Blood Patents (Class 210/782)
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Patent number: 6759007Abstract: Systems and methods for processing blood use at least one fluid activated pump and at least one fluid activated valve. The systems and methods apply positive and negative fluid pressures to operate the pump and valve. Different pressure conditions are applied to the pump and the valve, to insure that a valve used in conjunction with a pump is not overcome by the pressure applied to operate the pump, and that both the valve and pump are not overcome by normal system processing pressures.Type: GrantFiled: September 3, 1999Date of Patent: July 6, 2004Assignee: Baxter International Inc.Inventors: Tom Westberg, James D Jacobson
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Patent number: 6752777Abstract: Platelets are collected from blood by delivering blood from a blood source to a centrifugal separator and operating the separator to separate plasma from the blood. The separated plasma is collected in a plasma collecting bag. After a predetermined amount of plasma has been collected in the bag, the plasma is circulated between the bag and the separator. That procedure is repeated at least once to build-up the amount of collected blood. Then platelets are collected by delivering additional blood to the separator and circulating plasma between the separator and the plasma collecting bag at an accelerating circulation rate while rotating the rotor to remove platelets from the separator. The platelets are collected in a platelet collecting bag. Then, blood remaining in the separator is returned to the blood source.Type: GrantFiled: October 5, 1999Date of Patent: June 22, 2004Assignee: Terumo Kabushiki KaishaInventors: Yoshiki Takagi, Atsushi Suzuki
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Patent number: 6730055Abstract: Methods and apparatus particularly involving the separation of blood into blood components and the collection of such components are disclosed. In one aspect, an extracorporeal method for the collection of plasma and red blood cells is provided, wherein the collection of plasma and red blood cells may occur simultaneously or subsequently utilizing the same dual stage blood processing vessel. The flow of blood to the blood processing vessel and return of uncollected blood components may be provided via a single needle, wherein blood is removed from and returned to a donor/patient during alternating blood removal and blood return submodes. Platelet separation and collection options are also described. In either case, prior to red blood cell collection, a set-up phase may be carried out to set a predetermined hematocrit and AC ratio. Replacement fluid delivery may optionally also be provided either substantially continuously during any collection phase(s) and/or in a bolus mode.Type: GrantFiled: March 9, 2001Date of Patent: May 4, 2004Assignee: Gambro Inc.Inventors: Marlene Bainbridge, Muriel Keller, Timothy M. Gordon, Michael J. McAteer, Scott D. Butzke
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Publication number: 20040079707Abstract: Collection systems and methods use a separation chamber that receives blood or a suspension containing red blood cells and performs a separation process including separation of red blood cells from the blood or suspension. The separation chamber contains, during the separation process, a red blood cell volume. An outlet line is coupled to the separation chamber to remove red blood cells from the chamber device, at least in part, while the separation process occurs. A collection container is coupled to the outlet line to receive a volume of red blood cells removed from the separation chamber. A controller includes a processing function that, during the separation process, includes comparing the volume of red blood cells received by the collection container to a selected targeted red blood cell collection volume to derive a difference.Type: ApplicationFiled: October 24, 2002Publication date: April 29, 2004Applicant: Baxter International Inc.Inventors: Kelly B. Smith, Matthew Muller
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Patent number: 6719901Abstract: A system for the production of autologous thrombin, comprising a centrifuge including a blood reservoir for receiving and separating an autologous anticoagulated blood sample having multiple inactive blood components and means for removing at least one of said inactive blood components upon separation, and a dispenser having at least two collection chambers for receiving said at least one of said inactive blood components, wherein a first collection chamber activates a first portion of said inactive blood component and stores the resulting coagulated blood component comprising a clot and said autologous thrombin.Type: GrantFiled: April 9, 2001Date of Patent: April 13, 2004Assignee: Medtronic, Inc.Inventors: Victor D. Dolecek, Robert F. Baugh, John G. Rivera, William F. McKay, Jeffery C. Marx
