Abstract: Measuring device of the present invention includes a plurality of measuring sites for generating a plurality of optical paths and various dilutions. The range for concentration measurement and the measurement accuracy are enhanced due to the plurality of optical path length, and the interference on the measurement ranges and results caused by the concentration or the turbidity of suspended solid is reduced and removed by water sample dilution, and thus the characteristic wavelengths of the components in the water are measured. Next, the information of spectrum database is used to determine the ingredients which may exist in the water (qualitative analysis), and UV-VIS-NIR absorbance spectrum analysis is used to obtain the concentration of the respective ingredients in the water at the same time (quantitative analysis).

Abstract: Among other things, a first surface is configured to receive a sample and is to be used in a microscopy device. There is a second surface to be moved into a predefined position relative to the first surface to form a sample space that is between the first surface and the second surface and contains at least part of the sample. There is a mechanism configured to move the second surface from an initial position into the predefined position to form the sample space. When the sample is in place on the first surface, the motion of the second surface includes a trajectory that is not solely a linear motion of the second surface towards the first surface.

Abstract: In a particle analyzing apparatus including a capillary for passing through a fluid containing particles to be analyzed, an optical system is employed to collect fluorescent light emitted from particles or substances labeled to the particles with improved collection efficiency preserving resolution of the instrument. The optical system may include a first collection lens attached to the capillary and a first reflection element arranged adjacent to the first collection lens configured to reflect fluorescent light of one or more wavelengths. The optical system may include a second collection lens attached to the capillary and a second reflection element arranged adjacent to the second collection lens configured to reflect fluorescent light of one or more wavelengths.

Abstract: A method and apparatus to calculate the optical density of a fluid (110) traveling through a narrow gap (30) with a set width. Typically, a densitometer employs a light source (10) that is configured to transmit light across the gap and a detector, opposite the light source (10), configured to detect light transmitted from the light source, across the gap, for calculating the optical density of the fluid. The apparatus and method further include a transparent element (120), the transparent element part of a set of replaceable transparent elements, each replaceable transparent element having a particular width, the width less than the width of the gap. Typically, the transparent element is moved into the gap between the light source and the detector to narrow the effective sampling width of the gap for calculating the optical density of the fluid. In some examples, the transparent element is further configured to rotate in the gap to enhance the flow of the fluid through the gap.

Abstract: A cuvette comprising a cuvette wall for limiting a sample reception space for receiving a fluid sample is disclosed. The cuvette wall is adapted to allow a traversal of measurement radiation through the fluid sample situated within the sample reception space. An information presenter is fixed at the cuvette wall. The information presenter wirelessly provides data to be transferred to an external data reception module. The data to be transferred relates to the cuvette. Further, an optical measurement apparatus is described.

Abstract: Methods and apparatus for downhole fluid analysis are disclosed. An example method includes obtaining first measurements from a first spectrometer and a second spectrometer when a light source is on, obtaining second measurements from the first spectrometer and the second spectrometer when the light source is off and calibrating the first spectrometer based on the first measurements and the second measurements.

Abstract: Disclosed are apparatus, kits, methods, and systems that include a radiation source configured to direct radiation to a sample; a detector configured to measure radiation from the sample; an electronic processor configured to determine information about the sample based on the measured radiation; a housing enclosing the source, the detector, and the electronic processor, the housing having a hand-held form factor; an arm configured to maintain a separation between the sample and the housing, the arm including a first end configured to connect to the housing and a second end configured to contact the sample; and a layer positioned on the second end of the arm, the layer being configured to contact the sample and to transmit at least a portion of the radiation from the sample to the detector.

Abstract: Aspects of the present disclosure include a flow cell nozzle configured to propagate light emitted by a sample in a flow stream upstream by total internal reflectance. Flow cell nozzles according to certain embodiments include a nozzle chamber having a proximal end and a distal end and a nozzle orifice positioned at the distal end of the nozzle chamber where the flow cell nozzle is configured to propagate light emitted from a sample in the flow stream upstream through the flow cell nozzle orifice by total internal reflectance toward the proximal end of the nozzle chamber. Systems and methods employing the subject flow cell nozzles are also provided.

