Blood Patents (Class 210/782)
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Patent number: 7771590Abstract: A method and apparatus for separating and concentrating a selected component from a multi-component material. The multi-component material may include a whole sample such as adipose tissue, whole blood, or the like. The apparatus generally includes a moveable piston positioned within a separation container and a withdrawal tube that is operable to interact with a distal end of the collection container past the piston. Material can be withdrawn through the withdrawal tube.Type: GrantFiled: August 23, 2005Date of Patent: August 10, 2010Assignee: Biomet Manufacturing Corp.Inventors: Michael D. Leach, James M. McKale
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Publication number: 20100170858Abstract: The invention relates to a cartridge (1) for accommodating blood bags (35), which is provided for the separation of blood components for the application in a centrifuge. The cartridge (1) has a partition wall (3) which separates a blood bag section (5) positioned radially inside from a product section (7) positioned radially outside, and a cover (9) disposed in a mounting position above the blood bag section (5). The cover (9) is connected to the partition wall (3) pivotally in a first point (11) and detachably in a second point (13), so that the blood bag section (5) is freely accessible by means of laterally pivoting the cover (9) out of the way. The cartridge is applicable in the rotor of a centrifuge.Type: ApplicationFiled: June 4, 2008Publication date: July 8, 2010Inventors: Klaus-Gunter Eberle, Roland Biset
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Patent number: 7745106Abstract: Methods and devices for preparing a solid-fibrin web are provided. One method may include drawing blood from a patient, separating plasma from the blood, contacting the plasma with a calcium-coagulation activator and concurrently coagulating and axially centrifuging the plasma to form the solid-fibrin web. The solid-fibrin web may be suitable for regenerating body tissue in a living organism. Devices used in the methods may also be provided.Type: GrantFiled: June 26, 2003Date of Patent: June 29, 2010Assignee: Cascade Medical Enterprises, LLCInventors: Roberto C. Beretta, Nicholas A. Grippi
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Patent number: 7744821Abstract: A blood bag cup, which is designed as a double cup with two individual cups with two separate chambers, one for accommodating the withdrawal and inflation bag and one for accommodating the satellite bag. The respective chamber for the satellite bags is preferably jointed. Advantages are an extremely high separation efficiency factor with maximum plasma yield with pure plasma and more than 50% time savings based on the doubled design of the double-chambered double cup.Type: GrantFiled: September 20, 2005Date of Patent: June 29, 2010Assignee: Andreas Hettich GmbH & Co. KGInventors: Guenter Eberle, Liese Eberle, legal representative
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Patent number: 7740760Abstract: A concentrator is used for concentrating a fluid, particularly a plasma component out of blood, for treatment of a patient. The concentrator apparatus includes a main housing defining a centrifuge chamber, that also holds the filter. The concentrator allows viewing of the fluid after centrifuging, with an outlet port positionable at a height corresponding to the level of the fraction of the fluid to be further concentrated. Once the fluid is centrifuged, a portion of the fluid is drawn through the outlet, and then pressured past the filter to further concentrate the fluid using the same vessel as used for centrifuging. The same plunger is preferably used to draw centrifuged fluid from the centrifuge chamber as to pressure the centrifuged fluid past the filter.Type: GrantFiled: October 31, 2007Date of Patent: June 22, 2010Assignee: Circle Biologics, LLC.Inventors: Thomas Coull, Matthew R. Kyle, Louis S. Kidder
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Patent number: 7736907Abstract: A device and a method for collecting blood and separating blood plasma as a liquid sample using a channel that absorbs the liquid sample by capillary forces. To obtain a uniform filling of the channel with the liquid sample and an effective separation, deaeration takes place in a transverse direction to the main filling direction or to the longitudinal direction of the channel, immediately downstream of a separation device in an inlet region of the channel.Type: GrantFiled: June 3, 2005Date of Patent: June 15, 2010Assignee: Boehringer Ingelheim microParts GmbHInventors: Gert Blankenstein, Ralf-Peter Peters
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Patent number: 7727534Abstract: Reovirus can be used to selectively remove ras-mediated neoplastic cells from a cellular composition. It is of particular interest to purge autographs which may contain neoplastic cells with reovirus before transplanting the autographs back into the recipient, thereby reducing the risk of introducing or reintroducing neoplastic cells into the recipient.Type: GrantFiled: May 30, 2007Date of Patent: June 1, 2010Assignee: Oncolytics Biotech Inc.Inventors: Donald Morris, Bradley G. Thompson, Matthew C. Coffey
