (16, 19, 20), flows from an inlet (6) to an outlet (13), and a port (5) for diverting flow from the outlet during moderate flows whereby the debris entrained in the liquid is removed. A floor (11) wherein the separator is raised to form a hump (43) adjacent to or in which the opening (5) is located.
    Type: Grant
    Filed: May 11, 2001
    Date of Patent: March 22, 2005
    Assignee: Water Solutions (AUST) Pty Ltd.
    Inventor: Donald Ian Phillips
  • Patent number: 6827221
    Abstract: A mill classifier, particularly a roller mill classifier, has a strip rotor and a concentrically arranged guide vane ring with flow-optimized guide vanes and flow channels for a parallel incoming and outgoing flow without constriction or with widening and a diffuser effect. The flow-optimized guide vanes with an incident flow tube with vertical rotation axis and at least one guide plate are arranged adjustably for a tangential to radial incident flow of the strip rotor.
    Type: Grant
    Filed: October 1, 2002
    Date of Patent: December 7, 2004
    Assignee: Loesche GmbH
    Inventors: Horst Brundiek, Winfried Ruhkamp
  • Patent number: 6695147
    Abstract: This invention provides an extraction device and a method for extracting desired particles from a sample stream containing the desired particles. The device has a sample stream inlet, an extraction stream inlet, and an extraction channel in fluid communication with the sample stream inlet and the extraction stream inlet. The extraction channel is for receiving a sample stream from the sample stream inlet in adjacent laminar flow with an extraction stream from the extraction stream inlet. A sequestering material within the extraction channel captures desired particles in the extraction stream. A by-product stream outlet in fluid communication with the extraction channel receives a by-product stream comprising at least a portion of the sample stream form which desired particles have been extracted. A product outlet in fluid communication with the extraction channel receives a product which has the sequestering material and at least a portion of the desired particles.
    Type: Grant
    Filed: October 12, 1999
    Date of Patent: February 24, 2004
    Assignee: University of Washington
    Inventors: Paul Yager, James P. Brody
  • Patent number: 6316451
    Abstract: A compound of formula (1) wherein R1 is hydrogen, hydroxy, a group of formula OR5 wherein R5 is C1-C6 alkyl, C2-C6 alkenyl or C3-C8 cycloalkyl, halogen, amino which may be unsubstituted or mono or disubstituted by C1-C6 alkyl, C2-C6 alkenyl, aralkyl, acyl or trifluoroacetyl; R2 is hydrogen, hydroxy, a group NR6R7 wherein R6 and R7 independently represent hydrogen, an optionally substituted C1-C6 alkyl, C2-C6 alkenyl, C3-C8 cycloalkyl or, taken together with the nitrogen atom, represent an optionally substituted C3-C8 heterocyclic ring; R3 is hydrogen, hydroxy, R4 is a 2-substituted thiazolyl or imidazolyl system and the pharmaceutically acceptable salt thereof, is useful in the treatment of amyloidosis. Processes for the preparation and pharmaceutical compositions are also described.
    Type: Grant
    Filed: September 26, 2000
    Date of Patent: November 13, 2001
    Assignee: Pharmacia & Upjohn S.p.A.
    Inventors: Sergio Mantegani, Gabriella Traquandi, Tiziano Bandiera, Jacqueline Lansen, Mario Varasi
  • Publication number: 20010022283
    Abstract: Dense, tramp material, is efficiently separated in a comminuted cellulosic fibrous material feed system, for example in a chemical cellulose digester feed system, in a simple but effective matter. By merely utilizing a generally vertical conduit and a slurry flow within it (which may be augmented by high speed liquid introduction), that is caused to turn in a radiused path, centrifugal force allows separation of the tramp material into a cavity beneath the radius transition without requiring any mechanical element to engage the slurry. Appropriate purges, baffles, and discharge mechanisms may be provided. Alternatively, a tramp material separator may be built into an otherwise conventional metering screw in a digester feed system, or one or more centrifugal separators can be provided downstream of the slurry pump in a chip slurry transport system or digester feed system.