Abstract: A probe having a probe head in which is formed an opening for receiving a sample to be analyzed, the head comprising a pair of optical interfaces disposed at an opposing inner surface of the opening to delimit a path for optical radiation through the opening, wherein one of the pair of optical interfaces comprises a transparent element adapted to permit optical radiation in one or more wavelength regions of interest to travel between the probe head and the opening, the optical probe comprising a movable diaphragm in which one of the pair of optical interfaces is located for movement therewith and an actuator operably connected to the diaphragm to control its movement so as to vary the path length wherein the probe head comprises a hinge system cooperable with the actuator to move the optical interface in the movable diaphragm in an arc to vary the path length.

Abstract: Example methods and apparatus for obtaining suspended particle information are disclosed. A disclosed example method includes emitting light from a light source, dividing the light source into a first path and a second path, and directing the first path to a first container comprising a plurality of particles in a suspension material. The example method also includes directing the second path to a second container containing a suspension material devoid of particles, retrieving a first transmission value of the first path through the first container, and retrieving a second transmission value of the second path through the second container.

Abstract: A laser emitting section 59A and a laser receiving section 59B for measuring an oxygen concentration are provided on two sides of an inspection area so as to be moved toward and away from a bag-shaped container 1. Gas-filled chambers 61 provided on the end faces of the laser emitting section 59A and the laser receiving section 59B are brought into contact with the gas phase portion of the container 1 to keep a constant thickness of the gas phase portion. A tilting device 81 is provided to press the container 1, which is held by a container holder 16, from both sides with a container pressing member 88 and tilts the container 1 in a vertical plane. When an oxygen concentration is measured, the tilting device 81 tilts the bag-shaped container 1 to measure the gas phase portion at the shoulders of the container 1.

Abstract: The present invention relates to a method and system for repairing and refurbishing a microplate reader of the Flipr type which has a water cooled argon laser light source. The old laser is removed and replaced with a high power (300 to 500 mW) air cooled solid state laser as a replacement place on its own support and focused and wired to replace the old laser. The new product operates at lower power consumption yet provides accurate measurements.

Abstract: An environmental cell assembly for use in microscopy and spectroscopy applications, including: an environmentally sealed body assembly configured to selectively hold and contain a sample; a plurality of ports manufactured into one or more surfaces of the body assembly for one or more of evacuating the body assembly and injecting a gas into or removing a gas from the body assembly; a port manufactured into a surface of the body assembly for receiving a translating stage configured to move the sample within the body assembly; and a port manufactured into a surface of the body assembly for receiving one or more lenses utilized in a microscopy or spectroscopy application; wherein the one or more lenses are disposed adjacent the sample without intervening structures disposed there between. The cell assembly also includes a port manufactured into a surface of the body assembly for retaining a window and providing visualization of the sample.

Abstract: Methods and apparatuses for measuring a light absorbance are provided. The method measures light absorbance of at least one detection chamber of a microfluidic device, including the detection chamber and at least one reference chamber. The detection chamber may accommodate a test subject. The method includes detecting a plurality of reference transmitted light intensities for the at least one reference chamber and estimating a value between the plurality of reference transmitted light intensities through nonlinear approximation. The estimated value is then applied to light absorbance measurement of the detection chamber to reduce a light absorbance error of the detection chamber.

Abstract: The present disclosure relates generally to systems and methods for determining the absorption coefficient and the optical density of a fluid as they relate to the wavelength of incident radiation. Specifically, ultraviolet light-emitting diodes (UV LEDs) or the like that emit ultraviolet (UV) radiation or the like are used as sources for irradiating the interior of an integrating chamber that is designed to increase the path length of the radiation through the fluid, thus enhancing the detection limits of the absorption coefficient and the optical density according to Beer's Law.

Abstract: A portable, tabletop fluid sampling device simplifies spectral analysis to produce an accurate but inexpensive chromatic fingerprint for fluid samples. In one embodiment, the sampling device uses an array of variable wavelength LED emitters and photodiode detectors to measure Rayleigh scattering of electromagnetic energy from the fluid sample contained in a cuvette. Either the fluid itself, or particles suspended in the fluid can then be identified by performing spectral pattern matching to compare results of a spectral scan against a library of known spectra. A wide range of applications include substance identification, security screening, authentication, quality control, and medical diagnostics.

