Antithrombogenic Membrane Patents (Class 210/321.62)
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Patent number: 11529444Abstract: Dialysis systems comprising actuators that cooperate to perform dialysis functions and sensors that cooperate to monitor dialysis functions are disclosed. According to one aspect, such a hemodialysis system comprises a user interface model layer, a therapy layer, below the user interface model layer, and a machine layer below the therapy layer. The user interface model layer is configured to manage the state of a graphical user interface and receive inputs from a graphical user interface. The therapy layer is configured to run state machines that generate therapy commands based at least in part on the inputs from the graphical user interface. The machine layer is configured to provide commands for the actuators based on the therapy commands.Type: GrantFiled: June 15, 2020Date of Patent: December 20, 2022Assignee: DEKA Products Limited PartnershipInventors: Michael J. Wilt, Todd A. Ballantyne, Jason A. Demers
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Patent number: 11253819Abstract: System, devices, and method for the production of thin film composite hollow fiber membranes on a hollow fiber support structure. The system includes a comb and roller device, or comb and dual roller device, which can be used to define a submerged travel path in a first solution bath for a hollow fiber. The combs and rollers control the amount of time the hollow fiber spends in the first solution. The first solution contains a first monomer, and the hollow fiber is impregnated with the first monomer. The amount of impregnation depends on the time spent in the first solution. Subsequent immersion in a second solution containing a second monomer results in the formation of a thin film composite hollow fiber membrane.Type: GrantFiled: May 14, 2020Date of Patent: February 22, 2022Assignee: Saudi Arabian Oil CompanyInventor: Seung-Hak Choi
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Patent number: 10022478Abstract: A medical device is provided including a base member and a coating layer containing an antithrombogenic material and covering a surface of the base member. The antithrombogenic material contains a copolymer having a repeating unit (A) represented by the following formula (1): wherein R11 is a hydrogen atom or a methyl group, Z is an oxygen atom or —NH—, R12 is a C1-6 alkylene group, R13 and R14 are each independently a C1-4 alkyl group, and R15 is a C1-2 alkylene group, and a repeating unit (B) represented by the following formula (2): wherein R21 is a hydrogen atom or a methyl group, R22 is a C1-6 alkylene group, and R23 is a C1-4 alkyl group. The repeating unit (A) is contained in a proportion of 1 to 7 mol % based on all the structural units of the copolymer.Type: GrantFiled: June 27, 2016Date of Patent: July 17, 2018Assignee: TERUMO KABUSHIKI KAISHAInventors: Takao Anzai, Kaori Nishida
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Patent number: 8733557Abstract: The present invention relates to a substrate including a compound having blood anticoagulation activity and a hydrophilic polymer compound, wherein the amount of elution of the compound having blood anticoagulation activity is less than 0.6 ?g/ml, and a manufacturing method of a substrate, wherein after a compound having blood anticoagulation activity and a hydrophilic compound brought in contact with a substrate are irradiated with radiation, unreacted components are washed out.Type: GrantFiled: September 13, 2007Date of Patent: May 27, 2014Assignee: TORAY Industries, Inc.Inventors: Hirokazu Sakaguchi, Hiroshi Takahashi, Yoshiyuki Ueno, Hiroyuki Sugaya
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Publication number: 20140131276Abstract: The present invention relates to a device for extracorporeal removal of harmful agents from blood or blood com-Components, comprising full length heparin immobilized on a solid substrate by covalent end point attachment. The present invention also relates to a method for extracorporeal removal of a harmful agent from mammalian blood or blood components. The present invention further relates to a process for covalent end point attachment of full length heparin to a solid substrate.Type: ApplicationFiled: January 15, 2014Publication date: May 15, 2014Inventors: Olle LARM, Tomas Bergström, Jonas AXELSSON, Lars ADOLFSSON, Robert S. WARD, Keith MCCREA