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Patent number: 7708710Abstract: Methods are disclosed for collecting and separating whole blood into one or more components. A disposable blood separation fluid circuit is provided which is adapted to cooperate with a reusable separation controller. The fluid circuit includes a fluid flow path for communication with a blood source and at least one container in fluid communication with the fluid flow path. The fluid flow path is connected to a blood source and quantities of whole blood are collected in the container and one other location within the fluid circuit. The source is then disconnected from the disposable fluid circuit. The quantities of whole blood are centrifugally processed, with processing of at least a portion of one of the quantities beginning after the source is disconnected from the fluid circuit.Type: GrantFiled: April 16, 2004Date of Patent: May 4, 2010Assignee: Fenwal, Inc.Inventors: Kyungyoon Min, Richard I. Brown
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Patent number: 7694828Abstract: A method and apparatus for obtaining various components of a multi-component material. Generally, a component of a whole blood sample may be concentrated from a patient and re-introduced to the same patient. For example, a clotting component, such as thrombin, from a whole blood sample may be extracted and concentrated in an apparatus and collection to be reapplied or reintroduced into a patient.Type: GrantFiled: April 27, 2005Date of Patent: April 13, 2010Assignee: Biomet Manufacturing Corp.Inventors: Matthew J Swift, Barry F Hecker, Michael D Leach
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Publication number: 20100081196Abstract: A method for separating a volume of whole blood contained in a separation bag into at least three components comprising centrifuging the separation bag so as to separate therein a first inner layer comprising plasma, a second intermediate layer comprising platelets, a third intermediate layer comprising lymphocytes, monocytes and granulocytes and a fourth outer layer comprising red blood cells, transferring, into a plasma component bag connected to the separation bag, a plasma component and transferring into a mononuclear cell component bag a mononuclear cell components.Type: ApplicationFiled: December 8, 2009Publication date: April 1, 2010Applicant: CARIDIANBCT, INC.Inventors: Thomas FELT, Bruce GIBBS, Brian HOLMES
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Patent number: 7682329Abstract: A method and apparatus for red blood collection and filtration is provided wherein a red blood cell collection assembly provides for leukoreduction filtration concurrent with or soon after the red blood cell separation and collection procedure. Such procedures involve filtering the separated red blood cells in a diluted state after and/or prior to flushing the filter with storage solution. Storage solution may thus be passed through the leukoreduction filter before, with and/or after the RBCs have been filtered therethrough. The red blood cell collection, filtration and storage assembly is preferably preconnected to a blood component separation disposable assembly, including, for example, a centrifuge vessel and a blood removal/return assembly for removing blood from a donor, passing the blood to the centrifuge vessel for separation of the blood into components for collection and providing for filtration of the separated red blood cell component.Type: GrantFiled: April 6, 2006Date of Patent: March 23, 2010Assignee: CaridianBCT, Inc.Inventors: Bruce W. Gibbs, Jon Herskovits
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Patent number: 7673758Abstract: Methods of producing collection tubes are presented. The methods include providing a separator substance that can rapidly polymerize in a short time to a desired hardness and disposing the separator substance within the lumen of the tube. The separator substance is formulated to have a density between an average density of a serum fraction of whole blood and a cell-containing fraction of whole blood, and to be flowable with whole blood. Upon centrifugation of a tube having blood, the separator substance forms a barrier between the whole blood fractions. The barrier rapidly hardens forming a solid barrier when triggered by a suitable energy source.Type: GrantFiled: November 1, 2007Date of Patent: March 9, 2010Assignee: The Regents of the University of CaliforniaInventor: Jane Emerson
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Patent number: 7674388Abstract: Contemplated whole blood separators tubes include a curable composition with a density intermediate to the density of serum and the cell-containing fraction. After centrifugation, the curable composition is located between the serum and the cell-containing fraction and preferably irradiated with UV light to initiate a curing reaction in which the curable composition solidifies to a barrier that is immobilized and resistant to breakdown at freezing temperatures and extended storage.Type: GrantFiled: August 4, 2006Date of Patent: March 9, 2010Inventor: Jane F. Emerson
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Publication number: 20100042037Abstract: Method and apparatus for separating plasma from blood in a separation vessel and further separator the separated plasma into desired plasma proteins in a plasma separator fluidly connected to the separation vessel to receive the separated plasma.Type: ApplicationFiled: April 24, 2009Publication date: February 18, 2010Applicant: CARIDIANBCT, INC.Inventors: Thomas J. FELT, Frank CORBIN, III, Steven Gage URDAHL