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Patent number: 6716187Abstract: A single-use system for separating blood and producing platelet concentrates includes an elongated container for receiving blood from a patient. The container has a movable plunger mounted within the blood container for expressing blood fractions separated during centrifugation of the container through a first port mounted at one end of said container, a second port mounted on the plunger, and a third port mounted on a plunger rod attached to the plunger.Type: GrantFiled: July 7, 2000Date of Patent: April 6, 2004Assignee: Implant Innovations, Inc.Inventors: Glen E. Jorgensen, Bruce Berckmans, III
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Patent number: 6709412Abstract: Systems and methods separate blood cells from whole blood and pump the separated blood cells through an in-line leukofilter to a blood cell storage container. The leukofilter has a filtration medium enclosed within a flexile housing. The systems and methods employ a fixture to restrain expansion of the flexible filter housing during operation of the pump. The fixture has a bracket to enable its releasable attachment to the blood processing device employed to carry out the separation process.Type: GrantFiled: October 13, 2001Date of Patent: March 23, 2004Assignee: Baxter International Inc.Inventors: Mark Vandlik, Michael J Kast, Kelly B Smith
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Patent number: 6709413Abstract: The platelet gel manufacturer includes a platelet gel applicator, a controllable platelet receptacle, a controllable coagulant receptacle, and a controllable platelet gel receptacle. The controllable platelet receptacle is fluidly coupled to the closed corporeal system, the controllable coagulant receptacle is fluidly coupled to the controllable platelet gel receptacle, and the controllable platelet gel receptacle is fluidly coupled to the platelet gel applicator. The controllable platelet receptacle is operable to receive the platelet rich plasma obtained from the patient by the closed corporeal system, and controllably deliver the platelet rich plasma to the controllable platelet gel receptacle. The controllable coagulant receptacle is operable to store a coagulant used to produce platelet gel, and controllably deliver the coagulant to the controllable platelet gel receptacle.Type: GrantFiled: September 1, 2000Date of Patent: March 23, 2004Assignee: Riverview HospitalInventors: Nancy Chance, Rochelle Strong
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Publication number: 20040026341Abstract: A system and method are used in connection with processing of blood components. The processing of blood components may involve centrifugal separation and/or filtering of the blood components. In some examples, at least some blood components are centrifugally separated in a chamber and then filtered via a filter rotating along with a centrifuge rotor, wherein the filter is located closer than the chamber to an axis of rotation of the rotor. The filter may include a porous filtration medium configured to filter leukocytes, platelets, and/or red blood cells. Some examples include a pressure sensor sensing pressure of pumped blood components. The sensed pressure may be used in connection with controlling the pumping of the blood products and/or in connection with determining the location of an interface associated with the blood products. Other uses of the sensed pressure are also possible.Type: ApplicationFiled: April 16, 2003Publication date: February 12, 2004Inventors: Niclas Hogberg, Emanuel Hallgren, Peter Pihlstedt, Brian M. Holmes, Lars Persson, Lars Strandberg, Geert Van Waeg, Frank Corbin
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Publication number: 20030233064Abstract: This invention provides an apparatus and methods to consistently separate and concentrate selected blood components. The system includes, e.g., a computerized fluid handling system to transfer blood components between a centrifugal blood separation disc, containers and a concentrator.Type: ApplicationFiled: April 23, 2003Publication date: December 18, 2003Applicant: Interpore OrthopaedicsInventors: Douglas M. Arm, Michael Ponticiello, Surinder Mathur, Andrew G. Hood
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Patent number: 6652476Abstract: A method and apparatus for producing blood component products. In one embodiment, a plurality of a predetermined type of blood component is harvested from a source of whole blood. At least two on-line yield determination techniques are utilized to determine the yield for the harvested blood components. One is a predetermined yield prediction technique and the second is a predetermined yield monitoring technique, each of which are individually calibrated in relation to a predetermined off-line yield determination technique. The predetermined yield prediction and monitoring techniques each provide the yield for the harvested blood components and each is then utilized to provide a determined yield. Consequently, when the harvested blood components are packaged the determined yield my be associated therewith, thereby providing a blood component product.Type: GrantFiled: October 17, 2001Date of Patent: November 25, 2003Assignee: Gambro, Inc.Inventors: Robert Warner Langley, Larry Joe Dumont
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Patent number: 6649072Abstract: A novel method for producing an autologous platelet rich blood composition is described. The resulting blood composition is useful in procedures for enhancing bone fusion, hemostasis, and repairing soft tissue in animals.Type: GrantFiled: November 16, 2001Date of Patent: November 18, 2003Inventors: Robert Brandt, Michael Buzenius
