Abstract: Provided is a vial rubber stopper using multiple types of rubber to prevent the vial rubber stopper from being scraped and from sticking to a presser plate. The vial rubber stopper includes: a cap portion having a flange; a piercing area formed to have a recess at a top surface of the cap portion and configured to traverse longitudinally the cap portion in an axial direction from the recess to a bottom surface of the cap portion; and a leg portion formed on the bottom surface of the cap portion in a way of extending downward and located outside the piercing area with respect to an axial center of the cap portion. The piercing area is formed of rubber having rubber hardness from 20 to 35, and the top surface other than the recess of the cap portion is formed of rubber having rubber hardness from 58 to 90.

Abstract: There is provided a vial cap with which, when there is a possibility that a cover which covers a stopper for a vial has come off and the stopper for the vial has been contaminated at a stage prior to use, the fact can easily be recognized. The vial cap is a resin vial cap (1) to be attached to a mouth portion (72) of a vial (70) to fix a stopper (74) fitted into the mouth portion (72) so that the stopper may not come off the mouth portion (72). The vial cap (1) is provided with a cap main body (8) that has an upper opening (6) formed therein and a cover (40) that covers the upper opening (6) of the cap main body (8). The cap main body (8) has a plurality of pin-receiving holes (10) formed therein, and the cover (40) has a plurality of fixing pins (46). Each pin-receiving hole (10) and a fixing pin (46) that is paired with the pin-receiving hole (10) are formed in complementary shapes.

Abstract: A medical rubber closure according to the present invention includes a disc-shaped flange portion and a leg portion formed to be continuous to a lower surface side of the flange portion, and a region at the lower surface side of the flange portion and the leg portion are made of a nitrile based rubber, a region at a top surface side of the flange portion is made of a butyl based rubber, and the leg portion is laminated with a coating layer made of a fluorine based resin film.

Abstract: The application relates to a closing element for closing a container for samples for analysis, particularly biological samples. The application also relates to an assembly of a container and a closing element connected to the container. The application also relates to a device and method for analyzing samples. The closure comprises a vent channel (6) with a bacterial filter (7), a penetrable element (5) and the vent channel is configured to be connected with an analyzer and can be opened and closed.

Abstract: A specimen container for urine and other liquids is provided having a container lid, an elastomeric septum, a cup, and a non-porous seal. The elastomeric septum covers a septum hole in the lid, and the non-porous seal is affixed to the lid such that it creates a liquid-tight boundary between the septum and the chamber within the bottle. The septum includes a depressed portion and an area of minimum thickness shaped to allow an implement to pass through the area of minimum thickness. The depressed portion may also include a pre-cut which allows the implement to pass through the septum more easily.

Abstract: Systems and methods for a fluid reservoir for use with a fluid infusion device which is automatically filled are provided. A set connector for use with a fluid reservoir of a fluid infusion device includes a body for defining a fluid flow path out of the fluid reservoir. The body includes at least one locking tab that cooperates with a portion of the fluid infusion device to removably couple the body to a proximal end of the fluid reservoir. The body is movable between a first position, in which the fluid flow path is obstructed, and a second position, in which the fluid flow path is open.

Abstract: A protective cap (1) for application on a medical device such as a medical vial (2) comprising a membrane holder (3) in which a resilient membrane (18) is mounted. The protective cap (1) is provided with connection means (10) for connecting the cap (1) to the medical device (2). The resilient membrane (18) comprises a piercing portion (20) and a sealing portion (22) and is mechanically and/or adhesively held in the protective cap (1) and is arranged to be brought into sealing contact with a receiving portion of the medical device (2) when the protective cap (1) is applied on the medical device (2).

Abstract: A cap for use in enteral feeding from a container. The cap includes a base and an insert cutter. The base has a top surface, a bottom surface, and an outer ring. The top surface has a protruding port suitable for insertion of a spike connector. The protruding port defines a spike insertion chamber extending from a spike connector insert aperture to a spike connector outlet aperture. The outer ring is configured for attachment to a container having a mouth. The insert cutter has a first end portion attached to the bottom surface of the base and about an edge of the spike connector outlet aperture and a second end portion extending over at least a portion of the spike connector outlet aperture. The insert cutter is capable of flexing in an insertion direction of a spike connector inserted through the spike insertion chamber.