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Patent number: 7648452Abstract: A device for loading a set of bags into the rotor of a centrifuge including a loading container having an annular rim extending outwardly such that the annular rim rests on the turn table of the rotor.Type: GrantFiled: July 3, 2008Date of Patent: January 19, 2010Assignee: CardianBCT, Inc.Inventors: Brian M. Holmes, Johan-Petter Hagström, Per-Olov Lundberg, Geert Van Waeg, Peter Nordgren
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Patent number: 7648639Abstract: A method for separating a volume of a composite liquid into at least a first component and a second component is performed in a centrifuge cooperating with a separation bag containing the volume of composite liquid. The separation bag is connected to at least a first component bag and a second component bag. The separation bag is spun so as to centrifuge the volume of composite liquid and cause the sedimentation of the at least first and second components. When the at least first and second components have sedimented, the first component is transferred at least one first transfer flow rate into the first component bag. When the first component has been transferred into the first component bag, the second component is transferred into the intermediate component bag at least one second transfer flow rate that is different from the at least one first transfer flow rate.Type: GrantFiled: December 14, 2007Date of Patent: January 19, 2010Assignee: CaridianBCT, IncInventors: Brian M. Holmes, Peter Pihlstedt, Geert Van Waeg
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Patent number: 7629176Abstract: A tube and float system for use in separation and axial expansion of the buffy coat includes a transparent or semi-transparent, flexible sample tube and a rigid separator float having a specific gravity intermediate that of red blood cells and plasma. The float includes a main body portion of reduced diameter to provide a clearance gap between the inner wall of the sample tube and the float. One or more protrusions on the main body portion serve to support the flexible tube. During centrifugation, the centrifugal force causes the diameter of the flexible tube to expand and permit density-based axial movement of the float in the tube. The float further includes a pressure relief system to alleviate pressure build up in the trapped red blood cell blood fraction below the float, thereby preventing red blood cells from being forced into the annular gap containing the buffy coat layers.Type: GrantFiled: February 11, 2008Date of Patent: December 8, 2009Assignee: Battelle Memorial InstituteInventors: Thomas Haubert, Vince Contini, Steve Grimes, Randy Jones, Stephen C. Wardlaw
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Patent number: 7625351Abstract: Provided herein is an innovative hemoperfusion system and method including a thermal-fused broad-spectrum biocidal iodinated interactive polymer for the treatment of biological contaminants in body fluids. In one exemplary embodiment, the system and method utilizes a Triosyn® thermal fused broad-spectrum iodinated interactive polymer, included in a hemoperfusion column, for devitalizing high levels of cell-free microorganisms in whole blood and biological fluids in relation with the characterization of blood cells viability and function post-treatment.Type: GrantFiled: September 10, 2004Date of Patent: December 1, 2009Assignee: Triosyn Holding, Inc.Inventor: Pierre Messier
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Publication number: 20090236297Abstract: A plasma concentrator having a concentrator chamber, concentrator gel beads, a filter, and an agitator. The agitator end is positioned in the concentrator chamber and supported for rotation about its central axis and for reciprocal movement along its central axis. A filter is selected to block effective flow of plasma therethrough under ambient gravity conditions and permit plasma and plasma concentrate flow therethrough under centrifugal forces of the separation gravity. A method concentrates plasma by removing water without significantly denaturing the fibrinogen in the plasma. Then centrifugal force can be applied to the concentrated plasma in an amount sufficient to separate a substantial portion of the plasma concentrate from the beads.Type: ApplicationFiled: June 2, 2009Publication date: September 24, 2009Applicants: Hanuman, LLC, Biomet Biologics, Inc.Inventors: Randel Dorian, Michael D. Leach, Richard Wood Storrs
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Patent number: 7588692Abstract: The present invention is directed to a method and system that separates first particles from second particles, or white blood cells from red blood cells, by sedimentation in a fluid chamber with debulking of one of the first or second particles or red blood cells through the inlet of the fluid chamber. The method and system further includes fractionation of the remaining particles or white blood cells into selected subsets. In one embodiment of the instant invention a blood product containing white blood cells is loaded in a separation chamber, a diluting or sedimenting agent is added to encourage rouleaux formation of any red blood cells, the cells are sedimented and the red blood cells are removed.Type: GrantFiled: February 28, 2007Date of Patent: September 15, 2009Assignee: CaridianBCT, Inc.Inventors: Glenn Delbert Antwiler, Linda A. Taylor
