Abstract: A graphical user interface for a medical instruments for a Renal Replacement Therapy is disclosed that includes a pictogram representation of the fluid path of an extracorporeal blood circuit that represents fluid lines, pumps and sensors. To assist the user in responding to alarms and rectifying faults in the system the source of a potential trouble is animated. The location of a trouble spot is easily identified by flashing of the corresponding element of the pictogram, change of color or thickness of a corresponding line.

Abstract: Apparatus is disclosed for the safety monitoring of a dialyzer including at least one holder for holding a container for a powdered substance in which the holder includes a supply end for supplying a liquid to the container and a delivery end for delivering liquid containing the powdered substance from the container to a concentrate pump. The apparatus includes a first supply conduit for supplying water to the supply end of the holder for delivery to the container, a first delivery conduit for delivering the water containing the powdered substance from the delivery end of the holder to the concentrate pump, and a second supply conduit which is connectable to either the delivery end of the holder or to the first delivery conduit. Methods for the safety monitoring of dialyzers are also disclosed.

Abstract: A cost effective solution preparing apparatus includes a chamber which is divided into two compartments by a movable partition; a dissolving solution supply line for supplying a dissolving solution to the first compartment of the chamber; a solution tank connected with the first compartment and the second compartment through a first solution preparing line and through a second solution preparing line, respectively; a transporting pump provided in the second solution preparing line; a concentration meter; a solution transporting line for transporting the solution prepared and filled in the second compartment to a point of use; and a circulating line, in which the solution tank is exemplified as a U-shape tank constructed of a relatively small-diameter upstream tank portion and a relatively large-diameter downstream tank portion, and at least one filter is provided in a downstream portion of the downstream tank portion.

Abstract: A dialysis system and a method for automatically priming a dialyzer are provided. The priming of the dialyzer is accomplished in two steps; namely, the use of a blood pump to prime a dialyzer followed by the use of the blood pump and a dialysate pump to prime the dialyzer. The dialysis system filters a fluid through an extracorporeal circuit, a balanced flow loop and a dialysate loop which is connected to the dialyzer. The dialysis system and method may prevent air or air bubbles from entering the blood stream of a patient during dialysmis. Moreover, the dialysis system may be, for example, a hemodialysis or peritoneal dialysis system.

Abstract: A dialysis machine includes an extracorporeal blood circuit having an arterial pipe and a venous pipe respectively connected to an inlet and an outlet of a blood compartment of a filter. The blood compartment and a dialysis liquid compartment of the filter are separated by a semi-permeable membrane. The machine is configured to determine a sequence of infusion of a liquid in the extracorporeal blood circuit, from at least one characteristic value correlated with the concentration of the blood and/or a filtration efficiency of the filter, and to infuse the infusion solution in the arterial pipe and in the venous pipe in accordance with the determined infusion sequence.

Abstract: Method for in-line preparation of liquid for an extracorporeal blood treatment apparatus, which makes provision for placing a filter in correspondence with each of two successive filtration stations, for carrying out a liquid preparation cycle, for removing the filter which operates in correspondence with said first filtration station, for placing in correspondence with said first station the filter which operated in correspondence with the second filtration station, for placing a new filter in correspondence with the second post and for launching a new sterile liquid preparation cycle. The invention also provides a device for implementing the described method and an apparatus for extracorporeal blood treatment, which incorporates this device.

Abstract: A sterilized fluid management kit for use in renal replacement therapy isolates a replacement fluid container from touch contamination and provides for sterilization of replacement fluid by filtering using an installed filter that is hermetically connected to the replacement fluid container. A method is described where replacement fluid is automatically generated before treatment.

Abstract: In a blood dialysis system including a source of substitution fluid (10) and a blood dialysis machine, a hemodiafiltration system having a first dialyzer (1) including a first blood compartment (4) having a first blood inlet which receives blood to be cleaned and a first blood outlet which discharges partially diafiltered blood and a first dialysate compartment (5) having a first dialysate inlet and a first dialysate outlet, means (8) for mixing the partially diafiltered blood with substitution fluid from the source to obtain a blood/substitution fluid mixture, and a second hemofilter (2) including a second blood compartment (11) having a second blood inlet which receives the blood/substitution fluid mixture and a second blood outlet which discharges filtered blood and a second permeate compartment (12) having a second permeate outlet.

