Fluid Containers (e.g., Cells Or Cuvettes) Patents (Class 356/246)
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Patent number: 11187224Abstract: A microfluidic chip orients and isolates components in a sample fluid mixture by two-step focusing, where sheath fluids compress the sample fluid mixture in a sample input channel in one direction, such that the sample fluid mixture becomes a narrower stream bounded by the sheath fluids, and by having the sheath fluids compress the sample fluid mixture in a second direction further downstream, such that the components are compressed and oriented in a selected direction to pass through an interrogation chamber in single file formation for identification and separation by various methods. The isolation mechanism utilizes external, stacked piezoelectric actuator assemblies disposed on a microfluidic chip holder, or piezoelectric actuator assemblies on-chip, so that the actuator assemblies are triggered by an electronic signal to actuate jet chambers on either side of the sample input channel, to jet selected components in the sample input channel into one of the output channels.Type: GrantFiled: October 9, 2019Date of Patent: November 30, 2021Assignee: ABS GLOBAL, INC.Inventors: Zheng Xia, Yu Zhou, John Larsen, Guocheng Shao, Shane Peterson, Marjorie Faust
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Patent number: 11162941Abstract: An immunoassay cartridge is disclosed that can enhance the reliability of an antigen-antibody reaction while increasing a speed of an antigen-antibody reaction. An immunoassay cartridge includes a reaction chamber and a fluorescence sensor assembly. A plurality of antibodies or antigens is attached to an inner surface including a bottom surface of the reaction chamber closest to the sensor. The fluorescence sensor assembly is disposed on a bottom surface of the reaction chamber. Since the bottom surface of the reaction chamber and the upper surface of the fluorescence sensor assembly are arranged to coincide with each other, even if fluid is repeatedly moved in a first direction after the fluid moves in a second direction in the reaction chamber and then moved in the first direction, there is no obstacle in the movement of the fluid. Thus, it is possible to increase the probability of antigen-antibody reaction in the reaction chamber.Type: GrantFiled: January 29, 2018Date of Patent: November 2, 2021Assignee: OPTOLANE TECHNOLOGIES INC.Inventors: Do Young Lee, Kyung Hak Choi
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Patent number: 11150130Abstract: Aspects of the disclosure relate to a multi-pass gas cell that includes a set of two or more reflectors, an input collimating optical component, and an output focusing optical component. The input and output optical components are integrated with at least one of the two or more reflectors. For example, the input and output optical components may be integrated on opposite ends of a single one of the reflectors or may be integrated on the same end of a single reflector. The input and output optical components may further be integrated with different reflectors. In some examples, the set of reflectors and optical components may be fabricated within the same substrate.Type: GrantFiled: March 3, 2020Date of Patent: October 19, 2021Assignee: SI-WARE SYSTEMSInventors: Yasser M. Sabry, Mohammad Sakr, Bassam A. Saadany, Momen Anwar, Mohamed H. Al Haron
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Patent number: 11143638Abstract: An apparatus includes a flow cell body, a plurality of electrodes, an imaging assembly, and one or more barrier features. The flow cell body defines one or more flow channels and a plurality of wells defined as recesses in the floor of each flow channel. Each well is fluidically coupled with the corresponding flow channel. The flow cell body further defines interstitial surfaces between adjacent wells. Each well defines a corresponding depth. Each electrode is positioned in a corresponding well of the plurality of wells. The electrodes are to effect writing of polynucleotides in the wells. The imaging assembly is to capture images of polynucleotides written in the wells. The one or more barrier features are positioned in the wells, between the wells, or above the wells. The one or more barrier features contain reactions in each well, reduce diffusion between the wells, or reduce optical cross-talk between the wells.Type: GrantFiled: May 26, 2020Date of Patent: October 12, 2021Assignee: ILLUMINA, INC.Inventors: Tarun Khurana, Ali Agah, Aathavan Karunakaran, Stanley Hong, Merek Siu, Arvin Emadi, Craig Ciesla
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Patent number: 11131680Abstract: The present invention is directed to a cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, in particular a blood sample, comprising a cartridge body having at least one measurement cavity formed therein and having at least one probe element arranged in said at least one measurement cavity for performing a test on said sample liquid; and a cover being attachable on said cartridge body; wherein said cover covers at least partially said at least one measurement cavity and forms a retaining element for retaining said probe element in a predetermined position within said at least one measurement cavity. The invention is directed to a measurement system and a method for measuring viscoelastic characteristics of a sample liquid.Type: GrantFiled: July 23, 2019Date of Patent: September 28, 2021Assignee: C A Casyso GmbHInventors: Axel Schubert, Jose J. Romero-Galeano, Max Kessler