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Publication number: 20090139937Abstract: Contemplated compositions and methods allow for in-situ formation of a rigid seal layer in a blood collection tube between a cell-depleted phase and a cell-enriched phase. Preferably, the seal layer is formed upon brief UV irradiation and comprises an acrylate, a methacrylate, an epoxy, a urethane, and/or a thiol-ene polymer.Type: ApplicationFiled: December 9, 2008Publication date: June 4, 2009Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Jane Emerson, Srinivasa Raghavan, Kunshan Sun
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Patent number: 7534616Abstract: This invention describes a method for pumping or delivering fluids utilizing a flexible vessel subject to controlled pressures within another pressure vessel. The pressure vessel can be sourced with positive and/or negative (e.g., vacuum) pressure.Type: GrantFiled: November 8, 2002Date of Patent: May 19, 2009Assignee: Therakos, Inc.Inventor: Dennis A. Briggs
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Patent number: 7513882Abstract: This invention provides a method for controlling a fluid separation system, preferably a blood apheresis system having a leukocyte reduction chamber. The method utilizes a three-level alarm system. A first-level alarm condition is triggered in response to a pressure drop in the system to less than or equal to a specified system pressure and pauses fluid flow in at least a portion of the system. A second-level alarm condition is triggered in response to a specified number of said pressure drops within a specified period and reduces the flow rate of the fluid in the system. The alarm conditions may also trigger a visible and/or audible alarm. These alarm levels permit flow through the leukocyte reduction chamber to continue when the pressure drop is caused by a non-serious, self-resolving or easily-correctable condition such as misalignment of system components.Type: GrantFiled: September 8, 2006Date of Patent: April 7, 2009Assignee: CaridianBCT, Inc.Inventors: Thomas J. Felt, Marlene Adele Bainbridge
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Patent number: 7510540Abstract: An autotransfusion device having: a first line and a first pump, the first line being connected to the inlet of a blood centrifugation cell, and branches of the first line being (i) connected to a red blood cell container, (ii) provided with a coupling, and (iii) being suitable to be connected to the patient; a second line connected to the outlet of a blood centrifugation cell and two branches of the second line being provided with two couplings; and a third line and a second pump, the third line being connected to the first line in an intermediate position between the first pump and the blood centrifugation cell, and branches of the third line (i) being connected to a physiological solution container and (ii) being provided with a coupling.Type: GrantFiled: November 16, 2004Date of Patent: March 31, 2009Assignee: Sorin Group Italia S.r.l.Inventors: Margherita Valluzzi, Giampaolo Simonini
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Publication number: 20090014395Abstract: Blood processing systems and methods establish on line communication between a container and a source of blood containing leukocytes and platelets, such as a human donor. The systems and methods create a centrifugal field between the source of blood and the container that separates from the blood an unfinished suspension of platelets having a first physiologic characteristic different than the desired physiologic characteristic. The systems and methods pump the unfinished platelet suspension outside the centrifugal field through a finishing device. The finishing device changes the first physiologic characteristic to the desired physiological characteristic, thereby creating the finished platelet suspension. The systems and methods convey the finished platelet suspension from the finishing device directly into the container. The systems and methods function without interrupting the on line communication between the container and the source of blood.Type: ApplicationFiled: July 25, 2008Publication date: January 15, 2009Inventor: Daniel F. Bischof
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Patent number: 7465285Abstract: A control deck and system for controlling and driving blood fluids through an extracorporeal blood circuit kit. In one aspect, the invention is a deck having an improved mechanism for securing a cassette in place during treatment operations. The improved deck comprises catches for slidably receiving tabs of the cassette and one or more rotating clamps for locking and securing the cassette in a loaded position. In another aspect the invention is a system for controlling and driving blood fluids having infrared communication abilities to transmit and receive real time data. In still another aspect, the invention is a system for controlling and driving blood fluids having an upright tower design that reduces the footprint of the system. In this embodiment, a centrifuge chamber is positioned in an upper portion of the system while the control deck and photoactivation chamber are located in a base portion of the system.Type: GrantFiled: June 1, 2006Date of Patent: December 16, 2008Assignee: Therakos, Inc.Inventors: Mchael Hutchinson, Dennis Briggs, Stephen Gara, Tom Walters
