Abstract: In some embodiments, an affixed group of pharmaceutical vials with frangible connectors includes: a plurality of pharmaceutical vials arranged as a group of pharmaceutical vials, each of the plurality of pharmaceutical vials shaped and positioned to minimize a total volume of the group of pharmaceutical vials, each of the pharmaceutical vials including at least one external side with a surface configured to reversibly mate with a corresponding external side and a surface of an adjacent pharmaceutical vial; and a plurality of frangible connectors, wherein at least one frangible connector is affixed to the surface of at least two of the plurality of pharmaceutical vials within the group of pharmaceutical vials, and at least one frangible connector is affixed to each of the plurality of pharmaceutical vials.

Abstract: A method and system for evaluating crack intensity on polymeric sheet based on predetermined scale of crack intensity grades, which includes the steps of a) recording digital image of at least portion of surface of polymeric sheet using apparatus for recording digital images; and b) automatic classification of crack intensity by computer-implemented program for pattern recognition by means of trained artificial neural network, including 1) inputting digital image or one or more subareas of digital image to trained artificial neural network as input data, 2) classification by artificial neural network by assigning grade from predetermined scale of crack intensity grades to digital image or one or more subareas and 3) outputting assigned grade or grades for digital image and/or one or more subareas as output data, wherein artificial neural network is trained in advance in learning phase with plurality of digital images or subareas thereof of polymeric sheet surface portions.

Abstract: Liquid transfer devices with an integral telescopic vial adapter for use with an infusion liquid container and an initially non-punctured intact discrete injection vial. The integral telescopic vial adapter is configured for initial telescopic snap mounting on a discrete injection vial leaving its injection vial stopper non-punctured until a subsequent compaction for puncturing the injection vial stopper. The integral telescopic vial adapter includes a safety catch mechanism for precluding advertent compaction from a pre-compacted state to a compacted state. The integral telescopic vial adapter includes a clamping arrangement for irreversibly clamping same in its final compacted state.

Abstract: A receptacle cap includes a probe recess configured to receive a probe inserted therein to thereby frictionally secure the receptacle cap to the probe, and a closed lower end of the receptacle is insertable into an open end of a reaction receptacle to close the reaction receptacle. The receptacle cap and the reaction receptacle include interlocking features for securing the receptacle cap to the reaction receptacle.

Abstract: An object is to provide a method for producing a port that can shorten the time for production.

Abstract: A cap assembly for closing an opening in a vessel may include a stopper and a rigid cap adapted to fit over the stopper and onto a vessel. The stopper may include a polymer body adapted to fit an opening of the vessel and a tubular portion defining an internal passageway extending through the polymer body. The rigid cap may include a pressure based locking mechanism adapted to engage the vessel under a unidirectional force and a tamper evident feature.

Abstract: The invention relates to a connector for a medical package containing a liquid. The connector comprises a lower section which has a connecting piece for a container of said medical package and a passageway which is closed by a septum, as well as an upper section which is provided with a cap that covers the septum and can be broken off, said septum having, on a top side, a plurality of connections in the form of elevations, for a spike and/or for a needle.

Abstract: A septum contains at least one internal chamber along the central axis of the septum. The chamber provides relief space into which the sealing sections of the septum can deform as a needle passes through the septum. Incorporation of the chamber reduces surface area contact and friction between the septum and needle, which results in reduced septum tearing and reduced production of particulate matter from abrasion.

Abstract: Methods and systems disclosed herein provide systems and methods for maintaining sterile conditions inside of a biological-fluid container during an entire process of delivery, incubation, centrifugation, and extraction of fluid. The methods and systems also provide systems and methods for localized extraction of a portion of a biological fluid.

Abstract: A container and closure combination, for the containment of fluids and extraction therefrom by way of an extraction tube. The container comprises a closed volume with an opening configured to close the opening of the container; the closure is provided with an aperture such that the closure, upon fitment to the container opening, cannot be removed therefrom. The aperture of the closure comprises a unitary elastic unidirectional valve member that can operate in a first, closed condition, to prevent a flow of fluid from the container; and a second, operational condition, with an extraction tube sealingly engaged with respect to the valve, to permit an extraction of fluid from the container through the tube.