Abstract: A bottle for containing pharmacological and/or nutritional active substances is described. The bottle comprises a closing cap pierceable by the pressure exerted with the luer of a needle-free syringe. The closing cap is made as a single piece including a check valve and closing lips which can be opened by introducing a syringe luer and can be elastically closed back upon the extraction of the luer introduced, and a membrane which is pierceable and elastically resealable to hermetically close the inlet end of the check valve.

Abstract: A bottle neck insert can include a cylindrical body having a first end and a second end, the cylindrical body having a plurality of rings; a flange provided at the first end, the flange protruding outwardly from the cylindrical body in a radial direction of the cylindrical body; and a valve section at the second end, the valve section having at least one slit, wherein the flange is configured to seat the insert onto a neck of a bottle and the valve section is configured to allow a pipette to pass through. A bottle storage system, can include a bottle having a neck with a smooth interior surface; an insert that is configured to fit inside the neck of the bottle; and a pipette assembly that is configured to proceed through the insert into the bottle.

Abstract: A biopsy device includes a probe, a holster, and a tissue sample holder for collecting tissue samples. The probe includes a needle and a hollow cutter. The tissue sample holder includes a housing having a plurality of chambers that are configured to receive a plurality of strips connected by at least one flexible member. The flexible member is configured to permit the strips to pivot relative to each other such that the strips can shift between a flat configuration and a arcuate configuration. The tissue sample holder is rotatable to successively index each chamber to the cutter lumen such that tissue samples may be collected in the strips. The strips may be removed from the tissue sample holder and placed in a tissue sample holder container for imaging of tissue samples.

Abstract: Subsequently, the medical implant coated with the liquid punctures the membrane 14 which, until then, protected the powder 18 situated below it from external influences. The medical implant is then immersed in the powder 18. The liquid film on the surface of the medical implant causes the powder 18 to adhere well to the surface thereof.

Abstract: Device for solid-phase microextraction and analysis of substances to be analyzed, in particular in a gas chromatograph, with at least one collector, which is made of sorbent and/or adsorbent material and is placed on a rod-like support, and with at least one sample container, which is sealed with a pierceable partition wall and into which the collector is introduced piercing the partition wall for a sampling time, wherein the sealing of the sample container is assembled from the pierceable partition wall and a clamping ring, which can be mounted on the sample container and presses the partition wall together with a sealing element onto an upper rim of the sample container, and which comprises a socket in which a fitting of a transport adapter which is attached to a handling end of the rod-like support can be anchored detachably and with sealing surface pressure after the collector is inserted into the sample container following piercing the partition wall.

Abstract: The present invention relates to a package, and more particularly to a package for sterile fluids, such as contrast media. More particularly the invention relates to a package comprising a container, a stopper (40), a cap (50) and a flip cover (60).

Abstract: A self-disinfecting medication vial cap assembly for a medication vial includes a needle-penetrable assembly base configured for attachment to the medication vial; an assembly cap carried by the assembly base, the assembly base and the assembly cap having a cap interior and the assembly cap positional between closed and open positions; a rupturable antiseptic pouch attached to the assembly base and the assembly cap in the cap interior; and an antiseptic contained in the antiseptic pouch. The antiseptic pouch remains intact in the closed position of the assembly cap. The antiseptic pouch ruptures and the antiseptic is discharged onto the assembly base upon movement of the assembly cap from the closed position to the open position.

Abstract: Vial containers including a collar which is attached to a vial or incorporated into a vial cap, a cap designed to receive a portion of the collar while covering the vial, and a container designed to receive a portion of the collar and encase the body of the vial are described herein. The collar, generally, includes a means for reversibly attaching to the cap and container.

Abstract: The present invention relates to an assembly (101) comprising: an injection device (1) comprising a container (2) for a product, said container comprising a distal tip (3), an adaptor (5) comprising a ring (6) mounted onto said distal tip (3), characterized in that said assembly (101) further comprises a heat-shrinkable film (9) covering part (2a) of said container (2) and part (5a) of said adaptor (5), said film (9) maintaining said adaptor (5) blocked in rotation and in translation with respect to said container (2) when said film (9) is in its heat-shrunk condition. The invention further relates to a method for manufacturing such an assembly.

Abstract: A container adapted to store and transport an injectate is disclosed. The container includes a divider which extends from an open top end toward a closed bottom end, the divider spaced apart from the closed bottom end to define an opening and separating the container into a first fluid path on a first side of the divider through which fluid can enter the container through the inlet port and a second fluid path on a second side of the divider through which fluid can enter the opening and exit the container through the outlet port. The second fluid path includes at least one filter between the opening and the open top end through which fluid can pass from the first fluid path to the second fluid path but through which at least one component of the injectate cannot pass.