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Publication number: 20080290048Abstract: A device and method thereof for at least partially fractioning or separating fluid from higher density and/or solid particles contained in liquid samples are disclosed. The present invention provides a movable or drivable device having a flow path defined by inner and outer wall surfaces and arranged such that the flow velocity of the liquid sample along the outer wall surface is higher than the flow velocity along the opposite inner wall surface. The flow path provides elements to at least delay the flow of the liquid sample along the outer wall surface. The device is, e.g., suitable for the separation of blood, e.g., of plasma from at least red blood cells, and from red and white blood cells to achieve blood plasma with high purity for analytical reasons.Type: ApplicationFiled: June 2, 2008Publication date: November 27, 2008Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.Inventors: Rainer Jaeggi, Patrick Griss, Hans-Peter Wahl
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Patent number: 7442315Abstract: The present invention relates to a separation device notably for a flow-force fractionation of suspended substances in a liquid carrier, said separation device comprising a separation channel and a counter-channel. The object of the present invention is mainly the separation of living cells, preferably of human origin, in particular cells which are found in body fluids.Type: GrantFiled: June 23, 2005Date of Patent: October 28, 2008Assignee: Universite de LimogesInventors: Philippe Cardot, Serge Battu, Robert Sarrazin
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Patent number: 7442178Abstract: A blood processing centrifuge comprising: a rotor having an axis of rotation and being controllably spun around the axis, a mechanism for processing whole blood within the rotor while spinning, a computer controlling blood processing operations, the computer being mounted to the rotor and spinning therewith.Type: GrantFiled: March 9, 2005Date of Patent: October 28, 2008Inventor: Jacques Chammas
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Patent number: 7431932Abstract: Reovirus can be used to selectively remove ras-mediated neoplastic cells from a cellular composition. It is of particular interest to purge autographs which may contain neoplastic cells with reovirus before transplanting the autographs back into the recipient, thereby reducing the risk of introducing or reintroducing neoplastic cells into the recipient.Type: GrantFiled: September 26, 2005Date of Patent: October 7, 2008Assignee: Oncolytics Biotech Inc.Inventors: Donald Morris, Bradley G. Thompson, Matthew C. Coffey
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Publication number: 20080210645Abstract: A concentrator is used for concentrating a fluid, particularly a plasma component out of blood, for treatment of a patient. The concentrator apparatus includes a main housing defining a centrifuge chamber, that also holds the filter. The concentrator allows viewing of the fluid after centrifuging, with an outlet port positionable at a height corresponding to the level of the fraction of the fluid to be further concentrated. Once the fluid is centrifuged, a portion of the fluid is drawn through the outlet, and then pressured past the filter to further concentrate the fluid using the same vessel as used for centrifuging. The same plunger is preferably used to draw centrifuged fluid from the centrifuge chamber as to pressure the centrifuged fluid past the filter.Type: ApplicationFiled: October 31, 2007Publication date: September 4, 2008Applicant: Millennium Medical Technologies, Inc.Inventors: Thomas Coull, Matthew Kyle, Louis S. Kidder
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Patent number: 7413652Abstract: A system for the production of a blood component composition is provided. The system includes a centrifuge having a blood reservoir for receiving and separating a blood sample into multiple components; a dispenser disposed outside of the centrifuge having a first collection chamber containing an activation agent and a second collection chamber containing one or more medicinal agents; means for removing a first portion at least one separated blood component from the centrifuge to the first container and a second portion to the second collection chamber, wherein the first collection chamber activates the first portion and stores the resulting clot and thrombin; a filter for separating the thrombin from the clot; and a nozzle for entraining and mixing the thrombin with the second portion containing the one or more medicinal components.Type: GrantFiled: April 26, 2005Date of Patent: August 19, 2008Assignee: Arteriocyte Medical Systems, Inc.Inventors: Victor D. Dolecek, Robert F. Baugh, John G. Rivera, William F. McKay, Jeffery C. Marx
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Patent number: 7413665Abstract: A system for separating a composite fluid into component parts thereof, including: a centrifuge having a rotor with a separation space and at least two valve members disposed thereon and a container set having a separation container adapted to be disposed in the separation space of the rotor and first and second collection containers connected to the separation container by a first and a second tubes. The tubes are adapted to be disposed in operative relationship with the valve members so that flow through the tubes may be controlled thereby. Three components of the composite fluid may be separated therefrom by the present system and two components may be moved to the collection containers. The container set may further include a third collection container connected to the separation container by a tube, and a third component may thus be moved to this third container.Type: GrantFiled: December 15, 2006Date of Patent: August 19, 2008Assignee: Gambro BCT, Inc.Inventors: Brian M. Holmes, Johan-Petter Hagström, Per-Olov Lundberg, Geert Van Waeg, Peter Nordgren