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Patent number: 8501008Abstract: The invention relates to a method for reducing the number of leukocytes in blood through treating the blood in an arrangement of a plurality of fibers based on organic polymers, whereby the blood is channeled along the fibers and whereby the reduction in leukocytes from the blood occurs essentially through adsorption on the fibers, characterized in that the plurality of fibers based on organic polymers is fixed in a housing with an inlet arrangement and an outlet arrangement, and that the blood is channeled via the inlet arrangement into the housing, flows through the housing with the plurality of fibers made from organic polymers, and exits the housing via the outlet arrangement, that the arrangement of the fibers shows a high degree of order, that the blood flows along the external surface of the fibers, and that the fibers cause a generation of the complement activation product C5a in a concentration of at least 10 ?g per m2 of fiber surface.Type: GrantFiled: September 2, 2006Date of Patent: August 6, 2013Assignee: Membrana GmbHInventors: Horst-Dieter Lemke, Frank Wiese, Bodo von Harten, Martin König, Wolfgang Ramlow
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Publication number: 20120275955Abstract: In some embodiments, the present invention generally relates to the separation of blood within a device to form plasma or serum. In some embodiments, the present invention generally relates to the removal of fluids, such as blood, contained within a device. For example, a device may be applied to the skin of a subject to receive blood from the subject and pass the blood through a separation membrane, which separates the blood into plasma and a portion concentrated in blood cells. As another example, blood or plasma may be allowed to clot within the device and serum (the unclotted portion of the blood) may be withdrawn from the device. The device may contain, in some cases, a vacuum source such as a pre-packaged vacuum to facilitate receiving of blood and/or passage of the blood through the separation membrane to produce plasma or serum.Type: ApplicationFiled: April 26, 2012Publication date: November 1, 2012Applicant: Seventh Sense Biosystems, Inc.Inventors: Ramin Haghgooie, Donald E. Chickering, III, Shawn Davis, Mark Michelman, Howard Bernstein, Kristin Horton
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Publication number: 20120129252Abstract: Methods and systems disclosed in the present application include membrane-like filters and methods and systems that employ these membrane-like filters to isolate circulating tumor cells and other abnormal cells from biological fluids, such as blood. The disclosed methods and systems use membrane-like filters that include a pattern or array of small, tapered apertures fabricated within a relatively thin but mechanically robust polymeric material that resists accumulation of biological-solution components and clogging during filtration of biological solutions.Type: ApplicationFiled: November 14, 2011Publication date: May 24, 2012Inventor: Ronald C. Seubert
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Patent number: 7985337Abstract: A device for reducing the number of leucocytes in blood comprising a plurality of hollow fibers based on organic polymers, whereby the hollow fibers have a lumen and a wall surrounding the lumen, said wall having an internal surface facing the lumen and an external surface, whereby the hollow fibers are arranged in a cylindrical housing with an inlet arrangement and an outlet arrangement and whereby an outer space is formed between the hollow fibers and the housing, which space is accessible for a fluid via the inlet arrangement and the outlet arrangement, characterized in that only the external surfaces of the hollow fibers are accessible for a fluid, that the lumina of the hollow fibers are not accessible for a fluid, that the arrangement of the hollow fibers shows a high degree of order and that the hollow fibers based on organic polymers cause a generation of the complement activation product C5a in a concentration of at least 10 ?g per m2 of fiber surface.Type: GrantFiled: January 10, 2008Date of Patent: July 26, 2011Assignee: Membrana GmbHInventors: Frank Heuser, Martin König, Horst-Dieter Lemke, Bodo Von Harten
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Publication number: 20110174733Abstract: The invention relates to a filter system for removing activated PMNs and mediators which are responsible for the activation thereof, and optionally mediators which are simultaneously, but independently of activated PMNs, responsible for a state of illness from body fluids, process for production thereof and use thereof. The inventive filter system for continuous removal of activated PMNs from blood consists of molecules which recognize and bind activated PMNs, molecules which recognize and bind PMN-activating mediators, molecules which recognize and bind C3a and/or C5a, biocompatible surfaces (carriers) on which the molecules a., b. and c. are bound covalently or adsorptively, a casing for accommodating the active carriers, valves and tubes. The field of use of the invention is medicine.Type: ApplicationFiled: August 27, 2009Publication date: July 21, 2011Inventor: Hans-Werner Heinrich