Abstract: The present invention provides a hemodialysis or hemodiafiltration system and method using two dialyzer stages (122, 138), wherein the temperature of a dialysate fluid stream of the first cartridge (122) is increased such that the blood in the first cartridge (122) is dialyzed or diafiltered at an elevated temperature, while blood in the second cartridge (138) is dialyzed or diafiltered against a dialysate stream at normal blood temperature. This results in an increased solute diffusivity and a corresponding increase in removal of blood substances by diffusion. When diafiltration is performed, an additional removal of substances occurs by convection as a larger portion of plasma water from a blood compartment (142) can be filtered across a semi-permeable membrance (140) at the same transmembrane pressure due to the reduced viscosity of the heated blood and plasma water.

Abstract: The present invention provides a dialysis machine that is readily moved by a patient, nurse or other operator. A display is provided on the front of the machine, which displays and controls various dialysis functions. The display is robust, mounted directly to the body and includes an open area that can be grasped by a person to move the entire machine. The combination display/handle enables the person to move the machine from the front of same and from odd angles with respect to the machine.

Abstract: An apparatus and method are provided for generating sterile infusion fluid from non-sterile infusion fluid produced by a machine. In one embodiment, the sterile infusion fluid is produced by a sterile fluid generating device that is an ancillary device designed to operate in conjunction with the existing machine. For example, the sterile fluid generating device is used in conjunction with a dialysis machine according to one embodiment resulting in sterile infusion fluid being produced.

Abstract: A method for measurement of mass and energy transfer parameters (clearance and dialysance) in hemodialysis. A sensor is provided in the dialysate flow path downstream of the dialyzer and means are provided to add concentrate upstream of the dialyzer. A pre-determined amount of a substance whose dialysance is to be measured is added upstream of the dialyzer. The amount of substance riot dialyzed in the dialyzer is measured downstream of the dialyzer by said sensor by integrating the concentration over time. Dialysance is calculated from the amount added upstream, the amount measured downstream and the dialysate flow. In case the substance is part of the dialysate the base concentration is subtracted during integration. The addition of the concentrate upstream of the dialyzer can be done manually or, alternatively by the mixing pump of the dialysis machine. Instead of an increase of the concentration with a concentrate dilution with water can be used as well.

Abstract: The present invention relates to a dialysis machine with a device for preparing dialysis solutions. Simple and reliable preparation of dialysis fluids of different concentrations is achieved by the fact that the device has a detector device, at least two connections and at least two interchangeable storage containers to hold the solution ingredients to be metered, each being connected to at least one connector, and with the connectors being connectable to the connections, and with the connectors or the areas of a connecting tube near the connectors having identification means which can be detected by the detector device. The present invention also relates to a connector for connecting a storage container with solution ingredients to a medical apparatus, where the connector or areas of a connecting tube near the connector has identification means. The present invention also relates to a method of detecting a connection of a solution ingredient storage container.

Abstract: A hemodialyzing unit includes a dialytic fluid supply line for feeding a dialytic fluid from a dialytic fluid supply/discharge unit to a dialyzer, a dialytic fluid discharge line for feeding a dialytic fluid discharged from the dialyzer to the dialytic fluid supply/discharge unit, and a bypass line for connecting both lines at an intermediate portion of each. A flow rate adjusting member is provided to a downstream supply line between a coupling portion for coupling the dialytic fluid supply line to the bypass line and the dialyzer. A wider range of treatments such as CHD (or CHDF), SHD (or SHDF), and HD (or HDF) can be conducted without employing a device for the exclusive use of the CHD or CHDF.