    Type: Application
    Filed: May 17, 2001
    Publication date: September 20, 2001
    Applicant: Andritz-Ahlstrom Inc.
    Inventors: Vic L. Bilodeau, R. Fred Chasse, James R. Prough, C. Bertil Stromberg, Craig A. Walley
  • Patent number: 6238523
    Abstract: The present invention provides an apparatus for decontaminating aqueous paper pulp, the apparatus comprising a decontaminating cell (12). The decontaminating cell (12) has an upper light contaminate collection hood (30) and/or a lower heavy contaminate collection trough (40). Paper pulp is provided to the cell (12) under a pulp head sufficient to purge the contaminates therefrom.
    Type: Grant
    Filed: May 8, 1998
    Date of Patent: May 29, 2001
    Assignee: SEP Technologies LLC
    Inventor: J. Alan Lawson
  • Patent number: 6213308
    Abstract: A item separating or debris eliminating system includes a tank and a pump for circulating water from one end of the tank around through a duct and back into the opposite end of the tank. A medium density object collector is located within the tank, and a light debris collector is located within the tank. A conveyor filter is included through which substantially all of the water in the tank is circulated. The debris eliminating system preferably also includes a high density object collector within the tank. The system can be used to separate a variety of objects having different densities and terminal velocities in a fluid. Most preferably, the system is utilized for separating debris from potatoes and the like produce.
    Type: Grant
    Filed: August 1, 1997
    Date of Patent: April 10, 2001
    Assignee: Recot, Inc.
    Inventor: Rick W. Bajema
  • Patent number: 6193070
    Abstract: A solids separation system may be used to separate solids, such as cuttings from drilling fluids used in well drilling operations. The system includes a settling tank having transverse baffles defining a fluid receiving chamber, a fluid output chamber and one or more intermediate chambers. Fluid introduced into the fluid receiving chamber can flow in a sinuous path through apertures in the baffles to the fluid output chamber. Solids settle to the bottom of the settling tank. A material conveyor, preferably an auger, extends along a bottom surface of the settling tank to an outlet port in the fluid receiving chamber. A centrifuge is connected to the output port to receive fluid in which solids have been concentrated. Fluid output from the centrifuge is reintroduced into the settling tank. The apparatus and method of the invention permit a single centrifuge to be used to handle a higher volume of fluid than is possible with conventional methods and apparatus. This provides significant cost savings.
    Type: Grant
    Filed: September 21, 1999
    Date of Patent: February 27, 2001
    Assignee: Grand Tank (International) Inc.
    Inventors: Brian Raymond Rowney, David King
  • Patent number: 6139684
    Abstract: A method and apparatus for decontaminating a liquid suspension comprising a decontaminating cell. The decontaminating cell has an upper light contaminate collection hood and/or a lower heavy contaminate collection trough. A method and apparatus are provided for decontaminating a liquid suspension by infusing the suspension with a gas, mechanically agitating the suspension, or providing chemical additives thereto. The liquid suspension is then directed to the decontaminating cell under a pressure head sufficient to purge the contaminates therefrom.
    Type: Grant
    Filed: October 9, 1998
    Date of Patent: October 31, 2000
    Assignee: SEP Technologies, Inc.
    Inventors: J. Alan Lawson, James W. Ramp
  • Patent number: 6109119
    Abstract: Sample focusing method and device for field-flow fractionation techniques that lead to improved detection, improved separation resolution, and a compressed sample plug while permitting a more straightforward quantitation of peaks and reliable large volume injections. The method and technique can be implemented in separations that are performed by a variety of field-flow fractionation techniques, including thermal FFF, electrical FFF, sedimentation FFF, gravitational FFF, dielectric FFF, photophoretic FFF, flow FFF, asymmetric flow FFF, and symmetric flow FFF. The sample focusing device can be integrally built into a separation channel or it can be manufactured as an attachable independent piece.