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Patent number: 11119032Abstract: An object of the present invention is to provide an optical multipass cell that is compact and low cost, does not require the installation of a cooling mechanism around the mirror, and can increase the number of reflections of laser light, and the present invention provides an optical multipass cell comprising a container (3) to which a sample gas is supplied and a pair of concave mirrors (5 and 7) arranged so as to face each other inside the container (3), a laser beam is incident into the container (3), and the laser beam is multiply reflected between the concave mirrors (5 and 7), wherein at least one convex lens (9) is arranged on the optical path of the laser beam that is multiply reflected between the pair of concave mirrors (5 and 7) so that the central axis (C2) thereof is inclined with respect to the central axis (C1) of the concave mirrors (5 and 7), and an acute angle formed by the central axis (C2) of the convex lens (9) and the central axis (C1) of the concave mirrors (5 and 7) is equal to or lesType: GrantFiled: May 22, 2019Date of Patent: September 14, 2021Assignee: TAIYO NIPPON SANSO CORPORATIONInventor: Takehiro Igarashi
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Patent number: 11112365Abstract: An optical device for determining the presence and/or concentration of analytes in a sample is presented. The optical device comprises a detector and a detection unit comprising optical path components. The detection unit has wavelength-dependent responsivity. The optical device further comprises a light source for emitting light of different respective usable wavelength ranges. The light is guidable through the optical path to the detector to generate baseline signals and response signals relative to the baseline signal indicative of the presence and/or concentration of analytes in the optical path. The intensity of the light reaching the detector is adjusted inverse to the wavelength-dependent responsivity with respect to at least two respective usable wavelength ranges so that a reduction of the ratio between the maximum baseline signal at one of the selected usable wavelength ranges and the minimum baseline signal at another of the selected usable wavelength ranges is obtained.Type: GrantFiled: March 1, 2018Date of Patent: September 7, 2021Assignee: Roche Diagnostics Operations, Inc.Inventors: Rik Harbers, Kurt Schildknecht
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Patent number: 11092519Abstract: A system for facilitating automated handling using laser ablation system is described that includes a sample generation system. In an embodiment, the sample generation system can include a sample chamber with a sample chamber body, a transmission window and a sealing member coupled to the sample chamber body, an inlet conduit extending through the sample chamber body and intersecting a sidewall of the interior space, and an outlet conduit extending through the sample chamber body and intersecting at least one of the sidewall of the interior or a lower surface of the sample chamber body; a placement system including a frame, and an actuator assembly coupled to the frame, where the actuator assembly is configured to place the sample adjacent to the sample chamber for laser ablation; and a laser configured to produce a laser beam that is propagated along a beam path to irradiate the sample.Type: GrantFiled: February 6, 2018Date of Patent: August 17, 2021Assignee: Elemental Scientific Lasers, LLCInventors: Shane Hilliard, Jay N. Wilkins, Erik B. Larsen, Robert W. Hutchinson, Ciaran J. O'Connor
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Patent number: 11080848Abstract: A diagnostic system performs disease diagnostic tests using at least an optical property modifying device and a mobile device. A user provides a biological sample from a patient to the optical property modifying device that reacts with a reagent in one or more reaction chambers of the device. The user captures one or more images of the one or more reaction chambers using an optical sensor of the mobile device. The diagnostic system can determine a quality level of the images based on factors such as skew, scale, focusing, shadowing, or white-balancing. Based on an analysis of the captured image, the diagnostic system can determine a test result of a disease diagnostic test for the patient. The diagnostic system may communicate the test result, as well as instructions for the disease diagnostic test, to the user via the mobile device.Type: GrantFiled: October 9, 2018Date of Patent: August 3, 2021Assignee: Lucira Health, Inc.Inventors: Ivan Krastev Dimov, Frank B. Myers, III, John Robert Waldeisen, Debkishore Mitra
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Patent number: 11075019Abstract: Certain embodiments of the present invention relate to a system and a method for producing a radiopharmaceutical, wherein the system is formed from and/or provides a microfluidic flow system. In certain embodiments, the system comprises a radioisotope isolation module, a radiopharmaceutical production module, a purification module and a quality control module.Type: GrantFiled: October 22, 2015Date of Patent: July 27, 2021Assignee: The University of HullInventors: Stephen James Archibald, Ping He, Nathan Joel Brown, Mark Duncan Tarn, Stephen John Haswell, Mohammad Mehdi Nasr Esfahani, Nicole Pamme, Richard Alexander
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Patent number: 11075054Abstract: A cell for use in a microscope has a pair of dies, the dies defining: a pair of slit-shaped windows disposed on opposite surfaces of the cell and arranged in perpendicular and spaced relation to one another to define a viewable volume interiorly of the cell at the region of overlap; a flow channel which includes the viewable volume and overlies and is substantially coterminous with one of the pair of slit-shaped windows; an elongate channel defined between the dies and leading towards the flow channel; and a conduit defined between the dies and coupling the elongate channel to the flow channel.Type: GrantFiled: April 12, 2019Date of Patent: July 27, 2021Inventors: Germán Sciaini, Ariel Petruk