Abstract: Provided is a plug that enables reliable and easy removal of a plug body together with a cover member from a tubular container without increasing an outwardly-bulging flange portion of a grip part of the plug body and is superior in productivity. A plug 1 for closing an open end of an open-ended tubular container 4. A cover member 3 is fitted on a plug body 2 including a press-fit part 2a and a grip part 2b. An engagement portion 3d is extended from a head plate 3a of the cover member 3 into a recess 2d in the upper surface of the plug body 2 to face an inside wall 2e surrounding the recess 2d. When an external force is applied to incline the head plate 3a with respect to the upper surface of the plug body 2, the engagement portion 3d is engaged to the inside wall 2e.

Abstract: The present invention provides a 99mTc-tetrofosmin radiopharmaceutical composition comprising tetrofosmin and a radioprotectant at a particular range of molar ratios. A kit and a multi-dose kit for the preparation of the radiopharmaceutical composition of the invention are also provided, as well as a process for the preparation of multiple unit patient doses of the radiopharmaceutical composition and a unit dose of the radiopharmaceutical composition.

Abstract: Plastics material seal (1) for containers (10), comprising a receiving region, for receiving an opening portion (10a) of a plastics material container, and comprising a puncturing region (2), which is suitable for being and intended to be penetrated by a piercing means in a predetermined piercing direction (L), this puncturing region (2) being arranged on a lid surface (1a) of the plastics material seal. According to the invention, the plastics material seal (1) comprises a reinforcing means (20), which is arranged offset from the puncturing region (2) in the piercing direction and which is suitable for increasing a force which counteracts the piercing means through the puncturing region (2) during the piercing process, the plastics material seal (1) advantageously being formed in a single part.

Abstract: The present invention inter alia relates to a valve arrangement comprising at least two ports, a valve body and a valve piston, wherein the valve piston is at least partially movably arranged in the valve body, wherein the valve arrangement is configured to disable a fluid flow between the at least two ports in a first position of the valve piston in the valve body and to enable the fluid flow in a second position of the valve piston in the valve body, and wherein at least one port of the valve arrangement is arranged in the valve piston and at least one port of the valve arrangement is arranged in the valve body.

Abstract: A specimen collection container includes inner and outer tubes. The inner tube includes a bottom end, a top end, and a sidewall extending therebetween defining an interior. The sidewall includes an inner surface and an outer surface having at least one annular protrusion extending therefrom. The inner tube includes at least one funnel portion adjacent the top end for directing a specimen into the inner tube interior, and an annular ring disposed about a portion of the outer surface of the sidewall adjacent the top end. The outer tube includes a bottom end, a top end, and a sidewall extending therebetween, the sidewall having an outer surface and an inner surface defining an annular recess adapted to receive a portion of the annular protrusion therein. The inner tube is disposed within the outer tube and a portion of the top end of the outer tube abuts the annular ring.

Abstract: A medicated module for an injection system to co-deliver at least two medicaments is disclosed where a primary delivery device containing a primary medicament accepts a medicated module containing a single dose of a secondary medicament and where both medicaments are delivered through a hollow needle. The medicated module does not require the user to manually engage a reservoir containing the secondary medicament. Instead, a rotating housing automatically activates the reservoir when the needle guard is retracted. The needle guard prevents accidental needle sticks after an injection, and locks after dose delivery.

Abstract: Multi-compartment pharmaceutical vials are described. In some embodiments, a multi-compartment pharmaceutical vial includes: a multi-compartment pharmaceutical storage region including a bottom wall, at least one outer wall and at least one interior wall, the bottom wall, the at least one outer wall and the at least one interior wall forming a plurality of pharmaceutical storage compartments, each pharmaceutical storage compartment including an aperture positioned opposite to the bottom wall of the pharmaceutical storage region; and an access region attached to the pharmaceutical storage region, the access region including a plurality of conduits, each with a first end and a second end, wherein the first end of each conduit is connected to one aperture in a pharmaceutical storage compartment, and the second end of each conduit circumscribes an aperture positioned opposite to the bottom wall.