Abstract: A cost effective apparatus for preparing dialysate solution which can finely adjust the concentration of dialysate solution is described. The apparatus comprises a chamber 2, the inside of which is divided into three compartments 21, 22, 23 by a movable partitions 24, 25, a dissolving solution supply line 1 for supplying dissolving solution to the first compartment 21, a solution tank 5, a dialysate solution preparing line 31 connecting the solution tank 5 and the first compartment 21, a dialysate solution preparing line 32 connecting the solution tank 5 and the third compartment 23, a transporting pump 4 provided in the dialysate solution preparing line 32, a powder supply means 7 provided above the solution tank 5, and a dialysate solution transporting line 6 for transporting the dialysate solution prepared and filled in the third compartment 23 to the point of use, a by-pass line 81, and a circulating line 91.

Abstract: The present invention provides automated peritoneal dialysis systems, methods of operating the systems and devices for performing same. A typical therapy performed by the present invention begins by draining dialysis solution that is already in the patient's peritoneal cavity. The system pumps fresh dialysate from one of a plurality of supply bags, through an in-line heater to the patient's peritoneal cavity. After a dwell period, the spent dialysate in the cavity is pumped out of the patient to a drain or other disposal means. The system then pumps fresh dialysate from the supply bags to the patient and the procedure is repeated as defined in the therapy protocol. The system can pump a last bag of dialysate to the peritoneal cavity for an extended dwell, such as a daytime dwell.

Abstract: A method, system and apparatus for performing peritoneal dialysis are provided. To this end, in part, a peritoneal dialysis apparatus is provided that includes a body provided with an operating portion and a display, a mounting portion provided on the body for detachably mounting a cassette, a pumping actuating device for setting a diaphragm in a positive and negative pressure state to distribute fluid from the dialysis fluid container to the drained fluid container, and a heater for heating an amount of dialysis fluid. The apparatus further includes a flow path switching device for opening/closing a flow path switching portion in order to form a flow path through which the heated dialysis fluid is distributed into and drained from a peritoneal cavity of a patient, and a controller for controlling operation of the operating portion, the display, the pumping actuating device, the heater, and the flow path switching device.

Abstract: A dialysate preparing apparatus in which concentration of dialysate can be finely adjusted is provided. The dialysate preparing apparatus comprises a chamber 2, the inside of which is divided into four compartments 21, 22, 23, 24 by movable partitions 25, 26, 27; a dissolving solution supply line 1 for supplying dissolving solution to the first compartment 21; a solution tank 5; dialysate preparing lines 31, 32 connecting the solution tank 5 with the first compartment 21 and with the second compartment 22, respectively; a transporting pump 4 provided in the dialysate preparing line 32; a concentration meter N; a powder supply means 7; and dialysate lines 61, 62 connecting the second compartment 22 and the fourth compartment 24 with a dialyzer D, respectively; a circulating line 81; and a waste liquid discharge line 9.

Abstract: A dialyzer in which a nearly cylindrical case is provided therein with a hollow fiber bundle made of a plurality of hollow fiber membranes, a blood flow path formed by lumens of the hollow fiber membranes, a dialyzate flow path formed by a space between the inner wall of the case and the hollow fiber membranes and a cylindrical heat-shrinkable tube provided on the outside of the hollow fiber bundle and at least a part of which can be shrunk by heating, and a method for manufacturing the dialyzer.

Abstract: A haemofiltration machine designed to work with a haemofilter comprises two compartments separated by a semipermeable membrane, one compartment having an inlet connected to a withdrawing tube for taking blood from the patient and an outlet connected to a blood return tube, the other having an outlet connected to a tube for removing used liquid.

Abstract: A dialysis apparatus includes a dialysis liquid circuit for circulating sodium chloride and sodium bicarbonate through a haemodialyzer and a circuit for infusing a patient with at least one solution containing at least one ionic substance “A” absent from the dialysis liquid. The substance “A” has a determined concentration (A)sol in the infusion solution.

Abstract: A method of supplying ready-to-use dialysis fluid in a machine for extracorporeal blood treatment, is described, said machine having, in addition to a dialyzer, at least one sterile filter divided by a microbe-retaining membrane into a first and second chamber. The temperature and/or conductivity of the dialysis fluid flowing through the sterile filter is monitored. To prevent dialysis fluid whose temperature and/or conductivity does not correspond to a preset temperature and/or conductivity value from flowing out of the second chamber of the sterile filter into the dialyzer after rinsing off the membrane of the sterile filter, the dialysis fluid flowing out of the sterile filter is first removed into the drain through a bypass line until the proper values are established. Only then is the dialyzer connected to the dialysis fluid path. In addition, the invention relates to a machine for extracorporeal blood treatment with a device for supplying ready-to-use dialysis fluid.