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Patent number: 7396452Abstract: An apparatus comprises an inlet to convey a first fluid comprising first and second components having different density into a rotating chamber such that an interface forms between at least portions of such components at a first location. At least one outlet removes at least one of the first and second components. A controller is adapted to introduce the first fluid and is operable to move the interface from the first location to a second location and to move the interface from the second location in a direction toward the first location and to return the interface to the second location. The controller is operable to determine a flow rate of the first or second component based, at least in part, on the time interval between when the interface moves from and returns to the second location. At least one sensing assembly is adapted to sense the location of the interface.Type: GrantFiled: June 29, 2006Date of Patent: July 8, 2008Assignee: Fenwal, Inc.Inventors: Kyungyoon Min, Richard I. Brown
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Patent number: 7396451Abstract: A system for separating a composite fluid into component parts thereof, including: a centrifuge having a rotor with a separation space and at least two valve members disposed thereon and a container set having a separation container adapted to be disposed in the separation space of the rotor and first and second collection containers connected to the separation container by a first and a second tubes. The tubes are adapted to be disposed in operative relationship with the valve members so that flow through the tubes may be controlled thereby. Three components of the composite fluid may be separated therefrom by the present system and two components may be moved to the collection containers. The container set may further include a third collection container connected to the separation container by a tube, and a third component may thus be moved to this third container.Type: GrantFiled: December 15, 2006Date of Patent: July 8, 2008Assignee: Gambo BCI, Inc.Inventors: Brian M. Holmes, Johan-Petter Hagström, Per-Olov Lundberg, Geert Van Waeg, Peter Nordgren
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Publication number: 20080128367Abstract: The inventive method for centrifugal separation of a determined volume of physiological liquid, in particular blood, at initial process step, consists in forming a flow of said liquid whose thickness is close to the size of largest particles (L3) contained therein at a volume ratio of <1%, in decelerating said liquid flow in order to increase the thickness thereof and to transfer said largest particles (L3) to the surface of the liquid phase (L1) which is nearest to a centrifugation axis and whose density is the greatest, in arranging, outside of said surface, a dead volume whose capacity is substantially equal to the volume of said largest particles (L3) and in removing a phase (L2) whose density is the lowest.Type: ApplicationFiled: February 1, 2006Publication date: June 5, 2008Inventor: Jean-Denis Rochat
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Patent number: 7374678Abstract: An apparatus that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at least three fractions in the apparatus. It also provides for a new method of extracting the buffy coat phase from a whole blood sample. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient.Type: GrantFiled: September 2, 2004Date of Patent: May 20, 2008Assignee: Biomet Biologics, Inc.Inventors: Michael Leach, Jennifer E. Woodell-May, Joel C. Higgins, Brandon Miller
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Patent number: 7371330Abstract: A particle sedimentation apparatus includes a rotation body rotatable about a rotation axis and a separation chamber formed in the rotation body, to cause sedimentation of particle suspension in the separation chamber upon rotation of the rotation body. The particles accumulate in a radially outward region of the separation chamber. A flow-rate-determining inflow channel having azimuthal path length with an inflow channel inlet and an inflow channel outlet is formed in the rotation body, the inflow channel inlet being arranged radially further inwardly than the inflow channel outlet, the inflow channel outlet being fluidically connected to the separation chamber and formed to introduce particle suspension into the separation chamber upon rotation of the rotation body. Furthermore, an outflow channel is formed in the rotation body with an outflow channel inlet and an outflow channel outlet, to at least partially drain supernatant liquid formed by sedimentation from the separation chamber.Type: GrantFiled: March 23, 2007Date of Patent: May 13, 2008Assignee: Albert-Ludwigs-Universitaet FreiburgInventors: Jens Ducree, Roland Zengerle, Stefan Haeberle, Thilo Brenner