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Patent number: 11067494Abstract: A multi-dimensional micro fluid focussing device. The device includes an apparatus for multi-dimensional micro fluid focussing. The device also includes an analyser for analysing the focused fluid. The apparatus includes a microchannel having an inlet defining a first region, a middle region and an outlet defining a second region. A first junction is formed at the intersection of the first region and the middle region. A second junction is formed at the intersection of the middle region and the second region. A first sheath positioned proximal to the first junction and a second sheath positioned at the second junction. The junctions formed, along with the positioning of the sheaths enable the multi-dimensional focusing of the fluid. The analyser includes a holder for removably retaining the apparatus. A microscope is positioned across the holder. A recording unit is coupled to the microscope.Type: GrantFiled: September 15, 2017Date of Patent: July 20, 2021Assignees: INDIAN INSTITUTE OF SCIENCE, DEPARTMENT OF BIOTECHNOLOGYInventors: Eluru Gangadhar, Sai Siva Gorthi
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Patent number: 11057599Abstract: An image analysis system includes a video camera that collects YUV color images of a liquid sample disposed between a capital and a pedestal, the color images being collected while a light source shines light through an optical beam path between the capital and the pedestal, and a processor adapted to i) obtain from the YUV color images a grayscale component image and a light scatter component image, and ii) obtain at least one binary image of the grayscale component image and at least one binary image of the light scatter component image.Type: GrantFiled: March 10, 2020Date of Patent: July 6, 2021Assignee: Thermo Electron Scientific Instruments LLCInventors: Alexander Grenov, Damian W. Ashmead, Kevin K. Kim, Francis J. Deck, Chris Xavier Kauffold
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Patent number: 11056322Abstract: A method for dry processing a substrate in a processing chamber is provided. The substrate is placed in the processing chamber. The substrate is dry processed, wherein the dry processing creates at least one gas byproduct. A concentration of the at least one gas byproduct is measured. The concentration of the at least one gas byproduct is used to determine processing rate of the substrate.Type: GrantFiled: August 3, 2017Date of Patent: July 6, 2021Assignee: Lam Research CorporationInventors: Yassine Kabouzi, Luc Albarede, Andrew D. Bailey, III, Jorge Luque, Seonkyung Lee, Thorsten Lill
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Patent number: 11041187Abstract: A digital assay for a micro RNA (miRNA) or other target analyte in a sample makes use of nanoparticles that absorb light at the resonant wavelength of a photonic crystal (PC). Such nanoparticles locally quench the resonant reflection of light from the PC when present on the surface of the PC. The nanoparticles are functionalized to specifically bind to the target analyte, and the PC surface is functionalized to specifically bind to the nanoparticles that have bound to the target analyte. The sample is exposed to the functionalized nanoparticles, and the individual nanoparticles bound to the PC surface can be identified and counted based on reduced intensity values in the reflected light from the PC. The number of bound nanoparticles that are counted in this way can be correlated to the abundance of the target analyte in the sample.Type: GrantFiled: October 25, 2018Date of Patent: June 22, 2021Assignee: The Board of Trustees of the University of IllinoisInventors: Brian T. Cunningham, Yue Zhuo, Brendan Harley, Ji Sun Choi, Thibault Marin, Yi Lu
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Patent number: 11035839Abstract: A method of determining saturate, aromatic, resin, and asphaltene (SARA) fractions of a hydrocarbon fluid sample, including: i) microfluidic mixing that forms a mixture including the hydrocarbon fluid sample and a solvent fluid that dissolves asphaltenes; ii) performing optical spectroscopy on the hydrocarbon fluid sample-solvent fluid mixture resulting from i); iii) microfluidic mixing that forms a mixture including the hydrocarbon fluid sample and a titrant fluid that precipitates asphaltenes; iv) microfluidically precipitating asphaltenes from the hydrocarbon fluid sample titrant fluid mixture resulting from iii); v) performing a microfluidic filtering operation that removes precipitated asphaltenes from the mixture resulting from iv) while outputting permeate; vi) performing optical spectroscopy on the permeate resulting from v); vii) determining an asphaltene fraction percentage of the hydrocarbon fluid sample based on the optical spectroscopy performed in ii) and vi); viii) sequentially separating saturType: GrantFiled: June 8, 2015Date of Patent: June 15, 2021Assignee: Schlumberger Technology CorporationInventors: Vincent Joseph Sieben, Farshid Mostowfi, Nejib Hamed, Alexander Stickel, Collins Obiosa-Maife