Abstract: A needle cannula for an injection device, extends along a central axis and comprises: a) a skin piercing distal end (133b), b) a proximal end (133a) configured for penetrating a seal structure (102b) of a medicament container (102), and c) a sidewall extending between the skin piercing distal end (133b) and the proximal end (133a), wherein the proximal end (133a) is defined by an angled surface (134) pointing proximally, the angled surface (134) defining a leading portion (134.1) and a heel portion (134.2), and wherein the angled surface (134) comprises a surface portion (134a, 134b) at the heel portion (134.2) forming an angle (?1) between 50 to 75 degrees with respect to the central axis, and further comprises a surface portion (134c) at the leading portion (134.1) forming an angle (?2) between 60 to 85 degrees with respect to the central axis. An injection needle assembly for an injection device and an injection device comprising such assembly are further described.

Abstract: A method is provided comprising loading shells into shell retention chambers of a shell management module, the shells including corresponding reservoirs configured to hold individual quantities of liquid, the shell retention chambers arranged in a predetermined pattern on a platform of the shell management module. The method further comprises orienting discharge ends of the shells along an actuation direction within the shell retention chambers, and covering the discharge ends with closure lids to seal bottoms of the corresponding reservoirs.

Abstract: A self-adhesive layered septum is disclosed. In one example, the septum includes a first outer layer including a thermoplastic elastomer such as a styrenic block copolymer, containing styrene ethylene butylene styrene (TPE-SEBS) capable of closing at least partially an aperture formed when a needle is inserted through the layer; an adhesive second layer for adhering the septum to a mouth area of a well or container to which the septum is attachable; and a thermoplastic third layer between the first and second layers, thermobonded to the first layer and providing better adherence for the adhesive layer. The first layer includes a recess and a vent, which reduce pressure differentials in use, but together with the third layer minimize evaporation through the septum.

Abstract: A present application relates to a valve assembly for use with a liquid container. The valve assembly includes a spout containing an opening to the liquid container, the spout being configured to form a liquid-tight seal with a housing. A sleeve extends through the housing toward the liquid container through the opening. A valve is secured to the housing and extending into the opening through the sleeve and forming a liquid-tight seal with the sleeve. The valve includes a body portion with a cutaway section and a leg fixed to the valve by a hinge, wherein the leg is configured to flex outwards against the sleeve upon insertion of a tube into the valve causing the cutaway section to open a flow channel to allow liquid to flow through the valve assembly.

Abstract: The present invention relates to new plasma or new platelet-rich plasma preparations, new cell dissociation methods, new cell associations or compositions, a method of preparation thereof, a use thereof, devices for the preparation thereof and preparations containing such a platelet-rich plasma preparation and cell associations or compositions. Specifically, the invention provides plasma or platelet-rich plasma alone or in cell composition preparations for use in tissue regeneration and bone regeneration and pain reduction.

Abstract: An object is to provide a port that is capable of securely preventing pulling-out of a sealing plug from a port body. Provided is a port including: a sealing plug through which a hollow needle can be pierced; a port body having a hollow structure with the sealing plug disposed therein; and a pulling-out preventing member to be attached to the port body. The port body includes: a part to be sealed that has a tubular shape with a first end and a second end opposite to the first end, and is configured so that the sealing plug is sealingly inserted into the part to be sealed; a connection part that has a tubular shape, is continuous with the first end of the part to be sealed, and has an outer periphery connected to the bag body to be filled with a medical liquid; and a part to be fitted that is formed in any one of an inner peripheral surface of the part to be sealed, an outer peripheral surface of the part to be sealed, and the second end of the part to be sealed.

Abstract: Embodiments of the present disclosure generally relate to caps, closures, seals, and containers, and control of flow of fluids. Certain embodiments can be used with fluids related to machinery, for instance, engine oil, brake fluid, coolant, transmission fluid, and power steering fluid. Certain embodiments of the present disclosure effectively hold and transfer a fluid or a fluid substance, further being able to open, close, and regulate fluid flow. Embodiments include a single piece tubular component that includes a cap interiorly attached to such tubular component with ribs, and a container having a tapered end. In certain embodiments, a tube is attached to the cap. In certain embodiments, a nozzle collar having a tapered end is adapted to attach to a container.