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Patent number: 6641552Abstract: A system compact enough to be located entirely beside the donor's chair, and able to process the blood while the donor is still resting in the chair after having donated the blood. The separated blood components (plasma and red blood cells) may be stored in their individual optimum environments immediately after the whole blood is drawn, and the blood does not need to be transported back to a separation laboratory for processing. The system includes a needle (72) (or other cannula-like device) for insertion into a vein of the donor and drawing whole blood therethrough, a rotor (2a) for holding the blood after it is drawn, and a motor (50) for spinning the rotor so as to cause the blood to separate into components, for example, plasma and red blood cells.Type: GrantFiled: February 1, 2000Date of Patent: November 4, 2003Assignee: Haemonetics CorporationInventors: Gordon F. Kingsley, Thomas D. Headley, Lise N. Halpern
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Publication number: 20030195455Abstract: An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.Type: ApplicationFiled: April 3, 2003Publication date: October 16, 2003Applicant: Gambro, Inc.Inventors: Marlene Adele Bainbridge, Brian M. Holmes
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Patent number: 6632191Abstract: A system for collecting red blood cells (RBCs) and other blood components that reduces the need for human intervention. A disposable set is provided having a port, an RBC container, a centrifuge rotor having a variable total volume, and a filter, along with tubing connecting the port, the container, the rotor and the filter. A control unit is also provided and includes a spinner in which the rotor may be held, a flow-control arrangement for controlling flow among the various components of the disposable set, and an electronic controller. The whole blood is directed by the flow-control arrangement from the port through the tubing to the rotor. The rotor includes an elastic diaphragm, and the control unit's flow-control arrangement includes a pump or other device for applying a positive and negative pressure to the rotor's elastic diaphragm. The spinner rotates the rotor so as to separate the whole blood into plasma and RBCs.Type: GrantFiled: March 17, 1999Date of Patent: October 14, 2003Assignee: Haemonetics CorporationInventors: Thomas D. Headley, Edward T. Powers
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Publication number: 20030191005Abstract: An apparatus and method for collecting whole blood and then separating it into components for subsequent use or storage. A self-contained bag set is used to collect the sample, which may then be placed into container adapted to fit into a centrifuge for separation of components. Each component is then sequentially extracted according to density, with a sensor present in the container to control the operation of valves directing the collection of each component. Each component may then be separated into its own storage container.Type: ApplicationFiled: April 8, 2002Publication date: October 9, 2003Inventors: Philip H. Coelho, Eric Sommer, Richard Klosinski, Jim Hobbs, Pablo Rubinstein
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Patent number: 6612975Abstract: A blood centrifuge with a drive assembly for transmitting an input rotation speed to a rotor with a sample reservoir at a desired rotation ratio. The drive assembly includes a base and an outer shell mounted to the base to rotate at an input rate. A bottom pulley is rigidly mounted to the base and attached to the outer shell with bearings. A top pulley is mounted to a center shaft of the outer shell to rotate with the outer shell about the central axis of the centrifuge. An internal drive belt is provided to transmit the rotation to the top pulley via a pair of transversely mounted idler pulleys that rotate with the outer shell. The top pulley is thus rotated at twice the input rate but in the same direction. A rotor assembly with the sample reservoir is attached to the top pulley to separate blood components.Type: GrantFiled: April 9, 2001Date of Patent: September 2, 2003Assignee: Medtronic, Inc.Inventors: David Malcom, Victor D. Dolecek
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Patent number: 6613009Abstract: An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.Type: GrantFiled: August 19, 1997Date of Patent: September 2, 2003Assignee: Gambro, Inc.Inventors: Marlene Adele Bainbridge, Brian M. Holmes
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Publication number: 20030155312Abstract: Blood is purified by removing the whole blood from a patient and feeding the blood into a manifold in a centrifuge. A purifying chamber is formed in the centrifuge from a plurality of co-arcuately arranged modules. The blood is supplied from the manifold to each of the modules. Each module contains a stack of dialysate membranes. Fresh dialysate is fed into the manifold and then to each of the modules. Under centrifugal force the cells are separated from the plasma. The plasma is purified by removing contaminants as a result of the action of the dialysate and membranes. The purified blood is returned to the patient by being fed back to the manifold and then to the patient. The used dialysate/contaminants are fed from the modules back to the manifold and out of the centrifuge.Type: ApplicationFiled: February 15, 2002Publication date: August 21, 2003Inventors: Ivars V. Ivansons, Dudley W.C. Spencer