Abstract: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optical cup or cuvette having a tapered surface; wherein the walls are angled to allow for better coating and better striations of the light, an optics system including an optical reader and a thermal controller; an optical analyzer; a cooling system; and an improved spectrometer. The system may utilize the disposable cartridge in the sample processor and the optical cup or cuvette in the optical analyzer.

Abstract: An absorption cell for microfluidic chemical analysis made from tinted or coloured polymers, for example polymethylmethacrylate (PMMA), in which microfluidic channels are cut. Light is coupled into the absorption cell via two windows (typically 200 um thick) that are retained at either end of the channel. Absorption is measured using a light source, such as a light emitting diode (LED) and a photodiode butted against the windows. Spurious scattered and/or reflected light is absorbed by the coloured polymer over the length of the measurement cell, while very little light loss occurs at the coupling windows.

Abstract: A flow cell module for use in a liquid sample analyzer includes a module housing, a liquid core waveguide mounted in the module housing to receive a flow of a liquid sample from a liquid sample source, an input optical fiber disposed in the module housing to transmit radiation from a radiation source to the liquid core waveguide, an input termination located on an input end of the input optical fiber, a first kinematic connection mechanism operative to bias the input termination in a first direction along a first axis while permitting displacement of the input termination in a first opposing direction along the first axis, and a second kinematic connection mechanism operative to bias the input termination in a second direction along a second axis while permitting displacement of the input termination in a second opposing direction along the second axis. The second axis is transverse to the first axis.

Abstract: An optical blood monitoring system for blocking unwanted light from reaching sensors in a sensor clip assembly fastened to a blood chamber connected in an extracorporeal blood treatment system. The sensor clip assembly includes opposing heads with LED emitters and photodetectors. In one embodiment, lenses in the heads are surrounded by shrouds extending from the lenses so that when the sensor clip assembly is fastened to the blood chamber the shrouds block unwanted light from reaching the photodetectors. Either alternatively or as a complement to the shrouds, the blood chamber includes an opaque portion or a portion colored to attenuate particular wavelengths of light to further enhance the overall ability of the blood chamber and sensor clip assembly to block unwanted light from reaching the photodetectors.

Abstract: A modular optical sensor system for fluid media has a measuring module which includes an exchangeable fluid chamber and an exchangeable optic holder. The fluid chamber has an inlet and an outlet as well as a measurement space for the fluid medium. The optic holder has at least one optical transmitter and at least one optical receiver. The optic holder is inserted within the measuring module relative to the fluid chamber in such a way that the radiation emitted by the optical transmitter traverses the measurement space for the fluid medium in the fluid chamber and impinges on the optical receiver.

Abstract: A method for forming a nanostructure penetrating a layer and the device made thereof is disclosed. In one aspect, the device has a substrate, a layer present thereon, and a nanostructure penetrating the layer. The nanostructure defines a nanoscale passageway through which a molecule to be analyzed can pass through. The nanostructure has, in cross-sectional view, a substantially triangular shape. This shape is particularly achieved by growth of an epitaxial layer having crystal facets defining tilted sidewalls of the nanostructure. It is highly suitably for use for optical characterization of molecular structure, particularly with surface plasmon enhanced transmission spectroscopy.

Abstract: Characteristics of a chemical or biological sample are detected using an approach involving light detection. According to an example embodiment of the present invention, an assaying arrangement including a light detector is adapted to detect light from a sample, such as a biological material. A signal corresponding to the detected light is used to characterize the sample, for example, by detecting a light-related property thereof. In one implementation, the assaying arrangement includes integrated circuitry having a light detector and a programmable processor, with the light detector generating a signal corresponding to the light and sending the signal to the processor. The processor provides an output corresponding to the signal and indicative of a characteristic of the sample.

Abstract: A mixing bag for use in bioprocessing in which a fluid is received and agitated using an internal fluid-agitating element driven by an external motive device is disclosed. The bag may include an integral sparger and sensor receiver. Related methods are also disclosed.

Abstract: A flow cell module for use in a liquid sample analyzer includes a module housing, a liquid core waveguide mounted in the module housing to receive a flow of a liquid sample from a liquid sample source, an input optical fiber disposed in the module housing to transmit radiation from a radiation source to the liquid core waveguide, an input termination located on an input end of the input optical fiber, a first kinematic connection mechanism operative to bias the input termination in a first direction along a first axis while permitting displacement of the input termination in a first opposing direction along the first axis, and a second kinematic connection mechanism operative to bias the input termination in a second direction along a second axis while permitting displacement of the input termination in a second opposing direction along the second axis. The second axis is transverse to the first axis.