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Publication number: 20110056882Abstract: Methods and materials for making an apparatus which duplicates the functionality of a physiological system is provided.Type: ApplicationFiled: August 16, 2010Publication date: March 10, 2011Applicants: THE CHARLES STARK DRAPER LABORATORY, MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE GENERAL HOSPITAL CORPORATIONInventors: Jeffrey T. Borenstein, Eli Weinberg, Brian K. Orrick, Eleanor M. Pritchard, Edward J. Barnard, Nicholas J. Krebs, Theodore Marentis, Joseph P. Vacanti, Mohammad Reza Kaazempur-Mofrad
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Publication number: 20110011786Abstract: A device for monitoring a parameter of a fluidic sample by microdialysis, the device comprising a permeable membrane, wherein the permeable membrane has a first surface to be brought in contact with the fluidic sample to traverse the permeable membrane (300), wherein the permeable membrane has a second surface to be brought in contact with a dialysis fluid, and wherein the first surface is smoother than the second surface.Type: ApplicationFiled: October 18, 2007Publication date: January 20, 2011Applicant: Joanneum Research Forschungsgesellschaft MBHInventors: Franz Feichtner, Lukas Schaupp, Hans Koehler
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Publication number: 20100176048Abstract: The present invention relates to a substrate including a compound having blood anticoagulation activity and a hydrophilic polymer compound, wherein the amount of elution of the compound having blood anticoagulation activity is less than 0.6 ?g/ml, and a manufacturing method of a substrate, wherein after a compound having blood anticoagulation activity and a hydrophilic compound brought in contact with a substrate are irradiated with radiation, unreacted components are washed out.Type: ApplicationFiled: September 13, 2007Publication date: July 15, 2010Inventors: Hirokazu Sakaguchi, Hiroshi Takahashi, Yoshiyuki Ueno, Hiroyuki Sugaya
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Publication number: 20100084331Abstract: A device for reducing the number of leucocytes in blood comprising a plurality of hollow fibers based on organic polymers, whereby the hollow fibers have a lumen and a wall surrounding the lumen, said wall having an internal surface facing the lumen and an external surface, whereby the hollow fibers are arranged in a cylindrical housing with an inlet arrangement and an outlet arrangement and whereby an outer space is formed between the hollow fibers and the housing, which space is accessible for a fluid via the inlet arrangement and the outlet arrangement, characterized in that only the external surfaces of the hollow fibers are accessible for a fluid, that the lumina of the hollow fibers are not accessible for a fluid, that the arrangement of the hollow fibers shows a high degree of order and that the hollow fibers based on organic polymers cause a generation of the complement activation product C5a in a concentration of at least 10 ?g per m2 of fiber surface.Type: ApplicationFiled: January 10, 2008Publication date: April 8, 2010Inventors: Frank Heuser, Martin König, Horst-Dieter Lemke, Bodo Von Harten
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Publication number: 20090206038Abstract: The invention concerns a composite support comprising a base support for the treatment of a biological fluid, in which: “the base support is essentially-constituted by a first polymer carrying anionic or anionizable groups;” at least a part of the surface of the base support is coated with a second polymer ionically bonded to the first polymer, the second polymer carrying the cationic or cationizable groups which are capable of forming an ionic bond with the anionic or anionizable groups of the first polymer; in which the second polymer is in the colloidal form and in mixture with a polyacid during application to the support, allowing the composite membrane to adsorb at least one entity containing anionic or anionizable groups by bonding with cationic or cationizable groups of the second polymer.Type: ApplicationFiled: September 6, 2006Publication date: August 20, 2009Applicant: GAMBRO LUNDIA ABInventor: Michel Thomas