Abstract: A metal child resistant container with a screw lid that comprises a main body, an inner cap that screws on to the main body forming an air tight seal, and an outer cap that is located over the inner cap. The outer cap prevents the user from directly interacting with the inner cap and requires the user to apply pressure to the outer cap. The inner cap has indentions that match with similar indentions stamped in or attached to the outer cap. When pressure is applied to the outer cap the inner cap and outer cap mover as one allowing the container to the open and closed. The container is further sealed by a foil seal and a desiccant material.

Abstract: Examples herein relate generally to reservoirs for use in water distribution systems within an appliance. The reservoir herein allows for the combination of various components prepared by separate manufacturing processes and for reducing waste of those manufacturing components. Specifically, the reservoir herein provides a stopper separable from and for use with a container and a cap.

Abstract: A plurality of caps are provided each with a visual coding of color and/or indicia for use with different sizes of bottles at least in accordance with a height of the bottles from a closed bottom end to an open top end for engaging each of the caps. Each of the caps has a tube mounted to, or through, an aperture extending through a top closed end of the cap to extend a selected length enabling one end of the tube to reach or extend along an interior surface of the bottom end of any of the bottles of the height to which the cap is coded for use therewith. The other end of tube is extendable to a bioreactor container. Each of the caps has another tube or port to another aperture of the cap to provide an air vent with an optional air filtering device.

Abstract: Methods and devices are provided for various insufflation sealing approaches for a trocar. For example, a trocar is provided that has a housing and a cannula extending therefrom. The housing and the cannula have a tool pathway extending therethrough for receiving a surgical tool, and the housing has an insufflation port therein. A variety of seal elements are provided that seal the insufflation port to prevent fluid flow into the port. The port and seal elements are configured to have a reduced profile to prevent interference between the trocar and a tissue surface during use.

Abstract: A needleless syringe connector cap to be provided to a container having an aperture at its top, said cap comprising an elastically deformable plastic valve body. Said valve body comprises a first and second passage, each passage extending through the valve body. Both passages comprise a cross-slit valve in the extreme lower end of said passage, embodied as an aeration valve. The first passage is adapted to receive a first tapered syringe tip and the second passage is adapted to receive a second tapered syringe tip, wherein when fluid is withdrawn from a container to which the cap is provided through the first (second) passage using a first (second) tapered syringe tip to which said first (second) passage is adapted, the second (first) cross-slit valve opens in response to an under pressure in said container resulting from said withdrawal, so as to aerate said container.

Abstract: A fluid transfer connector or adapter for coupling to a container or pharmacy bottle for facilitating the transfer of fluid or medicine from the bottle to a syringe, or from the syringe to the bottle. Optionally, an additional connector can be provided for coupling the fluid transfer connector to the syringe.

Abstract: Liquid transfer devices with an integral telescopic vial adapter for use with an infusion liquid container and an initially non-punctured intact discrete injection vial. The integral telescopic vial adapter is configured for initial telescopic snap mounting on a discrete injection vial leaving its injection vial stopper non-punctured until a subsequent compaction for puncturing the injection vial stopper. The integral telescopic vial adapter includes a safety catch mechanism for precluding advertent compaction from a pre-compacted state to a compacted state. The integral telescopic vial adapter includes a clamping arrangement for irreversibly clamping same in its final compacted state.

Abstract: Methods and systems disclosed herein provide systems and methods for maintaining sterile conditions inside of a biological-fluid container during an entire process of delivery, incubation, centrifugation, and extraction of fluid. The methods and systems also provide systems and methods for localized extraction of a portion of a biological fluid.

Abstract: A retortable container is formed with an opening formed defined by a projecting rim. The rim includes an external surface and securing structure formed thereon. A flexible membrane is sealed to the rim and closes the opening. A closure is provided having a molded plastic tubular ring and a separately formed molded plastic disk. The tubular ring includes an overlapping flange at a top and directed inwardly towards an inwardly positioned open area. The skirt includes an engagement structure for securing the closure to the external surface of the rim. The disk is separately attached to the ring within the open area after the retort process is applied to the sealed bottle.