Abstract: The portable dialysis machine may include an enclosure having a removable base. There may be a front panel having associated therewith multiple external connectors, smart function keys, a touch panel element and a voice activated sensor. The front panel may be in communication with an electronic circuit element having a controller in communication therewith. There may be a blood flow element and a hydraulic flow element. A water reservoir and power supply may be included. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.

Abstract: A dialysis system which does not need to use a physiological saline in replenishing a solution or cleaning and priming the dialysis system, does not need a troublesome setting operation and can easily and accurately set a flow rate of a replenisher solution. The dialysis system includes a closed-type water-removal control apparatus 1, a dialyzer 2, a fresh dialysate line 3 as well as a used dialysate line 4, an RO water pressurizing line 5, an RO water pressurizing pump 51 provided in the RO water pressurizing line 5, an artery side blood line 6, a blood pump 61 provided at the artery side blood line 6 and a vein side blood line 7. According to the dialysis system, by pressurizing RO water into a communication line of the used dialysate, dialysate is made to flow from a dialysate flow path 21 into a blood flow path 22 through a dialysis membrane 23 of the dialyzer 2 and the inside of a blood circulation path can be cleaned and primed.

Abstract: Dialyzers having an improved header design providing an improved flow of fluid, e.g., blood, into the interior of the dialyzer and specifically to the fiber bundle are provided. The dialyzer inlet header comprising a body that defines, at least in part, an end of the dialyzer. The inlet header includes an inlet channel providing fluid communication from an exterior of the dialyzer to an interior of the dialyzer, the inlet channel defining a fluid flow path that is axial to a fiber bundle located in the interior of the dialyzer. The dialyzer also includes at least one member for modifying the fluid flow path of a fluid as it exits the inlet channel. Methods of providing dialysis are also provided.

Abstract: A dialysis system which does not need to use a physiological saline in replenishing a solution or cleaning and priming the dialysis system, does not need a troublesome setting operation and can easily and accurately set a flow rate of a replenisher solution. The dialysis system includes a closed type water-removal control apparatus 1, a dialyzer 2, a fresh dialysate line 3 as well as a used dialysate line 4, a dialysate pressurizing line 5, a dialysate pressurizing pump 51 provided in the dialysate pressurizing line 5, an artery side blood line 6, a blood pump 61 provided in the artery side blood line 6 and a vein side blood line 7. According to the dialysis system, by pressurizing a dialysate into a communication line of the dialysate, the dialysate is made to flow from a dialysate flow path 21 into a blood flow path 22 through a dialysis membrane 23 of the dialyzer 2 and the inside of a blood circulation path can be cleaned and primed.

Abstract: An ozone hemodiafiltration device comprising a dialysate fluid circuit, extracorporeal circuit for blood and a replenishing solute circuit. The dialysate fluid circuit provides aseptic isotonic solution with mineral and nutrients in specific ratio to a dialyzer. The extracorporeal circuit for blood draws blood flow from human bodies, passes through the dialyzer, and turns back to human bodies. The replenishing solute circuit conducts the isotonic solution from the dialysate fluid circuit into a filter for re-filtration and the re-filtered isotonic solution is injected into human bodies through the extracorporeal circuit for blood. The device features on an ozone (O3) generator, which converts the reverse osmosis water into ozone water solution, disposed before the water inlet end of the dialysate fluid circuit. By controlling the flow of ozone water solution into the extracorporeal circuit for blood and the replenishing solute circuit, the ozone in blood keeps at 3-6 ppm concentrations.

Abstract: There is provided the use of a low molecular weight thrombin inhibitor for the manufacture of a medicament for the treatment by dialysis, particularly haemodialysis, of a patient in need of such treatment, in which the thrombin inhibitor is provided in the dialysing solution, as well as dialysing solutions and concentrates including low molecular weight thrombin inhibitors, such as melagatran.