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Patent number: 11029245Abstract: A flow cell device including a spherical optical element is disclosed. The spherical lens can be sealed to the body of the flow cell device in a manner that provides external optical access to a fluid in an analysis region of a flow path through the flow cell device. The seal can be provided by an elastomer, a polymer, or a deformable metal. The disposition of the spherical lens to the flow path enables in situ optical analysis of the fluid. An optical analysis device can be removably connected to the flow cell device to provide the optical analysis. In some embodiments the optical analysis device is a portable Raman spectrometer. The flow cell device can provide a supplementary interrogation interface, and/or an on board sensor device(s) to enable multivariate analysis and/or advanced triggering.Type: GrantFiled: June 26, 2020Date of Patent: June 8, 2021Assignee: MarqMetrix, Inc.Inventors: Giora Proskurowski, Brian James Marquardt
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Patent number: 11014843Abstract: A portable remote sensing system for real-time assessments of total suspended solids (TSS) in surface waters using above-water hyperspectral measurements. The system combines a miniature high signal-to-noise ratio spectrometer coupled to a credit card-size computer, lens, rechargeable battery, GPS, display panel, and dedicated software to derive TSS from above-water spectral measurements.Type: GrantFiled: March 27, 2018Date of Patent: May 25, 2021Inventor: Roy Armstrong
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Patent number: 11002752Abstract: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a cooling, heating and fan arrangement for maintaining a predetermined optimum temperature of the samples during testing; a visual, circumferential and axial alignment system for aligning the samples within the carousel; a transfer system for transferring the samples from the carousel to the centrifuge; a balancing system of minimizing the rotational vibrations of the centrifuge; a safety system and anti-tipping design for the sample containing system; liquid dispensing arms for dispensing the buffered saline solution; and discharge ports for discharging and disposing of the liquid removed from the samples to a location external of the system.Type: GrantFiled: March 22, 2019Date of Patent: May 11, 2021Assignees: POCARED Diagnostics LTD., Battelle Memorial InstituteInventors: Gal Ingber, William G. Atterbury, Dave Holley, Thomas A. Klausing, John S. Laudo, Jason A. Schaefer, Sherwood Talbert, John Tallarico
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Patent number: 11000852Abstract: A system for use in spectral analysis procedures can include a slide and a holder for carrying the slide. The slide includes a substrate forming a plurality of wells that are recessed relative to a surface of the substrate. Each of the wells forms a sample region that is recessed by a sample depth from the surface and a trough region that is recessed by a trough depth from the surface, the trough depth being greater than the sample depth. The holder includes a body defining a cavity between a first side and a second side of the body, a port for receiving the slide into the cavity, one or more first fenestrations on the first side, and one or more second fenestrations on the second side.Type: GrantFiled: April 20, 2017Date of Patent: May 11, 2021Assignee: Protein Dynamic Solutions, Inc.Inventors: Belinda Pastrana-Rios, Jose Javier Rodriguez-Toro
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Patent number: 10996230Abstract: The present invention is directed to a cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, in particular a blood sample, comprising a cartridge body having at least one measurement cavity formed therein and having at least one probe element arranged in said at least one measurement cavity for performing a test on said sample liquid; and a cover being attachable on said cartridge body; wherein said cover covers at least partially said at least one measurement cavity and forms a retaining element for retaining said probe element in a predetermined position within said at least one measurement cavity. The invention is directed to a measurement system and a method for measuring viscoelastic characteristics of a sample liquid.Type: GrantFiled: July 23, 2019Date of Patent: May 4, 2021Assignee: C A CASYSO GMBHInventors: Axel Schubert, Jose J. Romero-Galeano, Max Kessler
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Patent number: 10976236Abstract: Light detection systems for measuring light (e.g., in a flow stream) are described. Light detection systems according to embodiments include a light scatter detector, a brightfield photodetector and an optical adjustment component configured to convey light to the light scatter detector and to the brightfield photodetector. Systems and methods for measuring light emitted by a sample (e.g., in a flow stream) and kits having a light scatter detector, a brightfield photodetector and a beam splitter component are also provided.Type: GrantFiled: March 12, 2020Date of Patent: April 13, 2021Assignee: Becton, Dickinson and CompanyInventors: Jizuo Zou, Matthew Bahr, Eric D. Diebold
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Patent number: 10969329Abstract: An ellipsometer includes: a gantry; a polarization generator and a polarization analyzer mounted in the gantry; and a focusing lens disposed on a sample on a stage, wherein the sample is an object to be measured, wherein a vertical section of the focusing lens is a semi-circle.Type: GrantFiled: March 20, 2019Date of Patent: April 6, 2021Assignee: SAMSUNG DISPLAY CO., LTD.Inventor: Yongwoon Lim