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Patent number: 7358095Abstract: A tube and float system for use in separation and axial expansion of the buffy coat includes a transparent or semi-transparent, flexible sample tube and a rigid separator float having a specific gravity intermediate that of red blood cells and plasma. The float includes a main body portion of reduced diameter to provide a clearance gap between the inner wall of the sample tube and the float. One or more protrusions on the main body portion serve to support the flexible tube. During centrifugation, the centrifugal force causes the diameter of the flexible tube to expand and permit density-based axial movement of the float in the tube. The float further includes a pressure relief system to alleviate pressure build up in the trapped red blood cell blood fraction below the float, thereby preventing red blood cells from being forced into the annular gap containing the buffy coat layers.Type: GrantFiled: December 11, 2006Date of Patent: April 15, 2008Assignee: Battelle Memorial InstituteInventors: Thomas Haubert, Vince Contini, Steve Grimes, Randy Jones, Stephen C. Wardlaw
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Patent number: 7357897Abstract: Blood processing systems and methods convey blood cells from a blood cell source into a blood component collection flow channel that includes a blood cell storage container and an in-line filter to remove leukocytes from blood cells before entering the blood cell storage container. The systems and methods also convey additive solution from an additive solution source into the blood component collection flow channel. The systems and methods alternate the conveyance of blood cells through the filter with the conveyance of additive solution through the filter.Type: GrantFiled: January 10, 2005Date of Patent: April 15, 2008Assignee: Fenwal, Inc.Inventors: Kelly B Smith, Mark Vandlik, Michael Kast
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Patent number: 7354515Abstract: A concentrator is used for concentrating a fluid, particularly a plasma component out of blood, for treatment of a patient. The concentrator apparatus includes a main housing defining a centrifuge chamber, that also holds the filter. The concentrator allows viewing of the fluid after centrifuging, with an outlet port positionable at a height corresponding to the level of the fraction of the fluid to be further concentrated. Once the fluid is centrifuged, a portion of the fluid is drawn through the outlet, and then pressured past the filter to further concentrate the fluid using the same vessel as used for centrifuging. The same plunger is preferably used to draw centrifuged fluid from the centrifuge chamber as to pressure the centrifuged fluid past the filter.Type: GrantFiled: February 22, 2005Date of Patent: April 8, 2008Assignee: Millennium Medical Technologies, Inc.Inventors: Thomas Coull, Matthew R. Kyle, Louis S. Kidder
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Patent number: 7354415Abstract: Methods and apparatus particularly involving the separation of blood into blood components and the collection of such components are disclosed. In one aspect, an extra-corporeal method for the collection of plasma and red blood cells is provided, wherein the collection of plasma and red blood cells may occur simultaneously or subsequently utilizing the same dual stage blood processing vessel. The flow of blood to the blood processing vessel and return of uncollected blood components may be provided via a single needle, wherein blood is removed from and returned to a donor/patient during alternating blood removal and blood return submodes. Platelet separation and collection options are also described. In either case, prior to red blood cell collection, a set-up phase may be carried out to set a predetermined hematocrit and AC ratio. Replacement fluid delivery may optionally also be provided either substantially continuously during any collection phase(s) and/or in a bolus mode.Type: GrantFiled: April 20, 2004Date of Patent: April 8, 2008Assignee: Gambro BCT, Inc.Inventors: Marlene Bainbridge, Muriel Keller, Timothy M. Gordon, Michael J. McAteer, Scott D. Butzke
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Patent number: 7347932Abstract: A method for separating a volume of a composite liquid into at least a first component and a second component is performed in a centrifuge cooperating with a separation bag containing the volume of composite liquid. The separation bag is connected to at least a first component bag and a second component bag. The separation bag is spun so as to centrifuge the volume of composite liquid and cause the sedimentation of the at least first and second components. When the at least first and second components have sedimented, the first component is transferred at at least one first transfer flow rate into the first component bag. When the first component has been transferred into the first component bag, the second component is transferred into the intermediate component bag at at least one second transfer flow rate that is different from the at least one first transfer flow rate.Type: GrantFiled: February 20, 2004Date of Patent: March 25, 2008Assignee: Gambro BCT, Inc.Inventors: Brian M. Holmes, Peter Pihlstedt, Geert Van Waeg
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Publication number: 20070284320Abstract: A method and apparatus for separating blood into blood components using a separation vessel satellite bags mounted on a centrifuge rotor and a balancing assembly for the centrifuge to compensate for changes to the center of gravity.Type: ApplicationFiled: May 22, 2007Publication date: December 13, 2007Applicant: GAMBRO BCT, INC.Inventors: Thomas L. MENHENNETT, Brian M. HOLMES, Charles HAKE, Daniel A. JOSEPH, Per-Olov Jan LUNDBERG, Hans LINDELL, Johan-Petter Hagstrom