Abstract: A method and apparatus for detecting trace gas concentrations in the atmosphere. An absorption signal is provided that includes collected sunlight that has undergone absorption by a trace gas. The absorption signal is mixed with laser light at a nearby frequency to the absorption signal. An amplitude of a resulting RF signal is proportional to the concentration of the trace gas.

Abstract: An optical measurement device is adapted to measure characteristics of a measurement targeted fluid based on a transmitted inspection light. The device comprises a cell having an internal space for accommodating the measurement targeted fluid to flow therein and having a pair of opposing through holes for transmitting the inspection light, each of the through holes sealed with a transparent member. The device includes a projection optical system member having a port for projecting the inspection light and a light-receiving optical system member having a port for receiving the inspection light transmitted through the internal space. A base member is provided for supporting the cell, the projection optical system member, and the light-receiving optical system member in a configuration with gaps between the cell and the respective optical system members to accommodate movement in a predetermined range along a direction perpendicular to an optical axis of the inspection light.

Abstract: Micro cuvette assembly for examining biological samples has a first partial plate with one or more first cuvette surfaces and a second partial plate opposite the first and which also has one or more second cuvette surfaces. In an active position of the assembly, the second cuvette surfaces are arranged parallel and in register with the first cuvette surfaces and are spaced apart from the first cuvette surfaces whereby one or more micro cuvettes are formed. The first and second partial plates also have openings arranged in register with the cuvette surfaces and transparent bodies are provided as the cuvette surfaces. The first and second plates are completely penetrated by these openings and the transparent bodies are manufactured from a different material than the partial plates and span the openings close to a first surface of the partial plates.

Abstract: A sample detection apparatus (200) for detecting a fluidic sample flowing through a first flow cell (202) and flowing through a second flow cell (204) of a sample separation system (10), wherein the first flow cell (202) has a first path length (D) and the second flow cell (204) has a second path length (d) being smaller than the first path length (D), wherein the sample detection apparatus (200) comprises a data determining unit (206) configured for determining first data indicative of a first relation between a detection signal intensity and a concentration of the fluidic sample in the first flow cell (202), and configured for determining second data indicative of a second relation between a detection signal intensity and the concentration of the fluidic sample in the second flow cell (204), and a data combining unit (208) configured for combining the first data and the second data in accordance with a continuous weighting function to thereby derive a weighted relation between detection signal intensity and

Abstract: A system and method for the in-line analysis of protein-containing compositions for protein denaturation. The system and method employ providing a protein-containing composition in a container that can be directly used in an analytical method for evaluating the denaturation of a protein. The container can be directly employed in an analytical technique such as UV spectroscopy, circular dichroism, etc.

Abstract: Reference cell (8) for use with a fiber optic probe (1) comprising a base wall (11), upstanding walls (12) each having an optical window (13, 15), and a top wall (14) having a further optical window (16) adapted to allow light to pass to and from a fiber optic probe. The base wall (11) comprises a reflector (19) which reflects incident light from the fiber optic probe back to said probe (1). The top wall (14) has an attachment for receiving an emitting and a receiving end of a fiber optic probe (1). The cell (8) allows use of standard fiber optic probe (1) with other optical equipment when the path length and the probe optical characteristics require validation to international standards. The calibration of the probe (1) is analogous to calibration of laboratory spectrophotometers and can therefore be validated. The device (8) enables probes (1) to be used for applications where precision and accuracy are essential.

Abstract: A method and a particle analyzer are provided for determining a particle size distribution of a liquid sample including particles of a lower size range, particles of an intermediate size range, and particles of an upper size range. A dark-field image frame is captured in which the particles of the lower size range and the particles of the intermediate size range are resolved, and a bright-field image frame is captured in which the particles of the intermediate size range and the particles of the upper size range are resolved. Absolute sizes of the particles of the intermediate size range and the particles of the upper size range are determined from the bright-field image frame. Calibrated sizes of the particles of the lower size range are determined from the dark-field image frame by using the particles of the intermediate size range as internal calibration standards.