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Publication number: 20090131858Abstract: The present invention relates to ultrafiltration. In particular, the present invention provides nanoporous membranes having pores for generating in vitro and in vivo ultrafiltrate, devices and bioartificial organs utilizing such nanoporous membranes, and related methods (e.g., diagnostic methods, research methods, drug screening). The present invention further provides nanoporous membranes configured to avoid protein fouling with, for example, a polyethylene glycol surface coating.Type: ApplicationFiled: January 10, 2008Publication date: May 21, 2009Applicant: The Regents of the University of MichiganInventors: William H. Fissell, Shuvo Roy, Aaron Fleischman, Kenneth G. Goldman
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Patent number: 6967003Abstract: A membrane artificial lung performs gas exchange between blood and a gas via the membrane by flowing the blood in one side of the membrane and flowing oxygen or an oxygen-containing gas in the other side of the membrane. The membrane has a hollow fiber membrane of poly-4-methylpentene-1 and an oxygen permeation rate Q(O2) at 25° C. of from 1×10?6 to 3×10?3 (cm3(STP)/cm2·sec·cmHg) and an ethanol flux of from 0.1 to 100 ml/min·m2. The membrane has, in the side of the blood flow, a surface having an ionic complex derived from: quaternary aliphatic alkylammonium salts; and heparin or a heparin derivative. The quaternary alkylammonium salts are a quaternary aliphatic alkylammonium salt having from 22 to 26 carbon atoms in total and a quaternary aliphatic alkylammonium salt having from 37 to 40 carbon atoms in total.Type: GrantFiled: September 28, 2001Date of Patent: November 22, 2005Assignees: Dainippon Ink and Chemicals, Inc., Toyo Boseki Kabushiki KaishaInventors: Toru Takehisa, Kazunari Sakai, Susumu Kashiwabara, Hidenori Tanaka, Masaki Satoh, Hisateru Takano, Yoshiyuki Taenaka, Eisuke Tatsumi, Tomohiro Nishinaka
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Patent number: 6491656Abstract: An apparatus controls movement of fluids during an extracorporeal blood treatment session. A hollow cassette enclosure has a plurality of fluid input ports for receiving fluids into the enclosure and a plurality of fluid output ports for expelling fluids from the enclosure. Internal fluid passageways disposed within the hollow enclosure are provided for coupling together the fluid input ports, and the fluid output ports. At least one internal valve is disposed within the hollow enclosure for controlling movement of the fluid within the hollow enclosure. A filter is integrated into the cassette to filter the blood passing therethrough.Type: GrantFiled: November 21, 1997Date of Patent: December 10, 2002Assignee: Therakos, Inc.Inventor: Livingston B. Morris
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Patent number: 6300142Abstract: A apparatus for assaying glycated proteins and other analytes in biological samples such as blood, in which a sample is presented to the apparatus, includes an inlet port between moveable between first and second inlets, such that the inlet can be brought into liquid communication with each inlet in turn. The inlet port accommodates a filter or binder. The apparatus also includes a microprocessor operable via a key pad, at least one light emitter and at least one light detector, a display and driver, and an A to D converter, and is operatively connected to a power source.Type: GrantFiled: May 26, 2000Date of Patent: October 9, 2001Assignee: Provalis Diagnostics LTDInventors: David Andrewes, John Worthington Attridge, David Griffiths, John Phillip Vessey, John Anthony Odell, Felix Fernando, Anthony Stevenson, Mark Gresswell, John Curtis, David Alan Percival
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Patent number: 6234991Abstract: A continuous peritoneal dialysis is carried out by providing a dialyzer element having a filter membrane for being exposed within the peritoneal cavity and an interior dialysate passageway, the membrane having pores sufficient to allow diffusion of blood toxins, implanting the dialyzer element in the peritoneal cavity of a patient, infusing a transfer fluid into the patient's peritoneal cavity and continuously supplying substantially fresh dialysate fluid into interior dialysate passageway of the dialyzer element, directing the fluid along the passageway whereby it is exposed to the transfer fluid by diffusion through the membrane and whereby toxins from said transfer fluid are diffused into the dialysate in the dialyzer element to form toxic dialysate fluid, and continuously removing the toxic dialysate from said dialyzer element.Type: GrantFiled: August 24, 1999Date of Patent: May 22, 2001Assignee: Transvivo Inc.Inventor: Reynolds G. Gorsuch