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Patent number: 7297272Abstract: A separation apparatus and method are employed using a separation channel for rotation about an axis. Such channel includes radially spaced apart inner and outer side wall portions and an end wall portion. An inlet conveys fluid into the channel. A barrier is located in the channel intermediate of the inner and outer side wall portions. A first flow path communicates between upstream and downstream sides of the barrier. A collection region may be located downstream of the barrier for communication with the first flow path. An outer side wall section of the channel may be positioned radially outward of an upstream section thereof. The barrier may join the outer side wall portion along a substantial portion of an axial length of the channel. First and second exit flow paths may allow communication with the channel either upstream or downstream of the barrier or both.Type: GrantFiled: April 19, 2004Date of Patent: November 20, 2007Assignee: Fenwal, Inc.Inventors: Kyungyoon Min, Richard I. Brown, Alp Akonur
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Patent number: 7270645Abstract: A method and apparatus for producing blood component products. In one embodiment, a plurality of a predetermined type of blood component is harvested from a source of whole blood. At least two on-line yield determination techniques are utilized to determine the yield for the harvested blood components. One is a predetermined yield prediction technique and the second is a predetermined yield monitoring technique, each of which are individually calibrated in relation to a predetermined off-line yield determination technique. The predetermined yield prediction and monitoring techniques each provide the yield for the harvested blood components and each is then utilized to provide a determined yield. Consequently, when the harvested blood components are packaged the determined yield my be associated therewith, thereby providing a blood component product.Type: GrantFiled: January 26, 2005Date of Patent: September 18, 2007Assignee: Gambro BCT, IncInventors: Robert Warner Langley, Larry Joe Dumont
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Patent number: 7254879Abstract: In a method and apparatus for treating fluids, a pump delivers a fluid flow from a fluid source to a manifold. The manifold divides the fluid flow into first and second fluid flows, which are delivered from the manifold to a housing. The housing includes therein a first vortex nozzle positioned in opposed relationship to a second vortex nozzle. The first fluid flow enters the first vortex nozzle to create a first rotating fluid flow, and the second fluid flow enters the second vortex nozzle to create a second rotating fluid flow. The first and second vortex nozzles impinge the first and second rotating fluid flows in a collision chamber, thereby treating the fluid.Type: GrantFiled: September 23, 2003Date of Patent: August 14, 2007Assignee: Lancer Partnership, LtdInventors: Michael T. Romanyszyn, Perry McGuar
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Patent number: 7241281Abstract: An apparatus and method for collecting whole blood and then separating it into components for subsequent use or storage. A self-contained bag set is used to collect the sample, which may then be placed into container adapted to fit into a centrifuge for separation of components. Each component is then sequentially extracted according to density, with a sensor present in the container to control the operation of valves directing the collection of each component. Each component may then be separated into its own storage container.Type: GrantFiled: April 8, 2002Date of Patent: July 10, 2007Assignee: ThermoGenesis CorporationInventors: Philip H. Coelho, Eric Sommer, Richard Klosinski, Jim Hobbs
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Patent number: 7220593Abstract: A tube and float system for use in separation and axial expansion of the buffy coat includes a transparent or semi-transparent, flexible sample tube and a rigid separator float having a specific gravity intermediate that of red blood cells and plasma. The float includes a main body portion of reduced diameter to provide a clearance gap between the inner wall of the sample tube and the float. One or more protrusions on the main body portion serve to support the flexible tube. During centrifugation, the centrifugal force causes the diameter of the flexible tube to expand and permit density-based axial movement of the float in the tube. The float further includes a pressure relief system to alleviate pressure build up in the trapped red blood cell blood fraction below the float, thereby preventing red blood cells from being forced into the annular gap containing the buffy coat layers.Type: GrantFiled: October 3, 2002Date of Patent: May 22, 2007Assignee: Battelle Memorial InstituteInventors: Thomas Haubert, Vince Contini, Steve Grimes, Randy Jones, Stephan C. Wardlaw
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Patent number: 7211191Abstract: An apparatus and method for collecting whole blood and then separating it into components for subsequent use or storage. A self-contained bag set is used to collect the sample, which may then be placed into a device adapted to fit into a centrifuge for separation of components. Each component is then sequentially extracted according to density, with a sensor present in the device to control the operation of valves directing the collection of each component. Each component may then be separated into its own storage container.Type: GrantFiled: September 30, 2004Date of Patent: May 1, 2007Assignee: ThermoGenesis Corp.Inventors: Philip H. Coelho, Eric Sommer, Richard Klosinski, Jim Hobbs