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Patent number: 10962475Abstract: A sensor including: a substrate including a first surface and a second surface opposing to each other, the first surface being recessed to form a first groove, and the substrate further including at least two through holes penetrating through the second surface and a bottom surface of the first groove; a dielectric layer disposed to cover the first surface, and opposing to the first groove; a metal layer disposed on the bottom surface of the first groove and avoiding openings of the through holes on the bottom surface of the first groove, wherein the dielectric layer, the metal layer and an interval between the dielectric layer and the metal layer form a slit optical waveguide; and a grating formed on the dielectric layer, wherein the grating is used to implement wave vector matching of an incident light with a mode of the slit optical waveguide.Type: GrantFiled: August 17, 2018Date of Patent: March 30, 2021Assignee: SUZHOU INSTITUTE OF NANO-TECH AND NANO-BIONICS(SINANO), CHINESE ACADEMY OF SCIENCESInventors: Qin Chen, Li Liang, Long Wen, Xin Hu
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Patent number: 10955334Abstract: Among other things, the present invention is related to devices and methods for improving optical analysis of a thin layer of a sample sandwiched between containing between two plates.Type: GrantFiled: December 14, 2018Date of Patent: March 23, 2021Assignee: Essenlix CorporationInventors: Stephen Chou, Wei Ding, Ji Qi, Jun Tian, Wu Chou
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Patent number: 10946373Abstract: This disclosure is directed to exemplary embodiments of systems, methods, techniques, processes, products and product components that can facilitate users making improved absorbance or fluorescence measurements in the field of spectroscopy with reduced (minimal) sample waste, and increased throughput, particularly in the study of biological sciences. A method and device for photometric measurement of liquids. The method includes the steps of: The method includes the steps of; providing a pipette tip, the pipette tip being made of an optically clear body having an outer wall and an inner wall, the inner wall defining an inner space for receiving a liquid sample, the inner space providing a cross-sectional path length for light; positioning the pipette tip between a light source and a light collector; measuring light transmission through the liquid sample; adjusting the inner space of the pipette tip to change the cross-sectional length, and measuring light transmission through the liquid sample.Type: GrantFiled: April 22, 2020Date of Patent: March 16, 2021Assignee: Beacon Technologies, LLCInventors: Dale Lee Heintzelman, John Lloyd Bowman, Rick Jackson
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Patent number: 10948505Abstract: Apparatuses and methods for washing a plurality of fluid samples are disclosed herein. In an embodiment, a system for washing a plurality of fluid samples respectively located within a plurality of cuvettes includes a rotor configured to rotate the plurality of cuvettes about an axis, a traveler mechanism located beneath the rotor, the traveler mechanism configured to move a plurality of magnets parallel to the axis of rotation of the rotor to position the plurality of magnets so that each cuvette of the plurality of cuvettes is located adjacent to at least one magnet of the plurality of magnets, and a wash system located above the rotor, the wash system configured to at least one of inject fluid into or aspirate fluid from the plurality of the cuvettes, while the plurality of magnets suspend magnetic particles located within each of the plurality of cuvettes.Type: GrantFiled: February 24, 2016Date of Patent: March 16, 2021Assignee: HYCOR Biomedical, LLCInventors: Ronald Norman Diamond, Steve Michael Gann, Eric Darnell Hall, Tae Ho Hwang, John Lewis Morton, Anatoly Moskalev, Bruce Alan Sargeant, Dennis Edwin Rieger, Marinela Gombosev, Mark David Van Cleve
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Patent number: 10935487Abstract: Systems and methods of the present disclosure are directed to detecting species within a fluid using a multi-pass absorption cell and a spectrometer. The absorption cell includes a plurality of mirrors arranged in a manner such that a detection light traverses multiple passes through the fluid within the absorption cell. In some implementations, the detection light is reflected by the plurality of mirrors to form optical paths in more than one plane. The system also includes an electronic unit configured to receive and process spectral data from the spectrometer. In some implementations, the electronic unit communicates with at least one computational unit over a communication interface to send a portion of the spectral data for processing. The electronic unit may also receive processed data from the computational unit.Type: GrantFiled: October 22, 2018Date of Patent: March 2, 2021Assignee: Duvas Technologies LimitedInventor: Craig Sawyers
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Patent number: 10914732Abstract: The invention relates to a method for quantitatively determining biological analytes in an aqueous solution in the presence of one or more functionalised surfaces, wherein the aqueous solution comprises at least one type of biological analyte and at least one type of fluorescence marker, characterised in that the quantity and/or concentration of the biological analyte or analytes is determined by measuring the fluorescence emission of the unbound fluorescence markers, as well as to a devices for carrying out said method.Type: GrantFiled: March 5, 2015Date of Patent: February 9, 2021Assignee: PAIA BIOTECH GMBHInventor: Sebastian Giehring