Abstract: A pierceable, induction sealable seal for a container opening, the seal comprising a plurality of layers at least one of which is metallic and at least one of which is non-metallic, at least one of the non-metallic layers is complete and in use extends across a container opening to seal it. The area over which the at least one of the metallic layers extends is restricted to the region of the periphery of the seal whereby to facilitate induction sealing to the opening but to remain isolated from product in a container upon piercing of the seal.

Abstract: A lid for a drinking container in the structure of a baseball cap is disclosed. The baseball cap lid includes the normal features of a baseball cap and also includes an annular mounting portion for engaging the rim or lip of a cup, a preformed opening in one of the panels of the lid configured for receiving a straw for drinking liquid from the container, a flap and cover for covering the preformed hole, and stretchable portion on or near the annular mounting portion of the lid for securing the lid to the rim or lip of the cup.

Abstract: A flexible pouch and valve assembly is provided for aseptically storing a substance, dispensing multiple portions of the stored substance therefrom, and maintaining substance remaining in the pouch in an aseptic condition sealed with respect to ambient atmosphere. The flexible pouch and valve assembly are receivable within a relatively rigid housing, and are adapted to cooperate with a pump for pumping discrete portions of substance from the pouch and through the one-way valve to dispense the substance therefrom. The assembly comprises a flexible pouch defining therein a variable-volume storage chamber sealed with respect to the ambient atmosphere for aseptically storing therein multiple portions of the substance. A one-way valve of the assembly includes a valve body defining an axially-extending valve seat and at least one flow aperture extending through the valve body and/or the valve seat.

Abstract: An adaptor for coupling with a medical container having a collar closed by a septum including: a tubular body closed at a distal end with a transversal wall from which extends a hollow spike, and at a proximal end by a pierceable elastomeric piece including a cavity having a plurality of circumferentially distributed chambers, each chamber being connected to the hollow spike by a radial channel, the tubular body further receiving an intermediate piece including a plurality of through holes aligned on the chambers, a selecting member having a closure wall provided with one opening, capable of rotating so that the opening is successively aligned with each of the through holes, and a gripping member for securing the adaptor to the medical container. Also, an assembly including the adaptor and a medical container.

Abstract: The invention concerns reagent delivery system for an apparatus for processing of biological samples arranged on microscope slides, comprising a reagent section having one or more reagent containers; a slide section in which at least one microscope slide is arranged; a probe for dispensing a portion of reagent onto a predetermined microscope slide, and means for handling the probe. The probe comprises a continuous prove tubing element extending through a rigid probe member and connecting the probe tip to a pneumatic pressure regulation device. The reagent containers are adapted for cooperation with the probe tip. In this manner a high though-put and a very low carry over of fluid residues is achieved since there is no assembled parts making up the inside volume of the probe in which the fluid may be retained.

Abstract: A stopper and container body are molded in the same molding machine. An assembly device, such as a pick and place robot, transfers the stopper from one mold cavity into the opening in the container body located within another mold cavity, or vice versa, to assemble the stopper and container body. Then, the assembled container body and stopper are removed from the molding machine and transported to a needle filling and laser resealing station for filling and laser resealing. A laminar flow source directs a substantially laminar flow of air or sterile gas over the mold surfaces, stoppers and container bodies, and assembly device, to prevent contamination during assembly.

Abstract: Disclosed is a closure device for a container, which seals an opening (6) that opens at the top of a container (2) and has a rim (7) on its periphery. The closure device comprises a seal member (8) that is to cover the opening (6) on the top of the container (2), and a synthetic resin cap (9) that is to press the seal member (8) against the upper surface of the rim (7). The seal member (8) comprises a flange (10) to be mounted on the upper surface of the rim (7). The cap (9) comprises a top wall (15), a cylinder part (16), and a locking part (18). The top wall (15) is to be disposed above the flange (10). The cylinder part (16) hangs down from the outer circumference of the top wall (15). The locking part (18) is disposed on the inner surface of the cylinder part (16). After the cap (9) is pushed down, the locking part (18) locks at the under surface of the rim (7). The upper surface of the flange (10) has a compressible projection (29).

Abstract: A container and method for filling same. The container includes a penetrable and resealable portion that is resealable, and a container body having a sealed empty chamber in fluid communication with the penetrable and resealable portion for receiving therein a substance. The container also includes a base, a mid-portion, and an upper portion axially spaced from the base on an opposite side of the mid-portion relative to the base. Each of the base and upper portion define a laterally-extending dimension greater than a maximum laterally-extending dimension of the mid-portion. The method of filling the container includes penetrating the penetrable and resealable portion with an injection member and introducing a substance into the chamber, withdrawing the injection member while engaging the base of the body to substantially prevent upward movement of the body, and applying energy to the penetrable and resealable portion to form a gas-tight seal.