Abstract: A method of setting up a dialysis treatment in a dialysis machine (1) comprises the steps of: determining the conditions (U0, TWL, DT) of a dialysis treatment adapted to a specific patient; determining a first function (U(t)) of a first quantity (U) characterizing the dialysis treatment as a function of time (t), the first function (U(t)) satisfying the conditions (U0, TWL, DT) of the dialysis treatment and corresponding to a curve having a defined shape; determining a second function (C(t)) of a second quantity (C) characterizing the dialysis treatment, the second function (C(t)) being correlated with the first function (U(t)) by constants (M, N) determined experimentally and the second function (U(t)) corresponding to a curve having a shape of the same kind as the shape as the first curve.

Abstract: A method and apparatus for the preparation of solutions to be manufactured from at least two concentrates and a solvent. First and second concentrate holders are connected to a solvent source by respective feed lines and to a collection holder by respective discharge lines. The solvent source is connected to the first concentrate holder when a connector is in a first position and to the second concentrate holder when the connector is in a second position. Solvent flows through the first concentrate holder and the solution is led into the collection holder and, after the flushing of the concentrate from the first concentrate holder, the second concentrate holder is automatically connected through movement of the connector from the first to the second position, whereupon solvent flows through the second concentrate holder and the solution is likewise supplied to the collection holder.

Abstract: A dual-stage filtration system and methods for using the same include first and second filtration cartridges (122, 138) particularly suited for hemodiafiltration and/or hemodialysis As fluid enters the first filtration carridge (122), the hydrogenion concentration (pH) is reduced by exposing it to an acidic solution such as citric acid across a filter membrane (124). This stage allows for improved removal of certain toxins in the fluid, such as protein-bound substances that disassociate more readily from proteins at a lower pH.

Abstract: In contrast to the prior art, the essential components of dialyzing liquids are not provided as a dry concentrate or as a genuine solution at the place of dialysis, but as a suspension of undissolved or incompletely dissolved substances, preferably sodium chloride, optionally sodium acetate, in a solution of the remaining components.

Abstract: The present invention relates to a dialysis machine with an ozone generator. Two dialysate delivery pumps connect to a diluting tube inside the dialysis machine respectively, each of which is joined with a drug container. Reversed Osmosis water is drawn from one end of the diluting tube, flows into the drug container for producing the drugs of dialysate or chemicals for disinfection. While the other end of the diluting tube is connected to a dialyzer. The improvement of the device is in that an ozone generator is connected to the water inlet end of the diluting tube. The ozone generator includes an anode and a cathode for electrolysis of water. Water decomposes to hydrogen and ozone gas. The diluting tube is disinfected by ozone so as to avoid inconvenience of disinfecting and sterilizing the diluting tube and the risk of exposure to residual disinfectant chemicals.

Abstract: Disclosed is a portable hemodialyzer, which not only can relieve a patient from the pain of putting injection needles into two portions of the patient's body for hemodialysis, but also enables the hemodialysis to be safely performed even at home, so as to reduce the times by which the patient must visit the hospital, thereby largely reducing time and expense. In the portable hemodialyzer, an injection needle contains a separation film separating an introduction channel and a discharge channel from each other, which are formed in the injection needle. A blood exit is formed at a predetermined left side portion of the injection needle, while a blood entrance is formed at a predetermined right side portion of the injection needle.

Abstract: The present invention provides a hemodialysis or hemodiafiltration system and method using two dialyzer stages (122, 138), wherein the temperature of a dialysate fluid stream of the first cartridge (122) is increased such that the blood in the first cartridge (122) is dialyzed or diafiltered at an elevated temperature, while blood in the second cartridge (138) is dialyzed or diafiltered against a dialysate stream at normal blood temperature. This results in an increased solute diffusivity and a corresponding increase in removal of blood substances by diffusion. When diafiltration is performed, an additional removal of substances occurs by convection as a larger portion of plasma water from a blood compartment (142) can be filtered across a semi-permeable membrane (140) at the same transmembrane pressure due to the reduced viscosity of the heated blood and plasma water.