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Patent number: 10908054Abstract: One or more homogenizing elements are employed in a flow through, multi-detector optical measurement system. The homogenizing elements correct for problems common to multi-detector flow-through systems such as peak tailing and non-uniform sample profile within the measurement cell. The homogenizing elements include coiled inlet tubing, a flow distributor near the inlet of the cell, and a flow distributor at the outlet of the cell. This homogenization of the sample mimics plug flow within the measurement cell and enables each detector to view the same sample composition in each individual corresponding viewed sample volume. This system is particularly beneficial when performing multiangle light scattering (MALS) measurements of narrow chromatographic peaks such as those produced by ultra-high pressure liquid chromatography (UHPLC).Type: GrantFiled: September 10, 2019Date of Patent: February 2, 2021Assignee: WYATT TECHNOLOGY CORPORATIONInventors: Philip J. Wyatt, Vincent H. Hsieh, Mario Yasa, Barbara R. Maurer, David Cannell, Steven P. Trainoff
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Patent number: 10907192Abstract: A linearity standard includes a plurality of calibration solutions, each calibration solution having a different level of a reactant having a known response in a test strip and meter combination, and an electronic storage medium for storing calibration instructions and known responses for each solution of the plurality of calibration solutions.Type: GrantFiled: April 7, 2016Date of Patent: February 2, 2021Assignee: POLYMER TECHNOLOGY SYSTEMS, INC.Inventors: Gary L. Hughes, Aniruddha Patwardhan, Keith Moskowitz
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Patent number: 10859489Abstract: The present invention relates to a hand-held microfluidic detection device, comprising: —a microfluidic cell (M) having at least one chamber intended to at least contain a sample; —a support (S) comprising a housing for the removable attachment thereto of the microfluidic cell (M); —excitation light means arranged at least in part in the support (S) to side illuminate the at least one chamber of the microfluidic cell (M) to excite the sample contained therein; —an optical detector (D) configured and arranged to detect light emitted from the sample when excited with said side illumination; and —a casing (C) constituting an envelope into which at least the support (S) is housed and attached.Type: GrantFiled: July 3, 2018Date of Patent: December 8, 2020Assignees: FUNDACIÓ INSTITUT DE CIÈNCIES FOTÒNIQUES, INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS, IMAGINE OPTIC SPAIN SLInventors: Romain Quidant, Luis Miguel Fidalgo, Rafael Porcar
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Patent number: 10830691Abstract: A fluid sensor includes a housing and a thermal emitter in the housing to emit first thermal radiation into a detection volume of the housing at a first power level during a measurement interval and emit the first thermal radiation at a reduced first power level or not emit said first thermal radiation at all during an intermediate interval disposed outside of the measurement interval. The fluid sensor includes a measuring element in the detection volume to receive a radiation signal during the measurement interval. The fluid sensor includes a second thermal emitter in the housing to emit second thermal radiation at a second power level into the detection volume during the intermediate interval such that a thermal oscillation of thermal radiation in relation to an overall power level of the thermal radiation in the detection volume is at most ±50% during the measurement interval and the intermediate interval.Type: GrantFiled: April 16, 2019Date of Patent: November 10, 2020Assignee: INFINEON TECHNOLOGIES AGInventors: Christoph Glacer, Alfons Dehe, David Tumpold
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Patent number: 10809185Abstract: An object is the provision of an optical measuring device that can be carried readily due to its reduced size and that can suppress the incidence of light other than detection light upon a light receiving unit and thus can obtain a measurement result with high accuracy. The optical measuring device includes a first light guiding path forming body having therein a first light guiding path formed by a through hole extending linearly for allowing measurement light from a light source to be incident on a measuring position in which a measurement sample is disposed, and a second light guiding path forming body having therein a second light guiding path formed by a through hole extending linearly for guiding detection light having exited from the measuring position to a light receiving unit.Type: GrantFiled: March 22, 2018Date of Patent: October 20, 2020Assignee: Ushio Denki Kabushiki KaishaInventors: Shinji Taniguchi, Kyosuke Yamane, Kenichi Sabatake, Naoki Goto
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Patent number: 10793818Abstract: The purpose of the present invention is to provide a culture container capable of preventing a concave meniscus without using a jig. In order to achieve this purpose, the present invention provides a culture container (1A) provided with: a base (3) having a concave portion (4); and a water-repellent layer (5) formed on an outer edge region (411) of the bottom (41) of the concave portion (4) and the inner circumferential surface (42) of the concave portion (4). One of the surfaces of the water-repellent layer (5) is exposed to the space in the concave portion (4).Type: GrantFiled: August 19, 2016Date of Patent: October 6, 2020Assignee: TOCALO CO., LTD.Inventors: Shinichi Gomi, Kenichi Kagawa, Yusuke Yoda, Shinya Miki, Tatsuya Hamaguchi
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Patent number: 10792657Abstract: This invention provides microfluidic devices with graphene films as architectural materials and methods of fabrication and use thereof in X-ray analysis.Type: GrantFiled: December 4, 2017Date of Patent: October 6, 2020Assignee: University of MassachusettsInventors: Shuo Sui, Yuxi Wang, Christos Dimitrakopoulos, Sarah L. Perry