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Patent number: 6605223Abstract: An automated blood separation method and apparatus is described that allows for the separation of multiple units of blood simultaneously. The method and apparatus reliably and quickly separates blood into its components. An auto-balancing feature within the apparatus automatically preferably compensates for the changing state of imbalance, thereby eliminating the need for additional balancing steps during the separation process. The apparatus has a rotor into which a plurality of cassettes can be inserted. The cassettes have a number of sections for the containment of the whole blood and for the separated blood components, which are contained in disposable bags. The rotor is placed into a centrifuge assembly, and the blood components are then separated and transferred to the bags in the individual sections of the cassettes. Means for including secondary separation devices such as filters is included.Type: GrantFiled: October 22, 2001Date of Patent: August 12, 2003Assignee: MEDIcept, Inc.Inventors: Glen Jorgensen, Donald E. Barry
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Patent number: 6596180Abstract: A centrifuge system for the formation of an autologous platelet gel wherein all of the blood components for the gel are derived from a patient to whom the gel is to be applied. First a platelet rich plasma and a platelet poor plasma are formed by centrifuging a quantity of anticoagulated whole blood that was previously drawn from the patient. The platelet rich plasma or platelet poor plasma is then automatically drawn out of the centrifuge bag and proportioned into separate chambers in a dispenser. The first portion is activated where a clot is formed and thrombin is obtained. The thrombin is then latter mixed with the second portion to obtain a platelet gel.Type: GrantFiled: April 9, 2001Date of Patent: July 22, 2003Assignee: Medtronic, Inc.Inventors: Robert F. Baugh, Lisa M. Lim, Julie S. Johnston, John G. Rivera, Victor D. Dolecek
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Patent number: 6596179Abstract: Apparatus for withdrawing whole blood from a donor, separating the whole blood to obtain a target cell population and returning a selected one of either the target cell population or at least a portion of the whole blood remainder to the donor or patient. A disposable separation inset for use in association with a rotatable separation device of the apparatus may also be provided. The disposable inset may include a chamber for receiving a cell suspension that includes the target cell, a receptacle for containing particles having a binding site for selectively binding to the target cell and a means for introducing the particles into the chamber.Type: GrantFiled: February 16, 2001Date of Patent: July 22, 2003Assignee: Baxter International Inc.Inventors: Richard Giesler, John R. Chapman, Dale R. Ellis, Daniel F. Bischof
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Patent number: 6589155Abstract: A belt-driven blood centrifuge with side-mounted drive motor for rotating the centrifuge at a rotation speed selected to separate blood components. The centrifuge includes a drive shaft assembly rotated at an input rotation speed and a rotor assembly rotatably linked to the drive shaft assembly rotated at an output rotation speed twice the input rotational speed. A drive motor is provided with a drive pulley to drive a belt, a chain, and the like to provide the motive force to rotate the drive shaft at the input rotation speed. In one embodiment, a belt is provided to contact both the pulley of the drive motor and an outer surface of a rotatable shell of the drive shaft assembly. A base is included in the centrifuge upon which the drive shaft assembly is mounted. The drive motor is positioned adjacent the drive shaft assembly and mounted on the base.Type: GrantFiled: April 9, 2001Date of Patent: July 8, 2003Assignee: Medtronic, Inc.Inventor: Victor D. Dolecek
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Publication number: 20030102272Abstract: Systems and methods centrifugally separate whole blood into red blood cells, plasma, and a platelet concentrate. The systems and methods rotate a first rotating separation zone about a rotational axis, to separate whole blood into red blood cells and plasma constituent carrying platelets. Red blood cells separated are directed in a first circumferential flow direction toward a terminal wall, where blood flow is halted. Surface hematocrit is successively increased in the first circumferential flow direction by separating the plasma constituent from the red blood cells. Separated red blood cells are directed from the first rotating separation zone through a path where the surface hematocrit is the most. Plasma constituent separated is directed in a second circumferential flow direction opposite to the first circumferential flow direction toward a different region in the first rotating separation zone, where the surface hematocrit is the least.Type: ApplicationFiled: January 7, 2003Publication date: June 5, 2003Applicant: Baxter International Inc.Inventor: Richard I. Brown