Abstract: Device for solid-phase microextraction and analysis of substances to be analyzed, in particular in a gas chromatograph, with at least one collector, which is made of sorbent and/or adsorbent material and is placed on a rod-like support, and with at least one sample container, which is sealed with a pierceable partition wall and into which the collector is introduced piercing the partition wall for a sampling time, wherein the sealing of the sample container is assembled from the pierceable partition wall and a clamping ring, which can be mounted on the sample container and presses the partition wall together with a sealing element onto an upper rim of the sample container, and which comprises a socket in which a fitting of a transport adapter which is attached to a handling end of the rod-like support can be anchored detachably and with sealing surface pressure after the collector is inserted into the sample container following piercing the partition wall.

Abstract: In one embodiment described herein, a cartridge is provided comprising a cartridge frame; a plurality of diluents each in an expandable container; a plurality of reagents each in an expandable container; and a plurality of mixing vessels comprising empty expandable containers.

Abstract: A beverage dispensing system for dispensing alcoholic beverages includes a beverage dispensing package and a connector assembly configured to be coupled to the package. The package includes an outer container and at least one divider positioned within the outer container to form a plurality of compartments. The package also includes a plurality of inner containers, with one of the inner containers positioned within each of the compartments. Each inner container stores an alcoholic beverage and each container includes an outlet to enable the alcoholic beverage to be dispensed. The connector assembly includes a plurality of connectors for coupling to a respective outlet of the inner containers, and a dispensing line coupled to the connectors. The connector assembly couples the inner containers in flow communication with the dispensing line to enable the alcoholic beverages within each of the inner containers to be jointly dispensed through the dispensing line.

Abstract: The liquid cartridge for an industrial inkjet printer for printing goods has a film bag, a connector stub connected thereto, and a lower cap. The connector stub has an opening which is closed by the lower cap which has a lower rubber layer, a plastic layer formed by the connector stub, and a lower holder. The lower holder has a lower window which is situated above the opening. The lower holder is fastened to an outer side of the connector stub. The lower rubber layer and, underneath it, the plastic layer are situated below the lower window, and they are in contact with one another and with the lower holder.

Abstract: The invention relates to a polymer compound for a PVC-free sealing insert for twist crowns, wherein the Shore A hardness of the polymer compound is between 50 and 90 and in the compressive deformation test analogous to ASTM D395-97 Method B at 70 DEG. C. the polymer compound exhibits a compression set of 30-90%.

Abstract: Provided is a gas-blowing vaporizing and drying device, which includes: a sample tube in the form of a double tube including an inner tube for a solution and an outer tube for a gas, the inner tube protruding from one end of the outer tube by length L; and a collection container including a container body and a lid provided with a protrusion sleeve tube, the protrusion sleeve tube including a coupling portion at an end to be located outside the container body and a sleeve portion of a length equal to or longer than L having an open end to be located inside the container body, the coupling portion being designed to be coupled to the aforementioned one end of the outer tube in an air-tight manner.

Abstract: An insert is disclosed for use with a closed loop dispensing system. The insert is press-fitted into the throat of a liquid container. The insert includes a normally closed chemical valve which is opened when pierced by a vertically movable lance to permit the liquid in the container to be dispensed to a mixing machine or the like. The insert also includes a plurality of radially spaced-apart bi-directional valves which automatically permit air to be vented into the container. The bi-directional valves also permit off-gassing of gas in the container.

Abstract: A method for creating a sterile connection with a fluid in a container. The container has a sealing member sealing a first end of the container, and a barrier sealing a chamber in fluid communication with the sealing member. The method includes providing a valve sleeve assembly that includes a flexible sleeve having a barrier portion at an end of the flexible sleeve, a hollow first penetrator disposed within the flexible sleeve, and a hollow second penetrator at least partially disposed within the first penetrator. An interior of the flexible sleeve is sterile. The method also includes piercing the barrier portion and the barrier with the first penetrator, and displacing the second penetrator relative to the first penetrator and the sealing member to pierce the sealing member and establish the sterile connection with an interior of the container.