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Patent number: 10788414Abstract: A cover film for testing which can be well fixed to a substrate having a groove and with which a material that constitutes an adhesive layer does not invade into the groove and a specimen can be easily stored in the groove, providing a testing member including the cover film for testing, and providing a method of manufacturing the cover film for testing. The cover film for testing comprises a base material, a hydrophilic coating layer laminated on a surface of the base material, and an adhesive layer partially laminated on a surface of the hydrophilic coating layer opposite to the base material, whereby the cover film for testing has a region in which the adhesive layer is absent and the hydrophilic coating layer is exposed.Type: GrantFiled: March 19, 2018Date of Patent: September 29, 2020Assignee: LINTEC CORPORATIONInventors: Hiroki Hoshino, Masaya Todaka, Tomoo Orui
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Patent number: 10732113Abstract: An apparatus for imaging a includes an light source for illuminating the sample simultaneously in a line focus or an array of foci; and a sensor for detecting photons emitted or scattered from the sample simultaneously in an array of fields of view. An array of sub-observation volumes in the sample, from which photons are emitted or scattered during imaging, is defined by the volumes in space where the line focus or array of foci from the light source overlap with the corresponding array of field of views of the sensor. A cylindrical sample holder holds the sample at a surface and is rotatably arranged such that at least a portion of the sample can be transported through at least one of the sub-observation volumes by rotating the sample holder. The apparatus can be used in a high-throughput method of imaging.Type: GrantFiled: February 23, 2017Date of Patent: August 4, 2020Assignee: SINGLE TECHNOLOGIES ABInventors: Raoul Stubbe, Bengt Sahlgren, Johan Strömqvist
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Patent number: 10731123Abstract: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria, in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optics cup or cuvette having a tapered surface; wherein the walls are angled to allow for better coating and better striations of the light. The system may utilize the disposable cartridge in the sample processor and the optics cup or cuvette in the optical analyzer, wherein the optics cup also has a floor in the shape of an inverted arch.Type: GrantFiled: November 28, 2017Date of Patent: August 4, 2020Assignee: POCARED Diagnostics LTD.Inventors: Gal Ingber, Martha J. Rogers
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Patent number: 10716647Abstract: Systems for generating in-focus color images are provided. Related methods and devices are also provided.Type: GrantFiled: July 8, 2019Date of Patent: July 21, 2020Assignee: Align Technology, Inc.Inventor: Yosi Moalem
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Patent number: 10710080Abstract: Provided is a container for PCR enabling cell observation and a PCR treatment with a single container. In the container for PCR, a bottom surface 17a of an inside is flat, a shape of the bottom surface is a circular shape or a polygonal shape with four or more sides, a size of the bottom surface 17a is large so that a diameter L of an approximated circle circumscribing the bottom surface 17a is 0.05 mm? or more and 1 mm? or less, and an angle of an angle ? on a side surface side formed between a side surface 17b adjacent to the bottom surface 17a and the bottom surface 17a is 50° or more and 80° or less.Type: GrantFiled: August 31, 2018Date of Patent: July 14, 2020Assignee: FUJIFILM CorporationInventor: Yasuhisa Kaneko
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Patent number: 10697885Abstract: A flow cell device including a spherical optical element is disclosed. The spherical lens can be sealed to the body of the flow cell device in a manner that provides external optical access to a fluid in an analysis region of a flow path through the flow cell device. The seal can be provided by an elastomer, a polymer, or a deformable metal. The disposition of the spherical lens to the flow path enables in situ optical analysis of the fluid. An optical analysis device can be removably connected to the flow cell device to provide the optical analysis. In some embodiments the optical analysis device is a portable Raman spectrometer. The flow cell device can provide a supplementary interrogation interface, and/or an on board sensor device(s) to enable multivariate analysis and/or advanced triggering.Type: GrantFiled: February 15, 2019Date of Patent: June 30, 2020Assignee: MarqMetrix, Inc.Inventors: Giora Proskurowski, Brian James Marquardt
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Patent number: 10690657Abstract: A novel vial for holding a segment of epithelial tissue is provided. The vial is easy to assemble and allows horizontal alignment of the tissue sample. A device comprising the vial, to methods for generating the device, and to a multitude of said devices which allow medium throughput measurements of absorption, transport and/or secretion across an epithelial tissue are also provided.Type: GrantFiled: October 29, 2013Date of Patent: June 23, 2020Assignee: NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNOInventors: Helena Maria Wortelboer, Dimitri Grossouw