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Publication number: 20030066807Abstract: A platelet collection apparatus has a function of determining whether there is a tendency to increase or decrease in the number of collected platelets by using data, related to the concentration of platelets, obtained from a turbidity sensor, an expected number of to-be-collected platelets or a value related thereto; and a function of decreasing the amount of platelets to be collected in a subsequent platelet collection operation after plasma containing high-concentration platelets is collected in a plasma collection operation, if the function of determining on an increase/decrease tendency in the number of collected platelets determines that there is a tendency to increase in the number of collected platelets.Type: ApplicationFiled: September 19, 2002Publication date: April 10, 2003Inventor: Atsushi Suzuki
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Publication number: 20030052065Abstract: A system for transferring blood product between a blood storage bag and a processing bag. The system includes an airtight containment chamber for supporting therein one or more blood storage bags. A door is provided for access to the chamber and there is included an airtight fixture that allows tubing from the blood storage bag to exit the chamber. A fluid pump is coupled to the containment chamber for establishing either pressure or vacuum within the containment chamber. A controller controls the air pump to, in turn, control the transfer of a blood product.Type: ApplicationFiled: August 28, 2002Publication date: March 20, 2003Inventor: Keith Rosiello
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Patent number: 6527957Abstract: Methods are disclosed for the collection of red blood cells whereby whole blood is combined with an anticoagulant, red cells are separated from the whole blood and the separated red cells are combined with a storage solution. The red cells may be stored for an extended period of time.Type: GrantFiled: April 7, 1999Date of Patent: March 4, 2003Assignee: Baxter International Inc.Inventors: Jose C. Deniega, Daniel H. Duff, Maria D. Gudino, Donald H. Buchholz
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Patent number: 6517732Abstract: A method and apparatus for removing air from blood which contains air. The air-containing blood is conducted through a cyclone device as a rotating cyclone stream, so that centrifugal forces for the separation of the air from the blood are produced in the rotating cyclone stream.Type: GrantFiled: August 14, 2000Date of Patent: February 11, 2003Assignee: Convergenza AGInventors: Alexander Brockoff, Hans Plechinger
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Patent number: 6511411Abstract: A chamber for use in a rotating field to separate blood components is described. An inlet port near one end of the chamber introduces blood into the chamber for flow circumferentially about the rotational axis toward the opposite end of the chamber for separation into at least one blood component. At least one outlet port is juxtaposed next to the inlet port near the one end of the chamber for conveying one separated blood component from the channel. The chamber directs the one separated blood component to a collection region near the opposite end of the chamber. An enclosed interior collection passage within the channel leads from the collection region and directs the one collected component to the outlet port for transport from the chamber.Type: GrantFiled: September 13, 2000Date of Patent: January 28, 2003Assignee: Baxter International Inc.Inventor: Richard I. Brown
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Publication number: 20030018289Abstract: A system for interfacing with an operator in a blood component collection facility is disclosed. The operator administers one or more procedures in the blood component collection facility. The blood component collection facility removes at least one blood component from a donor and comprises a blood component collection instrument capable of being adapted to the donor. The operator facilitates interaction of the donor with the blood component collection facility.Type: ApplicationFiled: May 24, 2001Publication date: January 23, 2003Inventors: Kok-Hwee Ng, Grant Alexander Peterson, Wilified S. Winifred, Ian Ford
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Patent number: 6497674Abstract: An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.Type: GrantFiled: January 23, 1998Date of Patent: December 24, 2002Assignee: Gambro, Inc.Inventors: Chad C. Steele, Marlene Adele Bainbridge, Denise C. Garrison, Terry R. Wahl