Abstract: A printing fluid container for a printing fluid source for a printer system, wherein the printing fluid container comprises a sealing material layer being arranged in a closure device printing fluid outlet opening, the sealing material layer having a fluid outlet condition, in which the sealing material layer is pierced by engagement of a fluidic interconnect device of the printing fluid source and the closure device printing fluid outlet opening, as well as a printing fluid source, a printer system, a printer system arrangement and a method of filling a printing fluid source.

Abstract: An apparatus and method for sterile filling comprises de-contaminating a needle penetrable surface of a device including a needle penetrable septum and a sealed chamber in fluid communication with the needle penetrable septum. A filling needle penetrates the needle penetrable septum, introduces substance through the filling needle and into the chamber and is, in turn, withdrawn from the septum. A liquid sealant is applied to the penetrated region of the septum. Radiation or energy is applied to the liquid sealant to cure the liquid sealant from a liquid phase to a solid phase.

Abstract: A system includes a cap having an opening, and a septum configured to engage with the cap. The septum includes a first portion having a first width, and a second portion having a second width smaller than the first width. The second portion is sized and shaped to be received by the opening of the cap.

Abstract: A retortable container is formed with an opening formed defined by a projecting rim. The rim includes an external surface and securing structure formed thereon. A flexible membrane is sealed to the rim and closes the opening. A closure is provided having a molded plastic tubular ring and a separately formed molded plastic disk. The tubular ring includes an overlapping flange at a top and directed inwardly towards an inwardly positioned open area. The skirt includes an engagement structure for securing the closure to the external surface of the rim. The disk is separately attached to the ring within the open area after the retort process is applied to the sealed bottle.

Abstract: A flow through fluid sampling system includes a sample tube and a cap. The sample tube is configured to collect a sample of a fluid and has an open top. The cap is configured to be secured to the sample tube to close the open top. The cap includes an inflow port configured to allow fluid to enter the fluid sample tube, an outflow port configured to allow fluid to leave the sample tube.

Abstract: A cap system for sealing injectable drugs within a vial is disclosed. The system includes an elastomeric stopper, a retainer member, a locking member, a cap assembly and a piercing member. The retainer member is arranged to snap onto the vial and the locking member slid with respect to the retainer member to permanently seal the vial. The cap assembly includes a cap and a band and is coupled to the locking member. The cap releasably holds the piercing member. The band is arranged to be removed to enable the cap to move the piercing member to penetrate the stopper, whereupon the cap can be removed. The piercing member is arranged to be connected to a syringe or other instrument to withdraw the vial's contents.

Abstract: A closure with a self-resealing elastomeric septum has a shutter slidable between a closed position over the septum and an open position for exposing the septum. The shutter is spring biased towards the closed position, and may be pushed and held away from the closed position with the tip of an oral syringe to gain access for penetration of the elastomeric septum. The closure may have an upper portion mounted to a lower portion fastened for closing a container. A conduit extends through the upper and lower portions to the interior of the container. A break-away connection is adapted to preferentially break or separate when a sufficient bending or twisting force is applied to the upper portion relative to the lower portion. The conduit may be normally closed by a self-resealing elastomeric septum provided in the lower portion and a slidable shutter may be provided on the upper portion.

Abstract: A cleaning device for a medical implement such as a female Luer connector. The cleaning device includes a cap having an interior cavity and an opening adapted to receive a site of the medical implement. The interior cavity is defined by an interior wall that includes a male Luer protrusion extending in the direction of the opening from an end of the interior cavity opposite the opening. A skin of cleaning material overlies at least a portion of the interior wall. The cleaning material may be pre-loaded with a cleaning agent and is adapted to clean the site of the medical implement.

Abstract: An adaptor for coupling with a medical container filled with a number N of doses of a product including a gripping member for securing the adaptor to the medical container. The gripping member has at least one needle access port intended to face the outer surface of the septum of the medical container. The adaptor also includes a marking-device coupled to the needle access port, for designating to a user a not yet pierced area of said outer surface, for completing the next of the N successive piercings.