Abstract: A multipurpose hemofiltration system and method are disclosed for the removal of fluid and/or soluble waste from the blood of a patient. The system and method are equally applicable to adult, pediatric and neonatal patients. In one embodiment, the system continuously monitors the weight of infusate in a first reservoir and drained fluid in a second reservoir and compares those weights to corresponding predetermined computed weights. When necessary, the pumping rates of the infusate, drained fluid and blood are adjusted in order to achieve a preselected amount of fluid removal from the patient's blood in a preselected time period. Application of this system and method provide repeatable and highly precise results. Alternatively, predetermined patient parameters can be monitored and the adjustment of pumping rates may be responsive to these monitored parameters.

Abstract: The present invention relates to a dialysis machine with a device for preparing dialysis solutions. Simple and reliable preparation of dialysis fluids of different concentrations is achieved by the fact that the device has a detector device, at least two connections and at least two interchangeable storage containers to hold the solution ingredients to be metered, each being connected to at least one connector, and with the connectors being connectable to the connections, and with the connectors or the areas of a connecting tube near the connectors having identification means which can be detected by the detector device. The present invention also relates to a connector for connecting a storage container with solution ingredients to a medical apparatus, where the connector or areas of a connecting tube near the connector has identification means. The present invention also relates to a method of detecting a connection of a solution ingredient storage container.

Abstract: An apparatus for preparing dialysis liquid which includes a container holder 112 for holding a container 102 in the inverted state, the container having a tubular body portion which defines an internal volume for accommodating powder preparation for preparing dialysis liquid, a bottom wall defined at an end of the tubular body portion, and a sealing member for closing an outlet opening defined at the end of the tubular body portion opposite to the bottom wall, a cutter 118, movable toward and away from the sealing member, for cutting the sealing member, a concentrated liquid tank 114a provided under the container holder 112, a mesh member 116, horizontally disposed above the tank, for receiving the powder preparation which has fallen from the container 102, a nozzle 120 for applying water to the powder preparation, for preparing dialysis liquid, which has fallen on the mesh member from the container after the sealing member is cut by the cutter 118.

Abstract: A kidney dialysis machine includes a number of flexible members extending from the machine to corresponding receptacles at a patient station. The flexible members are arranged in a cable bundle at a point intermediate of the machine and the ends of the members. A retaining member is wrapped around the bundle to hold the bundle together. The retaining member is attached to a spring that has one end connected to the retaining member and an opposite end attached to the kidney dialysis machine. The spring holds the bundle off the floor.

Abstract: A dialysis machine having an extracorporeal blood circuit having an arterial pipe and a venous pipe respectively connected to an inlet and an outlet of a blood compartment of a filter having a blood compartment and a dialysis liquid compartment separated by a semi-permeable membrane;

Abstract: Apparatus is disclosed for the safety monitoring of a dialyzer including at least one holder for holding a container for a powdered substance in which the holder includes a supply end for supplying a liquid to the container and a delivery end for delivering liquid containing the powdered substance from the container to a concentrate pump. The apparatus includes a first supply conduit for supplying water to the supply end of the holder for delivery to the container, a first delivery conduit for delivering the water containing the powdered substance from the delivery end of the holder to the concentrate pump, and a second supply conduit which is connectable to either the delivery end of the holder or to the first delivery conduit. Methods for the safety monitoring of dialyzers are also disclosed.

Abstract: A method of hemodiafiltration including the steps of supplying a blood inflow, diafiltering the blood inflow using a first non-isosmotic dialysate fluid to provide a partially diafiltered blood outflow, mixing the partially diafiltered blood outflow with a substitution fluid to provide a blood/substitution fluid mixture, and diafiltering the blood/substitution fluid mixture using a second non-isosmotic dialysate fluid.

Abstract: Apparatus is disclosed for the safety monitoring of a dialyzer including at least one holder for holding a container for a powdered substance in which the holder includes a supply end for supplying a liquid to the container and a delivery end for delivering liquid containing the powdered substance from the container to a concentrate pump. The apparatus includes a first supply conduit for supplying water to the supply end of the holder for delivery to the container, a first delivery conduit for delivering the water containing the powdered substance from the delivery end of the holder to the concentrate pump, and a second supply conduit which is connectable to either the delivery end of the holder or to the first delivery conduit. Methods for the safety monitoring of dialyzers are also disclosed.