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Patent number: 6497823Abstract: A method for processing a biological fluid comprises the steps of collecting platelet-rich plasma (PRP) in a container containing a complement filter, centrifuging the PRP in the container to provide a supernatant layer comprising a volume of platelet-poor plasma (PPP) and a sediment layer including concentrated platelets, passing most of the volume of the PPP from the container, suspending the platelets in the remaining volume of PPP to provide a platelet suspension and storing the platelet suspension in the container for a storage period of at least about 24 hours while contacting the complement filter with at least a portion of the platelet suspension and removing complement from the platelet suspension.Type: GrantFiled: July 21, 2000Date of Patent: December 24, 2002Assignee: Pall CorporationInventors: Isaac Rothman, Thomas Gsell, Gerard R. Delgiacco, Richard Salinaro, Randy Garcez
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Patent number: 6495366Abstract: This invention describes a method for pumping or delivering fluids utilizing a flexible vessel subject to controlled pressures within another pressure vessel. The pressure vessel can be sourced with positive and/or negative (e.g., vacuum) pressure.Type: GrantFiled: September 3, 1999Date of Patent: December 17, 2002Assignee: Therakos, Inc.Inventor: Dennis A. Briggs
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Patent number: 6495051Abstract: A method for separating a blood component, e.g., fibrin monomer, from blood or plasma. The method utilizes a container with a reaction chamber for receiving the plasma. The reaction chamber is defined by a wall and an agent is supplied to the reaction chamber for converting the fibrinogen content of the plasma into a non-cross-linked fibrin polymer. The method also utilizes a device for centrifuging the reaction chamber with the plasma and the agent to a degree sufficient for separating the non-cross-linked fibrin polymer from the plasma, for depositing the polymer on the outer wall of the reaction chamber, and for expelling the remaining plasma from the reaction chamber. A solvent is supplied to the reaction chamber for dissolving the non-cross-linked fibrin polymer. The solvent is supplied to the reaction chamber in a first amount for dissolving the non-cross-linked fibrin polymer which is less than the total amount of solvent for dissolving the polymer.Type: GrantFiled: September 29, 2000Date of Patent: December 17, 2002Assignee: Bristol-Myers Squibb CompanyInventors: Gautom Bhaskar, Glenn Jorgensen
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Patent number: 6488860Abstract: The invention relates to a device and a method for separating whole blood into blood components. The device has a collecting container for collecting whole blood, a primary container, and one or a plurality of satellite containers downstream from the primary container. The collecting container is connected to the primary container via a branch line containing a leucocyte filter. In addition, a bypass line is provided between the collecting container and the primary container for creating a fluid connection that circumvents the leucocyte filter. The primary container is also connected, via an additive line, to an additive container containing an additive agent for storing a blood component. The method involves collecting the donor's whole blood in the collecting container and conveying it, via the bypass line, into the primary container. The whole blood located in the primary container is then separated by centrifuigation into an erythrocyte layer and a mixed layer of blood plasma and thrombocytes.Type: GrantFiled: March 24, 1998Date of Patent: December 3, 2002Assignee: Fresenius AGInventors: Giorgio Mari, Paolo Verri
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Publication number: 20020177799Abstract: The present invention is a blood separation system that is fully mechanized to collect blood from a patient, separate waste portions of the blood, wash the blood, and redirect the usable portions to a device for reinjecting the usable portions into the patient. The present invention prevents accidental activation of an improper operation that could cause harm to a patient or a shut down of the system by requiring confirmation of each step by an operator. The invention provides screen displays with detailed setup instructions, eliminating the need for secondary documentation that might not be allowed in a surgical environment. The invention also instructs the operator at the appropriate times to do certain manual steps such as opening and closing clamps. Since the opening and closing of clamps is a highly critical operation, confirmation of these steps is also required.Type: ApplicationFiled: July 8, 2002Publication date: November 28, 2002Inventors: John Rivera, Son Le, Daniel Cheek, Richard Matt, Roger P. Kaminski
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Patent number: 6482223Abstract: Wound closure methods and apparatus are provided which utilize blood fluid by activating the clotting cascade of blood fluid outside the body within a substantially enclosed sterile container then introducing the blood fluid to the wound site to complete clotting. Methods and apparatus for providing ways of inhibiting anti-coagulating agents and slowing fibrin clot degradation are also disclosed. Kits for practicing the invention singularly or in combination with and/or associated with preferred procedures are also disclosed. The present invention provides improved methods of creating hemostasis or control of bleeding at the site of wounds, particularly wounds created in arteries during procedures employing percutaneous access. The invention preferably includes the steps of acquiring an aliquot of a patient's blood, i.e.Type: GrantFiled: June 1, 2000Date of Patent: November 19, 2002Assignee: Closys CorporationInventors: Karol L. Nowakowski, James E. Olson, Edward T. Joseph, Daniel G. Ericson