    Type: Grant
    Filed: February 27, 1998
    Date of Patent: August 29, 2000
    Assignee: FFFractionation, LLC
    Inventors: Yong Jiang, Marcia E. Hansen, Michael E. Miller, Andreas M. Kummerow
  • Patent number: 6036028
    Abstract: An apparatus for separating out light materials from mineral raw materials is provided. The apparatus includes a charging device that has a charging tube provided with an eccentrically arranged inlet for tangential introduction of raw material. The apparatus also has an inner chamber for separating out coarse sand received from the charging tube, and an outer chamber that serves for sorting out fine sand pursuant to the fluidized bed process. The outer chamber communicates with an overflow chute of the charging tube via an inclined overflow surface. An impingement body is centrally disposed in the inner chamber while leaving free an outer annular gap. The charging tube opens out centrally above the impingement body. A perforated basket, for adjusting flow resistance, is disposed so as to be displaceable in the axis of the charging tube and bridges a space between the impingement body and the end of the charging tube.
    Type: Grant
    Filed: June 12, 1998
    Date of Patent: March 14, 2000
    Assignee: Allmineral Aufbereitungstechnik GmbH & Co. KG
    Inventors: Andreas Jungmann, Walter Strangalies, Thomas Neumann
  • Patent number: 6024227
    Abstract: Dense, tramp material, is efficiently separated in a comminuted cellulosic fibrous material feed system, for example in a chemical cellulose digester feed system, in a simple but effective matter. By merely utilizing a generally vertical conduit and a slurry flow within it (which may be augmented by high speed liquid introduction), that is caused to turn in a radiused path, centrifugal force allows separation of the tramp material into a cavity beneath the radius transition without requiring any mechanical element to engage the slurry. Appropriate purges, baffles, and discharge mechanisms may be provided. Alternatively, a tramp material separator may be built into an otherwise conventional metering screw in a digester feed system, or one or more centrifugal separators can be provided downstream of the slurry pump in a chip slurry transport system or digester feed system.
    Type: Grant
    Filed: August 4, 1997
    Date of Patent: February 15, 2000
    Assignee: Ahlstrom Machinery Inc.
    Inventors: Vic L. Bilodeau, R. Fred Chasse, James R. Prough, C. Bertil Stromberg, Craig A. Walley
  • Patent number: 5979664
    Abstract: Methods and apparatus for acoustic fiber fractionation using a plane ultrasonic wave field interacting with water suspended fibers circulating in a channel flow using acoustic radiation forces to separate fibers into two or more fractions based on fiber radius, with applications of the separation concept in the pulp and paper industry. The continuous process relies on the use of a wall-mounted, rectangular cross-section piezoelectric ceramic transducer to selectively deflect flowing fibers as they penetrate the ultrasonic field. The described embodiment uses a transducer frequency of approximately 150 kHz. Depending upon the amount of dissolved gas in water, separation is obtained using a standing or a traveling wave field.
    Type: Grant
    Filed: August 20, 1998
    Date of Patent: November 9, 1999
    Assignee: Institute of Paper Science and Technology, Inc.
    Inventor: Pierre Brodeur
  • Patent number: 5971158
    Abstract: This invention provides an extraction device and a method for extracting desired particles from a sample stream containing the desired particles. The device has a sample stream inlet, an extraction stream inlet, and an extraction channel in fluid communication with the sample stream inlet and the extraction stream inlet. The extraction channel is for receiving a sample stream from the sample stream inlet in adjacent laminar flow with an extraction stream from the extraction stream inlet. A sequestering material within the extraction channel captures desired particles in the extraction stream. A by-product stream outlet in fluid communication with the extraction channel receives a by-product stream comprising at least a portion of the sample stream form which desired particles have been extracted. A product outlet in fluid communication with the extraction channel receives a product which has the sequestering material and at least a portion of the desired particles.