Abstract: A stopper device including a stopper, cap and ring provided with tabs for locking onto a container neck and a body for handling the ring. The body includes a first mechanism for transmitting a thrust force to the ring and a second mechanism for activating the tabs. The ring and the handling body are respectively provided with first and second retainers that hold the handling body in a waiting position. The handling body is mobile parallel to the thrust force direction and in relation to the ring, between a first position activating the tabs of the ring and is mobile in translation only in the thrust force direction, and a second position that also activates the tabs and is immobilized in relation to the ring in axial translation. The tabs extend from a continuous edge of the ring and are each arranged in an opening with a closed contour.

Abstract: A gasket for a compressed gas cylinder arranged to operate with a gas cylinder having a neck with a top surface around a gas outlet and a side surface extending downwardly from the top surface. The gasket may include an upper portion arranged for positioning on the top surface of the cylinder and for making a seal with the top surface, and a lower portion extending downwardly from the upper portion and around the side surface of the neck of the cylinder, such that the lower portion is arranged to make a seal with the side surface of the gas cylinder. Face and gland seals may be established by the gasket with an opening that receives the gasket and an associated cylinder neck.

Abstract: A sealing cap for a body fluid container, and a body fluid collection device and system are disclosed. The sealing cap includes an inner cap placeable on an opening in the body fluid container forming a mouth, the inner cap has a shielding member which seals the mouth of the body fluid container, an outer cap resting on the inner cap, the outer cap being movable relative to the inner cap, and a channel member, wherein by a rotational movement the outer cap is movable between an first position in which the channel member is located separated from the shielding member and a second position in which the channel member extends through the shielding member, thereby establishing an open state of the shielding member, and wherein the shielding member returns to a closed state when the outer cap is moved back from the second position to the first position.

Abstract: A bottle cap that is an apparatus for containing heterogeneous materials, applied in the discharge direction of materials in a container, comprises: a main body coupled to a bottle neck; and a containing unit assembled inside the main body with a storage space. An activated unit is assembled in the center of the upper support unit of the main body. An activation unit for downward movement is coupled to the activated unit so that the activated unit may move downward by a separate activation unit. An opening/closing unit is coupled with the lower part of the activated unit with the above structure in order to seal an opening/closing hole of the storage space.

Abstract: Embodiments of the present invention feature devices and methods for containing one or more compounds. The inventions feature devices having an ampoule-like closure to preserve the integrity of materials contained therein with vial-like features to allow closure after opening. The devices are sized to be received in a tray or carousal of an autosampler.

Abstract: A plug in accordance with one aspect of the present invention is a plug for a container for containing a liquid, the plug comprising a plug body, a lid adapted to engage the plug body, and a columnar elastic body contained in the plug body and pierceable with an extraction needle; the plug body having an elastic body storage part for storing the elastic body, a liquid guide path communicating with the elastic body storage part, a plurality of axially extending longitudinal ribs formed on an inner wall surface facing the elastic body storage part, and axially extending groove parts formed between the plurality of longitudinal ribs, while a circle passing vertexes of the plurality of longitudinal ribs has a diameter smaller than that of the elastic body.

Abstract: A closure and method of making a closure are disclosed. The closure includes a cap body having a top portion and an opening extending therethrough defining a cavity in communication with said opening. A flow channel is defined within a portion of the cap body having an inlet and an outlet. A stopper is disposed within the cavity adjacent the outlet of the flow channel. The stopper is formed from a material adapted for flowing through the flow channel to form a pierceable portion, with at least one of the cap body and the stopper configured for closing a container.

Abstract: Provided is a biomaterial detecting device for confirming or detecting a biomaterial reaction, and more particularly to a biomaterial detecting device, which is formed in a stick type to thereby be immersed in a tube containing a biomaterial solution to be tested; has an upper portion with a cap structure to thereby induce reaction with a biomaterial, and thus facilitate confirmation and detection of the biomaterial; and is formed in a cap structure to thereby prevent evaporation of a sample and infiltration of an external material at the time of a biomaterial reaction in the tube, and thus improve reliability in analysis.