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Patent number: 6475175Abstract: The present invention is a blood separation system that is fully mechanized to collect blood from a patient, separate waste portions of the blood, wash the blood, and redirect the usable portions to a device for reinjecting the usable portions into the patient. The present invention prevents accidental activation of an improper operation that could cause harm to a patient or a shut down of the system by requiring confirmation of each step by an operator. The invention provides screen displays with detailed setup instructions, eliminating the need for secondary documentation that might not be allowed in a surgical environment. The invention also instructs the operator at the appropriate times to do certain manual steps such as opening and closing clamps. Since the opening and closing of clamps is a highly critical operation, confirmation of these steps is also required.Type: GrantFiled: April 8, 1999Date of Patent: November 5, 2002Inventors: John Rivera, Son Le, Daniel Cheek, Richard Matt, Roger P. Kaminski
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Publication number: 20020158029Abstract: A method and apparatus for controlling the washing step in a blood centrifugation cell in which washing solution is introduced into the blood centrifugation cell and the cell contains compacted red cells and supernatant at the beginning of the washing step. The apparatus comprises a computer that executes an algorithm that produces a first output that is the concentration of the supernatant in the supernatant-washing solution mixture.Type: ApplicationFiled: April 19, 2002Publication date: October 31, 2002Inventors: Ivo Panzani, Sergio Romagnoli, Massimo Belloni
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Publication number: 20020156439Abstract: The present invention is a collection container assembly comprising a container with a false bottom having a rounded open end and wherein the external dimensions of the container are substantially the same as a standard-sized blood collection tube but with a reduced internal volume.Type: ApplicationFiled: September 12, 1997Publication date: October 24, 2002Inventor: MICHAEL J. ISKRA
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Patent number: 6466879Abstract: Fluid processing systems and methods make use of a replenishable source containing a volume of a processing fluid that is dispensed during a processing period. A processor serves to sequentially pause and resume the processing period. The processor records weight values of the source at commencement of the processing period; upon pauses in the processing period; and upon resumptions of the processing period. At termination of the processing period, the processor generates a total volume value of processing fluid dispensed from the source during the processing period, which takes into account replenishment of the processing fluid when the processing period is paused. The systems and methods can be integrated into blood processing circuits to monitor the introduction of anticoagulant.Type: GrantFiled: July 13, 2000Date of Patent: October 15, 2002Assignee: Baxter International Inc.Inventors: Robert J Cantu, Russel Stinoff
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Patent number: 6465170Abstract: A method for depleting viral and molecular pathogens in a biological material containing one or several biological substances to be recovered is disclosed, wherein the biological material is admixed with an organic solvent, the solvent-admixed biological material is contacted with an ion exchanger, wherein the pathogens are adsorbed on the ion exchanger material, and at least one of the biological substances to be recovered does not interact or interacts only slightly with the ion exchanger, and the ion exchanger with the pathogens adsorbed thereon is sesparated from the biological material, a virus-depleted preparation of the biological substance being recovered.Type: GrantFiled: August 20, 2001Date of Patent: October 15, 2002Assignee: Baxter AktiengesellschaftInventors: Johann Eibl, Friedrich Dorner, Noel Barrett, Gerhard Polsler
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Publication number: 20020131891Abstract: Blood processing systems and methods convey blood cells from a blood cell source into a blood component collection flow channel that includes a blood cell storage container and an in-line filter to remove leukocytes from blood cells before entering the blood cell storage container. The systems and methods also convey additive solution from an additive solution source into the blood component collection flow channel. The systems and methods alternate the conveyance of blood cells through the filter with the conveyance of additive solution through the filter.Type: ApplicationFiled: October 13, 2001Publication date: September 19, 2002Applicant: Baxter International Inc.Inventors: Kelly B. Smith, Mark R. Vandlik, Michael J. Kast