Abstract: A machine and method for preparing dialysis fluid for a dialysis machine. Fresh water is mixed with one or more dialysis fluid concentrates. The mixture of water and concentrates is conveyed into an equalizing chamber by a proportioning unit at a predetermined flow rate independent of the dialysate flow rate. Metered addition of the concentrates is performed volumetrically and is monitored on the basis of the conductivity of the dialysis fluid, which is measured by conductivity sensors. Because the mixture of water and concentrates is always conveyed at the same flow rate, the composition of the dialysis fluid can be determined with a high accuracy and the proportioning can be performed accurately.

Abstract: An apparatus and method for alleviation of symptoms of inappropriate blood pressure and cramping from the removal of water during ultrafiltration hemodialysis and hemofiltration treatment. The invention uses oxygen concentration measured by sensors in various ways and at various points in the blood treatment circuitry to estimate parameters necessary to control the rate at which water is removed from the patient's blood.

Abstract: A set of bottles for containing dialysate chemical formulations, chemical cleaning agents or the like is described. The chemical formulation bottles come in two varieties, sodium bicarbonate and liquid acid formulations, each bottle having a slightly different shape. The different shapes cooperate with a bottle mounting structure in the dialysis machine to insure that bottles are correctly installed on their respective bottle opening mechanism. The bottles also have a detection feature comprising either a raised rim or groove extending around the periphery of the bottle. A sensor assembly in the bottle mounting and opening system detects the detection feature. The detection feature is used by the machine to distinguish between dialysate formulation bottles and chemical cleaning bottles, which do not have the detection feature. The detection feature prevents unintentional installation of the chemical bottle on the opening mechanism for the dialysate chemical formulation bottles.

Abstract: A hemodialysis system that is particularly suited for use in a non-clinical environment. The hemodialysis system includes a dialyzer, a pressurizable dialysate supply mechanism, a dialysate collection mechanism, an arterial line, a venous line, a first flow resistance, a second flow resistance, a third flow resistance and a control system. The dialyzer has a blood flow path and a dialysate flow path that are in communication through a membrane. The blood flow path has a blood entry port and a blood exit port. The dialysate flow path has a dialysate entry port and a dialysate exit port. The pressurizable dialysate supply mechanism is operably connected to the dialysate entry port. The dialysate collection mechanism is operably connected to the dialysate exit port. The arterial line is operably connected to the blood entry port. The venous line is operably connected to the blood exit port. The first flow resistance is operably connected between the dialysate supply mechanism and the dialyzer.

Abstract: An apparatus for use in whole body hypothermia includes a dialyzer having a blood side and a dialysate side separated by one or more dialysis membranes. A blood pump associated with the a blood circuit established on the blood side circulates blood through the dialyzer at high rates advantageous for hyperthermia treatments. A bypass is included whereby circulated blood can bypass the dialyzer. The bypass aids in preventing blood-side tensioning of dialyzer membranes thereby allowing proper membrane movement to assist in mixing a sorbent suspension circulated on the dialysate side of the dialyzer. A sorbent suspension composition for use as a dialysate in hemodialysis, especially when performed in conjunction with whole body hyperthermia, includes water, a surface adsorptive agent such as charcoal, a cation exchanger, and precipitated calcium phosphate. The precipitated calcium phosphate serves as a reservoir for calcium and phosphate ions to assist in controlling patient blood chemistries.

Abstract: A dialysis apparatus includes a dialysis liquid circuit for circulating sodium chloride and sodium bicarbonate through a haemodialyser and a circuit for infusing a patient with at least one solution containing at least one ionic substance “A” absent from the dialysis liquid. The substance “A” has a determined concentration (A)sol in the infusion solution.

Abstract: An apparatus for preparing dialysate concentrate includes a vessel, a controllable valve for regulating water flow to the vessel, a first sensing device for detecting when the liquid has reached a lower level, a second sensing device for detecting when the liquid has reached an upper level, a controller selectively responsive to one of the sensing devices, and a positionable switch for selecting to which of the sensing devices the controller is responsive.