Abstract: The disclosure relates to a cylindrical closure for a product-retaining container constructed for being inserted and securely retained in a portal-forming neck of said container, said closure comprising at least one thermoplastic polymer and at least one natural organic filler wherein the lateral surface of said closure has a hardness of 40 to 90 Shore A. Such closures are particularly suitable for sealingly closing wine bottles.

Abstract: A closure (2) for closing an opening of a container (1) for storing and removing sterile or moisture-sensitive media has a closure cap (3), which can be connected to the container in a fluid-tight manner, and a piercable, self-closing septum (20), which closes at least one removal opening (7) in the closure cap (3) in a fluid-tight manner, wherein the closure (2) has a rotatably mounted protective cap (4) with a cutout (5). The cutout (5) is arranged off-centre in the protective cap (4) and the closure cap (3) has off centre a closure region (9) which is not impinged by the at least one removal opening (7) and is larger than the cutout (5) in the protective cap (4). The closure (2) has a latching mechanism, which is suitable for arranging the protective cap (4) in relation to the closure cap (3) in such a way that the cutout (5) in the protective cap (4) is aligned either in line with the or a removal opening (7) in the closure cap (3) or at a distance from the removal opening or openings (7).

Abstract: A plastic body including a generally cylindrical upper portion having an open end configured for engagement with an automated pipettor. The plastic body further includes a plurality of longitudinally oriented ribs disposed on an inner surface of the open end of the upper portion and a plurality of concave recesses disposed on an outer surface of the upper portion. Each of the recesses is disposed directly opposite an associated one of the ribs, and each of the recesses extends along at least part of the length of the associated rib.

Abstract: A method for treating dialysate solutions used in dialysis wherein dialysate is treated in an early part of a dialysis treatment session by external infusion of bicarbonate solution into the dialysate circuit to eliminate the need for bicarbonate requirements in concentrates used for preparation of precursor dialysate (priming) solutions and/or for a solid bicarbonate layer in a sorbent cartridge. Dialysate is treated in a latter part of a dialysis treatment session by introduction of sterile dilution water to reduce sodium concentration in the dialysate. The method provides a more efficient and reduced use of dialysate fluids, electrolytes, sorbent cartridge materials, equipment scale, or any combinations of these, while maintaining purity standards and applicable physiological ranges for bicarbonate, sodium, and other dialysate solution components over the course of a dialysis treatment session.

Abstract: A chemical storage container enables easy installation of a chemical nozzle and a pressurized gas supply nozzle. The chemical storage container includes a metal can having a top opening, a chemical storage bag disposed in the metal can and an ejection member mounted to the chemical storage bag. The top opening of the metal can is closed by a lid to which a chemical nozzle and a pressurized gas supply nozzle are mounted. The chemical nozzle penetrates through the ejection member. A pressurized gas from the pressurized gas supply nozzle is supplied through the ejection member into a pressurization space formed between the metal can and the chemical storage bag.

Abstract: A therapeutic fluid delivery system including, in various examples, a first reservoir configured to house a first therapeutic fluid, a second reservoir configured to house a second therapeutic fluid, and an inlet port configured to receive a fluid delivery needle is described. The inlet port is configured for fluid communication between the fluid delivery needle and the first reservoir, and the inlet port is further configured for fluid communication between the fluid delivery needle and the second reservoir.

Abstract: Provided is a vial rubber stopper using multiple types of rubber to prevent the vial rubber stopper from being scraped and from sticking to a presser plate. The vial rubber stopper includes: a cap portion having a flange; a piercing area formed to have a recess at a top surface of the cap portion and configured to traverse longitudinally the cap portion in an axial direction from the recess to a bottom surface of the cap portion; and a leg portion formed on the bottom surface of the cap portion in a way of extending downward and located outside the piercing area with respect to an axial center of the cap portion. The piercing area is formed of rubber having rubber hardness from 20 to 35, and the top surface other than the recess of the cap portion is formed of rubber having rubber hardness from 58 to 90.