    Type: Grant
    Filed: June 13, 1997
    Date of Patent: October 26, 1999
    Assignee: University of Washington
    Inventors: Paul Yager, James P. Brody
  • Patent number: 5901853
    Abstract: An apparatus (310) for extracting impurities from a pulpous slurry. The apparatus has an auxiliary chamber (13) having an upper chamber (313) and a hydrocyclone (311) for further extracting impurities from the pulpous slurry. A conduit (58) returns a selected portion of the pulpous slurry back to a separation chamber for further processing.
    Type: Grant
    Filed: May 10, 1996
    Date of Patent: May 11, 1999
    Inventor: Robert S. Singleton, Jr.
  • Patent number: 5894935
    Abstract: Method and device for separating a fine-grained solid material into a fines fraction and a coarse fraction at a cut point size of below 50 .mu.m, preferably below approx. 10 .mu.m. The fine-grained solid is dispersed in a liquid capable of forming drops and this dispersion is forced into a defined sink flow with a superimposed rotational flow that is generated independently from the jink flow. The relationship between the two rates, namely the sink flow rate and the rotational flow rate, is dictated by the cut point size. The device includes a deflector wheel which has a direction of flow from the outside to the inside, and vanes are fitted in the wheel parallel to its rotational axis to form flow channels, whereby the feed dispersion is charged to the deflector wheel at its outer periphery.
    Type: Grant
    Filed: August 4, 1994
    Date of Patent: April 20, 1999
    Assignee: Hosokawa Alpine Aktiengesellschaft
    Inventor: Juergen Stein
  • Patent number: 5803270
    Abstract: Methods and apparatus for acoustic fiber fractionation using a plane ultrasonic wave field interacting with water suspended fibers circulating in a channel flow using acoustic radiation forces to separate fibers into two or more fractions based on fiber radius, with applications of the separation concept in the pulp and paper industry. The continuous process relies on the use of a wall-mounted, rectangular cross-section piezoelectric ceramic transducer to selectively deflect flowing fibers as they penetrate the ultrasonic field. The described embodiment uses a transducer frequency of approximately 150 kHz. Depending upon the amount of dissolved gas in water, separation is obtained using a standing or a traveling wave field.
    Type: Grant
    Filed: October 31, 1995
    Date of Patent: September 8, 1998
    Assignee: Institute of Paper Science & Technology, Inc.
    Inventor: Pierre Brodeur
  • Patent number: 5791491
    Abstract: An apparatus (110) for extracting impurities from a pulpous slurry. The apparatus has a housing (111) and an auxiliary chamber (113). The housing has a separation chamber (127) having stack of disks (159) spaced from each other so as to form channels (172) therebetween. The disks are mounted to a drive shaft (160) which is rotatably driven by a motor (161). The action of the rotating disks cause impurities to be projected to the outermost portion of the separation chamber while the desired pulpous fibers pass between through the channel to an accept tube (193) for collection.
    Type: Grant
    Filed: September 15, 1995
    Date of Patent: August 11, 1998
    Inventor: Robert Singleton, Jr.
  • Patent number: RE41762
    Abstract: The present invention provides a nanostructured device comprising a substrate including nanotroughs therein; and a lipid bilayer suspended on or supported in the substrate. A separation method is also provided comprising the steps of supporting or suspending a lipid bilayer on a substrate; wherein the substrate comprises nanostructures and wherein the lipid bilayer comprises at least one membrane associated biomolecule; and applying a driving force to the lipid bilayer to separate the membrane associated biomolecule from the lipid bilayer and to drive the membrane associated biomolecule into the nanostructures.
    Type: Grant
    Filed: June 30, 2008
    Date of Patent: September 28, 2010
    Assignee: STC.UNM
    Inventors: Gabriel P. Lopez, Steven R. J. Brueck, Linnea K. Ista