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Publication number: 20020128584Abstract: Automated systems and method for processing blood and other fluids are disclosed. The systems and methods utilize a disposable fluid circuit selected from one of two or more circuits. The circuits are mounted on a re-usable hardware component or module. The system includes a programmable controller including programs for use with the fluid circuits.Type: ApplicationFiled: March 6, 2001Publication date: September 12, 2002Inventors: Richard I. Brown, Kyungyoon Min, Rohit Vishnoi, Sandra Thom, Liam Farrell, Thomas Westberg
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Publication number: 20020120223Abstract: A blood purifying system, in which a patient is connected to a blood centrifuge, and certain components of the patient's blood are forwarded and further treated at a purifying station by a microscopic automatic review to identify undesirable organisms, and with a controlled laser blast focused on such identified undesirable organisms to destroy them as they pass through the purifying station. A patient having a suspected condition involving blood clots or undesirable organisms in the patient's bloodstream is connected so that the blood flows slowly through a purifying station where the stream is spread across a significant area in a very smooth layer enabling inspection by a laser scanner and pattern recognition system. When an undesired particle is detected, there is a double check of the pattern recognition, and, assuming recognition as undesirable, the organism is destroyed by a focused laser blast.Type: ApplicationFiled: February 20, 2001Publication date: August 29, 2002Inventor: Carl C. Kling
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Publication number: 20020104808Abstract: Platelet rich plasma and/or platelet concentrate is prepared by placing whole blood in a first chamber of a sterile processing disposable having two chambers. The processing disposable is subjected to a first centrifugation to separate red blood cells, and the resulting platelet rich plasma supernatant is decanted to the second chamber. The processing disposable is subjected to a second centrifugation to concentrate platelets. A volume of the platelet poor plasma supernatant in the second chamber is removed, and the platelets are re-suspended in the remaining plasma. The second chamber may contain anticoagulant to preclude aggregation of the platelets.Type: ApplicationFiled: March 27, 2002Publication date: August 8, 2002Inventors: Lou Blasetti, Sherwin V. Kevy
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Publication number: 20020090319Abstract: Systems and methods separate blood cells from whole blood and pump the separated blood cells through an in-line leukofilter to a blood cell storage container. The leukofilter comprises a filtration medium enclosed within a flexile housing. The systems and methods include a fixture to restrain expansion of the flexible filter housing during operation of the pump. The fixture includes a bracket to enable its releasable attachment to the blood processing device employed to carry out the separation process.Type: ApplicationFiled: October 13, 2001Publication date: July 11, 2002Applicant: Baxter International Inc.Inventors: Mark R. Vandlik, Michael J. Kast, Kelly B. Smith
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Patent number: 6409696Abstract: An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.Type: GrantFiled: October 10, 1997Date of Patent: June 25, 2002Assignee: Gambro, Inc.Inventors: Coy Toavs, John J. Kappus, Mark J. Brierton, David R. Shouldice, Jeffrey J. Blakeslee
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Patent number: 6398972Abstract: Platelet rich plasma and/or platelet concentrate is prepared by placing whole blood in a first chamber of a sterile processing disposable having two chambers. The processing disposable is subjected to a first centrifugation to separate red blood cells, and the resulting platelet rich plasma supernatant is decanted to the second chamber. The processing disposable is subjected to a second centrifugation to concentrate platelets. A volume of the platelet poor plasma supernatant in the second chamber is removed, and the platelets are re-suspended in the remaining plasma. The second chamber may contain anticoagulant to preclude aggregation of the platelets.Type: GrantFiled: June 30, 2000Date of Patent: June 4, 2002Assignee: Harvest Technologies CorporationInventors: Lou Blasetti, Sherwin V. Kevy
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Patent number: 6393369Abstract: A blood processor is provided with a computer and memory, and external to the blood processor there is provided a general purpose computer system programmed with a convenient interface for creating scripts; the general purpose computer system translates the scripts into custom interpretive code adapted for processing by the computer in the blood processor, and the code is written into the memory of the blood processor via the computer in the blood processor.Type: GrantFiled: April 30, 1999Date of Patent: May 21, 2002Assignee: Bristol-Myers Squibb CompanyInventor: Raymond A. Carr