Abstract: An injection member penetrates an elastic septum of a device defining a sealed, empty, sterile chamber in fluid communication with the septum. During penetrating, an annular interface is formed between the septum and the injection member extending axially between a penetration point on an interior surface of the septum in fluid communication with the sterile chamber, and an exterior surface of the septum engaging the injection member. The injection member is de-contaminated by (i) friction between the septum and injection member at the annular interface, and (ii) elongation of the septum at the annular interface. A substance is introduced through the injection member and into the sterile chamber of the device, the injection member is then withdrawn from the septum, the septum reseals itself at the resulting penetration aperture, and the chamber is maintained sterile throughout the foregoing steps.

Abstract: A pouring port of a container for liquid at one end of which a rubber stopper allowing the penetration of an injection needle therethrough is embedded, wherein: the pouring port is formed by welding a port part, at least the innermost layer of which forming the discharge channel thereof comprises a resin containing a COP-based resin as the main component, with a stopper body part, which holds the rubber stopper and comprises a resin containing a COP-based resin as the main component, via the resin layers containing the respective COP-based resins as the main component; and at least the resin constituting the stopper body part contains a rubber component in an amount of not more than 30% by mass, or has, in the main chain, a molecular structure represented by general formula (1) [wherein R represents a hydrogen atom or an organic group having 1 to 20 carbon atoms; and n represents an integer equal to or greater than 1] and contains a PE-based resin in an amount of 30% by mass or less, and/or contains an a

Abstract: The present invention relates to a package, and more particularly to a package for sterile fluids, such as contrast media. More particularly the invention relates to a package comprising a container, a connecting plug and a cap. The package hence includes an integrated connection for easily transferring the content of the container of the package, e.g. to a syringe, a tube or a cartridge.

Abstract: Device and method for needle penetrating and filling a chamber with a predetermined substance, and hermetically resealing a resulting needle hole in the device by applying radiation thereto. The needle penetrable and resealable portion defines a predetermined wall thickness in an axial direction thereof, and may include a thermoplastic that substantially prevents the formation of particles released into the chamber from the needle penetrable and resealable portion during penetration by and withdrawal of the needle. Such thermoplastic may include a predetermined amount of pigment that allows the thermoplastic to substantially absorb laser radiation at a predetermined wavelength, substantially prevent the passage of radiation through the predetermined wall thickness thereof, and hermetically seal a needle aperture formed in the needle penetration region thereof in a predetermined time period.

Abstract: A system includes a cap having an opening, and a septum configured to engage with the cap. The septum includes a first portion having a first width, and a second portion having a second width smaller than the first width. The second portion is sized and shaped to be received by the opening of the cap.

Abstract: This device comprises an elastomer stopper (501) and a cap (502) suitable for covering both the neck (12) of a container and the stopper in position in this neck. The cap comprises a ring (503) provided with means (503G) for locking it to the neck and an operating member (504). The operating member (504) is fitted with at least one deformable part (506C) for transmitting a thrust load (f2) parallel to a central axis (X503) of the ring (503), between two portions (505, 506) of this member (504) or between an external material (301) and this member (504). The load transmitting part (506C) is deformable between a first configuration in which its length (L506) parallel to the central axis (X503) is a first value and a second configuration in which this parallel length is a second value that is less than the first value.

Abstract: System, apparatuses, and methods for performing automated reagent-based analysis are provided. Also provided are methods for automated attachment of a cap to a reaction receptacle, and automated removal of a cap from a capped reaction receptacle.

Abstract: A device that has a device body defining an opening at one end thereof, a storage chamber within the device body for storing multiple doses of a substance therein, and a sliding stopper, sealing engageable with the device body, through which the chamber is filled. The stopper has a body and a flexible portion, which may be in the form of a plurality of flexible members, extending therefrom. The flexible portion or members are movable between first and second positions. In the first position, during filling, the portion or members are substantially laterally extending from the stopper body and engaging the opening of the device body. Accordingly, the axial position of the stopper with respect to the device body is secured during filling of the chamber therethrough. In the second position, after filling, the portion or members are substantially axially-extending from the stopper body and disengaged from the rim or opening of the device body. Accordingly, the stopper is axially slideable through the body.

Abstract: A cap having a core structure dimensioned to receive a pipette therethrough. The cap includes two axially aligned frangible seals that are affixed to the core structure in a spaced-apart relationship. The frangible seals are constructed so that air passageways are formed between the frangible seals and a pipette tip when the pipette tip penetrates the frangible seals. The cap optionally includes a filter interposed between the first and second frangible seals.