Abstract: According to embodiments of the present invention, an optical device is provided. The optical device includes an optical fiber comprising a core for propagation of light and a cladding surrounding the core, and at least one microchannel defined in the optical fiber extending at least partially through the cladding, wherein the at least one microchannel has a concave-shaped surface arranged to interact with an optical field of the light. According to further embodiments of the present invention, a method of forming an optical device and a method for determining a parameter of a fluid are also provided.

Abstract: Substrates and methods for in vitro determination of sunscreen protection factors (SPF) are disclosed.

Abstract: In one embodiment, a block for a physics package of an atomic sensor is provided. The block comprises one or more sections of optically transparent material defining a vacuum sealed chamber, and including a plurality of transmissive and reflective surfaces to define a plurality of light paths intersecting the vacuum sealed chamber. The one or more sections of optically transparent material include a first monolithic section defining at least a portion of the vacuum sealed chamber. The first monolithic section includes a first portion disposed across a first light path of the plurality of light paths such that light in the first light path is incident on the first portion of the first monolithic section.

Abstract: A device, system and method to measure an optical characteristic of a fluid, the device including a plurality of components consecutively arranged and coupled together via quasi kinematic or kinematic coupling. The consecutively arranged components define a void within the device. The void encloses a measuring set-up for measuring at least one optical characteristic of a fluid passing through a gap. The gap is located at an intersection between an optical path of the measuring set-up and a flow path of the fluid.

Abstract: A medical fluid delivery system includes a medical fluid delivery machine including a light source configured to generate a light beam; a polarizer configured to receive the light beam and to allow a portion of the light beam within the medical fluid to be transmitted through the polarizer, a photodetector to provide a measurement of an intensity of the light beam transmitted through a medical fluid and the polarizer; a medical fluid cassette operating with the medical fluid machine to pump the medical fluid, the medical fluid cassette loaded onto the medical fluid delivery machine such that the light source resides on a first side of the cassette and the photodetector resides on a second side of the cassette; and a computer configured to use the measurement of the intensity to determine whether the medical fluid can be delivered to a patient.

Abstract: In various embodiments of the invention, a unique construction for Light Emitting Diodes (LEDs) with at least one luminescent rod and extracting optical elements used to generate a variety of high brightness light sources with different emission spectra. In an embodiment of the invention, forced air cooling is used to cool the luminescent rod. In an embodiment of the invention, totally internal reflected light can be redirected outward and refocused. In another embodiment of the invention, light emitted by the luminescent rod is out-coupled for use in a variety of applications.

Abstract: A method for forming a nanostructure penetrating a layer and the device made thereof is disclosed. In one aspect, the device has a substrate, a layer present thereon, and a nanostructure penetrating the layer. The nanostructure defines a nanoscale passageway through which a molecule to be analyzed can pass through. The nanostructure has, in cross-sectional view, a substantially triangular shape. This shape is particularly achieved by growth of an epitaxial layer having crystal facets defining tilted sidewalls of the nanostructure. It is highly suitably for use for optical characterization of molecular structure, particularly with surface plasmon enhanced transmission spectroscopy.

Abstract: In a case of generating a main body of an analysis tool and a micro flow path chip as separate components, to obtain an accurate sample analysis result and to accurately adjust fluid temperature inside the micro flow path chip without damaging an analytical light receiving section of the micro flow path chip. In analysis tool body (10) that detachably holds micro flow path chip (30) in a fixed manner, notch section (21) is formed in mount surface (13) onto which micro flow path chip (30) is to be mounted. Notch section (21) is formed in a predetermined range including a part corresponding to optical path L of light emitted from a lens of optical unit (60) in a state where analysis tool (1) is arranged on heat block (50).

Abstract: The invention is a microplate mounting system for mounting a microplate relative to an optical reader to control an angle of incidence of an interrogation beam at the microplate and includes a reference plane with at least one set of mount features that engage one or both of the bottom of the microplate and the skirt of the and a first positioning mechanism that provides a reversible and predetermined separation in the z direction between a plane formed by the bottom of the microplate and the reader, to control the angle of incidence of the interrogation beam at the microplate by reversibly controlling the relative positioning of the microplate in the z direction through the engagement between the bottom and/or skirt of the microplate and the at least one set of mount features.