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Patent number: 10690593Abstract: The present invention is a sample analyzer 100 that makes it possible to accurately analyze a sample even when the sample is such as one in a state where particles are cross-linked, or one containing foreign bodies and that calculates an autocorrelation function from a detection signal obtained by irradiating a sample with inspection light L1, and from the autocorrelation function, analyzes the sample. In addition, the sample analyzer 100 includes: an autocorrelation function determination part 53 that determines whether or not the displacement amount of an autocorrelation function serving as a comparison target from an autocorrelation function serving as a reference is within a predetermined range; and a sample analysis part 54 that analyzes the sample with use of an autocorrelation function of which the displacement amount is determined by the autocorrelation function determination part 53 to be within the predetermined range.Type: GrantFiled: November 8, 2016Date of Patent: June 23, 2020Assignee: HORIBA, LTD.Inventor: Tetsuji Yamaguchi
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Patent number: 10684169Abstract: The present invention relates to an optical analysis device using a multi-light source structure, which allows acquisition of an optimized measurement result by adjusting the number of light sources depending on a concentration of an object to be measured, such as ocean spilled oil, etc., and a method therefor.Type: GrantFiled: September 8, 2017Date of Patent: June 16, 2020Assignee: Korea Institute of Ocean Science & TechnologyInventors: Sang Woo Oh, Moon Jin Lee
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Patent number: 10677724Abstract: A sample testing apparatus is disclosed for use in optical transmission analysis of fluid samples such as oils or engine oils. The apparatus comprises a transmission cell comprising first and second fixed walls (1,2) and a movable window (3) that is moved with respect to the first and second walls in and out of a test region (6). When the movable window (3) is moved into the test region (6) an optical path through a fluid sample in the cell is defined, the optical path through the sample comprising a portion extending through the or each gap (L1,L2) between a one of the first and second fixed walls (1,2) and the at least a portion of the first movable window (3). Also disclosed are methods of using the sample testing apparatus and methods of performing a measurement for use in optical transmission analysis of a fluid sample.Type: GrantFiled: April 19, 2018Date of Patent: June 9, 2020Assignee: Parker Hannifin Manufacturing (UK) Ltd.Inventors: Anthony Peter Foord, Stuart Lucas Lunt
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Patent number: 10677710Abstract: An analyzer of a component in a sample fluid includes an optical source and an optical detector defining a beam path of a beam, wherein the optical source emits the beam and the optical detector measures the beam after partial absorption by the sample fluid, a fluid flow cell disposed on the beam path defining an interrogation region in the a fluid flow cell in which the optical beam interacts with the sample fluid and a reference fluid; and wherein the sample fluid and the reference fluid are in laminar flow, and a scanning system that scans the beam relative to the laminar flow within the fluid flow cell, wherein the scanning system scans the beam relative to both the sample fluid and the reference fluid.Type: GrantFiled: November 29, 2018Date of Patent: June 9, 2020Assignee: 1087 SYSTEMS, INC.Inventor: Matthias Wagner
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Patent number: 10670516Abstract: Provided is an optical concentration sensor protective casing, including an outer cover and a bubble isolation shield. The bubble isolation shield is embedded on the inner side of the outer cover. The outer cover is provided with a convection hole. The bubble isolation shield is provided with a liquid intake hole. Further provided is an optical concentration testing device including the protective casing.Type: GrantFiled: February 26, 2016Date of Patent: June 2, 2020Assignee: DONGGUAN ZHENGYANG ELECTRONIC MECHANICAL CO., LTD.Inventor: Yi-Hsin Ku
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Patent number: 10639626Abstract: Provided in part herein are multiple-tube devices that contain a region of reduced wall thickness, which devices facilitate biological fluid processing and analysis. Also provided in part herein are methods of manufacturing and using such devices.Type: GrantFiled: November 6, 2014Date of Patent: May 5, 2020Assignee: BIOTIX, INC.Inventors: Arta Motadel, Peter Paul Blaszcak
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Patent number: 10639632Abstract: A disposable cartridge may have a fluid analysis chip for receiving a fluid to be analyzed. The fluid analysis chip may be attached to a fluid preparation unit of the disposable cartridge and may include a base layer. The fluid analysis chip may also include a spacer layer disposed over the base layer, the spacer layer including a microchannel formed therein, the microchannel being configured to guide a flow of the fluid to be analyzed within the fluid analysis chip. The fluid analysis chip may also include a cap layer disposed over the spacer layer, the cap layer including an inlet and an outlet for establishing fluid communication with the microchannel included in the spacer layer, and an interface layer disposed over the cap layer, the interface layer being configured to attach the fluid analysis chip to the fluid preparation unit of the disposable cartridge.Type: GrantFiled: February 1, 2017Date of Patent: May 5, 2020Assignee: Pixcell Medical Technologies, Ltd.Inventors: Avishay Bransky, Liron Shlomo, Nir Rotem