Abstract: Relates to a micro cuvette assembly (1), comprising a first partial plate (2) with one or more first cuvette surfaces (3) and a second partial plate (4) which is arrangeable relative to the first partial plate and has at least one or more second cuvette surfaces (5) which, in an active position of the micro cuvette assembly (1), are arranged in register plane-parallel to the first cuvette surfaces (3) and spaced apart by a distance (6), thus forming, in the active position of the micro cuvette assembly (1), one or more micro cuvettes (7) in which a liquid volume (8) applied previously to one of the cuvette surfaces (3,5) is held between these two cuvette surfaces (3,5).

Abstract: In a particle analyzing apparatus including a capillary for passing through a fluid containing particles to be analyzed, an optical system is employed to collect fluorescent light emitted from particles or substances labeled to the particles with improved collection efficiency preserving resolution of the instrument. The optical system may include a first collection lens attached to the capillary and a first reflection element arranged adjacent to the first collection lens configured to reflect fluorescent light of one or more wavelengths. The optical system may include a second collection lens attached to the capillary and a second reflection element arranged adjacent to the second collection lens configured to reflect fluorescent light of one or more wavelengths.

Abstract: An apparatus for aligning a capillary column with one or more excitation fibers and with one or more optical lens elements for Capillary Electrophoresis. The apparatus includes two identical blocks having a plurality of grooves for positioning and aligning the capillary column with the one or more excitation fibers, and a plurality of lens seats for optically coupling the lens element with the capillary column. Each block includes a male and female part for mating the two identical blocks together.

Abstract: An optical waveguide is provided comprising a non-solid core layer surrounded by a solid-state material, wherein light can be transmitted with low loss through the non-solid core layer. A vapor reservoir is in communication with the optical waveguide. One implementation of the invention employs a monolithically integrated vapor cell, e.g., an alkali vapor cell, using anti-resonant reflecting optical waveguides, or ARROW waveguides, on a substrate.

Abstract: The invention concerns a sample chamber used for monitoring the concentrations of components of additives in a printing process liquid for maintaining predetermined desired concentrations of components of additives in a printing process liquid, wherein the actual concentrations of components are determined followed by redosing of measured components to a predetermined desired concentration.

Abstract: A method of detecting a level of anesthesia agent in an anesthesia vaporizer is disclosed. The anesthesia agent forms a column of liquid within an external indicator; the method projects a beam of light into the external indicator. The method further receives the beam of light after the beam of light has traveled through the column of liquid, and detects when the level of anesthesia agent drops below a predetermined level.

Abstract: An automatic optical measurement system (100) is provided. The measurement system (100) includes a sample vial (10) and an automatic optical measurement apparatus (90) configured to receive the sample vial (10). The automatic optical measurement apparatus (90) is configured to detect a presence of the sample vial (10) in the automatic optical measurement apparatus (90) and measure a light intensity of light substantially passing through the sample vial (10) if the sample vial (10) is present. The measured light intensity is related to sample material properties of a sample material within the sample vial (10).

Abstract: A solution sample holding method between two light-transmitting plate-like members for measuring light passing through a minute amount of solution sample, comprises a dripping step and a covering step. The dripping step is to drip a minute amount of solution sample in a drip area of a sample mounting face of a first light-transmitting member. The sample mounting face also includes a liquid-repellent area surrounding the drip area. The covering step is to cover the solution sample with a second light-transmitting member and to maintain a predetermined distance between the first light-transmitting member and the second light-transmitting member. The liquid-repellent area of the sample mounting face is covered with a liquid-repellent substance. The minute amount of solution sample is held in contact with the two light-transmitting members.

Abstract: A concentration measuring device for determining a concentration of gas or particles in a measurement volume includes at least one housing having an opening for communication with the measurement volume, a light source for transmitting measurement light through the housing into the measurement volume, a light receiver for receiving the measurement light after its passage through the measurement volume and an evaluation unit which is designed for determining the concentration of gas or particles from the measurement light received at the light receiver. In accordance with the invention at least one body of solid material is arranged in the at least one housing such that the measurement light path largely passes through the at least one solid body within the housing, with the portion of the measurement light path within the at least one housing not passing through the at least one solid body having a specified total length.